Berberine effect on muscle growth

[purpleskulltrooper]

I don't use berberine personally so I haven't read this article myself yet but here's a chatgpt summary for all those on here who do:

Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine - PMC

Defects in insulin/IGF-1 signaling stimulate muscle protein loss by suppressing protein synthesis and increasing protein degradation. Since an herbal compound, berberine, lowers blood levels of glucose and lipids, we proposed that it would improve ...

pmc.ncbi.nlm.nih.gov

This study tested whether berberine (a plant compound known to improve blood sugar) could help prevent muscle loss. Instead, researchers found the opposite.

• Main finding: Berberine actually causes muscle atrophy (muscle loss) in both normal and diabetic mice.
• It does this in two major ways:
  1. Decreases protein synthesis (muscle building)
  2. Increases protein degradation (muscle breakdown)
• The key driver is a protein called atrogin-1, which:
  • Speeds up muscle protein breakdown
  • Also reduces protein synthesis by lowering another important factor (eIF3-f)
• Berberine also:
  • Disrupts energy metabolism in muscle (via mitochondria)
  • Activates AMPK, which further increases atrogin-1 and suppresses muscle growth pathways
• When researchers improved mitochondrial function (using PGC-1α), the muscle damage effects were prevented, showing energy metabolism is a big part of the problem.

Edit: Ignore this berberine mogs. Might have to switch from reta soon

 

[Iblamegirthquake]

why should anyone rep a chatgpt summary bro

 

[norwoodingmanlet]

I don't use berberine personally so I haven't read this article myself yet but here's a chatgpt summary for all those on here who do:

Atrogin-1 Affects Muscle Protein Synthesis and Degradation When Energy Metabolism Is Impaired by the Antidiabetes Drug Berberine - PMC

Defects in insulin/IGF-1 signaling stimulate muscle protein loss by suppressing protein synthesis and increasing protein degradation. Since an herbal compound, berberine, lowers blood levels of glucose and lipids, we proposed that it would improve ...

pmc.ncbi.nlm.nih.gov

This study tested whether berberine (a plant compound known to improve blood sugar) could help prevent muscle loss. Instead, researchers found the opposite.

• Main finding: Berberine actually causes muscle atrophy (muscle loss) in both normal and diabetic mice.
• It does this in two major ways:
  1. Decreases protein synthesis (muscle building)
  2. Increases protein degradation (muscle breakdown)
• The key driver is a protein called atrogin-1, which:
  • Speeds up muscle protein breakdown
  • Also reduces protein synthesis by lowering another important factor (eIF3-f)
• Berberine also:
  • Disrupts energy metabolism in muscle (via mitochondria)
  • Activates AMPK, which further increases atrogin-1 and suppresses muscle growth pathways
• When researchers improved mitochondrial function (using PGC-1α), the muscle damage effects were prevented, showing energy metabolism is a big part of the problem.

better insulin sense usually always in the end leads to better glucose uptake.... soooooooo more muscle growth

 

[purpleskulltrooper]

why should anyone rep a chatgpt summary bro

What makes you think I gaf about useless reputation points on this site

 

[Grievous]

First off it was injected so the effects were much stronger
But secondly the mice were laying around doing nothing compared to humans who would be active and likely doing resistance training

u could give any mice something via injection and expect them to have negative effects

even if this does occur in humans its extremely negligible

it mainly happened because it was administered via injection not oral

Berberine forever mogs metformin
and reta mogs berberine
and insulin mogs reta

for insulin resistance