Clearing two misunderstandings about HGH and IGF-1

enchanted_elixir

enchanted_elixir

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  • Misconception #1: They're two completely different hormones.
    • Answer: They are interlinked. HGH gets converted into IGF-1 in the body by the liver. When the conversion is complete, it is taken by the body to grow your bones.

  • Misconception #2: HGH > IGF-1 or you need BOTH!
    • Answer: Remember the conversation part we discussed earlier? Why inject HGH and have it be converted before it can take effect (and the conversion isn't even 100% efficient) when you could just inject IGF-1 and get it to act instantly with 100% efficiency. You really only need IGF-1.
 
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igf1 what role does it play in bone remodeling?
 
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  • Misconception #1: They're two completely different hormones.
    • Answer: They are interlinked. HGH gets converted into IGF-1 in the body by the liver. When the conversion is complete, it is taken by the body to grow your bones.

  • Misconception #2: HGH > IGF-1 or you need BOTH!
    • Answer: Remember the conversation part we discussed earlier? Why inject HGH and have it be converted before it can take effect (and the conversion isn't even 100% efficient) when you could just inject IGF-1 and get it to act instantly with 100% efficiency. You really only need IGF-1.
Can you outgrow your genetic limits with hgh or igf1?
 
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based scientist
 
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alright sir since you are so knowledgeable just tell me with a simple yes or no will i lose my hair if i inject it
 
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alright sir since you are so knowledgeable just tell me with a simple yes or no will i lose my hair if i inject it
Nope, the reverse actually since it is a growth factor hormone.
 
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Nope, the reverse actually since it is a growth factor hormone.
but there has to be a catch right? some kind of terrible side effect? if there isnt then why isnt everyone younger than 20 injecting that shit for the life of them? i did absolutely zero research since i thought id never need that (im 6 5 lol) but hearing about all these benefits it may just be a good addition to the t boosting stack
 
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Acromegaly is NOT the way to grow your fucking bones.
default.jpg

BRB looking like this.
BRB increasing your cancer chances.
BRB becoming diabetic.

It has been proven that IGF-1 AND HGH don't increase contractile tissue aka muscle.

First, in healthy adult humans, the administration of growth hormone is lipolytic and causes an increase in serum free fatty acids.

This in turn inhibits glucose uptake by major target tissues and is the basis for the hyperglycemia and insulin resistance associated with acromegaly.

HGH also causes increased water absorption by the intestine and increased sodium retention at the tubular level leading to increased fluid accumulation, carpal tunnel syndrome, and high blood pressure.

IGF-1 has 3 variants (this is the hormone that is sought to increase with chronic administration of hGH). And only IGF-1ec (MGF) has been shown to have important effects at the level of muscle hypertrophy. In fact, exogenous administration of IGF-1 increases protein synthesis throughout the body, but does NOT increase muscle protein synthesis, since IGF-1ec is responsible for muscle protein synthesis. IGF-1ec is a variant of IGF-1 which is produced locally in the muscle, generally under a mechanical stimulus.

It has been known for almost 3 decades that the administration of growth hormone does not appear to cause an additional increase in muscle mass or strength that resistance training provides in any healthy young athlete with an average age of 23 years (According to Crist et al 1988; Yarasheki et al. 1992, 1993; Deyssig 1993 Dan Duchaine in his book was the one who popularized the abuse of HGH, it is known that the use of supraphysiological doses can have fatal consequences (Takala et al. 1999) Taaffe et al. (1994, 1996) showed that in healthy elderly men (mean age 70.3 years) the increase in myofibrillar CSA and strength were not different between those who followed a resistance training program in combination with recombinant human growth hormone or placebo.

In two other studies, both in 31 elderly men (mean age> 70 years), hGH + exercise had no additional effect on the Placebo + exercise group on strength gains, power, or muscle hypertrophy after 12 weeks ( Lange et al. 2002) or 6 months (Hennessey et al. 2001) of administration and training.

Although it is true that increases in whole-body protein synthesis have been observed both in untrained young subjects (mean age 23 years; Yarasheski et al. 1992) and in older age (mean age 67 years; Yarasheski et al. 1995 ) who performed weight training in combination with hGH relative to those who received placebo, but interestingly, this effect was not reflected in protein synthesis rates of the quadriceps, which suggests that the effects of hGH are not exerted at the level of the musculoskeletal tissue. Yarasheski et al. (1993) also demonstrated that there was no effect of hGH administration for 2 weeks on quadriceps protein synthesis rates or whole-body protein breakdown in young and experienced weightlifters (mean age 23 years).

The data suggests that there is no beneficial effect of administering hGH in combination with an exercise program to increase muscle mass.

So the effects of hGH on fat-free mass are possibly due to water retention, which is a known side effect of hGH administration, or to an increase in the size of soft tissues due to the stimulating effects of hGH in collagen synthesis.


I'm fucking tired of the HGH meme in this forum.
 
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Can i use MGF C terminal to grow my clavicles? C terminal has shorter half life.
Just use IGF-1, I don't know why you'd resort to a splice to be honest.
 
  • Hmm...
Reactions: Tallooksmaxxer
  • Misconception #1: They're two completely different hormones.
    • Answer: They are interlinked. HGH gets converted into IGF-1 in the body by the liver. When the conversion is complete, it is taken by the body to grow your bones.

  • Misconception #2: HGH > IGF-1 or you need BOTH!
    • Answer: Remember the conversation part we discussed earlier? Why inject HGH and have it be converted before it can take effect (and the conversion isn't even 100% efficient) when you could just inject IGF-1 and get it to act instantly with 100% efficiency. You really only need IGF-1.
Do you know about pharmacy human growth hormone brands?
 
but there has to be a catch right? some kind of terrible side effect? if there isnt then why isnt everyone younger than 20 injecting that shit for the life of them? i did absolutely zero research since i thought id never need that (im 6 5 lol) but hearing about all these benefits it may just be a good addition to the t boosting stack
It's relatively expensive, and a lot of people are teenagers which would have to sneak it into their house. MK-677, an alternative can cause diabetes if you don't take countermeasures.

The only side effect I can think of with excessive, and I mean EXCESSIVE IGF-1 is acromegaly.
 
Acromegaly is NOT the way to grow your fucking bones.
default.jpg

BRB looking like this.
BRB increasing your cancer chances.
BRB becoming diabetic.

It has been proven that IGF-1 AND HGH don't increase contractile tissue aka muscle.

First, in healthy adult humans, the administration of growth hormone is lipolytic and causes an increase in serum free fatty acids.

This in turn inhibits glucose uptake by major target tissues and is the basis for the hyperglycemia and insulin resistance associated with acromegaly.

HGH also causes increased water absorption by the intestine and increased sodium retention at the tubular level leading to increased fluid accumulation, carpal tunnel syndrome, and high blood pressure.

IGF-1 has 3 variants (this is the hormone that is sought to increase with chronic administration of hGH). And only IGF-1ec (MGF) has been shown to have important effects at the level of muscle hypertrophy. In fact, exogenous administration of IGF-1 increases protein synthesis throughout the body, but does NOT increase muscle protein synthesis, since IGF-1ec is responsible for muscle protein synthesis. IGF-1ec is a variant of IGF-1 which is produced locally in the muscle, generally under a mechanical stimulus.

It has been known for almost 3 decades that the administration of growth hormone does not appear to cause an additional increase in muscle mass or strength that resistance training provides in any healthy young athlete with an average age of 23 years (According to Crist et al 1988; Yarasheki et al. 1992, 1993; Deyssig 1993 Dan Duchaine in his book was the one who popularized the abuse of HGH, it is known that the use of supraphysiological doses can have fatal consequences (Takala et al. 1999) Taaffe et al. (1994, 1996) showed that in healthy elderly men (mean age 70.3 years) the increase in myofibrillar CSA and strength were not different between those who followed a resistance training program in combination with recombinant human growth hormone or placebo.

In two other studies, both in 31 elderly men (mean age> 70 years), hGH + exercise had no additional effect on the Placebo + exercise group on strength gains, power, or muscle hypertrophy after 12 weeks ( Lange et al. 2002) or 6 months (Hennessey et al. 2001) of administration and training.

Although it is true that increases in whole-body protein synthesis have been observed both in untrained young subjects (mean age 23 years; Yarasheski et al. 1992) and in older age (mean age 67 years; Yarasheski et al. 1995 ) who performed weight training in combination with hGH relative to those who received placebo, but interestingly, this effect was not reflected in protein synthesis rates of the quadriceps, which suggests that the effects of hGH are not exerted at the level of the musculoskeletal tissue. Yarasheski et al. (1993) also demonstrated that there was no effect of hGH administration for 2 weeks on quadriceps protein synthesis rates or whole-body protein breakdown in young and experienced weightlifters (mean age 23 years).

The data suggests that there is no beneficial effect of administering hGH in combination with an exercise program to increase muscle mass.

So the effects of hGH on fat-free mass are possibly due to water retention, which is a known side effect of hGH administration, or to an increase in the size of soft tissues due to the stimulating effects of hGH in collagen synthesis.


I'm fucking tired of the HGH meme in this forum.
But that's for muscle...
 
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Reactions: SteveRogers and Deleted member 17448
Acromegaly is NOT the way to grow your fucking bones.
default.jpg

BRB looking like this.
BRB increasing your cancer chances.
BRB becoming diabetic.

It has been proven that IGF-1 AND HGH don't increase contractile tissue aka muscle.

First, in healthy adult humans, the administration of growth hormone is lipolytic and causes an increase in serum free fatty acids.

This in turn inhibits glucose uptake by major target tissues and is the basis for the hyperglycemia and insulin resistance associated with acromegaly.

HGH also causes increased water absorption by the intestine and increased sodium retention at the tubular level leading to increased fluid accumulation, carpal tunnel syndrome, and high blood pressure.

IGF-1 has 3 variants (this is the hormone that is sought to increase with chronic administration of hGH). And only IGF-1ec (MGF) has been shown to have important effects at the level of muscle hypertrophy. In fact, exogenous administration of IGF-1 increases protein synthesis throughout the body, but does NOT increase muscle protein synthesis, since IGF-1ec is responsible for muscle protein synthesis. IGF-1ec is a variant of IGF-1 which is produced locally in the muscle, generally under a mechanical stimulus.

It has been known for almost 3 decades that the administration of growth hormone does not appear to cause an additional increase in muscle mass or strength that resistance training provides in any healthy young athlete with an average age of 23 years (According to Crist et al 1988; Yarasheki et al. 1992, 1993; Deyssig 1993 Dan Duchaine in his book was the one who popularized the abuse of HGH, it is known that the use of supraphysiological doses can have fatal consequences (Takala et al. 1999) Taaffe et al. (1994, 1996) showed that in healthy elderly men (mean age 70.3 years) the increase in myofibrillar CSA and strength were not different between those who followed a resistance training program in combination with recombinant human growth hormone or placebo.

In two other studies, both in 31 elderly men (mean age> 70 years), hGH + exercise had no additional effect on the Placebo + exercise group on strength gains, power, or muscle hypertrophy after 12 weeks ( Lange et al. 2002) or 6 months (Hennessey et al. 2001) of administration and training.

Although it is true that increases in whole-body protein synthesis have been observed both in untrained young subjects (mean age 23 years; Yarasheski et al. 1992) and in older age (mean age 67 years; Yarasheski et al. 1995 ) who performed weight training in combination with hGH relative to those who received placebo, but interestingly, this effect was not reflected in protein synthesis rates of the quadriceps, which suggests that the effects of hGH are not exerted at the level of the musculoskeletal tissue. Yarasheski et al. (1993) also demonstrated that there was no effect of hGH administration for 2 weeks on quadriceps protein synthesis rates or whole-body protein breakdown in young and experienced weightlifters (mean age 23 years).

The data suggests that there is no beneficial effect of administering hGH in combination with an exercise program to increase muscle mass.

So the effects of hGH on fat-free mass are possibly due to water retention, which is a known side effect of hGH administration, or to an increase in the size of soft tissues due to the stimulating effects of hGH in collagen synthesis.


I'm fucking tired of the HGH meme in this forum.
High inhibition manlet
 
Acromegaly is NOT the way to grow your fucking bones.
default.jpg

BRB looking like this.
BRB increasing your cancer chances.
BRB becoming diabetic.

It has been proven that IGF-1 AND HGH don't increase contractile tissue aka muscle.

First, in healthy adult humans, the administration of growth hormone is lipolytic and causes an increase in serum free fatty acids.

This in turn inhibits glucose uptake by major target tissues and is the basis for the hyperglycemia and insulin resistance associated with acromegaly.

HGH also causes increased water absorption by the intestine and increased sodium retention at the tubular level leading to increased fluid accumulation, carpal tunnel syndrome, and high blood pressure.

IGF-1 has 3 variants (this is the hormone that is sought to increase with chronic administration of hGH). And only IGF-1ec (MGF) has been shown to have important effects at the level of muscle hypertrophy. In fact, exogenous administration of IGF-1 increases protein synthesis throughout the body, but does NOT increase muscle protein synthesis, since IGF-1ec is responsible for muscle protein synthesis. IGF-1ec is a variant of IGF-1 which is produced locally in the muscle, generally under a mechanical stimulus.

It has been known for almost 3 decades that the administration of growth hormone does not appear to cause an additional increase in muscle mass or strength that resistance training provides in any healthy young athlete with an average age of 23 years (According to Crist et al 1988; Yarasheki et al. 1992, 1993; Deyssig 1993 Dan Duchaine in his book was the one who popularized the abuse of HGH, it is known that the use of supraphysiological doses can have fatal consequences (Takala et al. 1999) Taaffe et al. (1994, 1996) showed that in healthy elderly men (mean age 70.3 years) the increase in myofibrillar CSA and strength were not different between those who followed a resistance training program in combination with recombinant human growth hormone or placebo.

In two other studies, both in 31 elderly men (mean age> 70 years), hGH + exercise had no additional effect on the Placebo + exercise group on strength gains, power, or muscle hypertrophy after 12 weeks ( Lange et al. 2002) or 6 months (Hennessey et al. 2001) of administration and training.

Although it is true that increases in whole-body protein synthesis have been observed both in untrained young subjects (mean age 23 years; Yarasheski et al. 1992) and in older age (mean age 67 years; Yarasheski et al. 1995 ) who performed weight training in combination with hGH relative to those who received placebo, but interestingly, this effect was not reflected in protein synthesis rates of the quadriceps, which suggests that the effects of hGH are not exerted at the level of the musculoskeletal tissue. Yarasheski et al. (1993) also demonstrated that there was no effect of hGH administration for 2 weeks on quadriceps protein synthesis rates or whole-body protein breakdown in young and experienced weightlifters (mean age 23 years).

The data suggests that there is no beneficial effect of administering hGH in combination with an exercise program to increase muscle mass.

So the effects of hGH on fat-free mass are possibly due to water retention, which is a known side effect of hGH administration, or to an increase in the size of soft tissues due to the stimulating effects of hGH in collagen synthesis.


I'm fucking tired of the HGH meme in this forum.
IGF1 doesn’t grow muscle on its own you combine it with steroids for hyperplasia and hypertrophy both.
 
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Just use IGF-1, I don't know why you'd resort to a splice to be honest.
MGF steps up the stem cell production. Its cycled with mgf. MGF first and IGF later.
 
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So that damn fucking shake that increases your IGF-1 levels is good?
 
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IGF1 doesn’t grow muscle on its own you combine it with steroids for hyperplasia and hypertrophy both.
Hyperplasia hasn't been documented even in one single study in humans.
 
  • Misconception #1: They're two completely different hormones.
    • Answer: They are interlinked. HGH gets converted into IGF-1 in the body by the liver. When the conversion is complete, it is taken by the body to grow your bones.

  • Misconception #2: HGH > IGF-1 or you need BOTH!
    • Answer: Remember the conversation part we discussed earlier? Why inject HGH and have it be converted before it can take effect (and the conversion isn't even 100% efficient) when you could just inject IGF-1 and get it to act instantly with 100% efficiency. You really only need IGF-1.
What source did you use to get yours?
 
Can you have a liver problem where your liver doesn’t turn hgh into igf-1 ? How could you fix it
 
Can you have a liver problem where your liver doesn’t turn hgh into igf-1 ? How could you fix it
bro that would be severe growth hormone deficiency isnt that very unlikely
 
Aren't there benefits of HGH itself before it's converted to IGF1 or it's EVERYTHING solely related to IGF1?
 
They are synergistic, which is why bodybuilders will typically use both at the top level (kigtropin + increlex typically). If you only use IGF-1 you are losing some indirect benefits of HGH, and using them together means less HGH is needed with the associated metabolic damage done by HGH. IGF-1 if legit is very expensive so it's kinda dumb to use it on its own, it's pretty much only done by certain diabetics (HGH usage worsens insulin resistance).
 
They are synergistic, which is why bodybuilders will typically use both at the top level (kigtropin + increlex typically). If you only use IGF-1 you are losing some indirect benefits of HGH, and using them together means less HGH is needed with the associated metabolic damage done by HGH. IGF-1 if legit is very expensive so it's kinda dumb to use it on its own, it's pretty much only done by certain diabetics (HGH usage worsens insulin resistance).
what would a legit igf1 price be
 
what would a legit igf1 price be

pharma IGF-1 last I heard was about $2k for 40mg. IGF-1 LR3 from a research peptide site is more effective and way cheaper but there's plenty of fake stuff on the grey market. In general if you can't get a good LR3 source it's best to stick to hgh.
 
pharma IGF-1 last I heard was about $2k for 40mg. IGF-1 LR3 from a research peptide site is more effective and way cheaper but there's plenty of fake stuff on the grey market. In general if you can't get a good LR3 source it's best to stick to hgh.
opinion on qorepharm?
 
t has been proven that IGF-1 AND HGH don't increase contractile tissue aka muscle.
How dense are you? Not one user had mentioned muscle, we’re referring to bone.
That’s like someone saying “bro washing your hands with soap doesn’t clean your balls”, no fucking shit dumbass, we’re not trying to clean our balls.
 
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Reactions: Deleted member 8869 and AverageTevvezFan
  • Misconception #1: They're two completely different hormones.
    • Answer: They are interlinked. HGH gets converted into IGF-1 in the body by the liver. When the conversion is complete, it is taken by the body to grow your bones.

  • Misconception #2: HGH > IGF-1 or you need BOTH!
    • Answer: Remember the conversation part we discussed earlier? Why inject HGH and have it be converted before it can take effect (and the conversion isn't even 100% efficient) when you could just inject IGF-1 and get it to act instantly with 100% efficiency. You really only need IGF-1.
'Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies'

HGH is not only a precursor to IGF-1, meaning it almost 'creates' it when you inject HGH, but HGH has it's own effect on the bones too as per the study above.

Furthermore, injecting HGH is superior to any form of IGF-1 due to the duality of both injectable forms.

You can get IGF-1 DES or IGF-1 LR3.

IGF-1 DES lasts about 15 minutes in the body and will only affect the area you inject it into, which is a pain in the ass and which is why it only has very specific uses.

IGF-1 LR3 lasts 24 hours, but when IGF-1 is in your system for that long it latches on to not just the bones and muscle, but the rest of your tissues too. Why does this matter? Because it puts you at a far greater risk of developing cancerous tumours.

HGH takes the best of both worlds. It slowly releases safer amounts of IGF-1 throughout the entire body.

GGWP
 
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Reactions: ChristianChad
Is it worth to inject either at 18 with growth plates likely closed?
 
'Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies'

HGH is not only a precursor to IGF-1, meaning it almost 'creates' it when you inject HGH, but HGH has it's own effect on the bones too as per the study above.

Furthermore, injecting HGH is superior to any form of IGF-1 due to the duality of both injectable forms.

You can get IGF-1 DES or IGF-1 LR3.

IGF-1 DES lasts about 15 minutes in the body and will only affect the area you inject it into, which is a pain in the ass and which is why it only has very specific uses.

IGF-1 LR3 lasts 24 hours, but when IGF-1 is in your system for that long it latches on to not just the bones and muscle, but the rest of your tissues too. Why does this matter? Because it puts you at a far greater risk of developing cancerous tumours.

HGH takes the best of both worlds. It slowly releases safer amounts of IGF-1 throughout the entire body.

GGWP
what about rIGF? insubolic igf 1
 
'Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies'

HGH is not only a precursor to IGF-1, meaning it almost 'creates' it when you inject HGH, but HGH has it's own effect on the bones too as per the study above.

Furthermore, injecting HGH is superior to any form of IGF-1 due to the duality of both injectable forms.

You can get IGF-1 DES or IGF-1 LR3.

IGF-1 DES lasts about 15 minutes in the body and will only affect the area you inject it into, which is a pain in the ass and which is why it only has very specific uses.

IGF-1 LR3 lasts 24 hours, but when IGF-1 is in your system for that long it latches on to not just the bones and muscle, but the rest of your tissues too. Why does this matter? Because it puts you at a far greater risk of developing cancerous tumours.

HGH takes the best of both worlds. It slowly releases safer amounts of IGF-1 throughout the entire body.

GGWP
after your thread comes out and if my clavicle growth plates aren’t closed I’m gonna inject igf1 into my shoulders lol
 
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after your thread comes out and if my clavicle growth plates aren’t closed I’m gonna inject igf1 into my shoulders lol
is it really region dependent
 
  • Misconception #1: They're two completely different hormones.
    • Answer: They are interlinked. HGH gets converted into IGF-1 in the body by the liver. When the conversion is complete, it is taken by the body to grow your bones.

  • Misconception #2: HGH > IGF-1 or you need BOTH!
    • Answer: Remember the conversation part we discussed earlier? Why inject HGH and have it be converted before it can take effect (and the conversion isn't even 100% efficient) when you could just inject IGF-1 and get it to act instantly with 100% efficiency. You really only need IGF-1.
The problem is there are no easy assessable & affordable igf-1 sources
 
'Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies'

HGH is not only a precursor to IGF-1, meaning it almost 'creates' it when you inject HGH, but HGH has it's own effect on the bones too as per the study above.

Furthermore, injecting HGH is superior to any form of IGF-1 due to the duality of both injectable forms.

You can get IGF-1 DES or IGF-1 LR3.

IGF-1 DES lasts about 15 minutes in the body and will only affect the area you inject it into, which is a pain in the ass and which is why it only has very specific uses.

IGF-1 LR3 lasts 24 hours, but when IGF-1 is in your system for that long it latches on to not just the bones and muscle, but the rest of your tissues too. Why does this matter? Because it puts you at a far greater risk of developing cancerous tumours.

HGH takes the best of both worlds. It slowly releases safer amounts of IGF-1 throughout the entire body.

GGWP
What about the fact that HGH has to be converted, don't you think there's a conversion rate dilemma?
 
What about the fact that HGH has to be converted, don't you think there's a conversion rate dilemma?
I don't know what that means. All I know is that IGF-1 DES is mostly good for hyperplasia, and that HGH or peptides is better for framemaxxing/heightmaxxing as IGF-1 DES lasts 15 minutes. IGF-1 LR3 fully gives you tumours so that's both options out the window. If you mean that the HGH being metabolized takes a toll on the liver then I can understand where you're coming from but ultimately it's worth it anyway.
 
The problem is there are no easy assessable & affordable igf-1 sources
depending on what type of igf you want rIGF is cheapish
 
depending on what type of igf you want rIGF is cheapish
do u have any sources to decent igf for height growth? that are somewhat cheep and easily assessable?
 
do u have any sources to decent igf for height growth? that are somewhat cheep and easily assessable?
just dm me bro i have 2 sources depending on whatchu need
 

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