combination of ghrfs and gh? (HIGH IQ NEGROS GTFIH)

[birthdefect]

just gonna make this a rapid fire thread, please correct me if im wrong on this

from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week

this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph

it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result

in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

i know the graphs are turbo-imprecise, but its just to get the point across

 

[birthdefect]

@Stacyslayerᛉ
you're well versed with this stuff
please respond

 

[dancepilled]

you brilliant nigger im getting on 8ius when my gh arrives and have a fuckton of peptides left over from before I moved on to gh, like
90mg cjc, 70mg ghrp 2, and 40mg ipamorelin

can you advise me on how to exactly use them together? I also have huperzine a if its atleast mildly helpful w sst supression

 

[birthdefect]

you brilliant nigger im getting on 8ius when my gh arrives and have a fuckton of peptides left over from before I moved on to gh, like
90mg cjc, 70mg ghrp 2, and 40mg ipamorelin

can you advise me on how to exactly use them together? I also have huperzine a if its atleast mildly helpful w sst supression

the way i was imagining it was just taking a medium high dose of your choice of ghrh + ghrp analogue and take it with the gh

ipamorelin itself inhibits somatostatin, and i doubt huperzine a is really gonna do much, like how niggas think meclizine will inhibit fgfr3 instead of buying infigratinib

 

[birthdefect]

unbelievably brutal noreply pill, did i put this in the wrong section

 

[Cannoedskulled]

high iq post

 

[birthdefect]

high iq post

doesnt even matter if no one reads it
do you know anyone who i should tag

 

[nsabi67]

Did read

High iq although I don’t think it makes that much of a difference and your better of spending the money from the ghrp and ghrh on more hgh

 

[birthdefect]

Did read

High iq although I don’t think it makes that much of a difference and your better of spending the money from the ghrp and ghrh on more hgh

yea thats fair, no way to know unless someone tries tho. and unfortunately the benefit in local igf1 cant even be measured in a blood test

 

[maxismisha]

just gonna make this a rapid fire thread, please correct me if im wrong on this

from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 4520610

this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 4520601


exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 4520603

it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 4520606

in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

i know the graphs are turbo-imprecise, but its just to get the point across

Maximisha method

 

[Deleted member 307109]

just gonna make this a rapid fire thread, please correct me if im wrong on this

from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 4520610

this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 4520601


exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 4520603

it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 4520606

in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

i know the graphs are turbo-imprecise, but its just to get the point across

I'm doing MOD GRF 1-29 and GHRP is that a good way to go or would Ipa be better than GHRP?

 

[TheOsei]

just gonna make this a rapid fire thread, please correct me if im wrong on this

from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 4520610

this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 4520601


exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 4520603

it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 4520606

in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

i know the graphs are turbo-imprecise, but its just to get the point across

Or just moneymaxx and pin ur gh 3x a day 20/30/50%

 

[birthdefect]

Or just moneymaxx and pin ur gh 3x a day 20/30/50%

convenience + gh's stimulation of igf1 release still lasts about 1 day
its not as clean of a method, and im pretty sure combining secretagogues with gh would be more expensive than pinning just gh

 

[duduboy]

@ihatemySOST

 

[Boosie’s_Build]

I’m using cjc no dac and ipa 250mcg every night before bed. When I get my Sarms lgd10-20mg 8 wk then 4 wk 10-20 ostarine. With 500 hcg on. And Enclomiphene after. After I start Sarms I’m gonna start dosing cjc and ipa 200 mcg after wake up or after a lift and before bed. 5 days on 2 days off. What do u think u seem very knowledgeable. I’m taking this as a natty plus cycle for muscle and bone growth. I’ve read studies that lgd (and Sarms) do in fact increase bone density lgd test taken from lumbar spine.

 

[birthdefect]

I’m using cjc no dac and ipa 250mcg every night before bed. When I get my Sarms lgd10-20mg 8 wk then 4 wk 10-20 ostarine. With 500 hcg on. And Enclomiphene after. After I start Sarms I’m gonna start dosing cjc and ipa 200 mcg after wake up or after a lift and before bed. 5 days on 2 days off. What do u think u seem very knowledgeable. I’m taking this as a natty plus cycle for muscle and bone growth. I’ve read studies that lgd (and Sarms) do in fact increase bone density lgd test taken from lumbar spine.

cheeks tbh, why stick to orals if you're gonna take hcg anyways, may as well pin test
if you still wanna stick to oral androgens, microdosed halotestin or microdosed anavar+proviron is probably the next best, mostly as longitudinal growth stimulants
also bone density doesnt equal cortical growth

 

[Boosie’s_Build]

cortical growth

Thank u for this input I’ve put some more research into this have you heard of S-40503.
It shows promise.
“To confirm the bone anabolic effect, S-40503 was given to ovariectomized (OVX) rats for 2 months. The compound significantly increased the BMD and biomechanical strength of femoral cortical bone, whereas estrogen, anti-bone resorptive hormone, did not. The increase in periosteal mineral apposition rate (MAR) of the femur revealed direct bone formation activity of S-40503. It was unlikely that the osteoanabolic effect of the compound was attribute to the enhancement of muscle mass, because immobilized ORX rats treated with S-40503 showed a marked increase in BMD of tibial cortical bone without any actions on the surrounding muscle tissue. Collectively, our novel compound served as a prototype for SARMs, which had unique tissue selectivity with high potency for bone formation and lower impact upon sex accessory tissues”

Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis - PubMed

A novel nonsteroidal androgen receptor (AR) binder, S-40503, was successfully generated in order to develop selective androgen receptor modulators (SARMs). We evaluated the binding specificity for nuclear receptors (NRs) and osteoanabolic activities of S-40503 in comparison with a natural...

pubmed.ncbi.nlm.nih.gov

 

[Boosie’s_Build]

cheeks tbh, why stick to orals if you're gonna take hcg anyways, may as well pin test
if you still wanna stick to oral androgens, microdosed halotestin or microdosed anavar+proviron is probably the next best, mostly as longitudinal growth stimulants
also bone density doesnt equal cortical growth

Sticking to orals bc my parents would trip abt test more. I can get away with peptides. But I would get kicked out otherwise and I couldn’t afford all ts id I got kicked out.

 

[birthdefect]

Sticking to orals bc my parents would trip abt test more. I can get away with peptides. But I would get kicked out otherwise and I couldn’t afford all ts id I got kicked out.

Thank u for this input I’ve put some more research into this have you heard of S-40503.
It shows promise.
“To confirm the bone anabolic effect, S-40503 was given to ovariectomized (OVX) rats for 2 months. The compound significantly increased the BMD and biomechanical strength of femoral cortical bone, whereas estrogen, anti-bone resorptive hormone, did not. The increase in periosteal mineral apposition rate (MAR) of the femur revealed direct bone formation activity of S-40503. It was unlikely that the osteoanabolic effect of the compound was attribute to the enhancement of muscle mass, because immobilized ORX rats treated with S-40503 showed a marked increase in BMD of tibial cortical bone without any actions on the surrounding muscle tissue. Collectively, our novel compound served as a prototype for SARMs, which had unique tissue selectivity with high potency for bone formation and lower impact upon sex accessory tissues”

Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis - PubMed

A novel nonsteroidal androgen receptor (AR) binder, S-40503, was successfully generated in order to develop selective androgen receptor modulators (SARMs). We evaluated the binding specificity for nuclear receptors (NRs) and osteoanabolic activities of S-40503 in comparison with a natural...

pubmed.ncbi.nlm.nih.gov

first of all i assume you can source this? ive never even heard of this but assuming you can source it:
what makes you think it wont be suppressive like literally every other SARM in existence
how does it compare to other sarms that are far more readily available compared to this one
how would it compare to other bone forming agents that also most likely dont increase cortical thickening to a significant enough degree to where facial changes occur

 

[maxx92765]

Or just moneymaxx and pin ur gh 3x a day 20/30/50%

what would this do

 

[Boosie’s_Build]

Do u have a thread explaining the percent change needed for facial change/clavical/height change. Bc I see a lot of the ads about change but I never see numbers.

 

[Boosie’s_Build]

Do u have a thread explaining the percent change needed for facial change/clavical/height change. Bc I see a lot of the ads about change but I never see numbers.

I see in the study’s stuff like 10% cortical bone growth in femoral bone for example is that comparative to 1-2mm in height

 

[TheOsei]

what would this do

nah don't do what I did just pin 12iu before bed. 9iu minimum to be above natural levels, max 15iu.

 

[TheOsei]

what would this do

ignore that lol u don't want 24/7 sustained igf or you'll genuinely get acromegaly.
just pin everything before bed. minimum 9iu to beat natural levels, max 15iu.

 

[birthdefect]

I see in the study’s stuff like 10% cortical bone growth in femoral bone for example is that comparative to 1-2mm in height

cortical bone growth isnt how you grow taller, its how bone widens. longitudinal growth occurs through chondrocyte proliferation and their eventual hypertrophy, after which they die and ossify and shieet
it would just be a 10% increase on how thick the femur was before, not sure if in radius, diameter, or circumference tho

minimum 9iu to beat natural levels, max 15iu.

this isnt true, there was a study on someone who got acromegaly from 2iu daily
you arent really just injecting gh for the fuck of it, its to increase your igf1 z score to +2.0, and the amount needed to do that is individual
there is the fda guideline of 0.24-0.47mg/kg/week of gh as a guide tho, there is no hard set min max, just depends on weight

 

[Boosie’s_Build]

cortical bone growth isnt how you grow taller, its how bone widens. longitudinal growth occurs through chondrocyte proliferation and their eventual hypertrophy, after which they die and ossify and shieet
it would just be a 10% increase on how thick the femur was before, not sure if in radius, diameter, or circumference tho

this isnt true, there was a study on someone who got acromegaly from 2iu daily
you arent really just injecting gh for the fuck of it, its to increase your igf1 z score to +2.0, and the amount needed to do that is individual
there is the fda guideline of 0.24-0.47mg/kg/week of gh as a guide tho, there is no hard set min max, just depends on weight

Ur a fuckin beauty