Ankon
Iron
- Joined
- Feb 25, 2026
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Levobunolol eye drops
are a prescription beta-blocker used to lower high eye pressure (intraocular pressure) in patients with ocular hypertension or open-angle glaucoma
1. The 1999 Case (British Journal of Ophthalmology): A 68-year-old man reported his eyes changing from brown to blue after 5 years of using levobunolol twice daily.
2. The 2006 Case Series (IOVS/ARVO): This study reported on two additional patients (a 59-year-old and a 72-year-old) who experienced bilateral iris depigmentation after 10 and 8 years of chronic levobunolol use.
3rd case - Same as 1 and 2
Mechanism: Researchers hypothesize that levobunolol might have an affinity for pigmented tissue or could induce a pharmacological "Horner’s syndrome" state that leads to lightening.
Standard Side Effects: For the vast majority of users, levobunolol remains a non-pigment-changing beta-blocker, unlike prostaglandin analogs (e.g., Latanoprost), which frequently and permanently darken eye colour.
What I think: Maybe there should be a lot same cases like this I mean come on these are old people and they don't even use internet and this is not also a very big health issue that colour changing effect is completely normal
so my question is: is there any here on org who has experienced this iris depigmentation (the loss of brown pigment) while on this medication/eye drops. So please let me know
Should I take the risk and document it?
are a prescription beta-blocker used to lower high eye pressure (intraocular pressure) in patients with ocular hypertension or open-angle glaucoma
1. The 1999 Case (British Journal of Ophthalmology): A 68-year-old man reported his eyes changing from brown to blue after 5 years of using levobunolol twice daily.
2. The 2006 Case Series (IOVS/ARVO): This study reported on two additional patients (a 59-year-old and a 72-year-old) who experienced bilateral iris depigmentation after 10 and 8 years of chronic levobunolol use.
3rd case - Same as 1 and 2
Mechanism: Researchers hypothesize that levobunolol might have an affinity for pigmented tissue or could induce a pharmacological "Horner’s syndrome" state that leads to lightening.
Standard Side Effects: For the vast majority of users, levobunolol remains a non-pigment-changing beta-blocker, unlike prostaglandin analogs (e.g., Latanoprost), which frequently and permanently darken eye colour.
What I think: Maybe there should be a lot same cases like this I mean come on these are old people and they don't even use internet and this is not also a very big health issue that colour changing effect is completely normal
so my question is: is there any here on org who has experienced this iris depigmentation (the loss of brown pigment) while on this medication/eye drops. So please let me know
Should I take the risk and document it?
