D-Meth vs D-Amph?

[GatoradeTRZ8]

I get Attentin for 2,2€ per 5mg pill (pharma). I take 15mg 5x a week so monthly costs are around 130€.

I can get D-Meth powder (99,9% purity according to seller testing) for 72€/g if i buy 5g, so 21.6€ monthly costs.

Desoxyn(d meth) is fda approved even for kids. The reason its not often prescribed is because doctors are scared they get a bed rep just because it has the name "meth" in it. I want to know if its as safe as d amph in therapeutical dosages.

Some people claim that its neurotoxic even on therapeutical dosages (that the d-methylamphetamine damages parts and pieces in the dopamine and serotonin pathways)

But if that were true i dont think it would be fda approved

Thoughts?
@User28823
@Keylozz
@aids
@TsarTsar444

 

[ZyzzReincarnate]

D-ick in your mouth?

 

[GatoradeTRZ8]

Both amphetamine and methamphetamine are potent CNS stimulants with a few biomolecular targets and affected transporters in common; however, there are important pharmacodynamic differences between the two compounds.[Refnote 2] Both compounds are potent trace amine-associated receptor 1 (TAAR1) agonists (causing non-competitive inhibition of DAT, NET, and SERT) and inhibitors of VMAT2, SLC22A3, and SLC22A5.[Refnote 3] However, methamphetamine appears to bind at a different site at VMAT2 than amphetamine.[80] Methamphetamine also inhibits VMAT1, has agonist activity at all alpha-2 adrenergic receptor and sigma receptor subtypes, and is directly toxic to dopamine neurons in humans, whereas there is no evidence of acute amphetamine toxicity in humans.[46][51][64][70] Sigma receptor activity is known to potentiate the stimulant and neurotoxic effects of methamphetamine.[70][71]

In contrast to the adverse neuroplastic effects evident in methamphetamine addicts, long-term use of amphetamine or methylphenidate at therapeutic doses appears to produce beneficial changes in brain function and structure, such as normalization of the right caudate nucleus.

Role of Sigma Receptors in Methamphetamine-Induced Neurotoxicity - PMC

Methamphetamine (METH) is a widely abused substance world over. Currently, there is no effective pharmacotherapy to treat its effects. This necessitates identification of potential novel therapeutic targets. METH interacts with sigma (σ) receptors ...

pmc.ncbi.nlm.nih.gov

Found a study that says its neurotoxic but most say it is not

 

[ZyzzReincarnate]

Found a study

 

[GatoradeTRZ8]

f*ck you nigger

 

[weepmeep]

alpha-pvp, dob, dom, lsd high doses

 

[weepmeep]

also try mk-ultra psychedelic mental torture

 

[¿Nero]

also try mk-ultra psychedelic mental torture

 

[Greyascension]

It is dopamine toxic, you'll see when you feel emotionless for a few days depending on dose after stopping usage

 

[Greyascension]

It is dopamine toxic, you'll see when you feel emotionless for a few days depending on dose after stopping usage

Not hating on it though, amphetamines have their uses