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godhatesus
Iron
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Basically this thread is just going to establish chemical pathways which lead to increase osteoblastic activity and bone remodelling, disregarding the idea that bs builds scar tissue because idgaf about that rn.
So the pathway I'm looking at works through mechanotransduction, which just means applying force to the bone.
There are several other interesting mechanisms that cause similar signalling pathways to activate but the most important pathway is wnt/beta-catenin - mechanical loading has been shown to increase Wnt ligands, while sclerostin - an inhibitor of Wnt signalling - is suppressed by loading.
Essentially what this proves is that external forces do cause none growth, but what most people get wrong is that for simply stimulating bone growth you don't need to smash your face with a hammer. The force provided by eg a massage gun provides sufficient micro strains (1,500–3,000 µε, suggested in article listedhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10616261) to stimulate bone growth but there's no evidence to suggest the bone will grow in a certain way and not just remodel, so it's not really a nailed on fact but has potential because there are no studies suggesting otherwise. But I can't say the same about scar tissue, I haven't looked in to that. Icba to cite sources and go into more detail but can if anyone gaf. I know low effort but I don't have a lot of time
So the pathway I'm looking at works through mechanotransduction, which just means applying force to the bone.
- Piezo --> Ca2+
There are several other interesting mechanisms that cause similar signalling pathways to activate but the most important pathway is wnt/beta-catenin - mechanical loading has been shown to increase Wnt ligands, while sclerostin - an inhibitor of Wnt signalling - is suppressed by loading.
Essentially what this proves is that external forces do cause none growth, but what most people get wrong is that for simply stimulating bone growth you don't need to smash your face with a hammer. The force provided by eg a massage gun provides sufficient micro strains (1,500–3,000 µε, suggested in article listedhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10616261) to stimulate bone growth but there's no evidence to suggest the bone will grow in a certain way and not just remodel, so it's not really a nailed on fact but has potential because there are no studies suggesting otherwise. But I can't say the same about scar tissue, I haven't looked in to that. Icba to cite sources and go into more detail but can if anyone gaf. I know low effort but I don't have a lot of time
