Eating ONE meal a day is optimal: THE SCIENTIFIC PROOF.

[Jaynoyn523]

TLDR AT THE BOTTOM.
this is a short thread, not much detail.

1. METABOLIC FLEXIBILITY & INSULIN SENSITIVITY​

Every time you eat:​

• You raise blood glucose
• You release insulin to manage that glucose

With 3+ meals/day, you're:

• Constantly spiking insulin
• Reducing fasting windows
• Limiting time for autophagy, fat oxidation, and metabolic reset

Evidence:​

• Intermittent fasting and OMAD improve:
  • Insulin sensitivity
  • Fasting glucose levels
  • Glucagon/adiponectin levels
• Sutton et al., 2018 – Cell Metabolism: early time-restricted feeding (6-hour window) improved insulin sensitivity and blood pressure without weight loss.

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2. MITOCHONDRIAL EFFICIENCY & THE RANDLE CYCLE​

The Randle Cycle shows:​

When you constantly eat — especially carbs and fats together — the body’s ability to oxidize either fuel becomes impaired.

Eating 3 meals/day:

• Creates constant substrate competition (glucose vs fatty acids)
• Inhibits mitochondrial efficiency
• Leads to metabolic gridlock over time

OMAD:

• Reduces substrate competition
• Allows long periods of clean fat oxidation
• Enhances metabolic flexibility

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3. COGNITIVE CLARITY: THE FASTED BRAIN ADVANTAGE​

100% Elimination of hypoglycaemic-induced cognitive impairment.

In a fasted state:​

• The brain uses ketones + a trickle of glucose
• BDNF (Brain-Derived Neurotrophic Factor) rises
• Catecholamines (dopamine, norepinephrine) increase → alertness, focus

With 3 meals/day:

• Post-meal dips → insulin spike → serotonin dominance → brain fog, fatigue
• Constant digestion → diverted blood flow from the brain to the gut

Evidence:​

• Fasting boosts BDNF, neurogenesis, and synaptic plasticity. Dhunnoo et al., 2021 – Frontiers in Physiology: Intermittent fasting improves working memory and executive function.

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4. AUTOPHAGY, DNA REPAIR, AND CELLULAR CLEANUP​

With OMAD, you’re in a fasted state for ~22–23 hours:

• Activates autophagy (cellular cleanup)
• Increases NAD⁺, sirtuins, AMPK
• Suppresses mTOR long enough for regeneration

Eating 3 meals:

• Autophagy remains mostly inactive
• Glycogen stores never deplete enough to trigger real metabolic stress

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5. HORMONAL & LONGEVITY SIGNALING​

OMAD triggers:​

Hormone/Signal	Effect
GH (Growth Hormone) ↑	Fat burning, repair
AMPK ↑	Energy sensing, boosts mitochondrial biogenesis
Sirtuins ↑	DNA repair, longevity
Leptin sensitivity ↑	Appetite regulation, metabolic rate

With 3 meals:

• These signals are blunted
• You stay in fed/anabolic mode, which can accelerate aging when chronic

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TLDR:​

Metric	1 Meal/Day (OMAD)	3 Meals/Day
Insulin Load	Low	High
Fat Oxidation	Maximal	Suppressed
Mental Clarity	Enhanced	Fluctuates
Autophagy	Triggered	Inactive
Hormetic Stress	Engaged	Absent
Appetite Regulation	Reset	Disrupted

 

[Jaynoyn523]

@310reqiuem_ @dylanmaxing @jordanbarretv2

 

[JohnDoe]

Randle cycle doesn't matter if you aren't overeating and aren't overweight.

 

[Jaynoyn523]

Randle cycle doesn't matter if you aren't overeating and aren't overweight.

it does when you consume fat in conjunction with sugar, the body can only oxidise one at a time, doesn't matter if you're overweight or overeating. Also the average person is overeating, especially if they eat 3 meals a day.

 

[JohnDoe]

it does when you consume fat in conjunction with sugar, the body can only oxidise one at a time, doesn't matter if you're overweight or overeating. Also the average person is overeating, especially if they eat 3 meals a day.

It's all cope, people living to 90 or 100 eating multiple times a day mixing it all up.

 

[Jaynoyn523]

It's all cope, people living to 90 or 100 eating multiple times a day mixing it all up.

its not about living longer, its about optimising performance in every day life, you can live the same amount of time as a person eating once a day, but the person eating once a day will perform better in every day tasks. (given the person is eating optimally in their one meal and not eating pop tarts)

 

[JohnDoe]

its not about living longer, its about optimising performance in every day life, you can live the same amount of time as a person eating once a day, but the person eating once a day will perform better in every day tasks. (given the person is eating optimally in their one meal and not eating pop tarts)

How are you supposed to get all your nutrients in one meal?

 

[Saint Casanova]

How are you supposed to get all your nutrients in one meal?

If you save it until night you’ll be hungry enough to eat a huge meal

 

[JohnDoe]

If you save it until night you’ll be hungry enough to eat a huge meal

How can being hungry all day and weak/low energy be helpful, sounds like making things harder for yourself. You are able to get high performance just from eating normally and the right food twice a day. You can skip breakfast.

 

[Saint Casanova]

How can being hungry all day and weak/low energy be helpful, sounds like making things harder for yourself. You are able to get high performance just from eating normally and the right food twice a day. You can skip breakfast.

I know Kinobody does it and it works very well for him, but the juice probably helps more for training

 

[JohnDoe]

I know Kinobody does it and it works very well for him, but the juice probably helps more for training

I usually eat one meal a day but I do snack throughout the day, my appetite is terrible since I caught norovirus a while back. Optimizing gut health is my priority. Most things are connected in some way to your gut. And ofc to maximise nutriebt absorption it all starts in the gut

 

[Swarthy Knight]

Not reading allat.. but lifefuel if it's true

Been overreating goy slop since I'm on Mirtazpine tho

 

[Saint Casanova]

I usually eat one meal a day but I do snack throughout the day, my appetite is terrible since I caught norovirus a while back. Optimizing gut health is my priority. Most things are connected in some way to your gut. And ofc to maximise nutriebt absorption it all starts in the gut

How to fix gut health? Do you do parasite cleanses ?

I took diatomaceous earth with sugar and drank lots of kefir and that helped massively but I’m having issues again.

 

[Jaynoyn523]

How are you supposed to get all your nutrients in one meal?

?? are you being fr? lmao explain how it would be even remotely difficult to get all nutrients in one meal, if you eat like the average westerner then you don’t get all nutrients throughout 3 meals anyway lol