Does Dutasteride affect bone development?

[´´´´´´´´]

Finasteride doesn’t do shit for the simple fact type 2 5AR is not expressed in bone tissue.

People like Caster Semenya and the twins from that one study have masculine bones despite having underdeveloped dicks and facial hair because they’re deficient in Type 2 5AR

What about type 1 though? It is expressed in bone tissue.

Asking here because Looksmaxxing Questions has practically nobody if compared to this subforum

 

[lestoa]

after puberty bone development does not occur, dht for bones is a meme anyways

you should be good

 

[Leopold_]

after puberty bone development does not occur, dht for bones is a meme anyways

you should be good

How is DHT a meme for bones

 

[lestoa]

How is DHT a meme for bones

no sry you're absolutely right its a god molecule iam so sorry

Inject dht, eat dht, drink dht, smoke dht.

Bath in dht gel. Shov it up your motherfucking asshole.

Get a enema with dht from your balding doctor.

Instead of using lubricant during sex, just use DHT gel.

 

[lestoa]

How is DHT a meme for bones

its just not worth it to inject that garbage

 

[Leopold_]

its just not worth it to inject that garbage

lmao I'm not an advocate for injecting DHT, but it is the main driver for bone development, as well as for development of all male secondary characteristics like hair, voice, brow ridge, cheekbones, libido... if you are not prone to hair loss than you want higher levels of DHT especially during development.

 

[´´´´´´´´]

after puberty bone development does not occur

it does, flat bones don't stop growing. might require blasting aas but can still happen. psychodsk, loox and titusa got growth by doing so.

dht for bones is a meme anyways

androgens increase bone formation while estrogens inhibit bone resorption.

you have any anecdotes of people who started dut young and still grew into their face?

 

[lestoa]

it does, flat bones don't stop growing

I don't think its going to make that much of a difference, if you're balding take dut. The 0,1% of extra bone is not worth it to lose your hair.

How old are you ?

you have any anecdotes of people who started dut young and still grew into their face?

The twins from that one study are a good examples for this, you still can block DHT and have good bones.

Do you have a link to that study by any chance ? I can't find it right now.

 

[chadisbeingmade]

Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency - PubMed

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

pubmed.ncbi.nlm.nih.gov

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

5α-reductase-2 Deficiency’s Effect on Human Fertility - PMC

A most interesting and intriguing male disorder of sexual differentiation is due to 5α-reductase-2 isoenzyme deficiency. These males are born with ambiguous external genitalia due to a deficiency in their ability to catalyze the conversion of ...

pmc.ncbi.nlm.nih.gov

The two guys on the left have 0 DHT (both type 1 and type 2) (literally) and they still have a normal bone structure and an identical height, bone density and skeletal mass to their healthy siblings, it have a higher binding affinity to the androgen receptor but it doesn't cause the same physiological response.
The pubertal growth spurt (for men) is also induced by testosterone and not DHT.

Also 5AR is not very active in bone tissues and DHT is mainly a paracrine hormone (i.e it acts where it's produced while testosterone acts on the whole body despite being produced in the testes).

Considering they ended up same bone density, structure etc I wouldn’t be worried about nuking both type 1 and type 2 DHT. And don’t see many causes of bone structure even changing after 16/18, it usually seems to be just fat loss with age, not bigger bones.

 

[chadisbeingmade]

I don't think its going to make that much of a difference, if you're balding take dut. The 0,1% of extra bone is not worth it to lose your hair.

How old are you ?

The twins from that one study are a good examples for this, you still can block DHT and have good bones.

Do you have a link to that study by any chance ? I can't find it right now.

5α-reductase-2 Deficiency’s Effect on Human Fertility - PMC

A most interesting and intriguing male disorder of sexual differentiation is due to 5α-reductase-2 isoenzyme deficiency. These males are born with ambiguous external genitalia due to a deficiency in their ability to catalyze the conversion of ...

pmc.ncbi.nlm.nih.gov

 

[chadisbeingmade]

lmao I'm not an advocate for injecting DHT, but it is the main driver for bone development, as well as for development of all male secondary characteristics like hair, voice, brow ridge, cheekbones, libido... if you are not prone to hair loss than you want higher levels of DHT especially during development.

WTF is this TikTok tier knowledge. Show me how you concluded that DHT is the main fucking driver of bone development because it isn’t. There is nothing that points to it being so. It’s all point to Test being the main driver of bone development, even of brow ridge. I provided studies. And since when is cheekbones a secondary male characteristic JFL.

Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency - PubMed

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

pubmed.ncbi.nlm.nih.gov

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

5α-reductase-2 Deficiency’s Effect on Human Fertility - PMC

A most interesting and intriguing male disorder of sexual differentiation is due to 5α-reductase-2 isoenzyme deficiency. These males are born with ambiguous external genitalia due to a deficiency in their ability to catalyze the conversion of ...

pmc.ncbi.nlm.nih.gov

View attachment 3625302
The two guys on the left have 0 DHT (both type 1 and type 2) (literally) and they still have a normal bone structure and an identical height, bone density and skeletal mass to their healthy siblings, it have a higher binding affinity to the androgen receptor but it doesn't cause the same physiological response.
The pubertal growth spurt (for men) is also induced by testosterone and not DHT.

Also 5AR is not very active in bone tissues and DHT is mainly a paracrine hormone (i.e it acts where it's produced while testosterone acts on the whole body despite being produced in the testes).

Considering they ended up same bone density, structure etc I wouldn’t be worried about nuking both type 1 and type 2 DHT. And don’t see many causes of bone structure even changing after 16/18, it usually seems to be just fat loss with age, not bigger bones.

Dutasteride 2.5mg a day has also shown to regrow more hair than 5mg oral minox OP. After 18, it’s 100% worth saving your hairline for life over any theoretical minor bone growth you many get (which isn’t even due to DHT so there’s nothing to worry about, but even if it hypothetically was, I would save my hairline still).

Lowkey a better alternative for bones after 18 is to nuke DHT with Duta and blast Test and Tren JFL with RU to prevent hair loss.

 

[´´´´´´´´]

Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency - PubMed

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

pubmed.ncbi.nlm.nih.gov

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

5α-reductase-2 Deficiency’s Effect on Human Fertility - PMC

A most interesting and intriguing male disorder of sexual differentiation is due to 5α-reductase-2 isoenzyme deficiency. These males are born with ambiguous external genitalia due to a deficiency in their ability to catalyze the conversion of ...

pmc.ncbi.nlm.nih.gov

View attachment 3625302
The two guys on the left have 0 DHT (both type 1 and type 2) (literally)

What's your source as to them being deficient in type 1 5AR? The original article is behind a paywall and dates 1977. I didn't buy it, but I downloaded the book from which Derek interpreted this study through Z-Library. It's called Hallelujah Moments and pretty much summarizes innovations in modern medicine, one of them being Propecia. At no moment the study mentions which 5AR type the twins are deficient in (at least throughout the parts reproduced by the book), but I assume it's type 2 for the simple fact I have never seen a single case of type 1 5AR deficiency.

 

[Leopold_]

WTF is this TikTok tier knowledge. Show me how you concluded that DHT is the main fucking driver of bone development because it isn’t. There is nothing that points to it being so. It’s all point to Test being the main driver of bone development, even of brow ridge. I provided studies. And since when is cheekbones a secondary male characteristic JFL.



Dutasteride 2.5mg a day has also shown to regrow more hair than 5mg oral minox OP. After 18, it’s 100% worth saving your hairline for life over any theoretical minor bone growth you many get (which isn’t even due to DHT so there’s nothing to worry about, but even if it hypothetically was, I would save my hairline still).

Lowkey a better alternative for bones after 18 is to nuke DHT with Duta and blast Test and Tren JFL with RU to prevent hair loss.

This is a really important discussion that doesn’t get nearly enough attention on this forum. You incels better read this because it took me a long fucking time to type.


Here is what you’re right about:

- Patients with 5AR deficiency often have normal height and bone density, which shows that testosterone alone is sufficient to drive linear bone growth—especially in the long bones.
- Testosterone is key for the pubertal growth spurt and also contributes to increased bone mass, in part through its conversion to estrogen.
- DHT acts mostly locally and has less systemic impact on skeletal growth compared to testosterone.
- Bone density is not the same as craniofacial morphology—the studies you cited mostly talk about density and length, not the shape or structural differences in the bones.


Here is why I'm still right about DHT being important:


REASON 1:

- Testosterone drives overall growth and bone density across the body.
- DHT, on the other hand, has more localized effects—especially in androgen-sensitive areas like the jawline, brow ridge, cheekbones, and larynx.

So, while testosterone builds size, DHT is what shapes many of the features associated with sexual dimorphism.


REASON 2:

There’s solid scientific evidence that DHT is the main androgen responsible for masculinizing traits like:
- Facial bone development
-Genital differentiation
- Voice deepening
- Male-pattern hair growth

Even the 5AR-deficient cases you mentioned (which I took the time to read) support this point. These guys typically present with less masculinized facial features, underdeveloped genitalia, and sparse facial/body hair—unless they receive DHT or DHT analog treatment. You can instantly see that guy with DHT on the right has a way more masculine face, while the one on the left has a subhuman baby face.

Pretty much, their height and bone density are intact, but their secondary sexual traits are underdeveloped.


REASON 3:

The patients in these studies usually show a consistent pattern:
- Normal height
- Normal bone density
- Micropenis
- Minimal facial/body hair
- Reduced facial dimorphism
- Higher-pitched voices

This suggests that testosterone grows the body while DHT masculinizes it.


ALSO CHEEKBONES ARE TOTALLY DIMORPHIC:
There’s plenty of anthropological and endocrinological research that I'm too lazy to cite showing that males tend to have more prominent zygos, and this dimorphism coincides with surges in DHT levels.

 

[chadisbeingmade]

What's your source as to them being deficient in type 1 5AR? The original article is behind a paywall and dates 1977. I didn't buy it, but I downloaded the book from which Derek interpreted this study through Z-Library. It's called Hallelujah Moments and pretty much summarizes innovations in modern medicine, one of them being Propecia. At no moment the study mentions which 5AR type the twins are deficient in (at least throughout the parts reproduced by the book), but I assume it's type 2 for the simple fact I have never seen a single case of type 1 5AR deficiency.
View attachment 3625415

You may be right, it’s may only a type 2 deficiency. There isn’t much on it. Then again, idk how only you are? but I stand by this.

Dutasteride 2.5mg a day has also shown to regrow more hair than 5mg oral minox OP. After 18, it’s 100% worth saving your hairline for life over any theoretical minor bone growth you many get (which isn’t even due to DHT so there’s nothing to worry about, but even if it hypothetically was, I would save my hairline still).

 

[chadisbeingmade]

This is a really important discussion that doesn’t get nearly enough attention on this forum. You incels better read this because it took me a long fucking time to type.


Here is what you’re right about:

- Patients with 5AR deficiency often have normal height and bone density, which shows that testosterone alone is sufficient to drive linear bone growth—especially in the long bones.
- Testosterone is key for the pubertal growth spurt and also contributes to increased bone mass, in part through its conversion to estrogen.
- DHT acts mostly locally and has less systemic impact on skeletal growth compared to testosterone.
- Bone density is not the same as craniofacial morphology—the studies you cited mostly talk about density and length, not the shape or structural differences in the bones.


Here is why I'm still right about DHT being important:


REASON 1:

- Testosterone drives overall growth and bone density across the body.
- DHT, on the other hand, has more localized effects—especially in androgen-sensitive areas like the jawline, brow ridge, cheekbones, and larynx.

So, while testosterone builds size, DHT is what shapes many of the features associated with sexual dimorphism.


REASON 2:

There’s solid scientific evidence that DHT is the main androgen responsible for masculinizing traits like:
- Facial bone development
-Genital differentiation
- Voice deepening
- Male-pattern hair growth

Even the 5AR-deficient cases you mentioned (which I took the time to read) support this point. These guys typically present with less masculinized facial features, underdeveloped genitalia, and sparse facial/body hair—unless they receive DHT or DHT analog treatment. You can instantly see that guy with DHT on the right has a way more masculine face, while the one on the left has a subhuman baby face.

Pretty much, their height and bone density are intact, but their secondary sexual traits are underdeveloped.


REASON 3:

The patients in these studies usually show a consistent pattern:
- Normal height
- Normal bone density
- Micropenis
- Minimal facial/body hair
- Reduced facial dimorphism
- Higher-pitched voices

This suggests that testosterone grows the body while DHT masculinizes it.


ALSO CHEEKBONES ARE TOTALLY DIMORPHIC:
There’s plenty of anthropological and endocrinological research that I'm too lazy to cite showing that males tend to have more prominent zygos, and this dimorphism coincides with surges in DHT levels.

I will read now but recommending people use DHT derived steroids (like u did in other threads) will not give any of these benefits.

Are you advocating for DHT post puberty or only during puberty?

 

[Leopold_]

I will read now but recommending people use DHT derived steroids (like u did in other threads) will not give any of these benefits.

Are you advocating for DHT post puberty or only during puberty?

Only during puberty. Use in conjunction with 2% Ketoconazole shampoo 3x/wk, and use RU58841 if you start to see shedding.

 

[chadisbeingmade]

Only during puberty. Use in conjunction with 2% Ketoconazole shampoo 3x/wk, and use RU58841 if you start to see shedding.

Then there’s no debate JFL. I agree that post puberty, likely at 18, DHT isn’t useful and will only looksmin after puberty (elastin raped and hairline). No one should nuke DHT during puberty.

 

[Leopold_]

Then there’s no debate JFL. I agree that post puberty, likely at 18, DHT isn’t useful and will only looksmin after puberty (elastin raped and hairline). No one should nuke DHT during puberty.

bruh this debate was originally about finasteride during puberty. yes perfect I agree, you should DHTmax and never take finasteride during puberty, only consider taking if balding after puberty

 

[chadisbeingmade]

bruh this debate was originally about finasteride during puberty. yes perfect I agree, you should DHTmax and never take finasteride during puberty, only consider taking if balding after puberty

I don’t think so. I don’t think OP is in puberty, im not sure, he never said.

I think he is wondering (since facial bones are ever changing) if dht would effect their development and growth.

 

[chadisbeingmade]

Come to any conclusion brah?

USRF - Guevedoces of the Dominican Republic

USRF - The story of Guevedoces (literally, penis at 12 years) and how the investigation of this phenomenon lead to the development of finasteride (Proscar).

www.usrf.org

saw this also, similar case as above tho.

 

[Evgeniy291]

WTF is this TikTok tier knowledge. Show me how you concluded that DHT is the main fucking driver of bone development because it isn’t. There is nothing that points to it being so. It’s all point to Test being the main driver of bone development, even of brow ridge. I provided studies. And since when is cheekbones a secondary male characteristic JFL.



Dutasteride 2.5mg a day has also shown to regrow more hair than 5mg oral minox OP. After 18, it’s 100% worth saving your hairline for life over any theoretical minor bone growth you many get (which isn’t even due to DHT so there’s nothing to worry about, but even if it hypothetically was, I would save my hairline still).

Lowkey a better alternative for bones after 18 is to nuke DHT with Duta and blast Test and Tren JFL with RU to prevent hair loss.

Does fin also regrow hair? And what does RU do

 

[chadisbeingmade]

Does fin also regrow hair? And what does RU do

Unlikely. Will likely just halt hair loss and thicken existing hairs over time (not as fast and Duta).

RU is a topical anti-androgen.

With a 5ARi and RU it’s not uncommon to get regrowth.

 

[´´´´´´´´]

bruh this debate was originally about finasteride during puberty. yes perfect I agree, you should DHTmax and never take finasteride during puberty, only consider taking if balding after puberty

I don’t think so. I don’t think OP is in puberty, im not sure, he never said.

I think he is wondering (since facial bones are ever changing) if dht would effect their development and growth.

I was wondering what's the effect of dutasteride on facial bones after puberty. Nobody on their right mind should meddle with fin or dut during puberty. Thing is the face still grows because flat bones never truly stop growing.

My current conclusion is type 1 DHT doesn't do much, and even if it did I suppose it's nothing that couldn't be, at the very minimum, replicated by supraphysiological levels of both T and E2.

 

[Leopold_]

I was wondering what's the effect of dutasteride on facial bones after puberty. Nobody on their right mind should meddle with fin or dut during puberty. Thing is the face still grows because flat bones never truly stop growing.

My current conclusion is type 1 DHT doesn't do much, and even if it did I suppose it's nothing that couldn't be, at the very minimum, replicated by supraphysiological levels of both T and E2.

good shit brah