Do GLP1s not work as well overtime?

[ZyzzBrah]

I run tirz now, but i used to run reta. I remember pinning 2mg for the first time and being full after barely 3 bites, it was great, whereas near the end of my time using reta, I felt nothing on 7mg.

Do GLP1 agonists not work as well overtime? Receptor down regulation perhaps? Share your experiences.

 

[youngmogGod]

you’re spot on with the receptor down regulation. Ran reta 5 months just to stay sub 11% bodyfat. Ended up upping the dose several times and then hopping off completely because it became sub optimal.

 

[ZyzzBrah]

you’re spot on with the receptor down regulation. Ran reta 5 months just to stay sub 11% bodyfat. Ended up upping the dose several times and then hopping off completely because it became sub optimal.

fr shit give me heart palpitations too

just running 5mg tirz atm, mostly for the health benefits