Bad News; Pyrilutamide's Binding Affinity Is Lower Than Dht

[samskeyti]

I was chatting with open ai chat gpt, and asked a few questions about androgenetic alopecia treatments. Prior to this, I couldn't find any information about testosterone's, dht's and pyrilutamide's real binding affinites to androgen receptor. I found some data but they didn't seem reliable. The ai told me that according to the existing data, testosterone's binding affinity is 1.2 nanomolar while dht's value is 0.12 nanomolar. The lower the value is, the higher the binding affinity of the androgen to the receptor. The binding affinity of a ligand for a receptor is typically measured in molar units, such as nanomolars (nM) or picomolars (pM). A smaller numerical value for the binding affinity indicates a higher affinity, because it means that the ligand is able to bind to the receptor at lower concentrations. For example, a ligand with a binding affinity of 0.1 nM will bind to the receptor more readily than a ligand with a binding affinity of 1 nM, because the former ligand can bind at lower concentrations. Pyriliutamide's binding affinity turned out to be 0.28 nanomolar. This means that pyrilutamide's binding affinity is 4.28 times higher than that of testosterone which is great news because ru58841's binding affinity was just on par with testosterone, not even any higher. The bad news is that it's binding affinity is 2.33 times lower than dht. It's been rumoured to have a higher binding affinity than dht in tressless and hairlosstalk and it seems they are wrong. If those values are correct, combining dutasteride+pyrilutamide will lower the chance of losing hair to almost %0. Pyrilutemide will take on the remaining dht even though it has lower binding affinity since it will be able to outnumber it. Moreover, it'll be able to easily compete with testosterone. However, if you don't take fin/dut, a solo pyrilutamide treatment might not be any effective than finasteride, let alone dutasteride.

 

[balding17yomanletcel]

autism is strong

 

[HerpDerpson]

Doesn't matter, fin works.

 

[Deleted member 23558]

All this is true only if you believe dht is the only cause of hair loss ( which it isn’t)

 

[max_frisch]

take finasteride or dut

if something good comes out fine, if not, also fine

also pray for bayer/hopemedicine

 

[samskeyti]

I'm already on daily dutasteride and oral minoxidil and maintain my nw1 hair but i'd like to give up dutasteride in favour of a treatment which doesn't decrease serum dht levels. It looks like it's not going to be possible in the near future. By the way I'm 25 and fighting mbp since 18. It's very possible that I'll keep my hair at nw1 until a better treatment comes out.

 

[samskeyti]

All this is true only if you believe dht is the only cause of hair loss ( which it isn’t)

If dht isn't the leading reason, then why don't people with 5-ar deficiency go bald?

 

[Deleted member 23558]

If dht isn't the leading reason, then why don't people with 5-ar deficiency go bald?

That’s a false dichotomy . People with 5 at deficiency are trannies if you want to castrate yourself for hair then do it but dht is just one of the reasons you can have high dht and 5 at upregulation without going bald.

 

[samskeyti]

I meant that, it's androgens that are the root cause of androgenetic alopecia, not anything else. DHT has 10 times higher binding affinity than T, and 5 times more potent, that's why it's the leading cause. Testosterone can also cause hair loss if your follicles are sensitive enough. Some people claim that there are other factors than androgens for male pattern baldness, which I argue to be false. If that was correct, the rate of male pattern baldness, and the severity of it, would be at close percentages both for women and men. Castrated men also don't go bald, they shave their heads. The crucial point is to prevent mpb without a chemical or physical castration.