Compound tier list

[Bitchwhipper2]

S - Nandrolone, Ru-58841,

A - Accutane, LGD4033, GLP-1s, DUT, Minox, HCG, MT2, T3,

B - Test, Anavar, fin, Alendronate, HGH, Ghk-cu, Tret, Clenbuterol, Aromasin

C - Mk677, Cjc dac, Rad140, letrozole, anastrozole, Nolvadex, enclomiphene, DNP

D - clomid, tren, Lithium

F - All GHRPs

Post a compound and ill add it in

 

[Giorgio]

gonna have to create a whole new tier for gt20029

 

[chadbeingmade]

Var, (oral at least) Minox, Clen and Tret easily deserve D/F tier. No idea what the point of running Var is. It being hair safe is a misconception and it fucks your lipid profile beyond belief. All you’ll get is some extra lipolysis and some hardness since it’s a DHT derivi. Oral minox will make you a water balloon until you discontinue as well as make your skin look like it is that of a 40 year old. I can’t talk on topical, I haven’t tried. I will never touch minoxidil again. Clen will blow your heart up, was extremely retarded of me to ever use. Tret is redundant with much better alternatives.

DNP is an easy A for anyone that’s ever used. 9:1, fat loss:muscle loss ratio is unbelievable. Not even comparable to clen in terms of results and rate of loss, and has a much more favourable side effect profile than Clen.

Low dose Tren is valid for starve maxing due to its insane anti-catabolism. For no other reason is it needed. It’s an easy A tier for leanamxing on basically just protein for a short period like 4-6 weeks. We are only using it for the glucocorticoid receptor antagonism. It’s D tier for any other reason.

Enclo increases SHBG and prolactin and also decreases GH. It shit and D/F tier. To say it even aids in recovery is also extremely questionable. Despite the haarlem study being shit, it’s the only long term study thus far.

No reason to ever touch MK. It interferes with the insulin/GH/IGF-1 axis, it will cause insulin resistance over time, and eventually diabetes if abused. Using it alone is also really pointless and should be used in conjunction with a GHRH analog or receptor agonist. It has a longer half life than most GH secretagogue receptor agonists so using it with CJC-1295 (DAC) could work well for keeping serum GH elevated. Still don’t use it.

GLP1s are C tier IMO, with the exception of Reta for roiders being A tier for managing side effects. Nothing comes close to Cagrilintide. It’s an S tier compound. (Add to
your bone stack JFL, it literally increases Osteoblast activity)

gonna have to create a whole new tier for gt20029

In tier with the hundred if other hair loss compounds being tested that won’t be needed since Dut and RU is a hair loss cure.

 

[Jatt]

S - Nandrolone, Ru-58841,

A - Accutane, LGD4033, GLP-1s, DUT, Minox, HCG, MT2, T3,

B - Test, Anavar, fin, Alendronate, HGH, Ghk-cu, Tret, Clenbuterol, Aromasin

C - Mk677, Cjc dac, Rad140, letrozole, anastrozole, Nolvadex, enclomiphene, DNP

D - clomid, tren, Lithium

F - All GHRPs

Post a compound and ill add it in

reta

 

[Mainlander]

Dut accutane is S Tier

 

[Bitchwhipper2]

Var, (oral at least) Minox,

Oral minox is complete dogshit. Topical minox is a godscend

Clen and Tret easily deserve D/F tier. No idea what the point of running Var is. It being hair safe is a misconception and it fucks your lipid profile beyond belief. All you’ll get is some extra lipolysis and some hardness since it’s a DHT derivi.

Probably true. Only put put so high bc bbs glaze it like crazy
I personally wouldnt run it though.

Oral minox will make you a water balloon until you discontinue as well as make your skin look like it is that of a 40 year old. I can’t talk on topical, I haven’t tried. I will never touch minoxidil again.

Topical minox aging side effects are overstated to unfounded. Had no effect whatsoever on me with 0 bloat

Clen will blow your heart up, was extremely retarded of me to ever use.

Titrate slowly. Muscle retention is good, good energy, debloat.

Tret is redundant with much better alternatives.

Tret is redundant tbh. But I kindof lumped all topical retinoids in to the most recognizable one

DNP is an easy A for anyone that’s ever used. 9:1, fat loss:muscle loss ratio is unbelievable. Not even comparable to clen in terms of results and rate of loss, and has a much more favourable side effect profile than Clen.

Ive seen so many shit on dnp that I could bring myself to put it higher

Low dose Tren is valid for starve maxing due to its insane anti-catabolism. For no other reason is it needed. It’s an easy A tier for leanamxing on basically just protein for a short period like 4-6 weeks. We are only using it for the glucocorticoid receptor antagonism. It’s D tier for any other reason.

How does this anti catabolism compare to that of var?
Trens dogshit AA ratio is why I put it low

Enclo increases SHBG and prolactin and also decreases GH. It shit and D/F tier. To say it even aids in recovery is also extremely questionable. Despite the haarlem study being shit, it’s the only long term study thus far.

Enclomiphene deserves its spot given that its the most powerful SERM and is the best post sarm cycle therapy for those too broke to source hcg or are too pussy to inject.

No reason to ever touch MK. It interferes with the insulin/GH/IGF-1 axis, it will cause insulin resistance over time, and eventually diabetes if abused. Using it alone is also really pointless and should be used in conjunction with a GHRH analog or receptor agonist. It has a longer half life than most GH secretagogue receptor agonists so using it with CJC-1295 (DAC) could work well for keeping serum GH elevated. Still don’t use it.

Mk677 is unironically decent for what it is. Very overhated compound and I will die on that hill

In tier with the hundred if other hair loss compounds being tested that won’t be needed since Dut and RU is a hair loss cure.

Ru is not potent enough for some BBs really pushing their doses.

Context specific, but if its all its cracked up to be it will be a bit higher

 

[Posmo]

Oral minox is complete dogshit. Topical minox is a godscend

Probably true. Only put put so high bc bbs glaze it like crazy
I personally wouldnt run it though.

Topical minox aging side effects are overstated to unfounded. Had no effect whatsoever on me with 0 bloat

Titrate slowly. Muscle retention is good, good energy, debloat.

Tret is redundant tbh. But I kindof lumped all topical retinoids in to the most recognizable one

Ive seen so many shit on dnp that I could bring myself to put it higher

How does this anti catabolism compare to that of var?
Trens dogshit AA ratio is why I put it low

Enclomiphene deserves its spot given that its the most powerful SERM and is the best post sarm cycle therapy for those too broke to source hcg or are too pussy to inject.

Mk677 is unironically decent for what it is. Very overhated compound and I will die on that hill

Ru is not potent enough for some BBs really pushing their doses.

Context specific, but if its all its cracked up to be it will be a bit higher

Oral minox a joke how ?

 

[CD34]

Dutasteride, gh

 

[CD34]

Ozempic

 

[chadbeingmade]

How does this anti catabolism compare to that of var?
Trens dogshit AA ratio is why I put it low

Anabolic/Androgenic ratio isn’t the best metric most of the time. Pretty sure it is based on rats, and the androgenic factor is measured on their prostate only.

It mogs var to oblivion. Not even close.

Ru is not potent enough for some BBs really pushing their doses.

Depends on concentration and how many applications. Binding affinity isn’t the full story at all and provided high conc and absorption you can survive up to 350mg of Tren.

AR occupancy is approximated to be = [L]/([L]+K_d) (competitive, reversible system).
Tren at like 200mg/wk has a typical free conc. inside the scalp dermis of like 5-10nM (so 5-10ng/mL -> diffuses into scalp), has a K_d/IC50 of like 5-10nM, so the calculated AR occupancy is a third to two-thirds (33%-66%). Comparatively, DHT (after dut) has a typical free conc. inside the scalp dermis of about 0.3nM (>90% systemic suppression), the K_d/IC50 is like 0.5nM-1nM, giving a AR occupancy of like 23%-38%. RU of like 10% w/v, in 20% DMSO/EtOH with about a mL applied is gonna have about 5-20microM in typical free conc. in your scalp's dermis. Also a K_d/IC50 of like 50-100nM, thus an AR occupancy of like 98%-99%.

Even with the more conservative 100nM K_d, the dose/K_d ratio for RU is pretty much 100:1 against tren or DHT. That pushes tren + DHT occupancy down below like 1%-2% once RU diffuses into the follicle.

The reason this works is the sheer molar excess. For example, a 100mg/mL solution is close enough to 250mM, only 0.5%-1% of that needs to reach the dermal papilla to be >10microM locally. Also, dut removes 90%-95% of the background DHT, so RU's main job is beating tren/DHT.

So your net result using it once daily with 0.5mL or 1mL of like 10% w/v RU + 20% DMSO, is definitely great enough to safely say you hold pretty much total AR blockade for about 16hrs. You can apply a second, lighter one before bed to close that gap too.

 

[Bitchwhipper2]

Anabolic/Androgenic ratio isn’t the best metric most of the time. Pretty sure it is based on rats, and the androgenic factor is measured on their prostate only.

It mogs var to oblivion. Not even close.

Im not educated enough to make a counter argument

Depends on concentration and how many applications. Binding affinity isn’t the full story at all and provided high conc and absorption you can survive up to 350mg of Tren.

AR occupancy is approximated to be = [L]/([L]+K_d) (competitive, reversible system).
Tren at like 200mg/wk has a typical free conc. inside the scalp dermis of like 5-10nM (so 5-10ng/mL -> diffuses into scalp), has a K_d/IC50 of like 5-10nM, so the calculated AR occupancy is a third to two-thirds (33%-66%). Comparatively, DHT (after dut) has a typical free conc. inside the scalp dermis of about 0.3nM (>90% systemic suppression), the K_d/IC50 is like 0.5nM-1nM, giving a AR occupancy of like 23%-38%. RU of like 10% w/v, in 20% DMSO/EtOH with about a mL applied is gonna have about 5-20microM in typical free conc. in your scalp's dermis. Also a K_d/IC50 of like 50-100nM, thus an AR occupancy of like 98%-99%.

Even with the more conservative 100nM K_d, the dose/K_d ratio for RU is pretty much 100:1 against tren or DHT. That pushes tren + DHT occupancy down below like 1%-2% once RU diffuses into the follicle.

The reason this works is the sheer molar excess. For example, a 100mg/mL solution is close enough to 250mM, only 0.5%-1% of that needs to reach the dermal papilla to be >10microM locally. Also, dut removes 90%-95% of the background DHT, so RU's main job is beating tren/DHT.

So your net result using it once daily with 0.5mL or 1mL of like 10% w/v RU + 20% DMSO, is definitely great enough to safely say you hold pretty much total AR blockade for about 16hrs. You can apply a second, lighter one before bed to close that gap too.

Idk. I trust that mpmd exhausted every possible alternative option before quitting roids too much

Mirin your knowledge though

 

[iblamemygenes]

Oral minox is complete dogshit. Topical minox is a godscend

Probably true. Only put put so high bc bbs glaze it like crazy
I personally wouldnt run it though.

Topical minox aging side effects are overstated to unfounded. Had no effect whatsoever on me with 0 bloat

Titrate slowly. Muscle retention is good, good energy, debloat.

Tret is redundant tbh. But I kindof lumped all topical retinoids in to the most recognizable one

Ive seen so many shit on dnp that I could bring myself to put it higher

How does this anti catabolism compare to that of var?
Trens dogshit AA ratio is why I put it low

Enclomiphene deserves its spot given that its the most powerful SERM and is the best post sarm cycle therapy for those too broke to source hcg or are too pussy to inject.

Mk677 is unironically decent for what it is. Very overhated compound and I will die on that hill

Ru is not potent enough for some BBs really pushing their doses.

Context specific, but if its all its cracked up to be it will be a bit higher

Why is Tret redundant? @chadbeingmade

 

[Bitchwhipper2]

Why is Tret redundant? @chadbeingmade

Cause taz mogs it

 

[iblamemygenes]

Cause taz mogs it

Well if tret is redundant wouldn’t Taz be more redundant lmao. Or are you just saying if your already using Taz adding Tret is redundant (obviously)

 

[chadhamed]

Dianabol

 

[Bitchwhipper2]

Dianabol

F tier