at Osstivia | NEW COPE RELEASED

[hopelessromanticc]

The looksmax community has just become a complete cesspit of grifters and scammers and today I just found what the next grift is. Theres this chemical called osstivia which is supposed to “grow bone” made by ossialabs (not even a real lab just some curry in their basement dropshipping some random slop). If you go on their TikTok you won’t find any actual scientific studies or peer reviewed papers all ull find is some clips of them mixing random chemicals in a bottle and then throwing up images of random pathways and molecules without even explaining how osstivia is even supposed to in mechanism interact with those pathways and how that would even lead to bone growth. I went into their discord and ask their moderators to show how it’s supposed to grow bone and the best they can say is that it has molecules which can effect wnt catenin and other pathways. Little do the retards know that any fucking pill that effects density is going to effect bmp or wnt catenin Not to mention the active ingredient in osstivia doesn’t even have testing in humans and all their studies are based off of animal studies and even in the animal studies there was no morphology change all that happened is there was a slight bone density increase jfl
Idk how people put out this bs snake oil and anyone believes it just because they pretend to know what their talking about

It’s a Game of genetics boyo

 

[Orka]

The looksmax community has just become a complete cesspit of grifters and scammers and today I just found what the next grift is. Theres this chemical called osstivia which is supposed to “grow bone” made by ossialabs (not even a real lab just some curry in their basement dropshipping some random slop). If you go on their TikTok you won’t find any actual scientific studies or peer reviewed papers all ull find is some clips of them mixing random chemicals in a bottle and then throwing up images of random pathways and molecules without even explaining how osstivia is even supposed to in mechanism interact with those pathways and how that would even lead to bone growth. I went into their discord and ask their moderators to show how it’s supposed to grow bone and the best they can say is that it has molecules which can effect wnt catenin and other pathways. Little do the retards know that any fucking pill that effects density is going to effect bmp or wnt catenin Not to mention the active ingredient in osstivia doesn’t even have testing in humans and all their studies are based off of animal studies and even in the animal studies there was no morphology change all that happened is there was a slight bone density increase jfl
Idk how people put out this bs snake oil and anyone believes it just because they pretend to know what their talking about

It’s a Game of genetics boyo

It's so cringy seeing them do a bunch of performative lab work just to release an oral compound that does nothing

 

[CoalTheMineral]

jfl

 

[IBlameMaximus]

With all due respect, this was the most dumbest post I have ever read. Anything but debating us in the server. We have had several debates where people have tried to disprove the effectiveness of Osstivia, and they have all lost. Feel free to join the server again (that has 1.5k members) by looking up "ossialabs discord server" online or simply by going to the link on the website. You've already lost the argument by assuming that we are claiming it can magically grow the bones with little effort. Not understanding the concept of pathway modulation and how we are presenting it. Bro doesn't understand it's in tandem with chewing hard gum (like stronger gum extra tough 90 pieces pack)

There are no human studies but we are planning on doing that in the future. Rats aren't similar in gut and digestion yes, but we are pushing snedds predominantly to close one gap. We've had this dumb rat discussion various times but we are basically the human data, and so far it's been showing promise on the people who've used it. We are planning on making studies in the future. So again, rat studies are mainly used to choose a botanical. We are the human studies. We don't have 300000-1.5m dollars in our back pocket to buy a clinical randomized study yet lmao. But atleast we are trying to advance the science with what we have unlike the supplement industry. You are also forgetting that this needs to be paired with hard chewing, which is the mechanical load. Hypertrophic growth cartilage is present even in 30's for the mandibular condyle. People who buy osstivia and pair it with chewing hard gum (like stronger gum extra tough 90 pieces pack) are sub 20. They are taking advantage if chewing young. Those people who pair osstivia and chewing might also get zygo improvements as well aside from mandible improvements. the zygomatic bones are strained when chewing, which can lead to morphological results.

If this is the same user I think it is (Patrick Bateman NutBlud boy) then you left the server and decided to take the loss when it came to the debate on Humulus Japonicus SNEDDS. Why not upload the entire recording of the debate here? If that is not you, then why not ask more questions?

Again, The pathways Osstivia acts on are Bmp2, runx2, wnt/b-catenin, rankl, and others. Fructus Ligustri Lucidi in the formulation modulates canonical wnt. Wnt/b-catenin. You've never pointed out about how we are saying it's mandatory to pair with chewing for facial aesthetic results and how we are actually going towards making studies ourselves in the future. Literally all scientific studies on SNEDDS and the ingredients are online, on the website, in the server, etc. Oh and don't forget about SNEDDS too. Yeah man, the founder who's been researching for seven years would not spend thousands on something that wouldn't work lol.

DNR.

 

[James holder]

They are taking advantage if chewing young. Those people who pair osstivia and chewing might also get zygo improvements as well aside from mandible improvements. the zygomatic bones are strained when chewing, which can lead to morphological results.

No chewing gum is going to unfuse your zygomatic bone and chamge the angle.

 

[hopelessromanticc]

With all due respect, this was the most dumbest post I have ever read. Anything but debating us in the server. We have had several debates where people have tried to disprove the effectiveness of Osstivia, and they have all lost. Feel free to join the server again (that has 1.5k members) by looking up "ossialabs discord server" online or simply by going to the link on the website. You've already lost the argument by assuming that we are claiming it can magically grow the bones with little effort. Not understanding the concept of pathway modulation and how we are presenting it. Bro doesn't understand it's in tandem with chewing hard gum (like stronger gum extra tough 90 pieces pack)

There are no human studies but we are planning on doing that in the future. Rats aren't similar in gut and digestion yes, but we are pushing snedds predominantly to close one gap. We've had this dumb rat discussion various times but we are basically the human data, and so far it's been showing promise on the people who've used it. We are planning on making studies in the future. So again, rat studies are mainly used to choose a botanical. We are the human studies. We don't have 300000-1.5m dollars in our back pocket to buy a clinical randomized study yet lmao. But atleast we are trying to advance the science with what we have unlike the supplement industry. You are also forgetting that this needs to be paired with hard chewing, which is the mechanical load. Hypertrophic growth cartilage is present even in 30's for the mandibular condyle. People who buy osstivia and pair it with chewing hard gum (like stronger gum extra tough 90 pieces pack) are sub 20. They are taking advantage if chewing young. Those people who pair osstivia and chewing might also get zygo improvements as well aside from mandible improvements. the zygomatic bones are strained when chewing, which can lead to morphological results.

If this is the same user I think it is (Patrick Bateman NutBlud boy) then you left the server and decided to take the loss when it came to the debate on Humulus Japonicus SNEDDS. Why not upload the entire recording of the debate here? If that is not you, then why not ask more questions?

Again, The pathways Osstivia acts on are Bmp2, runx2, wnt/b-catenin, rankl, and others. Fructus Ligustri Lucidi in the formulation modulates canonical wnt. Wnt/b-catenin. You've never pointed out about how we are saying it's mandatory to pair with chewing for facial aesthetic results and how we are actually going towards making studies ourselves in the future. Literally all scientific studies on SNEDDS and the ingredients are online, on the website, in the server, etc. Oh and don't forget about SNEDDS too. Yeah man, the founder who's been researching for seven years would not spend thousands on something that wouldn't work lol.

DNR.

Your just saying vague bs that means literally nothing

Working on catenin or bmp does not mean bone is remodeling that also happens when bone gains density or has anything effect it at all. Again you can take a calcium pill and get those same effects in those pathways and then claim calcium grows bones you fucking retard

Stop selling snake oil and pretending it does shit the only reason you tell people to chew along with it is because you know osstivia doesn’t even do anything so you combine it with something that might actually do something to give the illusion that osstivia helped even if it didnt

 

[iblamebones000101]

The looksmax community has just become a complete cesspit of grifters and scammers and today I just found what the next grift is. Theres this chemical called osstivia which is supposed to “grow bone” made by ossialabs (not even a real lab just some curry in their basement dropshipping some random slop). If you go on their TikTok you won’t find any actual scientific studies or peer reviewed papers all ull find is some clips of them mixing random chemicals in a bottle and then throwing up images of random pathways and molecules without even explaining how osstivia is even supposed to in mechanism interact with those pathways and how that would even lead to bone growth. I went into their discord and ask their moderators to show how it’s supposed to grow bone and the best they can say is that it has molecules which can effect wnt catenin and other pathways. Little do the retards know that any fucking pill that effects density is going to effect bmp or wnt catenin Not to mention the active ingredient in osstivia doesn’t even have testing in humans and all their studies are based off of animal studies and even in the animal studies there was no morphology change all that happened is there was a slight bone density increase jfl
Idk how people put out this bs snake oil and anyone believes it just because they pretend to know what their talking about

It’s a Game of genetics boyo

Jfl to anyone who don’t do their own research

 

[Palan]

No chewing gum is going to unfuse your zygomatic bone and chamge the angle.

Well, obviously don't chew soft ass gum lol. In their discord server they literally recommend people a really hard gum, I have even tried the gum myself and it's actually really hard, that's called stronger gum extra tough (specifically the 90 pieces spearmint pack) Also the guy who helps market osstivia, the dude you replied to, literally said it MAY lead to zygo improvements. I will quote from what the founder and the marketer usually always say for this in their server, and if you disagree then you can also join the server for yourself and discuss

"You MAY potentially get zygo improvements since the zygomatic bones are strained when chewing. Which can lead to morphological changes. The reason it might change is because chewing provides dynamic oscillative strain to surrounding sutures."

Oh, and osstiva is a booster for exisiting stimulation by the way if you hadn't gotten that clear in your head already.

 

[Palan]

Your just saying vague bs that means literally nothing

Working on catenin or bmp does not mean bone is remodeling that also happens when bone gains density or has anything effect it at all. Again you can take a calcium pill and get those same effects in those pathways and then claim calcium grows bones you fucking retard

Stop selling snake oil and pretending it does shit the only reason you tell people to chew along with it is because you know osstivia doesn’t even do anything so you combine it with something that might actually do something to give the illusion that osstivia helped even if it didnt

Not gonna lie dude, you did not cook some single time here lol. Seems like you still don't understand anything about Osstivia. Osstivia is simply a booster for existing stimulation, even the dude you just replied to literally just said it won't magically grow bones. Here, answer my one question:

If i can demonstrate that chewing alone could change mandible morphology, even if slightly, would you concede that having a supplement that promotes osteoblast activity would improve chewing alone?

So, Osstivia is a bone modulation supplement and a good health supplement as well. You just seem to be hating for no reason, which is actually heartbreaking because all these guys are doing are just trying to advance the supplement industry with their supplements and skincare formulated with SNEDDS. You can literally just go to their discord server and debate or whatever about the supplement, read the product page description on their website, look into the ingredient Fructus Ligustru Lucidi, and etc but you decided to come and hate about it. If anyone one is reading this, please just join their server and ask questions. I use to be so skeptical as well and wanted to spread misinformation, but after chatting with them and doing research then it becomes more and more clear what it is.

 

[Palan]

Here is research on Fructus Ligustri Lucidi (a key ingredient in Osstivia) and SNEDDS. I will also be attaching a PDF file for better understanding too (This also came from their server), if anybody else wants to talk to the founders themselves in their discord server then please do. I am not going to lie, org is a bad place to learn about osstivia and it's pretty sad seeing others bash on it simply because they don't understand the science behind. Osstivia is simply a booster for existing stimulation. The reason why they use SNEDDS is because
SNEDDS literally increases bioavailability and permeability of active compounds. It helps bypass first-pass metabolism and leads to a good amount of the compounds to go straight to the bloodstream.

 

[6”3neartyronelite]

With all due respect, this was the most dumbest post I have ever read. Anything but debating us in the server. We have had several debates where people have tried to disprove the effectiveness of Osstivia, and they have all lost. Feel free to join the server again (that has 1.5k members) by looking up "ossialabs discord server" online or simply by going to the link on the website. You've already lost the argument by assuming that we are claiming it can magically grow the bones with little effort. Not understanding the concept of pathway modulation and how we are presenting it. Bro doesn't understand it's in tandem with chewing hard gum (like stronger gum extra tough 90 pieces pack)

There are no human studies but we are planning on doing that in the future. Rats aren't similar in gut and digestion yes, but we are pushing snedds predominantly to close one gap. We've had this dumb rat discussion various times but we are basically the human data, and so far it's been showing promise on the people who've used it. We are planning on making studies in the future. So again, rat studies are mainly used to choose a botanical. We are the human studies. We don't have 300000-1.5m dollars in our back pocket to buy a clinical randomized study yet lmao. But atleast we are trying to advance the science with what we have unlike the supplement industry. You are also forgetting that this needs to be paired with hard chewing, which is the mechanical load. Hypertrophic growth cartilage is present even in 30's for the mandibular condyle. People who buy osstivia and pair it with chewing hard gum (like stronger gum extra tough 90 pieces pack) are sub 20. They are taking advantage if chewing young. Those people who pair osstivia and chewing might also get zygo improvements as well aside from mandible improvements. the zygomatic bones are strained when chewing, which can lead to morphological results.

If this is the same user I think it is (Patrick Bateman NutBlud boy) then you left the server and decided to take the loss when it came to the debate on Humulus Japonicus SNEDDS. Why not upload the entire recording of the debate here? If that is not you, then why not ask more questions?

Again, The pathways Osstivia acts on are Bmp2, runx2, wnt/b-catenin, rankl, and others. Fructus Ligustri Lucidi in the formulation modulates canonical wnt. Wnt/b-catenin. You've never pointed out about how we are saying it's mandatory to pair with chewing for facial aesthetic results and how we are actually going towards making studies ourselves in the future. Literally all scientific studies on SNEDDS and the ingredients are online, on the website, in the server, etc. Oh and don't forget about SNEDDS too. Yeah man, the founder who's been researching for seven years would not spend thousands on something that wouldn't work lol.

DNR.

I wish I could beat the shit outta you grifting nigga

 

[Palan]

I wish I could beat the shit outta you grifting nigga

Chill bro, they don't even scam lol. There is enough research on the supplement, if you thought of it another way or misunderstood it then that's on you. They even have a discord server where you can self educate yourself and ask question on too

 

[hopelessromanticc]

Not gonna lie dude, you did not cook some single time here lol. Seems like you still don't understand anything about Osstivia. Osstivia is simply a booster for existing stimulation, even the dude you just replied to literally just said it won't magically grow bones. Here, answer my one question:

If i can demonstrate that chewing alone could change mandible morphology, even if slightly, would you concede that having a supplement that promotes osteoblast activity would improve chewing alone?

So, Osstivia is a bone modulation supplement and a good health supplement as well. You just seem to be hating for no reason, which is actually heartbreaking because all these guys are doing are just trying to advance the supplement industry with their supplements and skincare formulated with SNEDDS. You can literally just go to their discord server and debate or whatever about the supplement, read the product page description on their website, look into the ingredient Fructus Ligustru Lucidi, and etc but you decided to come and hate about it. If anyone one is reading this, please just join their server and ask questions. I use to be so skeptical as well and wanted to spread misinformation, but after chatting with them and doing research then it becomes more and more clear what it is.

Keep selling snake oil on a alt account you clown


Even chewing is barely going to do much for bone. At best it might cause slight thickness changes over years but nothing osstivia does is going to improve that because how osteoblasts work dumb fuck is they work in correlation to the force applied during mechanical stimulation.

Your low iq monkey brain thinks chewing + more osteoblasts = more bone doy doyyyyy

No dumb fuck osteoblasts only build bone when necessary and in turn ur body tries to generate an equilibrium between osteoblasts and osteoclasts. So you don’t need more osteoblasts to have more remodeling in fact adding more would literally not do shit unless you are deficient in it.

Osteoblasts don’t trigger bone growth at all on their own

They respond to signals from your body when they need to help build bone in a area and how much it needs to be applied

If you actually want more results from mechanical stimulation what you need is more of the actual stimulation. This is genuinely like a retard thinking giving more bricks to someone who is trying to build a house will make them build faster even if they’re lifting and placing down bricks at the same rate. This is only true in the specific case that the person doesn’t have enough bricks but simply giving them more than they need isn’t doing anything


Also even if we took ur dumb fuck idea that simply having more free osteoblasts = more bone growth. if you want to upregulate osteoblast activity there’s a lot more proven and tested stuff for that stuff that’s done way more testing than a few animal studies. You can literally go to ur local pharmacy and get some calcium pills and that will upregulate osteoblast count. Hell if you want something potent there’s peptides that are specifically made for upregulating osteoblast activity that would insanely mog any bullshit this company makes, yet there’s nothing that magically fucking happens when you take them. Theres nothing new that ostivia figured out that wasn’t already done so stop the larping high iq as if this bullshit snake oil is some magical source of anything.

 

[carti lover]

With all due respect, this was the most dumbest post I have ever read. Anything but debating us in the server. We have had several debates where people have tried to disprove the effectiveness of Osstivia, and they have all lost. Feel free to join the server again (that has 1.5k members) by looking up "ossialabs discord server" online or simply by going to the link on the website. You've already lost the argument by assuming that we are claiming it can magically grow the bones with little effort. Not understanding the concept of pathway modulation and how we are presenting it. Bro doesn't understand it's in tandem with chewing hard gum (like stronger gum extra tough 90 pieces pack)

There are no human studies but we are planning on doing that in the future. Rats aren't similar in gut and digestion yes, but we are pushing snedds predominantly to close one gap. We've had this dumb rat discussion various times but we are basically the human data, and so far it's been showing promise on the people who've used it. We are planning on making studies in the future. So again, rat studies are mainly used to choose a botanical. We are the human studies. We don't have 300000-1.5m dollars in our back pocket to buy a clinical randomized study yet lmao. But atleast we are trying to advance the science with what we have unlike the supplement industry. You are also forgetting that this needs to be paired with hard chewing, which is the mechanical load. Hypertrophic growth cartilage is present even in 30's for the mandibular condyle. People who buy osstivia and pair it with chewing hard gum (like stronger gum extra tough 90 pieces pack) are sub 20. They are taking advantage if chewing young. Those people who pair osstivia and chewing might also get zygo improvements as well aside from mandible improvements. the zygomatic bones are strained when chewing, which can lead to morphological results.

If this is the same user I think it is (Patrick Bateman NutBlud boy) then you left the server and decided to take the loss when it came to the debate on Humulus Japonicus SNEDDS. Why not upload the entire recording of the debate here? If that is not you, then why not ask more questions?

Again, The pathways Osstivia acts on are Bmp2, runx2, wnt/b-catenin, rankl, and others. Fructus Ligustri Lucidi in the formulation modulates canonical wnt. Wnt/b-catenin. You've never pointed out about how we are saying it's mandatory to pair with chewing for facial aesthetic results and how we are actually going towards making studies ourselves in the future. Literally all scientific studies on SNEDDS and the ingredients are online, on the website, in the server, etc. Oh and don't forget about SNEDDS too. Yeah man, the founder who's been researching for seven years would not spend thousands on something that wouldn't work lol.

DNR.

Give me it for free and I’ll test

 

[Palan]

Keep selling snake oil on a alt account you clown


Even chewing is barely going to do much for bone. At best it might cause slight thickness changes over years but nothing osstivia does is going to improve that because how osteoblasts work dumb fuck is they work in correlation to the force applied during mechanical stimulation.

Your low iq monkey brain thinks chewing + more osteoblasts = more bone doy doyyyyy

No dumb fuck osteoblasts only build bone when necessary and in turn ur body tries to generate an equilibrium between osteoblasts and osteoclasts. So you don’t need more osteoblasts to have more remodeling in fact adding more would literally not do shit unless you are deficient in it.

Osteoblasts don’t trigger bone growth at all on their own

They respond to signals from your body when they need to help build bone in a area and how much it needs to be applied

If you actually want more results from mechanical stimulation what you need is more of the actual stimulation. This is genuinely like a retard thinking giving more bricks to someone who is trying to build a house will make them build faster even if they’re lifting and placing down bricks at the same rate. This is only true in the specific case that the person doesn’t have enough bricks but simply giving them more than they need isn’t doing anything


Also even if we took ur dumb fuck idea that simply having more free osteoblasts = more bone growth. if you want to upregulate osteoblast activity there’s a lot more proven and tested stuff for that stuff that’s done way more testing than a few animal studies. You can literally go to ur local pharmacy and get some calcium pills and that will upregulate osteoblast count. Hell if you want something potent there’s peptides that are specifically made for upregulating osteoblast activity that would insanely mog any bullshit this company makes, yet there’s nothing that magically fucking happens when you take them. Theres nothing new that ostivia figured out that wasn’t already done so stop the larping high iq as if this bullshit snake oil is some magical source of anything.

Are you ever happy man? You need to chill with the ad hominem lol, all you do is say these insults but never deliver a promising point at all lol. It's like a nine year just learned about curse words lmao.

You are also dodging what the marketer and i said before, osstivia isn't going to magically grow bone obviously. It's simply a booster for existing stimulation. Just because I am defending a decent company actually trying to advance science with their supplements formulated with SNEDDS, that doesn't automatically mean I work with them or I am another account from them. Hell you could even check my join date or whatever. I also hope you do realize that hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible. The mandible still has genuine 3 dimensional remodeling and growth potential post puberty. We are talking about the MANDIBLE here, not the maxilla or anything else (zygos are a maybe though over time). Another thing is that there is more than just osteoblasts lol, there are multiple pathways involved in osstivia. RANKL-RANK/TRAF6-NF-kB/MAPK-NFATc1; OPG/RANKL/cathepsin K; Wnt/beta-catenin; RUNX2 osteogenesis.

The mandible does not remodel through magical unknown pathways. It remodels through osteoclast activity, osteoblast activity, matrix turnover, mineralization, cartilage maturation, subchondral bone remodeling, and ossification.

So when YOU dismiss RANKL, NFATc1, ALP, Wnt/β-catenin, MAPK/Akt, PTH/VDR/TRPV6, and BMD as if they are irrelevant, you are not exposing anything. You are showing that you do not understand what mandibular remodeling is built from.



RANKL/NFATc1 matters because mandibular remodeling requires osteoclast regulation.

OPG/RANKL matters because mandibular bone adaptation depends on the balance between resorption and deposition.

Cathepsin K and MMP-9 matter because matrix breakdown and turnover are part of remodeling.

ALP matters because mandibular bone formation requires mineralized matrix.

Wnt/β-catenin matters because it is tied to osteoblast differentiation and ossification.

RUNX2 matters because condylar growth and cartilage-to-bone transition rely on osteogenic differentiation.

MAPK/Akt matters because mandibular tissues respond to mechanical loading and differentiation signals through these intracellular pathways.

PTH/VDR/TRPV6 matters because mineral handling affects whether newly formed matrix can actually become mineralized bone.


So no, this is not “just BMD.” BMD is an endpoint.

The pathway activity behind it is the real point we are all talking about here. Your entire argument is basically:

“These studies only show osteoblast activity, osteoclast regulation, mineralization, Wnt signaling, MAPK/Akt signaling, RANKL modulation, and bone-density changes… therefore they have nothing to do with bone growth or remodeling.”

Bro. That IS growth and remodeling! Nobody serious has to pretend endpoint evidence exists where it does not


But pretending these pathways are irrelevant to mandibular growth and remodeling shows complete lack of knowledge about the science, it's embarrassing.

You did not even debunk the mechanism in any way, shape, or form.

You literally dodged the mechanism, changed the standard to direct facial-endpoint evidence, and then acted like you're smart.

The hard-chewing argument is also dumb
Of course mechanical loading matters. The mandible is mechanically responsive tissue.

But saying “only chewing works” while dismissing the biochemical pathways that determine how bone responds to loading is childish.

Mechanical stimulus is the signal.

Cells and pathways are the response system.

Osteoclasts, osteoblasts, Wnt/β-catenin, RUNX2, RANKL, MAPK/Akt, ALP, MMPs, and mineral metabolism are part of how that response happens.

So if a botanical affects remodeling-relevant pathways, it is not automatically irrelevant just because chewing is also involved.

That is like saying nutrition doesn't matter for muscle growth because lifting weights matters. Imagine saying that.

Compounds CAN modulate pathways, If it increases proliferation it would be enough to boost chewing results.

In conclusion, You ranting or trying to debunk anything showed you are uneducated on the product, the mechanistic effects, and bone biology.

So, lets move onto SNEDDS and why they even use it:

SNEDDS, or self-nanoemulsifying drug/dietary delivery systems, are formulation systems designed to improve how poorly soluble botanical compounds dissolve, disperse, and absorb in the body. Instead of treating FLL as some kind of a crude extract with unpredictable absorption, SNEDDS turns it into a more controlled delivery platform by using a precise formulation that form very small emulsion droplets when exposed to digestive fluid.

This matters because many plant derived compounds may show strong pathway activity in theory or in cells, but perform inconsistently in vivo because the body does not absorb them well enough.

With SNEDDS, the research direction changes from simply asking whether raw FLL affects broad outcomes like BMD to asking whether a standardized, better-absorbed FLL formulation can produce consistent exposure to its active compounds and measurable effects on remodeling-related pathways.

In other words, SNEDDS moves FLL research from crude botanical testing toward formulation based pharmacology, where solubility, absorption, bioavailability, dose consistency, and pathway response can be studied more precisely.

Oh and never compare a supplement to high affinity synthetics, you can literally just combine both if you want for better performance.


Supplement ≠ high affinity synthetics

At most their supplements can be used in clinical settings due to SNEDDS since it increases effectiveness of the compounds to more pharmacological levels, but it still separates itself with sh like high affinity synthetics, for obvious reasons.

You are also dodging another thing too, Osstivia provides various other health benefits as well.

Please also note that hard chewing literally grows and remodels the condyle, which leads to improvements in the mandible. That is the growth site of the mandible, That's where growth and rotation happens. The only claim they make is mandible, nothing else. Even the product page description of osstivia on their website talks about it, but guess what... you didn't even read it. You simply came to the conclusion or misunderstood it for a completely different thing. Please stop hating to hate, it's evident in your messages.

 

[Palan]

Give me it for free and I’ll test

go join their server and ask

 

[James holder]

Well, obviously don't chew soft ass gum lol. In their discord server they literally recommend people a really hard gum, I have even tried the gum myself and it's actually really hard, that's called stronger gum extra tough (specifically the 90 pieces spearmint pack) Also the guy who helps market osstivia, the dude you replied to, literally said it MAY lead to zygo improvements. I will quote from what the founder and the marketer usually always say for this in their server, and if you disagree then you can also join the server for yourself and discuss

"You MAY potentially get zygo improvements since the zygomatic bones are strained when chewing. Which can lead to morphological changes. The reason it might change is because chewing provides dynamic oscillative strain to surrounding sutures."

Oh, and osstiva is a booster for exisiting stimulation by the way if you hadn't gotten that clear in your head already.

"May" as in they know its cope but want more iqlets to shill it to. Might aswell buy vitimin d tablets.

 

[Palan]

"May" as in they know its cope but want more iqlets to shill it to. Might aswell buy vitimin d tablets.

The entire argument was on osstivia's effectiveness, it's pathways, and why it would help with the mandible. It's driving me crazy, but the whole point for it is to help with the mandible and provide health benefits as well. You can combine osstivia with vitamin d3, k2, and calcium since studies show it improves calcium retention, absorption, and deposition as well. The compounds in it show that it can affect vit d regulation. It's not gonna magically grow bones but simply help with existing stimulation. That's it. However, I understand the hate and when i saw their marketing I thought that was what they were claiming but by quickly looking at the product page description, it tells a different story. But yes, zygo improvements is a potential MAY over time (like i quoted before) since the zygomatic bones are strained when chewing. Which CAN lead to morphological changes. The reason it might change is because chewing provides dynamic oscillative strain to surrounding sutures. Seems like something you do for long enough to really see anything, they never guaranteed that though. It's just a potential improvement overtime.

 

[hopelessromanticc]

Are you ever happy man? You need to chill with the ad hominem lol, all you do is say these insults but never deliver a promising point at all lol. It's like a nine year just learned about curse words lmao.

You are also dodging what the marketer and i said before, osstivia isn't going to magically grow bone obviously. It's simply a booster for existing stimulation. Just because I am defending a decent company actually trying to advance science with their supplements formulated with SNEDDS, that doesn't automatically mean I work with them or I am another account from them. Hell you could even check my join date or whatever. I also hope you do realize that hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible. The mandible still has genuine 3 dimensional remodeling and growth potential post puberty. We are talking about the MANDIBLE here, not the maxilla or anything else (zygos are a maybe though over time). Another thing is that there is more than just osteoblasts lol, there are multiple pathways involved in osstivia. RANKL-RANK/TRAF6-NF-kB/MAPK-NFATc1; OPG/RANKL/cathepsin K; Wnt/beta-catenin; RUNX2 osteogenesis.

The mandible does not remodel through magical unknown pathways. It remodels through osteoclast activity, osteoblast activity, matrix turnover, mineralization, cartilage maturation, subchondral bone remodeling, and ossification.

So when YOU dismiss RANKL, NFATc1, ALP, Wnt/β-catenin, MAPK/Akt, PTH/VDR/TRPV6, and BMD as if they are irrelevant, you are not exposing anything. You are showing that you do not understand what mandibular remodeling is built from.



RANKL/NFATc1 matters because mandibular remodeling requires osteoclast regulation.

OPG/RANKL matters because mandibular bone adaptation depends on the balance between resorption and deposition.

Cathepsin K and MMP-9 matter because matrix breakdown and turnover are part of remodeling.

ALP matters because mandibular bone formation requires mineralized matrix.

Wnt/β-catenin matters because it is tied to osteoblast differentiation and ossification.

RUNX2 matters because condylar growth and cartilage-to-bone transition rely on osteogenic differentiation.

MAPK/Akt matters because mandibular tissues respond to mechanical loading and differentiation signals through these intracellular pathways.

PTH/VDR/TRPV6 matters because mineral handling affects whether newly formed matrix can actually become mineralized bone.


So no, this is not “just BMD.” BMD is an endpoint.

The pathway activity behind it is the real point we are all talking about here. Your entire argument is basically:

“These studies only show osteoblast activity, osteoclast regulation, mineralization, Wnt signaling, MAPK/Akt signaling, RANKL modulation, and bone-density changes… therefore they have nothing to do with bone growth or remodeling.”

Bro. That IS growth and remodeling! Nobody serious has to pretend endpoint evidence exists where it does not


But pretending these pathways are irrelevant to mandibular growth and remodeling shows complete lack of knowledge about the science, it's embarrassing.

You did not even debunk the mechanism in any way, shape, or form.

You literally dodged the mechanism, changed the standard to direct facial-endpoint evidence, and then acted like you're smart.

The hard-chewing argument is also dumb
Of course mechanical loading matters. The mandible is mechanically responsive tissue.

But saying “only chewing works” while dismissing the biochemical pathways that determine how bone responds to loading is childish.

Mechanical stimulus is the signal.

Cells and pathways are the response system.

Osteoclasts, osteoblasts, Wnt/β-catenin, RUNX2, RANKL, MAPK/Akt, ALP, MMPs, and mineral metabolism are part of how that response happens.

So if a botanical affects remodeling-relevant pathways, it is not automatically irrelevant just because chewing is also involved.

That is like saying nutrition doesn't matter for muscle growth because lifting weights matters. Imagine saying that.

Compounds CAN modulate pathways, If it increases proliferation it would be enough to boost chewing results.

In conclusion, You ranting or trying to debunk anything showed you are uneducated on the product, the mechanistic effects, and bone biology.

So, lets move onto SNEDDS and why they even use it:

SNEDDS, or self-nanoemulsifying drug/dietary delivery systems, are formulation systems designed to improve how poorly soluble botanical compounds dissolve, disperse, and absorb in the body. Instead of treating FLL as some kind of a crude extract with unpredictable absorption, SNEDDS turns it into a more controlled delivery platform by using a precise formulation that form very small emulsion droplets when exposed to digestive fluid.

This matters because many plant derived compounds may show strong pathway activity in theory or in cells, but perform inconsistently in vivo because the body does not absorb them well enough.

With SNEDDS, the research direction changes from simply asking whether raw FLL affects broad outcomes like BMD to asking whether a standardized, better-absorbed FLL formulation can produce consistent exposure to its active compounds and measurable effects on remodeling-related pathways.

In other words, SNEDDS moves FLL research from crude botanical testing toward formulation based pharmacology, where solubility, absorption, bioavailability, dose consistency, and pathway response can be studied more precisely.

Oh and never compare a supplement to high affinity synthetics, you can literally just combine both if you want for better performance.


Supplement ≠ high affinity synthetics

At most their supplements can be used in clinical settings due to SNEDDS since it increases effectiveness of the compounds to more pharmacological levels, but it still separates itself with sh like high affinity synthetics, for obvious reasons.

You are also dodging another thing too, Osstivia provides various other health benefits as well.

Please also note that hard chewing literally grows and remodels the condyle, which leads to improvements in the mandible. That is the growth site of the mandible, That's where growth and rotation happens. The only claim they make is mandible, nothing else. Even the product page description of osstivia on their website talks about it, but guess what... you didn't even read it. You simply came to the conclusion or misunderstood it for a completely different thing. Please stop hating to hate, it's evident in your messages.

Osstivia is neither going to grow bone nor boost bone growth. Both are false advertising snake oil
Also dumb fuck learn what a ad hominem is. Insulting someone isn’t a fucking ad hominem you incompetent retard. A ad hominem means when you insult only the person and use that as a basis for why ur correct or why their argument is false. I said ur stupid and ur claims are false and ur stupidity is the reason for making the claims.

Anyways let’s read the rest of this autist sperg on a alt account shits out of his mouth

“hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible. The mandible still has genuine 3 dimensional remodeling and growth potential post puberty. We are talking about the MANDIBLE here, not the maxilla or anything else (zygos are a maybe though over time). “

Wow dumb fuck it’s almost like I don’t say that in the message you replied to that mandible can still remodel but just at a very slow rate. Maybe you should try actually reading the messages before sperging to pretend you know what you’re talking about. Remodelling exists after puberty no shit but it is at a very low rate. Years upon years for minor differences. Ur not going to go from round jaw to prime brad pitt from chewing jfl. Not only will ur mouth adapt to the load anyways and in turn will require more load that isnt rlly possible but your also severely degrading ur teeth all for like less than 1 mm of bone. Also remodeling can mean more than just ur bone getting thicker or wider visually it can mean old bone is reaborbed and new bone is placed and it may or may not have structural changes

The actual changes you see from chewing is just soft tissue



“Another thing is that there is more than just osteoblasts lol”

there isn’t even evidence it does anything for stimulating osteoblasts in humans Letalone the rest of the buzzwords your going to name


“
The mandible does not remodel through magical unknown pathways. It remodels through osteoclast activity, osteoblast activity, matrix turnover, mineralization, cartilage maturation, subchondral bone remodeling, and ossification.”
Its so funny how in posting your ChatGPT slop you don’t atleast reread what your saying

Dumb fuck matrix turnover of bone is osteoblast and osteoclast activity. Mineralization is just downstream effects of osteoblast activity, cartilage maturation mainly only happens during puberty, subchondral bone remodeling is just osteoblasts/osteoclasts effects under the cartilage and ossification is basically just the combination of these

almost none of These are “different mechanisms” it’s just different locations or stages lmao

“So when YOU dismiss RANKL, NFATc1, ALP, Wnt/β-catenin, MAPK/Akt, PTH/VDR/TRPV6, and BMD as if they are irrelevant, you are not exposing anything. You are showing that you do not understand what mandibular remodeling is built from.”

Jfl the only 3 of those that might result in thicker bone is catenin and maybe ALP and AKT but if you also stimulate RANKL and NFATc1 ur also getting bone resorption JFL. So yes almost all of those are irrelevant in the context of trying to magically build bones from ur snake oil



“RANKL/NFATc1 matters because mandibular remodeling requires osteoclast regulation.

OPG/RANKL matters because mandibular bone adaptation depends on the balance between resorption and deposition.

Cathepsin K and MMP-9 matter because matrix breakdown and turnover are part of remodeling.”

You do realize osteoclasts will mean any new thickness added will just be reabsorbed dumb fuck?

Simply saying shit is “part of remodeling” means fuck all if all that’s being remodeled is that ur bone breaks down or remains the same thickness but just changes in mineral density

“ALP matters because mandibular bone formation requires mineralized matrix.”

Probably the only thing that might make sense here but this mainly increases density not thickness and can be increased through exercise or getting vitamin d you don’t need overpriced snake oil that has literallly 0 human testing


“Wnt/β-catenin matters because it is tied to osteoblast differentiation and ossification.”

Osteoblast differentiation and bone growth aren’t the same thing. When you injure ur bone ur body has high wnt catenin but that doesn’t mean it’s going to magically grow back longer than it used to be. That’s cause mainly all it does is either repair or help in turnover

“RUNX2 matters because condylar growth and cartilage-to-bone transition rely on osteogenic differentiation.”

Most of the cartilage that’s not fused in the jaw as an adult is just for elasticity of the jaw and proper functional jaw movement.


MAPK/Akt matters because mandibular tissues respond to mechanical loading and differentiation signals through these intracellular pathways.
Increased formation will still be balanced by increased resorption so this doesn’t matter. Your bone grows in order to respond to the mechanical stimulation and make the load more bearable. Not so that it can look more aesthetic

Wha will happen is there may be density changes but there won’t be any new size growth


“PTH/VDR/TRPV6 matters because mineral handling affects whether newly formed matrix can actually become mineralized bone”

Yeah and the new mineralized bone replaces the old bone that’s absorbed to make the new bone dumb fuck

“The pathway activity behind it is the real point we are all talking about here. Your entire argument is basically:

“These studies only show osteoblast activity, osteoclast regulation, mineralization, Wnt signaling, MAPK/Akt signaling, RANKL modulation, and bone-density changes… therefore they have nothing to do with bone growth or remodeling.””
Wow great way of showing after all the responses you still can’t track what my statements are

Dumb fuck nobody was contending you can’t have bone remodeling changes
My point is the bone remodeling isn’t going to be the bone getting thicker it’s going to have new bone formed and then old bone absorbed
And even if this is how these pathways worked osstivia wouldn’t do fuck all because
1. There is no evidence it would do this in humans. There isn’t even good evidence it does it in animals Letalone humans.

Even in the few animal studies we have almost all of them except like 1 or 2 is in healthy and matured animals

Their mainly on osteoporosis mice trying to heal from injury and they measured how much it would help aid in less bone breakdown rather than new bone being added
2. It’s not targetted. Simply drinking some cope snake oil isn’t going to mean any of the proposed effects that wouldn’t even do anything either way is going to have any local effect on the bone even in theory


“But saying “only chewing works” while dismissing the biochemical pathways that determine how bone responds to loading is childish.”

Dumb fuck even chewing which is whats going to do more than any of the snake oil doesn’t work much if at all for bone morphology changes especially in adults

Bone only adapts to what is necessary. Even if hypothetically speaking you did chew what happens is the density changes and maybe after years you gain 0.1 mm of bone. After that you will need more load in order to actually gain anything more since it has now adapted to the same loads that it did previously

we can even use athletes and bodybuilders for example. They train their body all day and they have bigger and thicker muscles but their bone size doesn’t magically change from it. They have bigger bones than on average (cause they are just more naturally gifted given them being athletes) but there’s no evidence of any athlete bone significantly changing in size after training outside of the occasional late fusion. And by the way nothing this osstivia cope is going to do will give you the same bone changes of world class athletes so if even they get minimal to non noticeable results what do you think this cope would do?

“That is like saying nutrition doesn't matter for muscle growth because lifting weights matters. Imagine saying that.”
Flag on the play to the dumb fuck for the false analogy.
1. Muscle and bone growth aren’t the same thing they work completely differently
2. Nutriton helps in muscle growth as it gives the essential building blocks for repair. it doesn’t trigger new growth like ur low iq ass thinks. Even if you combine nutrition and working out it doesn’t magically get faster it’s only if you are deficient in one which is when it will grow slower. What actually aids in muscle growth is adding more intense training while staying at a equilibrium to where ur body has enough energy

“In conclusion, You ranting or trying to debunk anything showed you are uneducated on the product, the mechanistic effects, and bone biology.”

In conclusion you haven’t responded to literaly any point I made. Ur whole counter is summed up to listing off random chemicals (which btw we don’t even have evidence that osstivia works on) that you didn’t understand how they work and then thinking increasing them will mean faster bone growth like a dumb fuck when that’s not how it works at all. And then later on clearly showing you don’t even understand the critique

Snedds increase absorption but simply absorbing more snake oil doesn’t mean the snake oil is going to cure a disease

And if you are taking it systematically it’s not going to be localized regardless

You could take stuff like milk with snedds and probably have almost all of the effects and maybe better

In fact even the
Oleanolic acid which is the active ingredient in fll gets mogged by recombinant bmp2 and there are 0 studies where bmp2 does anything for bone thickness.

Also even if oleanolic acid worked for bone thickness you know ur dumb fuck company doesn’t realize that olives and apples have more oleanolic acid Than fll

Either way just stop scamming people with this slop and get a real job nobody is going to believe this with a iq of over 90

 

[probabawon]

Osstivia is neither going to grow bone nor boost bone growth. Both are false advertising snake oil
Also dumb fuck learn what a ad hominem is. Insulting someone isn’t a fucking ad hominem you incompetent retard. A ad hominem means when you insult only the person and use that as a basis for why ur correct or why their argument is false. I said ur stupid and ur claims are false and ur stupidity is the reason for making the claims.

Anyways let’s read the rest of this autist sperg on a alt account shits out of his mouth

“hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible. The mandible still has genuine 3 dimensional remodeling and growth potential post puberty. We are talking about the MANDIBLE here, not the maxilla or anything else (zygos are a maybe though over time). “

Wow dumb fuck it’s almost like I don’t say that in the message you replied to that mandible can still remodel but just at a very slow rate. Maybe you should try actually reading the messages before sperging to pretend you know what you’re talking about. Remodelling exists after puberty no shit but it is at a very low rate. Years upon years for minor differences. Ur not going to go from round jaw to prime brad pitt from chewing jfl. Not only will ur mouth adapt to the load anyways and in turn will require more load that isnt rlly possible but your also severely degrading ur teeth all for like less than 1 mm of bone. Also remodeling can mean more than just ur bone getting thicker or wider visually it can mean old bone is reaborbed and new bone is placed and it may or may not have structural changes

The actual changes you see from chewing is just soft tissue



“Another thing is that there is more than just osteoblasts lol”

there isn’t even evidence it does anything for stimulating osteoblasts in humans Letalone the rest of the buzzwords your going to name


“
The mandible does not remodel through magical unknown pathways. It remodels through osteoclast activity, osteoblast activity, matrix turnover, mineralization, cartilage maturation, subchondral bone remodeling, and ossification.”
Its so funny how in posting your ChatGPT slop you don’t atleast reread what your saying

Dumb fuck matrix turnover of bone is osteoblast and osteoclast activity. Mineralization is just downstream effects of osteoblast activity, cartilage maturation mainly only happens during puberty, subchondral bone remodeling is just osteoblasts/osteoclasts effects under the cartilage and ossification is basically just the combination of these

almost none of These are “different mechanisms” it’s just different locations or stages lmao

“So when YOU dismiss RANKL, NFATc1, ALP, Wnt/β-catenin, MAPK/Akt, PTH/VDR/TRPV6, and BMD as if they are irrelevant, you are not exposing anything. You are showing that you do not understand what mandibular remodeling is built from.”

Jfl the only 3 of those that might result in thicker bone is catenin and maybe ALP and AKT but if you also stimulate RANKL and NFATc1 ur also getting bone resorption JFL. So yes almost all of those are irrelevant in the context of trying to magically build bones from ur snake oil



“RANKL/NFATc1 matters because mandibular remodeling requires osteoclast regulation.

OPG/RANKL matters because mandibular bone adaptation depends on the balance between resorption and deposition.

Cathepsin K and MMP-9 matter because matrix breakdown and turnover are part of remodeling.”

You do realize osteoclasts will mean any new thickness added will just be reabsorbed dumb fuck?

Simply saying shit is “part of remodeling” means fuck all if all that’s being remodeled is that ur bone breaks down or remains the same thickness but just changes in mineral density

“ALP matters because mandibular bone formation requires mineralized matrix.”

Probably the only thing that might make sense here but this mainly increases density not thickness and can be increased through exercise or getting vitamin d you don’t need overpriced snake oil that has literallly 0 human testing


“Wnt/β-catenin matters because it is tied to osteoblast differentiation and ossification.”

Osteoblast differentiation and bone growth aren’t the same thing. When you injure ur bone ur body has high wnt catenin but that doesn’t mean it’s going to magically grow back longer than it used to be. That’s cause mainly all it does is either repair or help in turnover

“RUNX2 matters because condylar growth and cartilage-to-bone transition rely on osteogenic differentiation.”

Most of the cartilage that’s not fused in the jaw as an adult is just for elasticity of the jaw and proper functional jaw movement.


MAPK/Akt matters because mandibular tissues respond to mechanical loading and differentiation signals through these intracellular pathways.
Increased formation will still be balanced by increased resorption so this doesn’t matter. Your bone grows in order to respond to the mechanical stimulation and make the load more bearable. Not so that it can look more aesthetic

Wha will happen is there may be density changes but there won’t be any new size growth


“PTH/VDR/TRPV6 matters because mineral handling affects whether newly formed matrix can actually become mineralized bone”

Yeah and the new mineralized bone replaces the old bone that’s absorbed to make the new bone dumb fuck

“The pathway activity behind it is the real point we are all talking about here. Your entire argument is basically:

“These studies only show osteoblast activity, osteoclast regulation, mineralization, Wnt signaling, MAPK/Akt signaling, RANKL modulation, and bone-density changes… therefore they have nothing to do with bone growth or remodeling.””
Wow great way of showing after all the responses you still can’t track what my statements are

Dumb fuck nobody was contending you can’t have bone remodeling changes
My point is the bone remodeling isn’t going to be the bone getting thicker it’s going to have new bone formed and then old bone absorbed
And even if this is how these pathways worked osstivia wouldn’t do fuck all because
1. There is no evidence it would do this in humans. There isn’t even good evidence it does it in animals Letalone humans.

Even in the few animal studies we have almost all of them except like 1 or 2 is in healthy and matured animals

Their mainly on osteoporosis mice trying to heal from injury and they measured how much it would help aid in less bone breakdown rather than new bone being added
2. It’s not targetted. Simply drinking some cope snake oil isn’t going to mean any of the proposed effects that wouldn’t even do anything either way is going to have any local effect on the bone even in theory


“But saying “only chewing works” while dismissing the biochemical pathways that determine how bone responds to loading is childish.”

Dumb fuck even chewing which is whats going to do more than any of the snake oil doesn’t work much if at all for bone morphology changes especially in adults

Bone only adapts to what is necessary. Even if hypothetically speaking you did chew what happens is the density changes and maybe after years you gain 0.1 mm of bone. After that you will need more load in order to actually gain anything more since it has now adapted to the same loads that it did previously

we can even use athletes and bodybuilders for example. They train their body all day and they have bigger and thicker muscles but their bone size doesn’t magically change from it. They have bigger bones than on average (cause they are just more naturally gifted given them being athletes) but there’s no evidence of any athlete bone significantly changing in size after training outside of the occasional late fusion. And by the way nothing this osstivia cope is going to do will give you the same bone changes of world class athletes so if even they get minimal to non noticeable results what do you think this cope would do?

“That is like saying nutrition doesn't matter for muscle growth because lifting weights matters. Imagine saying that.”
Flag on the play to the dumb fuck for the false analogy.
1. Muscle and bone growth aren’t the same thing they work completely differently
2. Nutriton helps in muscle growth as it gives the essential building blocks for repair. it doesn’t trigger new growth like ur low iq ass thinks. Even if you combine nutrition and working out it doesn’t magically get faster it’s only if you are deficient in one which is when it will grow slower. What actually aids in muscle growth is adding more intense training while staying at a equilibrium to where ur body has enough energy

“In conclusion, You ranting or trying to debunk anything showed you are uneducated on the product, the mechanistic effects, and bone biology.”

In conclusion you haven’t responded to literaly any point I made. Ur whole counter is summed up to listing off random chemicals (which btw we don’t even have evidence that osstivia works on) that you didn’t understand how they work and then thinking increasing them will mean faster bone growth like a dumb fuck when that’s not how it works at all. And then later on clearly showing you don’t even understand the critique

Snedds increase absorption but simply absorbing more snake oil doesn’t mean the snake oil is going to cure a disease

And if you are taking it systematically it’s not going to be localized regardless

You could take stuff like milk with snedds and probably have almost all of the effects and maybe better

In fact even the
Oleanolic acid which is the active ingredient in fll gets mogged by recombinant bmp2 and there are 0 studies where bmp2 does anything for bone thickness.

Also even if oleanolic acid worked for bone thickness you know ur dumb fuck company doesn’t realize that olives and apples have more oleanolic acid Than fll

Either way just stop scamming people with this slop and get a real job nobody is going to believe this with a iq of over 90

oh baby what works then?

 

[morin]

Osstivia is neither going to grow bone nor boost bone growth. Both are false advertising snake oil
Also dumb fuck learn what a ad hominem is. Insulting someone isn’t a fucking ad hominem you incompetent retard. A ad hominem means when you insult only the person and use that as a basis for why ur correct or why their argument is false. I said ur stupid and ur claims are false and ur stupidity is the reason for making the claims.

Anyways let’s read the rest of this autist sperg on a alt account shits out of his mouth

“hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible. The mandible still has genuine 3 dimensional remodeling and growth potential post puberty. We are talking about the MANDIBLE here, not the maxilla or anything else (zygos are a maybe though over time). “

Wow dumb fuck it’s almost like I don’t say that in the message you replied to that mandible can still remodel but just at a very slow rate. Maybe you should try actually reading the messages before sperging to pretend you know what you’re talking about. Remodelling exists after puberty no shit but it is at a very low rate. Years upon years for minor differences. Ur not going to go from round jaw to prime brad pitt from chewing jfl. Not only will ur mouth adapt to the load anyways and in turn will require more load that isnt rlly possible but your also severely degrading ur teeth all for like less than 1 mm of bone. Also remodeling can mean more than just ur bone getting thicker or wider visually it can mean old bone is reaborbed and new bone is placed and it may or may not have structural changes

The actual changes you see from chewing is just soft tissue



“Another thing is that there is more than just osteoblasts lol”

there isn’t even evidence it does anything for stimulating osteoblasts in humans Letalone the rest of the buzzwords your going to name


“
The mandible does not remodel through magical unknown pathways. It remodels through osteoclast activity, osteoblast activity, matrix turnover, mineralization, cartilage maturation, subchondral bone remodeling, and ossification.”
Its so funny how in posting your ChatGPT slop you don’t atleast reread what your saying

Dumb fuck matrix turnover of bone is osteoblast and osteoclast activity. Mineralization is just downstream effects of osteoblast activity, cartilage maturation mainly only happens during puberty, subchondral bone remodeling is just osteoblasts/osteoclasts effects under the cartilage and ossification is basically just the combination of these

almost none of These are “different mechanisms” it’s just different locations or stages lmao

“So when YOU dismiss RANKL, NFATc1, ALP, Wnt/β-catenin, MAPK/Akt, PTH/VDR/TRPV6, and BMD as if they are irrelevant, you are not exposing anything. You are showing that you do not understand what mandibular remodeling is built from.”

Jfl the only 3 of those that might result in thicker bone is catenin and maybe ALP and AKT but if you also stimulate RANKL and NFATc1 ur also getting bone resorption JFL. So yes almost all of those are irrelevant in the context of trying to magically build bones from ur snake oil



“RANKL/NFATc1 matters because mandibular remodeling requires osteoclast regulation.

OPG/RANKL matters because mandibular bone adaptation depends on the balance between resorption and deposition.

Cathepsin K and MMP-9 matter because matrix breakdown and turnover are part of remodeling.”

You do realize osteoclasts will mean any new thickness added will just be reabsorbed dumb fuck?

Simply saying shit is “part of remodeling” means fuck all if all that’s being remodeled is that ur bone breaks down or remains the same thickness but just changes in mineral density

“ALP matters because mandibular bone formation requires mineralized matrix.”

Probably the only thing that might make sense here but this mainly increases density not thickness and can be increased through exercise or getting vitamin d you don’t need overpriced snake oil that has literallly 0 human testing


“Wnt/β-catenin matters because it is tied to osteoblast differentiation and ossification.”

Osteoblast differentiation and bone growth aren’t the same thing. When you injure ur bone ur body has high wnt catenin but that doesn’t mean it’s going to magically grow back longer than it used to be. That’s cause mainly all it does is either repair or help in turnover

“RUNX2 matters because condylar growth and cartilage-to-bone transition rely on osteogenic differentiation.”

Most of the cartilage that’s not fused in the jaw as an adult is just for elasticity of the jaw and proper functional jaw movement.


MAPK/Akt matters because mandibular tissues respond to mechanical loading and differentiation signals through these intracellular pathways.
Increased formation will still be balanced by increased resorption so this doesn’t matter. Your bone grows in order to respond to the mechanical stimulation and make the load more bearable. Not so that it can look more aesthetic

Wha will happen is there may be density changes but there won’t be any new size growth


“PTH/VDR/TRPV6 matters because mineral handling affects whether newly formed matrix can actually become mineralized bone”

Yeah and the new mineralized bone replaces the old bone that’s absorbed to make the new bone dumb fuck

“The pathway activity behind it is the real point we are all talking about here. Your entire argument is basically:

“These studies only show osteoblast activity, osteoclast regulation, mineralization, Wnt signaling, MAPK/Akt signaling, RANKL modulation, and bone-density changes… therefore they have nothing to do with bone growth or remodeling.””
Wow great way of showing after all the responses you still can’t track what my statements are

Dumb fuck nobody was contending you can’t have bone remodeling changes
My point is the bone remodeling isn’t going to be the bone getting thicker it’s going to have new bone formed and then old bone absorbed
And even if this is how these pathways worked osstivia wouldn’t do fuck all because
1. There is no evidence it would do this in humans. There isn’t even good evidence it does it in animals Letalone humans.

Even in the few animal studies we have almost all of them except like 1 or 2 is in healthy and matured animals

Their mainly on osteoporosis mice trying to heal from injury and they measured how much it would help aid in less bone breakdown rather than new bone being added
2. It’s not targetted. Simply drinking some cope snake oil isn’t going to mean any of the proposed effects that wouldn’t even do anything either way is going to have any local effect on the bone even in theory


“But saying “only chewing works” while dismissing the biochemical pathways that determine how bone responds to loading is childish.”

Dumb fuck even chewing which is whats going to do more than any of the snake oil doesn’t work much if at all for bone morphology changes especially in adults

Bone only adapts to what is necessary. Even if hypothetically speaking you did chew what happens is the density changes and maybe after years you gain 0.1 mm of bone. After that you will need more load in order to actually gain anything more since it has now adapted to the same loads that it did previously

we can even use athletes and bodybuilders for example. They train their body all day and they have bigger and thicker muscles but their bone size doesn’t magically change from it. They have bigger bones than on average (cause they are just more naturally gifted given them being athletes) but there’s no evidence of any athlete bone significantly changing in size after training outside of the occasional late fusion. And by the way nothing this osstivia cope is going to do will give you the same bone changes of world class athletes so if even they get minimal to non noticeable results what do you think this cope would do?

“That is like saying nutrition doesn't matter for muscle growth because lifting weights matters. Imagine saying that.”
Flag on the play to the dumb fuck for the false analogy.
1. Muscle and bone growth aren’t the same thing they work completely differently
2. Nutriton helps in muscle growth as it gives the essential building blocks for repair. it doesn’t trigger new growth like ur low iq ass thinks. Even if you combine nutrition and working out it doesn’t magically get faster it’s only if you are deficient in one which is when it will grow slower. What actually aids in muscle growth is adding more intense training while staying at a equilibrium to where ur body has enough energy

“In conclusion, You ranting or trying to debunk anything showed you are uneducated on the product, the mechanistic effects, and bone biology.”

In conclusion you haven’t responded to literaly any point I made. Ur whole counter is summed up to listing off random chemicals (which btw we don’t even have evidence that osstivia works on) that you didn’t understand how they work and then thinking increasing them will mean faster bone growth like a dumb fuck when that’s not how it works at all. And then later on clearly showing you don’t even understand the critique

Snedds increase absorption but simply absorbing more snake oil doesn’t mean the snake oil is going to cure a disease

And if you are taking it systematically it’s not going to be localized regardless

You could take stuff like milk with snedds and probably have almost all of the effects and maybe better

In fact even the
Oleanolic acid which is the active ingredient in fll gets mogged by recombinant bmp2 and there are 0 studies where bmp2 does anything for bone thickness.

Also even if oleanolic acid worked for bone thickness you know ur dumb fuck company doesn’t realize that olives and apples have more oleanolic acid Than fll

Either way just stop scamming people with this slop and get a real job nobody is going to believe this with a iq of over 90

You kinda blundered on the ad horm part ngl

 

[TrueManletLTN0311]

Chill bro, they don't even scam lol. There is enough research on the supplement, if you thought of it another way or misunderstood it then that's on you. They even have a discord server where you can self educate yourself and ask question on too

What’s the discord? I’m actually very interested in this topic as someone who is trying to get better zygos and groe their lower third.