idkmanimao
Zephir
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Drugs that increase facial bone mass (fastest to slowest):
1. HGH (Human Growth Hormone)
Raises IGF-1, which causes bone and cartilage growth—especially in the jaw, chin, brow ridge, and cheekbones. Works best if you're still growing (like at 14). Long cycles (6–12+ months) are needed for real facial change. Can cause permanent changes. High doses = higher risk of acromegaly.
2. MK-677 (Ibutamoren)
It mimics ghrelin and boosts HGH/IGF-1 naturally. It doesn’t shut down your system and is taken orally. Slower than HGH but still can grow facial bones if taken for many months. Better for younger people since your plates are still open.
3. Testosterone (and anabolic steroids like RAD-140)
Indirectly supports bone density and size by increasing IGF-1 and androgen activity in bone. Most of its bone effects are on jaw width, chin, and thickness of facial bones—not so much height or sharpness. Can give a more “masculine” skull structure. Not ideal alone for bone growth but helps with thickness and definition.
4. Trenbolone / DHT-based steroids (Masteron, DHT, etc.)
Extremely androgenic. Can lead to dense bone and stronger jaw features. Risky and aggressive. Not advised at all, especially for teens.
5. Insulin + HGH
Some pro bodybuilders use insulin with HGH to enhance bone growth and muscle volume. Dangerous. Can cause permanent organ growth and insulin resistance. Not smart to mess with as a teen.
6. IGF-1 LR3 or DES
This is the pure hormone that HGH eventually raises. Injecting it directly targets local bone/muscle growth. It’s very powerful, especially near bones (like in the jaw area), but not as commonly available and more expensive.
Mainline Hormones & Peptides
- Human Growth Hormone (HGH / Somatropin) – stimulates IGF-1, increases bone length and density, especially during puberty
- IGF-1 (Insulin-like Growth Factor 1) – the main driver of bone and tissue growth; very potent for the jaw, zygos, brow
- IGF-1 LR3 / DES IGF-1 – synthetic IGF-1 variants with longer half-life, often used to target site-specific growth
- MK-677 (Ibutamoren) – GH secretagogue, boosts endogenous GH/IGF-1 without suppressing testosterone, used to mimic HGH
- Tesamorelin – another GH secretagogue; more potent but less commonly available
- CJC-1295 with DAC / without DAC – peptide that increases GH release over time (especially when stacked with Ipamorelin)
- Ipamorelin – mild GH-releasing peptide, often stacked with CJC for longer GH pulse
- Hexarelin / GHRP-6 / GHRP-2 – older, stronger GH secretagogues; more appetite and cortisol sides
- PEG-MGF (Mechano Growth Factor) – a splice variant of IGF-1; plays a role in localized muscle and possibly bone repair
- HGH Fragment 176-191 – less relevant for bones, but sometimes confused with HGH (mainly fat loss)
- Testosterone – major natural driver of bone thickness, width, and density in adolescence
- Dihydrotestosterone (DHT) – potent metabolite of testosterone; extremely impactful on jawline, chin, brow, and facial masculinity
- RAD-140 (Testolone) – SARM with strong anabolic effects; mimics testosterone and may promote bone/cranial development
- LGD-4033 (Ligandrol) – another powerful SARM, promotes bone mineralization and lean tissue
- YK-11 – myostatin inhibitor + partial androgen; speculation it might enhance facial bone gain if taken long enough
- S23 – a dry, aggressive SARM with strong binding affinity to AR; may increase bone strength
- Oxandrolone (Anavar) – known to improve bone density with less growth plate closure risk
- Boldenone (Equipoise) – stimulates collagen and bone marrow activity
- Nandrolone (Deca Durabolin) – extremely potent on bones and joints, used clinically for osteoporosis
- Trenbolone – very aggressive; boosts IGF-1, bone density, and mineral retention (but comes with insane side effects)
- Vitamin D3 (Cholecalciferol) – absolutely essential for calcium absorption and bone formation
- Vitamin K2 (MK-4 / MK-7) – directs calcium into bones instead of arteries, synergistic with D3
- Calcium – base mineral for bones, but works best with D3 and K2
- Magnesium – important co-factor in bone matrix formation
- Zinc – supports testosterone production and bone tissue development
- Boron – helps maintain bone strength and regulates sex hormones
- Collagen Peptides / Hydrolyzed Collagen – provides amino acids for bone and skin regeneration
- Creatine Monohydrate – increases IGF-1 expression slightly, supports lean mass and possibly cranial growth
- Ashwagandha – mildly increases testosterone and bone density
- Tongkat Ali – natural T-booster, may support skeletal growth via hormonal regulation
- Fadogia Agrestis – speculative T-booster, very little bone-specific data
- Deer Antler Velvet – contains IGF-1 and growth factors, though bioavailability is questionable
- Colostrum – rich in growth factors, possibly supports bone and tissue growth
- MK-2866 (Ostarine) – SARM that has shown improvement in bone mineral density in trials
Experimental / Less Common Pathways
- BMPs (Bone Morphogenetic Proteins) – signaling molecules that directly induce bone growth (not supplements, used in biotech)
- TGF-beta (Transforming Growth Factor) – regulates bone cell differentiation, key in early facial formation
- Wnt Signaling Modulators – experimental class of drugs that can directly impact craniofacial bone development
- FGF-23 Inhibitors – fibroblast growth factors that affect phosphate and bone remodeling
- Myostatin Inhibitors (e.g., Follistatin) – mostly for muscle, but some evidence suggests it alters bone density
- RANKL Inhibitors / Denosumab – used clinically to stop bone breakdown, may increase bone mass indirectly
now stop talking, i'm trying to fix my rep post ratios
