DMSO + GHK-Cu

[NorwoodAscender]

ik this is asking alot due to the state of the forum but does anyone know if its possible to dissolve GHK-Cu in DMSO and apply it topically?

would rather do this than take the time of having to pin that shit every single day.

@Dyorotic @NZb6Air @Clavicular

 

[Deleted member 15225]

No it is only effective when injected. Pinning doesn't even take much time either. If it was effective as a topical then everyone would be using it.

 

[Hernan]

ik this is asking alot due to the state of the forum but does anyone know if its possible to dissolve GHK-Cu in DMSO and apply it topically?

would rather do this than take the time of having to pin that shit every single day.

@Dyorotic @NZb6Air @Clavicular

You could but

it is only effective when injected.

 

[NZb6Air]

idk they dont say it, maybe cause it's too unstable in dmso (?)

DMSO works well enough to associate with the rest of the molecule, so it's appropriate for regular GHK

but ghkcu needs PBS cause the ionic solution stabilizes the added copper, otherwise the copper-nitrogen bonds are likely to break


You can prolly dissolve it in DMSO just without guarantee of integrity

BAC water is also a gamble on how much u're actually getting since it has lower ion concentration than saline

I estimate it's more stable in bac than dmso tho since there's H+ and OH- (water), i think just up your number of Injections rather than switching to DMSO

they use saline IV injections in studies anyway

 

[tit]

ik this is asking alot due to the state of the forum but does anyone know if its possible to dissolve GHK-Cu in DMSO and apply it topically?

would rather do this than take the time of having to pin that shit every single day.

@Dyorotic @NZb6Air @Clavicular

Yes, it is possible to dissolve GHK-Cu (Copper Tripeptide-1) in DMSO (dimethyl sulfoxide) and apply it topically, but there are some important considerations to keep in mind.





Why Dissolve GHK-Cu in DMSO?





• Solubility: GHK-Cu is typically water-soluble, but it can also dissolve in solvents like DMSO. DMSO is commonly used in topical applications due to its ability to enhance the absorption of compounds through the skin.


• Enhanced Penetration: DMSO has unique properties that allow it to carry other molecules (like GHK-Cu) through the skin more efficiently, which can potentially enhance the peptide’s activity.





Key Considerations:





1. Purity of DMSO: It is essential to use pharmaceutical-grade or high-purity DMSO. Lower grades can contain impurities that may irritate the skin or lead to undesirable side effects.


2. Concentration: GHK-Cu is generally used at low concentrations (around 0.05% to 1%) for skin applications. When dissolving in DMSO, ensure you dilute it to an appropriate concentration that is safe for topical use.


3. Skin Sensitivity: DMSO is a strong solvent and can cause skin irritation, redness, or itching in some people. When applied, it may also give a garlic-like odor on the skin. Always patch test on a small area before applying it more broadly.


4. Sterility: Since DMSO increases skin permeability, it can also enhance the absorption of contaminants or bacteria on the skin. Clean the skin thoroughly before applying any DMSO-based solution.


5. Stability: GHK-Cu can be sensitive to light and air, which may degrade its effectiveness. Make sure to store the solution in a dark, airtight container if you plan to keep it for any length of time.


6. Absorption and Carrier: DMSO’s ability to penetrate the skin means that it will carry not only the GHK-Cu but also any other substances on your skin into the deeper layers. This makes cleanliness very important.





Method for Dissolving GHK-Cu in DMSO:





1. Prepare DMSO: Start with a clean, sterilized container.


2. Dissolve GHK-Cu: Add a small amount of GHK-Cu powder to the DMSO, stirring until fully dissolved.


3. Dilution: Depending on the desired concentration, you may want to dilute the DMSO-GHK-Cu solution with water or another carrier like saline or a skin-friendly oil.


4. Application: Apply a small amount topically, but patch test it first to ensure there are no adverse reactions.





In summary, yes, you can dissolve GHK-Cu in DMSO and use it topically, but be cautious about the concentration, skin irritation, and ensuring the skin is clean before application.