Cortisol DOESN’T Bloat (Explanation)

[s3emblance]

Cortisol is usually talked about as a cause of water retention by binding to mr receptor, and it have up to 1000x the affinity of aldosterone. That’s why taking a selective MR receptor antagonist is so cardioprotective.

That said, in normal physiology, 11β-HSD2 in the distal nephron converts cortisol to cortisone, which cannot bind to the mineralocorticoid receptor. That said, in people with some kind of hypercortisolism like Cushings or drugs that mimic cortisol like prednisone, the enzyme can become overwhelmed and cortisol can reach the distal nephron and bind to MR.

 

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Although to be fair probably some cortisol gets past this machinery

 

[Ezzah]

Cortisol is usually talked about as a cause of water retention by binding to mr receptor, and it have up to 1000x the affinity of aldosterone. That’s why taking a selective MR receptor antagonist is so cardioprotective.

That said, in normal physiology, 11β-HSD2 in the distal nephron converts cortisol to cortisone, which cannot bind to the mineralocorticoid receptor. That said, in people with some kind of hypercortisolism like Cushings or drugs that mimic cortisol like prednisone, the enzyme can become overwhelmed and cortisol can reach the distal nephron and bind to MR.

Are cigarettes going to cook me aside from skin texture

 

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Are cigarettes going to cook me aside from skin texture

If they help you get leaner it’s prolly a net positive just use taz and estriol to counteract the collagen degradation

 

[Aether_]

Cortisol is usually talked about as a cause of water retention by binding to mr receptor, and it have up to 1000x the affinity of aldosterone. That’s why taking a selective MR receptor antagonist is so cardioprotective.

That said, in normal physiology, 11β-HSD2 in the distal nephron converts cortisol to cortisone, which cannot bind to the mineralocorticoid receptor. That said, in people with some kind of hypercortisolism like Cushings or drugs that mimic cortisol like prednisone, the enzyme can become overwhelmed and cortisol can reach the distal nephron and bind to MR.

Got brutally knowledge mogged in that area.

 

[s3emblance]

Got brutally knowledge mogged in that area.

Kinda reductionism though

 

[Aether_]

Kinda reductionism though

Yes you did that well actually but I was in a rush and i'm just not that informed there will read later and inform myself when i'm at home