Dopamine maxxing with mucuna pruriens, green tea extract + quercetin phytosome?

Bewusst

Bewusst

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Mucuna pruriens contains dopamine precursor L-DOPA naturally and can be bought OTC. The enzyme aromatic L-amino acid decarboxylase finally converts L-DOPA into dopamine, which requires pyridoxal 5'-phosphate (the bioactive form of vitamin B6) as a cofactor. Since mucuna pruriens is a source of levodopa, you'd skip the previous steps of dopamine synthesis, hydroxylation of phenylalanine to tyrosine and then L-DOPA via phenylalanine/tyrosine hydroxylase, both of which are dependent on tetrahydrobiopterin and non-heme ferrous iron.

Unfortunately, L-DOPA is quickly decarboxylated to dopamine before it reaches the brain. Unlike levodopa, dopamine can't cross the blood brain barrier. That's why in the treatment of Parkinson's, levodopa is always combined with a peripheral DOPA decarboxylase inhibitor like carbidopa and sometimes also a catechol-O-methyltransferase inhibitor to decrease peripheral breakdown of L-DOPA, reduce side effects and increase the amount of levodopa that makes it into the brain.

Green tea catechines and quercetin were found to have DDC, COMT and/or MAO inhibiting properties. In one study, only (+)-catechin was able to significantly inhibit COMT-mediated L-DOPA methylation in vivo but quercetin and (-)-epicatechin were not, likely due to poor bioavailability. But then again, rats metabolize plant chemicals differently than humans. Quercetin phytosome has up to 20-fold higher oral bioavailability than standard quercetin supplements. @Seth Walsh do you know of any other somewhat effective and safe DDC/COMT inhibitors you don't need a prescription for? Would green tea extract and quercetin phytosome be enough to make mucuna pruriens work?

Any ideas? Has anyone used mucuna pruriens with or without natural or pharmaceutical DOPA decarboxylase/COMT inhibitors? @CupOfCoffee

@TsarTsar444 @Cope @DrTony
 
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@Rush
 
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Sounds smart tbh, would love a dopamine maxxing guide ngl
 
Bromantane and 9mebc (use sunscreen for this though)
 
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Bromantane and 9mebc (use sunscreen for this though)
9-Methyl-β-carboline looks interesting but it's still a research chemical. Have you used it?
 
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9-Methyl-β-carboline looks interesting but it's still a research chemical. Have you used it?
No but there were studies done on it, super good results
 
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@quakociaptockh
 
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EGCg (green tea extract) blocks peripheral L-dopa conversion well enough so it can be used in place of carbidopa.

Quick test: if you feel like puking, your L-dopa got converted before reaching brain. (Or you overdosed, but then it's over anyway.)

I wanna say, it's not a very strong antidepressant and none of a stimulant. You just feel marginally calmer. I don't know what you're looking for, but if it's antidepressant, stimulant and lowinhibmax, try adrenosterone.
 
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Didn't notice a difference from doing either methods. Even dopamine agonists like Cabergoline, Lisuride, and Metergoline had negligible effects on me. Best way to get a noticeable spike in dopamine is to take a dopamine-releasing agent like an amphetamine such as Adderall or 3-FA or a phenidate such as Ritalin or Isopropylplphendiate and then reset your dopamine receptors with abstinence and an NMDA antagonist like Memantine.
 
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EGCg (green tea extract) blocks peripheral L-dopa conversion well enough so it can be used in place of carbidopa.

Quick test: if you feel like puking, your L-dopa got converted before reaching brain. (Or you overdosed, but then it's over anyway.)

I wanna say, it's not a very strong antidepressant and none of a stimulant. You just feel marginally calmer. I don't know what you're looking for, but if it's antidepressant, stimulant and lowinhibmax, try adrenosterone.
Any downsides to L-DOPA/mucuna pruriens supplementation?
 
Would this fix my anhedonia? I have no emotions for 10 years
 
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Would this fix my anhedonia? I have no emotions for 10 years
Maybe. I had been anhedonic for quite some time myself but it subsided eventually when I started taking P5P, methylfolate and methylcobalamine and drinking sugar free energy drinks/diet pepsi (aspartame -> phenylalanine + adenosine antagonism from caffeine). I'm a smoker tho and nicotine increases the expression of the tyrosine hydroxylase gene. I suppose all these things combined led to increased dopamine synthesis. Taking mucuna pruriens would theoretically be a shortcut in that process. Have you been taking any drugs?
 
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Maybe. I had been anhedonic for quite some time myself but it subsided eventually when I started taking P5P, methylfolate and methylcobalamine and drinking sugar free energy drinks/diet pepsi (aspartame -> phenylalanine + adenosine antagonism from caffeine). I'm a smoker tho and nicotine increases the expression of the tyrosine hydroxylase gene. I suppose all these things combined led to increased dopamine synthesis. Taking mucuna pruriens would theoretically be a shortcut in that process. Have you been taking any drugs?
I was on SSRIs but I had been anhedonic even way before I had SSRIs at the ageof 10. I feel like I can't be saved tbh. Haven't felt nostalgia, happiness,sadness,anger for 10 years
 
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It seems that what matters actually is not the level of dopamine, but amplitude.

It's the same with serotonin. SSRI only increase level of serotonin, while reducing amplitude and that makes you feel numb.

I recommend ascethism, nofap, noporn, fasting, cold showers and unironically prayer. Good supplements are alcar and citicolone that restore dopamine receptors.

L-dopa + EGCg gives me marginal anxiolytic effect.
Cabergoline is good for erections, but destroys receptors long term.

I never tried addreall, because my current stack works good enough to sail the world of wageslaving. But I might try it in the future for social lowinhibmax. I have some blackpill proofs that it works.


Would this fix my anhedonia? I have no emotions for 10 years
Me too, buddy, me too.

Do roids. Start with DHEA and pregnenolone, then adrenosterone. PCT with ATD.
 
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Didn't notice a difference from doing either methods. Even dopamine agonists like Cabergoline, Lisuride, and Metergoline had negligible effects on me. Best way to get a noticeable spike in dopamine is to take a dopamine-releasing agent like an amphetamine such as Adderall or 3-FA or a phenidate such as Ritalin or Isopropylplphendiate and then reset your dopamine receptors with abstinence and an NMDA antagonist like Memantine.
Nice to see you back! One of the best posters on the site
 
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Nice to see you back! One of the best posters on the site
Haha, thanks man. A lot had been going on in my personal life so I took a hiatus. Good to see you’re still here.
 
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Bromantane and 9mebc (use sunscreen for this though)
DONT use these together *SEROTONIN SYNDROME*

9mebc is definitely a MAOI. Bromantane may or may not have serotonin reuptake inhibition effects. But this combo definitely is not pleasant. Causing serious nausea and GI issues.

I wouldn't use any of the following together:
Bromantane
Tongkat Ali
Cistanche
9MEBC

Experience is anecdotal
 
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DONT use these together *SEROTONIN SYNDROME*

9mebc is definitely a MAOI. Bromantane may or may not have serotonin reuptake inhibition effects. But this combo definitely is not pleasant. Causing serious nausea and GI issues.

I wouldn't use any of the following together:
Bromantane
Tongkat Ali
Cistanche
9MEBC

Experience is anecdotal
Yo @CookiesAndCream wants you to PM him
 
9-Methyl-β-carboline looks interesting but it's still a research chemical. Have you used it?
I had a bad experience with it. Made my skin very bad. ~2 months of use. Didn't notice any positive benefits tbh.
 
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DONT use these together *SEROTONIN SYNDROME*

9mebc is definitely a MAOI. Bromantane may or may not have serotonin reuptake inhibition effects. But this combo definitely is not pleasant. Causing serious nausea and GI issues.

I wouldn't use any of the following together:
Bromantane
Tongkat Ali
Cistanche
9MEBC

Experience is anecdotal
Why not?
 
Bromantane and 9mebc (use sunscreen for this though)
Have you used 9mebc yet? From what I remember it was kinda weird but it did work. I'm gonna avoid the powder and use the capsules this time. I think 15mg daily for 10 days per month is the best protocol, alongside 10-15mg bromantane year round.

Yeah 9mebc messed up my skin even during winter :hnghn: :hnghn:
 
I had a bad experience with it. Made my skin very bad. ~2 months of use. Didn't notice any positive benefits tbh.
Placebo maybe idk
 
Placebo maybe idk
I tried dming you but you have dms off (low t deathnic wristlet trait)

Where do I get ghk from?
And how do I inject it,is it the same needles used for MT2?
 
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I tried dming you but you have dms off (low t deathnic wristlet trait)

Where do I get ghk from?
And how do I inject it,is it the same needles used for MT2?
Followed you so you'll be able to DM. At work rn so I'll probs reply in like 4 hours. I'll let you know about all that stuff later :)

(low t deathnic wristlet trait) ☠️ :lul:
 
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Just have sex incel
 

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