erdafitnib

[serg]

what do you guys know?

 

[Lardass]

what

 

[topology]

I just searched it up and I could make a lot of connections back to vosoritide. Are you asking regarding height?

 

[serg]

I just searched it up and I could make a lot of connections back to vosoritide. Are you asking regarding height?

Yeah, i wanna grow to 6'4

It does have some connections with voso

 

[Lardass]

I just searched it up and I could make a lot of connections back to vosoritide. Are you asking regarding height?

wait its a real thing? deadass just thought he smacked the keyboard

 

[topology]

Yeah, i wanna grow to 6'4

It does have some connections with voso

You're not going to grow off inhibiting fgfr3. I believe the trials with Vosoritide demonstrated that. That's why it's so expensive, they need to make the money back some how since the condition is so rare. If it did apply to basically everyone they could market it way more broadly.

 

[topology]

wait its a real thing? deadass just thought he smacked the keyboard

Google is your friend, bud.

 

[Lardass]

Google is your friend, bud.

no shit bro but why would I google something when I thought he just spammed random letters

 

[serg]

You're not going to grow off inhibiting fgfr3. I believe the trials with Vosoritide demonstrated that. That's why it's so expensive, they need to make the money back some how since the condition is so rare. If it did apply to basically everyone they could market it way more broadly.

Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer - npj Precision Oncology

Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated limited clinical effectiveness. Herein, we evaluated the transforming activity and...

www.nature.com

Inhibition of FGFR signaling with infigratinib improves linear bone growth in the female Aga2/+ mouse model of osteogenesis imperfecta - PMC

Osteogenesis imperfecta, a genetically heterogeneous disorder, is characterized by brittle bones with recurrent fractures as well as short stature. A recent study investigating cellular signaling in growth plate chondrocytes identified an increased ...

pmc.ncbi.nlm.nih.gov

Accelerated Linear Growth during Erdafitinib Treatment: An FGFR-Related, but Growth Factor and Sex Steroid-Independent Mechanism? - PMC

Growth acceleration during postnatal growth only occurs during puberty as a physiological event and during catch-up growth mediated by growth-promoting therapies in growth disorders. Here we report on novel observations of skeletal symptoms during ...

pmc.ncbi.nlm.nih.gov

https://pubmed.ncbi.nim.nih.gov/25257751/

 

[topology]

no shit bro but why would I google something when I thought he just spammed random letters

To confirm your belief.

 

[topology]

w

Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer - npj Precision Oncology

Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated limited clinical effectiveness. Herein, we evaluated the transforming activity and...

www.nature.com

Inhibition of FGFR signaling with infigratinib improves linear bone growth in the female Aga2/+ mouse model of osteogenesis imperfecta - PMC

Osteogenesis imperfecta, a genetically heterogeneous disorder, is characterized by brittle bones with recurrent fractures as well as short stature. A recent study investigating cellular signaling in growth plate chondrocytes identified an increased ...

pmc.ncbi.nlm.nih.gov

Accelerated Linear Growth during Erdafitinib Treatment: An FGFR-Related, but Growth Factor and Sex Steroid-Independent Mechanism? - PMC

Growth acceleration during postnatal growth only occurs during puberty as a physiological event and during catch-up growth mediated by growth-promoting therapies in growth disorders. Here we report on novel observations of skeletal symptoms during ...

pmc.ncbi.nlm.nih.gov

https://pubmed.ncbi.nim.nih.gov/25257751/

Study 1.
Irrelevant to height.


Study 2.
Final height outcomes not included. Short-term observations. No controlled follow-up to adult height or comparison to expected final stature.


Study 3.
In mice, not humans. "Final height" in mice is not directly translatable to human adult stature. It does not measure adult mouse height after growth plate closure.


Study 4.
Irrelevant to the drug you mentioned.

--

Regardless, even if I am mistaken about the vosoritide studies as I heard a while back, you're still going off a misconception. FGFR3 does not massively inhibit growth. If it did, then gigantism wouldn't be much off the standard deviation. The "break" is only slight and the gains would be modest at best. All the other pathways work in harmony to put these "breaks." You also have to realize t3/t4 is the main limiter based off my hypothesis ( https://looksmax.org/threads/lowering-t3-t4-can-make-you-taller.1935006/ ).

 

[serg]

Study 1.
Irrelevant to height.


Study 2.
Final height outcomes not included. Short-term observations. No controlled follow-up to adult height or comparison to expected final stature.


Study 3.
In mice, not humans. "Final height" in mice is not directly translatable to human adult stature. It does not measure adult mouse height after growth plate closure.


Study 4.
Irrelevant to the drug you mentioned.

--

Regardless, even if I am mistaken about the vosoritide studies as I heard a while back, you're still going off a misconception. FGFR3 does not massively inhibit growth. If it did, then gigantism wouldn't be much off the standard deviation. The "break" is only slight and the gains would be modest at best. All the other pathways work in harmony to put these "breaks." You also have to realize t3/t4 is the main limiter based off my hypothesis ( https://looksmax.org/threads/lowering-t3-t4-can-make-you-taller.1935006/ ).

I'm really looking for modest results, im already 6'2 but i think ill be hardstuck for the rest of my life.

That thread is good, only time i've seen you actually contributing on this forum

 

[topology]

I'm really looking for modest results, im already 6'2 but i think ill be hardstuck for the rest of my life.

Having every single pathway optimized at this point won't get you much taller. Your plates are already mostly exhausted. Just let the course of it run & get LLS for a couple inches if absolutely needed considering you claimed to have hundreds of thousands.

That thread is good, only time i've seen you actually contributing on this forum

There's not much to contribute to this forum other than height & everything would be hypothetical. There is no point in me posting as trials would take a long while to confirm/debunk my beliefs and no one here studies height enough to debunk what I say. Also, no one would/could run most my ideas. They're either dangerous or experimental at the safest.

 

[serg]

Having every single pathway optimized at this point won't get you much taller. Your plates are already mostly exhausted. Just let the course of it run & get LLS

I won't make myself disabled just to go for a couple inches.

2 inches is all im looking for anyways

 

[topology]

I won't make myself disabled just to go for a couple inches.

2 inches is all im looking for anyways

You won't go disabled. 2 inches is a very small amount. The average patient gets like 4-5 inches & is able to properly run and do anything you'd want.

You could just run Romosozumab + a Bisphosphonate for bone strength if that's your concern. The timing/drugs may differ from clinic to clinic. 2 inches though wouldn't need anything.

 

[serg]

You won't go disabled. 2 inches is a very small amount. The average patient gets like 4-5 inches & is able to properly run and do anything you'd want.

Temporarily, 1 year is a very long time

2 inches though wouldn't need anything.

You're saying i'll grow?
My father is 6'3

 

[topology]

Temporarily, 1 year is a very long time

I doubt it's going to be that long considering you're going in for about 1/3 of the average treatment.

You're saying i'll grow?
My father is 6'3

I was saying nothing is needed for bone strength when the issue is 2 inches. You likely will grow though since you stated you're 16 or something.

 

[serg]

I doubt it's going to be that long considering you're going in for about 1/3 of the average treatment.

Im not considering LL, maybe in 20 years when the average height is like 6'3

I was saying nothing is needed for bone strength when the issue is 2 inches. You likely will grow though since you stated you're 16 or something.

Sounds good, thanks bro

 

[topology]

Im not considering LL, maybe in 20 years when the average height is like 6'3

Sounds good, thanks bro

Yep, no problem.

 

[terlound]

what do you guys know?

helps grow, but DO NOT TAKE IT. It has FATAL side effects fgfr3 inhibs like erdafitnib are CRAZY dangerous

 

[bullethill]

Study 1.
Irrelevant to height.


Study 2.
Final height outcomes not included. Short-term observations. No controlled follow-up to adult height or comparison to expected final stature.


Study 3.
In mice, not humans. "Final height" in mice is not directly translatable to human adult stature. It does not measure adult mouse height after growth plate closure.


Study 4.
Irrelevant to the drug you mentioned.

--

Regardless, even if I am mistaken about the vosoritide studies as I heard a while back, you're still going off a misconception. FGFR3 does not massively inhibit growth. If it did, then gigantism wouldn't be much off the standard deviation. The "break" is only slight and the gains would be modest at best. All the other pathways work in harmony to put these "breaks." You also have to realize t3/t4 is the main limiter based off my hypothesis ( https://looksmax.org/threads/lowering-t3-t4-can-make-you-taller.1935006/ ).

I think a 19.8 cm yearly growth rate after a period of no growth on every patient with growth plates open and no bone age development or fusing during or after treatment is affecting the final height more positively than negative especially if your on ur last cm’s

 

[Sub --0]

Study 1.
Irrelevant to height.


Study 2.
Final height outcomes not included. Short-term observations. No controlled follow-up to adult height or comparison to expected final stature.


Study 3.
In mice, not humans. "Final height" in mice is not directly translatable to human adult stature. It does not measure adult mouse height after growth plate closure.


Study 4.
Irrelevant to the drug you mentioned.

--

Regardless, even if I am mistaken about the vosoritide studies as I heard a while back, you're still going off a misconception. FGFR3 does not massively inhibit growth. If it did, then gigantism wouldn't be much off the standard deviation. The "break" is only slight and the gains would be modest at best. All the other pathways work in harmony to put these "breaks." You also have to realize t3/t4 is the main limiter based off my hypothesis ( https://looksmax.org/threads/lowering-t3-t4-can-make-you-taller.1935006/ ).

erdafitnib actually showed some proof of growth, though not in a safe way. https://pmc.ncbi.nlm.nih.gov/articles/PMC11152661/#tbl1

 

[topology]

erdafitnib actually showed some proof of growth, though not in a safe way. https://pmc.ncbi.nlm.nih.gov/articles/PMC11152661/#tbl1

That study and any further ones you can find have been debunked. They are not reliable in any sense.

 

[Sub --0]

That study and any further ones you can find have been debunked. They are not reliable in any sense.

how so? im curious as to how this one has been debunked

 

[Sub --0]

That study and any further ones you can find have been debunked. They are not reliable in any sense.

the study isnt even saying that "you will grow on this" in fact he developed scoliosis from how fast he grew. His bone age was also found to be much younger. In theory the mechanism seems to work.

 

[Invidia]

what do you guys know?

panFGFR inhibitor. inhibits FGFR1-4 i believe.a sideeffects are fearmongered. trials showed other FGFR and VEGF inhibitors widened and "opened" plates. not many studies could be completly fucking cap. too lazy to link the study. ordered it a week ago and will update