Klump
No.1 Ranked Bloatcel
- Joined
- Sep 8, 2021
- Posts
- 156
- Reputation
- 121
TLDR
Starting weight: 170kg / 374.7lbs | Current weight: 138.8kg / 308.8lbs
Taken a couple months before starting Reta. Topless picture that is closest to start date. Also this is not me at my biggest JFL
Week 10
Week 20
I added Tesamorelin to the protocol for better sleep and to combat loose skin. So it’s no longer Retatrutide as the only cutting agent. To say my weight loss is all due to Reta would be disingenuous and confounding the results so far.
Reta
"12 weeks ON / 4 weeks OFF to avoid receptor burnout" This directly contradicts every clinical trial ever published. Trust the data first, then take TikTok “experts” and their anecdotes with a pinch of salt. If you are a bloatcel and want real, consistent results? Follow the clinical data for predictable results. I’ve already dropped 18.35% of my body mass in just 20 weeks.
Here’s the hard data from 48-week trials:
• 4mg maintenance: 17% average weight loss
• 8mg maintenance: 23% average weight loss
• 12mg maintenance: 24% (Phase 2) → up to 29% (Phase 3) average loss
I see people stacking GLPs instead of just upping the dose like in trials. Why? Which clinical trial did that? What these people are doing has yet to be researched and we have no idea the effects it could have.
If you are not feeling the effects, are not losing weight, or progress stalls? INCREASING THE DOSE is probably a better and proven idea. Early trials tried rushing straight to maintenance the result; massive dropout rates due to GI issues. That’s the only reason we hold doses for 4 weeks. Not for “receptor recovery”, not for “resetting”, just to manage side effects. Let me repeat: if the dose is no longer effective, move up if you are still in titration.
Titration Facts
Eli Lilly Phase 3 Protocol:
2mg → 4mg → 8mg → 12mg (maintenance) | Increase every 4 weeks | 48 Weeks
My Protocol:
2mg → 4mg → 6mg → 8mg (maintenance) | Current: Week 20
I was planning to go to 12mg, but what’s the point? At 8mg I’m still dropping weight fast, so there is no need.
Why didn’t I jump straight to 8mg? I still had pebble shits. Adjusted titration (e.g. 2→4→8→9→12mg) is done for people with digestion problems. Slowing down the increases to handle side effects, still honours the protocol used in trials.
CONCLUSION
If you have zero side effects on 4mg? You could skip 6mg, but it may be an effective dose for you or cause a stall. The standard schedule does this anyway, and no trial has studied 6mg as a dose. I should add that I started tesamorelin during week 11 for sleep and skin benefits. I’ve started another protocol to prevent loose skin. 65 lbs lost and no loose skin yet is a great sign. However I can’t prove this would not have happened if I did not take Tesa. That’s the problem with N-of-1 studies.
I’m ahead of the pace versus all other trials and likely to meet or beat the 12mg trial at a 8mg dose.
Where’s The Evidence? Alternative Protocols
For those of you who are microdosing (0.5-1mg/week) or stacking Tirzepatide and Reta for example, or doing 12 weeks on 4 weeks off, please share your experience. There is no clinical research on these protocols. We know weight loss is possible doing these things, but is it as effective. Please add weight loss tracking with GLP-1s used, dosages, and % body mass lost, that would be a great start. Things like this will be a great help to the community.
Starting weight: 170kg / 374.7lbs | Current weight: 138.8kg / 308.8lbs
Taken a couple months before starting Reta. Topless picture that is closest to start date. Also this is not me at my biggest JFL
Week 10
Week 20
I added Tesamorelin to the protocol for better sleep and to combat loose skin. So it’s no longer Retatrutide as the only cutting agent. To say my weight loss is all due to Reta would be disingenuous and confounding the results so far.
Reta
"12 weeks ON / 4 weeks OFF to avoid receptor burnout" This directly contradicts every clinical trial ever published. Trust the data first, then take TikTok “experts” and their anecdotes with a pinch of salt. If you are a bloatcel and want real, consistent results? Follow the clinical data for predictable results. I’ve already dropped 18.35% of my body mass in just 20 weeks.
Here’s the hard data from 48-week trials:
• 4mg maintenance: 17% average weight loss
• 8mg maintenance: 23% average weight loss
• 12mg maintenance: 24% (Phase 2) → up to 29% (Phase 3) average loss
I see people stacking GLPs instead of just upping the dose like in trials. Why? Which clinical trial did that? What these people are doing has yet to be researched and we have no idea the effects it could have.
If you are not feeling the effects, are not losing weight, or progress stalls? INCREASING THE DOSE is probably a better and proven idea. Early trials tried rushing straight to maintenance the result; massive dropout rates due to GI issues. That’s the only reason we hold doses for 4 weeks. Not for “receptor recovery”, not for “resetting”, just to manage side effects. Let me repeat: if the dose is no longer effective, move up if you are still in titration.
Titration Facts
Eli Lilly Phase 3 Protocol:
2mg → 4mg → 8mg → 12mg (maintenance) | Increase every 4 weeks | 48 Weeks
My Protocol:
2mg → 4mg → 6mg → 8mg (maintenance) | Current: Week 20
I was planning to go to 12mg, but what’s the point? At 8mg I’m still dropping weight fast, so there is no need.
Why didn’t I jump straight to 8mg? I still had pebble shits. Adjusted titration (e.g. 2→4→8→9→12mg) is done for people with digestion problems. Slowing down the increases to handle side effects, still honours the protocol used in trials.
CONCLUSION
If you have zero side effects on 4mg? You could skip 6mg, but it may be an effective dose for you or cause a stall. The standard schedule does this anyway, and no trial has studied 6mg as a dose. I should add that I started tesamorelin during week 11 for sleep and skin benefits. I’ve started another protocol to prevent loose skin. 65 lbs lost and no loose skin yet is a great sign. However I can’t prove this would not have happened if I did not take Tesa. That’s the problem with N-of-1 studies.
I’m ahead of the pace versus all other trials and likely to meet or beat the 12mg trial at a 8mg dose.
Where’s The Evidence? Alternative Protocols
For those of you who are microdosing (0.5-1mg/week) or stacking Tirzepatide and Reta for example, or doing 12 weeks on 4 weeks off, please share your experience. There is no clinical research on these protocols. We know weight loss is possible doing these things, but is it as effective. Please add weight loss tracking with GLP-1s used, dosages, and % body mass lost, that would be a great start. Things like this will be a great help to the community.
