Cortical Destabilization–Reintegration Therapy (CDRT) (SELF EXPERIMENTATION) Fix your bad habits.

[BR32]

CDRT Overview​

I've been toying about the idea of running a protocol centered around Psylocybin and Dihexa with the goal of improving my executive functioning and habits.

The plan is to take a macro dose of psylocybin followed by therapy with Dihexa, microdosing psylocybin, and stimulants.

The goal of the macro dose is to disrupt your brains default mode network (DMN) and put your brain into window of high neural plasticity. This means your brain is more malleable and capable of relearning. It weakens the autopilot circuits that promote bad habits and reduces the dominance of habitual thought patterns.

DMN disruption doesn’t “teach” the brain anything directly it only destabilizes habitual attractor states, increasing potential for experience-dependent plasticity.

Think of the DMN as your brains behavioral autopilot

Micro dosing the following week is to maintain the DMN disruption and and promote activity dependent plasticity which was catalyzed by the macro dose. I would combine this with dihexa to cement the neural connections that were primed by DMN disruption and to promote structural plasticity and synaptogenesis.

Stimulants would be used to boost executive network engagement and amplify behavioral reinforcement. (For this case I recommend a dopaminergic stimulant like dextroamphetamine)

Behavioral Integration​

Behavioral integration is key: The macro dose opens the plasticity window, Dihexa increase the structural capacity for new connections, micro dosing extends the macro doses impacts, and stimulants boost attention and salience for the activated neural circuits.

However none of this creates new habits automatically. You must deliberately practice the behaviors you want reinforced during the brains plastic window. Only behaviors that are actively engaged during this window get "tagged" for long term potentiation. Habits, routines, skills, or thought patterns that aren’t reinforced will not strengthen.

If you aren’t actively performing the behaviors/habits you want, the brain will just reinforce whatever circuits happen to be active. This includes bad behaviors/habits.

If you are watching porn, scrolling, etc you will reinforce that behavior in your brain.

• Macro dose → opens plasticity window
• Dihexa to enhance structural plasticity
• Following ~1 week → microdosing + behavioral integration
• Stimulus/dopamine engagement should be paired with the specific behaviors you want to reinforce

Risks and Candidacy

​

Unfortunately not everyone is a good candidate for this therapy. Threat sensitivity, baseline anxiety, and salience processing are the most important factors when determining if you’re a good fit for the drugs. Efficacy will differ based on your unique neuroprofile and individual drug response and ability to “tolerate” the drugs.

Additional important factors are family history of mental illness (Psychosis, bipolar 1, severe OCD, severe depression), cognitive flexibility/stabilty, poor emotional regulation, or inability to tolerate ego dissolution.

If you are a person with high baseline anxiety, high threat sensitivity, and high impulsivity do not attempt this. You will reinforce bad behaviors.

Recent substance use and addiction status is also a risk factor. This therapy could be helpful in quitting drugs/addictions but you run the risk of amplifying your addiction.

Cannabis use presents a particular concern as THC down regulates your CB1 receptors which severely both synaptic plasticity and the brain's ability to shift between goal-directed and habitual behaviors. I will be abstaining from cannabis for several months before running this protocol myself. I abused cannabis so my endocannabinoid system is more down regulated than most peoples so I need more time.

TLDR​

In summary, the protocol is a theoretical attempt to leverage high neural plasticity windows to retrain behaviors and strengthen desired habits. Its efficacy depends almost entirely on candidate suitability, strict behavioral integration, and careful control of environmental and neurochemical variables. Missteps can reinforce undesired behaviors or exacerbate psychiatric risk.

This overview is theoretical and based on neuroscience principles. It is not a recommendation for self-experimentation, as the interventions described carry significant psychological, behavioral, and physiological risk.

 

[BR32]

@Orka @tomahawk @aids @birthdefect

 

[BR32]

If this shit is retarded ill edit the thread right now and change the name

just tell me

 

[tomahawk]

Very good theory very good thread definitely will try in the next 4 years

 

[caerulean]

I would combine this with dihexa to cement the neural connections that were primed by DMN disruption and to promote structural plasticity and synaptogenesis.

?

 

[i cant lie cant lie]

dnr yet

but vyvanse mog

 

[One Rep Max]

just take shrooms

 

[BR32]

?

Dihexa promotes the formation of new synapses and dendrites between neurons.

 

[BR32]

just take shrooms

Won't facilitate long term behavioral change

 

[BR32]

Won't facilitate long term behavioral change

I've taken a lot of shrooms and I still have shit habits

 

[birthdefect]

CDRT Overview​

I've been toying about the idea of running a protocol centered around Psylocybin and Dihexa with the goal of improving my executive functioning and habits.

The plan is to take a macro dose of psylocybin followed by therapy with Dihexa, microdosing psylocybin, and stimulants.

The goal of the macro dose is to disrupt your brains default mode network (DMN) and put your brain into window of high neural plasticity. This means your brain is more malleable and capable of relearning. It weakens the autopilot circuits that promote bad habits and reduces the dominance of habitual thought patterns.

DMN disruption doesn’t “teach” the brain anything directly it only destabilizes habitual attractor states, increasing potential for experience-dependent plasticity.

Think of the DMN as your brains behavioral autopilot

Micro dosing the following week is to maintain the DMN disruption and and promote activity dependent plasticity which was catalyzed by the macro dose. I would combine this with dihexa to cement the neural connections that were primed by DMN disruption and to promote structural plasticity and synaptogenesis.

Stimulants would be used to boost executive network engagement and amplify behavioral reinforcement. (For this case I recommend a dopaminergic stimulant like dextroamphetamine)

Behavioral Integration​

Behavioral integration is key: The macro dose opens the plasticity window, Dihexa increase the structural capacity for new connections, micro dosing extends the macro doses impacts, and stimulants boost attention and salience for the activated neural circuits.

However none of this creates new habits automatically. You must deliberately practice the behaviors you want reinforced during the brains plastic window. Only behaviors that are actively engaged during this window get "tagged" for long term potentiation. Habits, routines, skills, or thought patterns that aren’t reinforced will not strengthen.

If you aren’t actively performing the behaviors/habits you want, the brain will just reinforce whatever circuits happen to be active. This includes bad behaviors/habits.

If you are watching porn, scrolling, etc you will reinforce that behavior in your brain.

• Macro dose → opens plasticity window
• Dihexa to enhance structural plasticity
• Following ~1 week → microdosing + behavioral integration
• Stimulus/dopamine engagement should be paired with the specific behaviors you want to reinforce

Risks and ​

Candidacy​

​

Unfortunately not everyone is a good candidate for this therapy. Threat sensitivity, baseline anxiety, and salience processing are the most important factors when determining if you’re a good fit for the drugs. Efficacy will differ based on your unique neuroprofile and individual drug response and ability to “tolerate” the drugs.

Additional important factors are family history of mental illness (Psychosis, bipolar 1, severe OCD, severe depression), cognitive flexibility/stabilty, poor emotional regulation, or inability to tolerate ego dissolution.

If you are a person with high baseline anxiety, high threat sensitivity, and high impulsivity do not attempt this. You will reinforce bad behaviors.

Recent substance use and addiction status is also a risk factor. This therapy could be helpful in quitting drugs/addictions but you run the risk of amplifying your addiction.

Cannabis use presents a particular concern as THC down regulates your CB1 receptors which severely both synaptic plasticity and the brain's ability to shift between goal-directed and habitual behaviors. I will be abstaining from cannabis for several months before running this protocol myself. I abused cannabis so my endocannabinoid system is more down regulated than most peoples so I need more time.

TLDR​

In summary, the protocol is a theoretical attempt to leverage high neural plasticity windows to retrain behaviors and strengthen desired habits. Its efficacy depends almost entirely on candidate suitability, strict behavioral integration, and careful control of environmental and neurochemical variables. Missteps can reinforce undesired behaviors or exacerbate psychiatric risk.

This overview is theoretical and based on neuroscience principles. It is not a recommendation for self-experimentation, as the interventions described carry significant psychological, behavioral, and physiological risk.

mirin plan but idk anything about the brain or nootropics in general

 

[One Rep Max]

Won't facilitate long term behavioral change

propranolol changed my life
crosses the blood brain barrier and erases inhib

 

[BR32]

bump

 

[caerulean]

Dihexa promotes the formation of new synapses and dendrites between neurons.

If I recall correctly, the evidence for that comes from rodent and in vitro studies rather than humans. I am not aware of any published human clinical data, but do correct me if I am wrong.

 

[BR32]

If I recall correctly, the evidence for that comes from rodent and in vitro studies rather than humans. I am not aware of any published human clinical data, but do correct me if I am wrong.

You're correct thats why this therapy is totally theoretical. The user is relying on anecdotes and rodent data.

 

[caerulean]

The user

Why are you referring to yourself in the third person?

 

[BR32]

Why are you referring to yourself in the third person?

Well I havnen't done it yet and I was trying to be general

 

[jeoyw9192]

@hej1377

 

[birthdefect]

CDRT Overview​

I've been toying about the idea of running a protocol centered around Psylocybin and Dihexa with the goal of improving my executive functioning and habits.

The plan is to take a macro dose of psylocybin followed by therapy with Dihexa, microdosing psylocybin, and stimulants.

The goal of the macro dose is to disrupt your brains default mode network (DMN) and put your brain into window of high neural plasticity. This means your brain is more malleable and capable of relearning. It weakens the autopilot circuits that promote bad habits and reduces the dominance of habitual thought patterns.

DMN disruption doesn’t “teach” the brain anything directly it only destabilizes habitual attractor states, increasing potential for experience-dependent plasticity.

Think of the DMN as your brains behavioral autopilot

Micro dosing the following week is to maintain the DMN disruption and and promote activity dependent plasticity which was catalyzed by the macro dose. I would combine this with dihexa to cement the neural connections that were primed by DMN disruption and to promote structural plasticity and synaptogenesis.

Stimulants would be used to boost executive network engagement and amplify behavioral reinforcement. (For this case I recommend a dopaminergic stimulant like dextroamphetamine)

Behavioral Integration​

Behavioral integration is key: The macro dose opens the plasticity window, Dihexa increase the structural capacity for new connections, micro dosing extends the macro doses impacts, and stimulants boost attention and salience for the activated neural circuits.

However none of this creates new habits automatically. You must deliberately practice the behaviors you want reinforced during the brains plastic window. Only behaviors that are actively engaged during this window get "tagged" for long term potentiation. Habits, routines, skills, or thought patterns that aren’t reinforced will not strengthen.

If you aren’t actively performing the behaviors/habits you want, the brain will just reinforce whatever circuits happen to be active. This includes bad behaviors/habits.

If you are watching porn, scrolling, etc you will reinforce that behavior in your brain.

• Macro dose → opens plasticity window
• Dihexa to enhance structural plasticity
• Following ~1 week → microdosing + behavioral integration
• Stimulus/dopamine engagement should be paired with the specific behaviors you want to reinforce

Risks and Candidacy

​

Unfortunately not everyone is a good candidate for this therapy. Threat sensitivity, baseline anxiety, and salience processing are the most important factors when determining if you’re a good fit for the drugs. Efficacy will differ based on your unique neuroprofile and individual drug response and ability to “tolerate” the drugs.

Additional important factors are family history of mental illness (Psychosis, bipolar 1, severe OCD, severe depression), cognitive flexibility/stabilty, poor emotional regulation, or inability to tolerate ego dissolution.

If you are a person with high baseline anxiety, high threat sensitivity, and high impulsivity do not attempt this. You will reinforce bad behaviors.

Recent substance use and addiction status is also a risk factor. This therapy could be helpful in quitting drugs/addictions but you run the risk of amplifying your addiction.

Cannabis use presents a particular concern as THC down regulates your CB1 receptors which severely both synaptic plasticity and the brain's ability to shift between goal-directed and habitual behaviors. I will be abstaining from cannabis for several months before running this protocol myself. I abused cannabis so my endocannabinoid system is more down regulated than most peoples so I need more time.

TLDR​

In summary, the protocol is a theoretical attempt to leverage high neural plasticity windows to retrain behaviors and strengthen desired habits. Its efficacy depends almost entirely on candidate suitability, strict behavioral integration, and careful control of environmental and neurochemical variables. Missteps can reinforce undesired behaviors or exacerbate psychiatric risk.

This overview is theoretical and based on neuroscience principles. It is not a recommendation for self-experimentation, as the interventions described carry significant psychological, behavioral, and physiological risk.

correct me if im wrong but as far as i can tell
you take shrooms to cause the neuroplasticity, then you microdose shrooms and take dihexa to maintain the neuroplasticity increase while promoting the growth of new synapses, and then add in the behaviours you want, ideally with a dopamine stimulus.
if my understanding is correct, i would assume dihexa isnt the only thing that can trigger synaptogenesis? and i would assume other agents that target synaptogenesis more upstream or downstream also exist, thus the potential for microdosing multiple agents like this could perhaps be better.
correct me if im wrong on this, just a suggestion

 

[hej1377]

@hej1377

Im mirin, psilocybin induced neuoropladticity is fucking legit, an hdac on this and its basicslly like making a custom braon

 

[BR32]

correct me if im wrong but as far as i can tell
you take shrooms to cause the neuroplasticity, then you microdose shrooms and take dihexa to maintain the neuroplasticity increase while promoting the growth of new synapses, and then add in the behaviours you want, ideally with a dopamine stimulus.
if my understanding is correct, i would assume dihexa isnt the only thing that can trigger synaptogenesis? and i would assume other agents that target synaptogenesis more upstream or downstream also exist, thus the potential for microdosing multiple agents like this could perhaps be better.
correct me if im wrong on this, just a suggestion

You're correct, there are likely other agents that can trigger synaptogenesis which could be used in combination with dihexa or replace it.

 

[BR32]

Im mirin, psilocybin induced neuoropladticity is fucking legit, an hdac on this and its basicslly like making a custom braon

That was the goal, obviously this theory needs a lot of workshopping. I'm open to all suggestions.

 

[LTNUser]

I need help quitting fapping

 

[BR32]

I need help quitting fapping

Could help.

All theoretical tho.

Can someone tag mfs who are tapped in w nootropics?

 

[BR32]

@birthdefect

I was doing some research and I haven’t found a compound other than dihexa which produces actual dendritic spine growth and new synaptic connections in preclinical models and works independently of acute neurotransmitter effects.

 

[BR32]

@Pharmascension

 

[BR32]

@Starborn

 

[karmacita901]

tag me in the result thread

 

[BR32]

tag me in the result thread

Gonna be in a minute

 

[birthdefect]

@birthdefect

I was doing some research and I haven’t found a compound other than dihexa which produces actual dendritic spine growth and new synaptic connections in preclinical models and works independently of acute neurotransmitter effects.

dihexa is really the only one? crazy
like hej recommended, have you looked into hdaci? i know i recommended you crebinostat (it actually has a new derivative called neurinostat now) but i know its practically impossible to source outside of a custom synthesis order
i know that crebinostat is actually an analogue of vorinostat designed to penetrate the brain better, and then neurinostat is a more optimised analogue. perhaps you could look into microdosed vorinostat

 

[jeoyw9192]

Gonna be in a minute

Tag me too thanks

 

[BR32]

dihexa is really the only one? crazy
like hej recommended, have you looked into hdaci? i know i recommended you crebinostat (it actually has a new derivative called neurinostat now) but i know its practically impossible to source outside of a custom synthesis order
i know that crebinostat is actually an analogue of vorinostat designed to penetrate the brain better, and then neurinostat is a more optimised analogue. perhaps you could look into microdosed vorinostat

I'll take a look into vorinostat.

Mechanistically it lines up, I overlooked hdac inhibitors.

 

[birthdefect]

I'll take a look into vorinostat.

Mechanistically it lines up, I overlooked hdac inhibitors.

do tag once the results come bhai