Bewusst
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Mucuna pruriens contains dopamine precursor L-DOPA naturally and can be bought OTC. The enzyme aromatic L-amino acid decarboxylase finally converts L-DOPA into dopamine, which requires pyridoxal 5'-phosphate (the bioactive form of vitamin B6) as a cofactor. Since mucuna pruriens is a source of levodopa, you'd skip the previous steps of dopamine synthesis, hydroxylation of phenylalanine to tyrosine and then L-DOPA via phenylalanine/tyrosine hydroxylase, both of which are dependent on tetrahydrobiopterin and non-heme ferrous iron.
Unfortunately, L-DOPA is quickly decarboxylated to dopamine before it reaches the brain. Unlike levodopa, dopamine can't cross the blood brain barrier. That's why in the treatment of Parkinson's, levodopa is always combined with a peripheral DOPA decarboxylase inhibitor like carbidopa and sometimes also a catechol-O-methyltransferase inhibitor to decrease peripheral breakdown of L-DOPA, reduce side effects and increase the amount of levodopa that makes it into the brain.
Green tea catechines and quercetin were found to have DDC, COMT and/or MAO inhibiting properties. In one study, only (+)-catechin was able to significantly inhibit COMT-mediated L-DOPA methylation in vivo but quercetin and (-)-epicatechin were not, likely due to poor bioavailability. But then again, rats metabolize plant chemicals differently than humans. Quercetin phytosome has up to 20-fold higher oral bioavailability than standard quercetin supplements. @Seth Walsh do you know of any other somewhat effective and safe DDC/COMT inhibitors you don't need a prescription for? Would green tea extract and quercetin phytosome be enough to make mucuna pruriens work?
Any ideas? Has anyone used mucuna pruriens with or without natural or pharmaceutical DOPA decarboxylase/COMT inhibitors? @CupOfCoffee
@TsarTsar444 @Cope @DrTony
Unfortunately, L-DOPA is quickly decarboxylated to dopamine before it reaches the brain. Unlike levodopa, dopamine can't cross the blood brain barrier. That's why in the treatment of Parkinson's, levodopa is always combined with a peripheral DOPA decarboxylase inhibitor like carbidopa and sometimes also a catechol-O-methyltransferase inhibitor to decrease peripheral breakdown of L-DOPA, reduce side effects and increase the amount of levodopa that makes it into the brain.
Green tea catechines and quercetin were found to have DDC, COMT and/or MAO inhibiting properties. In one study, only (+)-catechin was able to significantly inhibit COMT-mediated L-DOPA methylation in vivo but quercetin and (-)-epicatechin were not, likely due to poor bioavailability. But then again, rats metabolize plant chemicals differently than humans. Quercetin phytosome has up to 20-fold higher oral bioavailability than standard quercetin supplements. @Seth Walsh do you know of any other somewhat effective and safe DDC/COMT inhibitors you don't need a prescription for? Would green tea extract and quercetin phytosome be enough to make mucuna pruriens work?
Any ideas? Has anyone used mucuna pruriens with or without natural or pharmaceutical DOPA decarboxylase/COMT inhibitors? @CupOfCoffee
@TsarTsar444 @Cope @DrTony
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