
Evgeniy291
Certified hardmaxxer
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**Short Answer:**Yes I feel a low inhibitors and my life is been much better, that's why I don't rot as much
Disagree. While datura *may* induce lasting psychological changes in some users (via traumatic delirium or neurochemical disruption), there’s **no evidence** it permanently reduces inhibition safely.
**Key Points:**
1. **Neurotoxicity ≠ Therapy**
- Anticholinergics like scopolamine can cause long-term cognitive damage (*memory loss, confusion*) but not targeted "rewiring" of social anxiety.
- Anecdotes of "permanent" effects likely stem from brain injury or psychological trauma (e.g., dissociation after delirium).
2. **Rebound Effects**
- Chronic use worsens baseline anxiety/depression (cholinergic rebound, receptor dysregulation).
- Example: [This study](https://pubmed.ncbi.nlm.nih.gov/30192928/) links anticholinergics to dementia risk.
3. **Placebo/Nocebo**
- Extreme experiences (e.g., surviving delirium) can alter self-perception, but this is unpredictable and often harmful.
**Safer Alternatives for Long-Term Change:**
- **Behavioral therapy** (CBT for social anxiety).
- **Controlled medications** (e.g., beta-blockers like propranolol for situational inhibition).
- **Neuroplasticity tools** (meditation, exposure therapy).
**TL;DR:** Datura’s "permanent" effects are either damage or delusion. The brain adapts—but not in a way you’d want.