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Iron
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Cheep bone stack for appositional growth
Linoleic acid:
LA ( linoleic acid ) I made a post on it and how it increse periostial bone formation by 220%, increased Cortial thickness by
38% and periostial perimeter by 15% while having 0 effects on Endocortial thickness meaning it's extremely biast towards the periosteum of bones.
Doses : 0.05mg per kg split into 3-5 x a day subq so If u need 5 mg ideally do 1mg 5x a day subq
Hadjod/Cissus quadrangularis:
Cissus quadrangularis ( CQ) down regulate RANKL ( via TNF-a IL-6 and IL-17 down regulation ) and other bone resorption markers such as CTX and TRAPb5 while pushing bone formation markers such as APL and P1NP increases runX2 mRNA stabilises and prevents the degradation of b-catetin and drives osteoblast activity thru activating p38 MPAK and erk1/2 and also increasing serum pth and promoting other anti osteoclastogenic markers such as ( IFN-y IL-4 IL-10 ) . Cq has also been observed to not only prevent the bone loss of Oxr rats but also increase the Cortial thickness and visually making the bone wider then the sham groups as seen in these pictures
QC also has the cool effects at promoting the up regulation of Hif-1 and vegf in bones promoting angiogenesis and further driving osteoblast activity while suppressing ostoclast one via hif1.
Doses: 41mg per kg split into 2 doses so if u need 5g a day use 2.5 mg 2x a day
Flubiprofen:
Flubiprofen is a NSAID clad drug when used in low doses it can decrease osteoclast number by 62-70% while also down regulating RANKL and up regulating OPG and inhibiting/ interrupting TRAF6 thus halting the activation of NG-kB and also directly activating intercellular caspase-3 leading to apoptosis in ostoclast hence why u see the 70% drop. It also drives osteoblast count and w apposition rate by having protective effects on EP2 and EP4 at low does this focuses intercellular accumulation of b-catetin this up regulating runX2 and osterix leading to that 64% Increse in bone formation on the surface of the bones.
Doses: 5.5-8.5 mg 5-7x a week
Roxadusant + DFO:
I’ve made a post on these 2 and how we could use them to mimic a vfl ko like environment that’s super anabolic for bone growth but ill sum it up in short here :
Roxadustant strips away the PHD enzyme that lets the vfl protein recognise hif 1/2 and DOF strips away the iron cofactor ( the enzymes needed for vfl to function ) this causes like a massive spike in hif1/2 and mimics a super low oxygen environment and it causes a huge up regulation of wnt and vegf = pushes ostoblast activity and periostial expansion
Doses: Roxadusant 1.5-2mg per kg DFO 7-10mg pet kg
( optional from under here )
Carfilzomib/Brotezobim
Carfilzomib/Brotezobim (car/brot ) are both proteasome inhibitor. They both Inhbit the break down of runx2,b-catetin smad1/5 and hif-1 while also lowering sots and dkk1 at the same time thus pushing the wnt path way in an overt active state that would promote ostoblast differentiation and osteogenesis while also halting osteoclast via also down regulating RANKL.
Doses: I’d recommend to use brot as it can be administered subq as well while car needs to be iv these drugs need to be cycled in this manner as well
Day 1-4-8-11 then a 10 day break u only take 2-2.5 subq on the days I listed and then take a 10 day break after.
Abalo:
Abalo is a pthrp it binds to the pthr1 receptors and detached much faster then teri or regular pth hormone thus creating a more bone anabolic environment pushing ostoblast count more the osteoclast as seen in teri or in high levels of pth hormone it increases the proliferation and survival of osteoblast via the spike in cAMP and activation of PAK. Abalo is also known to inhibit sots and pth hormone is pth hormone is known to decrease dkk1 mRNA by 90% and systemic levels by 20-30% so in theory abalo would do the same if not even more and if forced massive spikes in collagen type l and alkaline phosphatase.
Doses: 100-200 mcg ed can split it if u do 200 mcg in 100 2x a day wont have much catabolic effects especially if paired with a proteasome inhibitor .
Linoleic acid:
LA ( linoleic acid ) I made a post on it and how it increse periostial bone formation by 220%, increased Cortial thickness by
38% and periostial perimeter by 15% while having 0 effects on Endocortial thickness meaning it's extremely biast towards the periosteum of bones.
Doses : 0.05mg per kg split into 3-5 x a day subq so If u need 5 mg ideally do 1mg 5x a day subq
Hadjod/Cissus quadrangularis:
Cissus quadrangularis ( CQ) down regulate RANKL ( via TNF-a IL-6 and IL-17 down regulation ) and other bone resorption markers such as CTX and TRAPb5 while pushing bone formation markers such as APL and P1NP increases runX2 mRNA stabilises and prevents the degradation of b-catetin and drives osteoblast activity thru activating p38 MPAK and erk1/2 and also increasing serum pth and promoting other anti osteoclastogenic markers such as ( IFN-y IL-4 IL-10 ) . Cq has also been observed to not only prevent the bone loss of Oxr rats but also increase the Cortial thickness and visually making the bone wider then the sham groups as seen in these pictures
QC also has the cool effects at promoting the up regulation of Hif-1 and vegf in bones promoting angiogenesis and further driving osteoblast activity while suppressing ostoclast one via hif1.
Doses: 41mg per kg split into 2 doses so if u need 5g a day use 2.5 mg 2x a day
Flubiprofen:
Flubiprofen is a NSAID clad drug when used in low doses it can decrease osteoclast number by 62-70% while also down regulating RANKL and up regulating OPG and inhibiting/ interrupting TRAF6 thus halting the activation of NG-kB and also directly activating intercellular caspase-3 leading to apoptosis in ostoclast hence why u see the 70% drop. It also drives osteoblast count and w apposition rate by having protective effects on EP2 and EP4 at low does this focuses intercellular accumulation of b-catetin this up regulating runX2 and osterix leading to that 64% Increse in bone formation on the surface of the bones.
Doses: 5.5-8.5 mg 5-7x a week
Roxadusant + DFO:
I’ve made a post on these 2 and how we could use them to mimic a vfl ko like environment that’s super anabolic for bone growth but ill sum it up in short here :
Roxadustant strips away the PHD enzyme that lets the vfl protein recognise hif 1/2 and DOF strips away the iron cofactor ( the enzymes needed for vfl to function ) this causes like a massive spike in hif1/2 and mimics a super low oxygen environment and it causes a huge up regulation of wnt and vegf = pushes ostoblast activity and periostial expansion
Doses: Roxadusant 1.5-2mg per kg DFO 7-10mg pet kg
( optional from under here )
Carfilzomib/Brotezobim
Carfilzomib/Brotezobim (car/brot ) are both proteasome inhibitor. They both Inhbit the break down of runx2,b-catetin smad1/5 and hif-1 while also lowering sots and dkk1 at the same time thus pushing the wnt path way in an overt active state that would promote ostoblast differentiation and osteogenesis while also halting osteoclast via also down regulating RANKL.
Doses: I’d recommend to use brot as it can be administered subq as well while car needs to be iv these drugs need to be cycled in this manner as well
Day 1-4-8-11 then a 10 day break u only take 2-2.5 subq on the days I listed and then take a 10 day break after.
Abalo:
Abalo is a pthrp it binds to the pthr1 receptors and detached much faster then teri or regular pth hormone thus creating a more bone anabolic environment pushing ostoblast count more the osteoclast as seen in teri or in high levels of pth hormone it increases the proliferation and survival of osteoblast via the spike in cAMP and activation of PAK. Abalo is also known to inhibit sots and pth hormone is pth hormone is known to decrease dkk1 mRNA by 90% and systemic levels by 20-30% so in theory abalo would do the same if not even more and if forced massive spikes in collagen type l and alkaline phosphatase.
Doses: 100-200 mcg ed can split it if u do 200 mcg in 100 2x a day wont have much catabolic effects especially if paired with a proteasome inhibitor .
