Does MORE Dutasteride = MORE Shedding?

[powerliftercoco]

Is the shed from 1mg or even 2.5 mg Dutasteride, more intense than the shed from 0.5mg?

 

[PharmaPhaggot]

Might be a small difference but shouldn't be too big of a difference as the difference in the dht blocked is only 90-95% compared to 99%

 

[Adee]

dutasteride dose

How much mg of dut should I take daily? Is the difference between 0.5mg and 2.5mg massive? Also heard ppl experience good results on low dosages like 0.25mg with either dut or fin

looksmax.org

 

[powerliftercoco]

dutasteride dose

How much mg of dut should I take daily? Is the difference between 0.5mg and 2.5mg massive? Also heard ppl experience good results on low dosages like 0.25mg with either dut or fin

looksmax.org

I would use 2.5mg, I just don’t have the money to get 2.5mg of pharma Dut.

Powders are not very viable in Spain, customs confiscates them.

 

[Adee]

I would use 2.5mg, I just don’t have the money to get 2.5mg of pharma Dut.

Powders are not very viable in Spain, customs confiscates them.

I mean you can just take 5 of 0.5mg's

 

[powerliftercoco]

Might be a small difference but shouldn't be too big of a difference as the difference in the dht blocked is only 90-95% compared to 99%

Yeah but scalp DHT changes from 50 to 80%, or somewhere along those lines.

Maybe it pushes an even more aggresive shed.

My thoughts are that maybe if it was balding and not shed, by upping dose it might make the shed stop

But it might as well make the shed even more crazy

 

[powerliftercoco]

I mean you can just take 5 of 0.5mg's

It’s expensive as fuarkkkkk

 

[PharmaPhaggot]

Yeah but scalp DHT changes from 50 to 80%, or somewhere along those lines.

Maybe it pushes an even more aggresive shed.

My thoughts are that maybe if it was balding and not shed, by upping dose it might make the shed stop

But it might as well make the shed even more crazy

Isnt it like 70-85%? I might be mistaken as its a while ago i looked at the studies but shoudlnt be to bad still and worth it in the end

Im definitely buying the raw powder as soon as i move out and can logistically order it instead of what i have to do now and be super carefull and pickey with delivery options and cope with my 0,5mg ed

 

[powerliftercoco]

Isnt it like 70-85%? I might be mistaken as its a while ago i looked at the studies but shoudlnt be to bad still and worth it in the end

Im definitely buying the raw powder as soon as i move out and can logistically order it instead of what i have to do now and be super carefull and pickey with delivery options and cope with my 0,5mg ed

The 2.5-mg dose was also better than the 0.5-mg dose at suppressing scalp DHT (79% vs. 51%), whereas it was only marginally better at suppressing serum DHT (96% vs. 92%).

Yeah I wish I could get raw powder. They should make 2.5mg pharma pills bro hahaha

 

[PharmaPhaggot]

The 2.5-mg dose was also better than the 0.5-mg dose at suppressing scalp DHT (79% vs. 51%), whereas it was only marginally better at suppressing serum DHT (96% vs. 92%).

Yeah I wish I could get raw powder. They should make 2.5mg pharma pills bro hahaha

Pretty sure there is like 1 brand that does that for prostate issue, let me double check

No i coulsnt find shit ove 0,5

 

[powerliftercoco]

Pretty sure there is like 1 brand that does that for prostate issue, let me double check

No i coulsnt find shit ove 0,5

Hahahaha

Yeah man, sucks.

It would make it way cheaper for the people who use 0.5mg/day. Since Dut’s half life is so long you could just take one 2.5mg pill twice a week and you would be good.

Just like people buy the 5mg Fin to save costs

 

[PharmaPhaggot]

Hahahaha

Yeah man, sucks.

It would make it way cheaper for the people who use 0.5mg/day. Since Dut’s half life is so long you could just take one 2.5mg pill twice a week and you would be good.

Just like people buy the 5mg Fin to save costs

Yeah since all eu soruces are giga expensive i just bought some topical sollution for like 30$ which should last 600 days at 0,5mg, its pg free but still kinda disgusting to gobble down some oil once a week but its only 0,7ml

 

[Chad]

Just take 2.5mg Dut or hydraulic press to neurocranium, your hair will thank you in the long run.

If you can’t afford 5 softgels or don’t know how to formulate your own just add piss cheap Dut tablets from India to your current dose of Dut and eat them like candy. Tablets have a relative absorption of like 70 soemthing % IIRC of softgel.

Impact of Formulation on the Pharmacokinetics of Dutasteride: Results from Two Phase I Studies - PubMed

The bioavailability of, and peak exposure to, dutasteride are influenced by the formulation of the administered medication. These studies demonstrate the importance of formulation for obtaining the optimal pharmacokinetic properties of dutasteride.

pubmed.ncbi.nlm.nih.gov

 

[powerliftercoco]

Tablets have a relative absorption of like 70 soemthing % IIRC of softgel.

That’s still hella good though, and I take mine with a fatty meal and all my other fat soluble supplements, so maybe absorbtion is even better.

I have China pills rn, India is impossible in Spain unfortunately.

I’ll just take more pills I guess hahaha

 

[Chad]

That’s still hella good though, and I take mine with a fatty meal and all my other fat soluble supplements, so maybe absorbtion is even better.

I have China pills rn, India is impossible in Spain unfortunately.

I’ll just take more pills I guess hahaha

It comes to like 45% but there is variability in both the absorption of the softgel and tab. Softgel would be Avodart I think since it’s by GlaxoSmithKline so that would be 0.4-0.94 (0.6 commonly accepted), and then the 0.76 relative to that has a confidence interval of 0.64-0.84.

 

[powerliftercoco]

It comes to like 45% but there is variability in both the absorption of the softgel and tab. Softgel would be Avodart I think since it’s by GlaxoSmithKline so that would be 0.4-0.94 (0.6 commonly accepted), and then the 0.76 relative to that has a confidence interval of 0.64-0.84.

The absorption of the Avodart doesn’t really matter though, right?

I suppose the general studies where they test the 2.5mg are done with those, since it’s the standard. But maybe I’m wrong, and they did their own formulation for the studies and they had an even higher absorption %.

If it was done with Avodart then a 0.76 with respect to Avodart is very good. It it was with another formulation then we gotta start taking 5mg

 

[powerliftercoco]

The absorption of the Avodart doesn’t really matter though, right?

As I speculated, the main study where we get the data that 2.5mg Dut suppresses 79% scalph DHT vs 51% with 0.5mg most probably used Avodart softgels.

I can assume this because they used commercially available drugs for Finasteride, so I'd guess they used Avodart for Dutasteride too, since they also mentioned it at some point (references below).

And to chose the different concentrations they just dosed accordingly, so for the 0.05mg Dut daily a singular 0.5mg pill every 10 days is what they probably did (they also mention Dutasteride's long half-life).

So pills, instead of softgels, are not that bad at all. Just divide the theoretical softgel dose by 0.76 and you are good.

2.5mg Avodart ≈ 3.3mg China/India pills

Unless you wanna just formulate your own from powder, it's much cheaper than going pharma grade.

Now the question is, are the pills just pressed powder or do they contain something else that facilitates absorbtion? Because if they don't then why not just take a bit more raw powder (same dose as pills, 3.3mg) instead of going through the hassle of formulating your own softgel?

@axon @chadisbeingmade @SlayerJonas @m0ss26 @optimisticzoomer

 

[axon]

As I speculated, the main study where we get the data that 2.5mg Dut suppresses 79% scalph DHT vs 51% with 0.5mg most probably used Avodart softgels.

I can assume this because they used commercially available drugs for Finasteride, so I'd guess they used Avodart for Dutasteride too, since they also mentioned it at some point (references below).

And to chose the different concentrations they just dosed accordingly, so for the 0.05mg Dut daily a singular 0.5mg pill every 10 days is what they probably did (they also mention Dutasteride's long half-life).

So pills, instead of softgels, are not that bad at all. Just divide the theoretical softgel dose by 0.76 and you are good.

2.5mg Avodart ≈ 3.3mg China/India pills

Unless you wanna just formulate your own from powder, it's much cheaper than going pharma grade.

Now the question is, are the pills just pressed powder or do they contain something else that facilitates absorbtion? Because if they don't then why not just take a bit more raw powder (same dose as pills, 3.3mg) instead of going through the hassle of formulating your own softgel?

@axon @chadisbeingmade @SlayerJonas @m0ss26 @optimisticzoomer

View attachment 4400365View attachment 4400366

These called „Dutasteride Tablets“ are not just pressed raw powder. They don’t have that Oil inside like Avodart, but contain certain lipohilic carriers and binding agents which help the absorption process. They are not optimal, like the things inside Avodart, but still are important for the absorption process.



Which exactly is quite different and depends on the brand of the Dutasteride tablets. But the whole point is they matter.

So taking these pills, like 3,3mg (as you said correctly) maybe with a fatty meal is a good approach. Don’t use raw powder if possible

Thats my view and that topic. Always open for discussion


Btw the last 2-3 months i researched a lot the „raw dutasteride“ powder theory and also took 20mg for a few months. I will make a huge thread soon and explain why taking raw Powder is NOT optimal. Doesn’t matter if u take it with MCT, fatty meal, etc etc
You should ALWAYS use Avodart, or the compensatory amount of cheap Indian Dutasteride capsules, if you manage to order from there.

 

[powerliftercoco]

Btw the last 2-3 months i researched a lot the „raw dutasteride“ powder theory and also took 20mg for a few months. I will make a huge thread soon and explain why taking raw Powder is NOT optimal. Doesn’t matter if u take it with MCT, fatty meal, etc etc.

Thank you for your insight!

Looking forward to that thread