estrogen 2

[Sachlichkeit]

We have already discussed how important estrogen is, you cannot remove estrogen from the body forever, death.

Use of AI's to delay puberty and more recently as HRT for men in modern day by blocking aromatase enzyme is medical standard for height growth.

The medical standard is 11y.o, research stopped in 2005.

Nobody wants to open the door to designer puberty, epigenetic permanent modulation, basically soft eugenics, (which is what we are doing here.)

1. AI's
Arimidex
Exemestane
Anastrazole
Anastrazole is the most effective at zeroing out estrogen and is what was used in the initial studies, exemestane and anastrazole are the weaker ones.

2. SERMS
SELECTIVE ESTROGEN RECEPTOR MODULATORS do exactly what they say. they modulate estrogen receptors. Ideally in minecraft you would put estrogen at maybe 10-15 to delay senescence then further minimize their effects by modulating the receptors using,
1. tamoxifen
2 raloxifene
Raloxifene acts as a weaker estrogen in growth plates, meaning it should theoretically slow fusion but it produces the opposite effect in studies. Maybe dose dependent. idk, not worth.
I been using serms for breast tissue/gyno mitigation paired with AI's
Tamox however has been shown to delay epiphyseal fusion in teens, resulting in an increase in predicted adult height. Dosage was 10mg bid (2x/day.) can be 1x but anything estrogen related YOU ARE GETTING HOTFLASHES post menopausal woman style, maybe jointpain, etc, lmao. so bid was to smooth out side effects

So if u r "heightmaxxing," GH, tamox, letro, probably sprinting or some sort of mechanical stimulation inb4 maasai more free game yw

NOW.

Androgens increase estrogen receptor A sensitivity in the body through crosstalk AS WELL as increasing erA density. So you can have very low estrogen, do steroids, and because you have upregulated both density and sensitivity, plates will still close. So estrogen when on cycle behaves differently, its stronger, I think it's the one of the body's counterbalance mechanisms. So theoretically 10 pg/ml e2 might feel like 30-40pg/ml on gear. So most people on cycle with ZERO estrogen control are on some accidental convoluted form of estrogen therapy as well.
erA activation is what closes growth plates.

SERDS. Selective Estrogen Receptor Degrader

It just deletes erA. plates wont close. Androgen skeletal anabolism, IGF1 transcription in growth plates, anabolism now applies to height with v little downsides in terms of longitudinal growth.

Serds shut off estrogen everywhere. So this is dangerous obviously. they are oncology drugs for breast cancer.

the best is an intramuscular injection and OLD SERD known as Fulvestrant.

Ngl, I don't really want any of u boys to drop dead in gym because there is no estrogen in your cardiovascular system, so this is all theoretical. What I say is not gospel my posts are more of an open journal.

Theres a loading schedule, 500mg injections split between two into each asscheek.
500mg D1, D15, D29, then 1x/mo

If you don't load it could take 4 months to reach full saturation, the drug also has a half life of 40-50 days.

Just a theoretical cycle would be 1.5/2mos, first being a loading month, and second being 1 injection.

Or weakening the loading period intentionally, only getting partial ERA destruction. rudimentary write up for theoretical application, I would run it like oldhead steroid cycle, a month or a little over with partial ERA destruction rather than full, paired with heavy gh and androgens for short aggressive growth period

I'd do it if long plates were open then maybe write a post on how I almost died doing pushups because of cardiovascular strain, or maybe 2 months of straight zero estrogen asexual anhedonic misery.

This is probably the most dangerous drug i've written about

 

[aids]

Anastrazole is the most effective at zeroing out estrogen and is what was used in the initial studies, exemestane and anastrazole are the weaker ones.

 

[aids]

Arimidex is just a brand of anastrazole by the way

 

[theübermenschboy]

We have already discussed how important estrogen is, you cannot remove estrogen from the body forever, death.

Use of AI's to delay puberty and more recently as HRT for men in modern day by blocking aromatase enzyme is medical standard for height growth.

The medical standard is 11y.o, research stopped in 2005.

Nobody wants to open the door to designer puberty, epigenetic permanent modulation, basically soft eugenics, (which is what we are doing here.)

1. AI's
Arimidex
Exemestane
Anastrazole
Anastrazole is the most effective at zeroing out estrogen and is what was used in the initial studies, exemestane and anastrazole are the weaker ones.

2. SERMS
SELECTIVE ESTROGEN RECEPTOR MODULATORS do exactly what they say. they modulate estrogen receptors. Ideally in minecraft you would put estrogen at maybe 10-15 to delay senescence then further minimize their effects by modulating the receptors using,
1. tamoxifen
2 raloxifene
Raloxifene acts as a weaker estrogen in growth plates, meaning it should theoretically slow fusion but it produces the opposite effect in studies. Maybe dose dependent. idk, not worth.
I been using serms for breast tissue/gyno mitigation paired with AI's
Tamox however has been shown to delay epiphyseal fusion in teens, resulting in an increase in predicted adult height. Dosage was 10mg bid (2x/day.) can be 1x but anything estrogen related YOU ARE GETTING HOTFLASHES post menopausal woman style, maybe jointpain, etc, lmao. so bid was to smooth out side effects

So if u r "heightmaxxing," GH, tamox, letro, probably sprinting or some sort of mechanical stimulation inb4 maasai more free game yw

NOW.

Androgens increase estrogen receptor A sensitivity in the body through crosstalk AS WELL as increasing erA density. So you can have very low estrogen, do steroids, and because you have upregulated both density and sensitivity, plates will still close. So estrogen when on cycle behaves differently, its stronger, I think it's the one of the body's counterbalance mechanisms. So theoretically 10 pg/ml e2 might feel like 30-40pg/ml on gear. So most people on cycle with ZERO estrogen control are on some accidental convoluted form of estrogen therapy as well.
erA activation is what closes growth plates.

SERDS. Selective Estrogen Receptor Degrader

It just deletes erA. plates wont close. Androgen skeletal anabolism, IGF1 transcription in growth plates, anabolism now applies to height with v little downsides in terms of longitudinal growth.

Serds shut off estrogen everywhere. So this is dangerous obviously. they are oncology drugs for breast cancer.

the best is an intramuscular injection and OLD SERD known as Fulvestrant.

Ngl, I don't really want any of u boys to drop dead in gym because there is no estrogen in your cardiovascular system, so this is all theoretical. What I say is not gospel my posts are more of an open journal.

Theres a loading schedule, 500mg injections split between two into each asscheek.
500mg D1, D15, D29, then 1x/mo

If you don't load it could take 4 months to reach full saturation, the drug also has a half life of 40-50 days.

Just a theoretical cycle would be 1.5/2mos, first being a loading month, and second being 1 injection.

Or weakening the loading period intentionally, only getting partial ERA destruction. rudimentary write up for theoretical application, I would run it like oldhead steroid cycle, a month or a little over with partial ERA destruction rather than full, paired with heavy gh and androgens for short aggressive growth period

I'd do it if long plates were open then maybe write a post on how I almost died doing pushups because of cardiovascular strain, or maybe 2 months of straight zero estrogen asexual anhedonic misery.

This is probably the most dangerous drug i've written about

High quality poster.

 

[Sachlichkeit]

sorry man I wrote this early in morning I meant to say letrozole obv
height studies are conducted with letrozole
anastrazole is the less strong, non steroidal
exemestane (which I confused with arimidex,) is the steroidal AI, also at similar strengths to anastrazole
E2 rebound thus gyno coming off of AI's is a real risk so its better to hop on, titrate, then slowly lower doses for anas and letro, with exemestane that is a non issue

 

[looks4life]

xemestane (which I confused

y want any of u boys to drop dead in gym because there is no estrogen in you

We have already discussed how important estrogen is, you cannot remove estrogen from the body forever, death.

Use of AI's to delay puberty and more recently as HRT for men in modern day by blocking aromatase enzyme is medical standard for height growth.

The medical standard is 11y.o, research stopped in 2005.

Nobody wants to open the door to designer puberty, epigenetic permanent modulation, basically soft eugenics, (which is what we are doing here.)

1. AI's
Arimidex
Exemestane
Anastrazole
Anastrazole is the most effective at zeroing out estrogen and is what was used in the initial studies, exemestane and anastrazole are the weaker ones.

2. SERMS
SELECTIVE ESTROGEN RECEPTOR MODULATORS do exactly what they say. they modulate estrogen receptors. Ideally in minecraft you would put estrogen at maybe 10-15 to delay senescence then further minimize their effects by modulating the receptors using,
1. tamoxifen
2 raloxifene
Raloxifene acts as a weaker estrogen in growth plates, meaning it should theoretically slow fusion but it produces the opposite effect in studies. Maybe dose dependent. idk, not worth.
I been using serms for breast tissue/gyno mitigation paired with AI's
Tamox however has been shown to delay epiphyseal fusion in teens, resulting in an increase in predicted adult height. Dosage was 10mg bid (2x/day.) can be 1x but anything estrogen related YOU ARE GETTING HOTFLASHES post menopausal woman style, maybe jointpain, etc, lmao. so bid was to smooth out side effects

So if u r "heightmaxxing," GH, tamox, letro, probably sprinting or some sort of mechanical stimulation inb4 maasai more free game yw

NOW.

Androgens increase estrogen receptor A sensitivity in the body through crosstalk AS WELL as increasing erA density. So you can have very low estrogen, do steroids, and because you have upregulated both density and sensitivity, plates will still close. So estrogen when on cycle behaves differently, its stronger, I think it's the one of the body's counterbalance mechanisms. So theoretically 10 pg/ml e2 might feel like 30-40pg/ml on gear. So most people on cycle with ZERO estrogen control are on some accidental convoluted form of estrogen therapy as well.
erA activation is what closes growth plates.

SERDS. Selective Estrogen Receptor Degrader

It just deletes erA. plates wont close. Androgen skeletal anabolism, IGF1 transcription in growth plates, anabolism now applies to height with v little downsides in terms of longitudinal growth.

Serds shut off estrogen everywhere. So this is dangerous obviously. they are oncology drugs for breast cancer.

the best is an intramuscular injection and OLD SERD known as Fulvestrant.

Ngl, I don't really want any of u boys to drop dead in gym because there is no estrogen in your cardiovascular system, so this is all theoretical. What I say is not gospel my posts are more of an open journal.

Theres a loading schedule, 500mg injections split between two into each asscheek.
500mg D1, D15, D29, then 1x/mo

If you don't load it could take 4 months to reach full saturation, the drug also has a half life of 40-50 days.

Just a theoretical cycle would be 1.5/2mos, first being a loading month, and second being 1 injection.

Or weakening the loading period intentionally, only getting partial ERA destruction. rudimentary write up for theoretical application, I would run it like oldhead steroid cycle, a month or a little over with partial ERA destruction rather than full, paired with heavy gh and androgens for short aggressive growth period

I'd do it if long plates were open then maybe write a post on how I almost died doing pushups because of cardiovascular strain, or maybe 2 months of straight zero estrogen asexual anhedonic misery.

This is probably the most dangerous drug i've written about

Was curious if the serms are worth it at all because of how much it lowers igf1? In your substack you say your using raloxifene, but here you say tamoxifen is better?

 

[lookingbad]

We have already discussed how important estrogen is, you cannot remove estrogen from the body forever, death.

Use of AI's to delay puberty and more recently as HRT for men in modern day by blocking aromatase enzyme is medical standard for height growth.

The medical standard is 11y.o, research stopped in 2005.

Nobody wants to open the door to designer puberty, epigenetic permanent modulation, basically soft eugenics, (which is what we are doing here.)

1. AI's
Arimidex
Exemestane
Anastrazole
Anastrazole is the most effective at zeroing out estrogen and is what was used in the initial studies, exemestane and anastrazole are the weaker ones.

2. SERMS
SELECTIVE ESTROGEN RECEPTOR MODULATORS do exactly what they say. they modulate estrogen receptors. Ideally in minecraft you would put estrogen at maybe 10-15 to delay senescence then further minimize their effects by modulating the receptors using,
1. tamoxifen
2 raloxifene
Raloxifene acts as a weaker estrogen in growth plates, meaning it should theoretically slow fusion but it produces the opposite effect in studies. Maybe dose dependent. idk, not worth.
I been using serms for breast tissue/gyno mitigation paired with AI's
Tamox however has been shown to delay epiphyseal fusion in teens, resulting in an increase in predicted adult height. Dosage was 10mg bid (2x/day.) can be 1x but anything estrogen related YOU ARE GETTING HOTFLASHES post menopausal woman style, maybe jointpain, etc, lmao. so bid was to smooth out side effects

So if u r "heightmaxxing," GH, tamox, letro, probably sprinting or some sort of mechanical stimulation inb4 maasai more free game yw

NOW.

Androgens increase estrogen receptor A sensitivity in the body through crosstalk AS WELL as increasing erA density. So you can have very low estrogen, do steroids, and because you have upregulated both density and sensitivity, plates will still close. So estrogen when on cycle behaves differently, its stronger, I think it's the one of the body's counterbalance mechanisms. So theoretically 10 pg/ml e2 might feel like 30-40pg/ml on gear. So most people on cycle with ZERO estrogen control are on some accidental convoluted form of estrogen therapy as well.
erA activation is what closes growth plates.

SERDS. Selective Estrogen Receptor Degrader

It just deletes erA. plates wont close. Androgen skeletal anabolism, IGF1 transcription in growth plates, anabolism now applies to height with v little downsides in terms of longitudinal growth.

Serds shut off estrogen everywhere. So this is dangerous obviously. they are oncology drugs for breast cancer.

the best is an intramuscular injection and OLD SERD known as Fulvestrant.

Ngl, I don't really want any of u boys to drop dead in gym because there is no estrogen in your cardiovascular system, so this is all theoretical. What I say is not gospel my posts are more of an open journal.

Theres a loading schedule, 500mg injections split between two into each asscheek.
500mg D1, D15, D29, then 1x/mo

If you don't load it could take 4 months to reach full saturation, the drug also has a half life of 40-50 days.

Just a theoretical cycle would be 1.5/2mos, first being a loading month, and second being 1 injection.

Or weakening the loading period intentionally, only getting partial ERA destruction. rudimentary write up for theoretical application, I would run it like oldhead steroid cycle, a month or a little over with partial ERA destruction rather than full, paired with heavy gh and androgens for short aggressive growth period

I'd do it if long plates were open then maybe write a post on how I almost died doing pushups because of cardiovascular strain, or maybe 2 months of straight zero estrogen asexual anhedonic misery.

This is probably the most dangerous drug i've written about

just talked bout no test cycle is best + how raloxifene could help for ERb while on no test

 

[Sachlichkeit]

just talked bout no test cycle is best + how raloxifene could help for ERb while on no test

yes 4 plates if u r going to roid zeroing out test completely except for little bit and hcg and using non aromatizables fletch method looks appealing but incredibly high risk and retarded

so still the standard is ai hgh for ISS which will put you into the lognormal distribution for height growth but yes if u wanted to be mega tall you would have to shut down local estrogen plate growth

 

[itsovveerrrr]

yes 4 plates if u r going to roid zeroing out test completely except for little bit and hcg and using non aromatizables fletch method looks appealing but incredibly high risk and retarded

so still the standard is ai hgh for ISS which will put you into the lognormal distribution for height growth but yes if u wanted to be mega tall you would have to shut down local estrogen plate growth

explain why it’s “high risk and retarded”, please. you refuse to bring up the fact you use an e2 base in compensation for no t base, stop fearmongering retard jfl

 

[Sachlichkeit]

explain why it’s “high risk and retarded”, please. you refuse to bring up the fact you use an e2 base in compensation for no t base, stop fearmongering retard jfl

its retarded because I said so end of story

yeah man let me eradicate the primary endogenous steroid in my body for a few theoretical inches not even talking about the other half being estrogen control

 

[Sachlichkeit]

explain why it’s “high risk and retarded”, please. you refuse to bring up the fact you use an e2 base in compensation for no t base, stop fearmongering retard jfl

but yes if u wanted to be mega tall you would have to shut down local estrogen plate growth

I agreed with u moron but that doesn't make it any less retarded

 

[itsovveerrrr]

its retarded because I said so end of story

yeah man let me eradicate the primary endogenous steroid in my body for a few theoretical inches not even talking about the other half being estrogen control

you’re so fucking stupid, please provide a scientific argument instead of your shit lowiq bro science

 

[Sachlichkeit]

you’re so fucking stupid, please provide a scientific argument instead of your shit lowiq bro science

be nice man

 

[lookingbad]

yes 4 plates if u r going to roid zeroing out test completely except for little bit and hcg and using non aromatizables fletch method looks appealing but incredibly high risk and retarded

so still the standard is ai hgh for ISS which will put you into the lognormal distribution for height growth but yes if u wanted to be mega tall you would have to shut down local estrogen plate growth

Just use something for ERB agonism nga; is that hard? s equol or genistein?? or maybe just use a strong neuroprotection stack that works on the neuropathways that e2 and thus ERB acts on right? but u cant arrive to that conclusion

 

[Sachlichkeit]

Just use something for ERB agonism nga; is that hard? s equol or genistein?? or maybe just use a strong neuroprotection stack that works on the neuropathways that e2 and thus ERB acts on right? but u cant arrive to that conclusion

ngl man idk why I respond to these things when I know none of u guys are actually going do it

if u were a month on of clearing out your e2 and test we could actually have a serious conversation rather than arguing on internet tier mental masturbation

 

[Stacyslayerᛉ]

Hell yeah I’ll run this shit asap.
It says it’s weaker on joint pain wich is a huge benefit.
Stumbled up on this compound a few weeks ago.
Had to lower my ai dose bc of joint pain.

 

[Zagro]

Are you sure you aren't exaggerating the CV risks?

 

[Sachlichkeit]

Are you sure you aren't exaggerating the CV risks?

yes that was hyperbole but im certain SERDS have more disastrous effects than AI's. Will u drop dead in gym? honestly, idk, probably not.
I view it more like a car running out of gas, u r running on fumes. u have had estrogen in ur body for 17yrs, it goes away for 3-4months ur body begins to drift into decay but theres no immediate "fentanyl overdose" moment. u could obv catch it and reverse post cycle

this is more of a mental masturbation thread

HGH & AI only put a person inside or slightly above the lognormal distribution for height as I believe they are more "plug and play" drugs

for ex. exo HGH counterregulates insulin desensitization as a compensatory mechanism, the downstream pathway is also bottlenecked by JAK2 & STAT5 whatever those are and SOCS proteins which shut down IGF-1 signaling when the HGH dose is supraphysiologic.

What I wasn't aware of was the NON systemic localized conversion of androgens into estrogen AT THE GROWTH PLATE, plate closure is partially from systemic estrogen, yes, but it is more contingent on local aromatase conversion at/in the bone. you cannot synthetically produce an aromatase deficient man using AI's as it only controls systemic estrogen. Thats why there is a height increase when using letrozole in teens, but its modest 2 inches I believe rather than the eunuchoid proportions of having either no aromatase enzyme or no testosterone to begin with.

you’re so fucking stupid, please provide a scientific argument instead of your shit lowiq bro science

Newgens have proposed something retarded but I admire the mental illness

shutting down the hpg axis with high dose non aromatizables & no test base. then supplementing with a little hcg/ or very low trt dosages.

will this work? idk.

regarding the "heightmaxxing" conversations via estrogen we are probably around hereView attachment 4655567

Gyazo

gyazo.com

 

[Sachlichkeit]

Was curious if the serms are worth it at all because of how much it lowers igf1? In your substack you say your using raloxifene, but here you say tamoxifen is better?

yes tamoxifen is better than raloxifene in studies and also has been shown to have negative effects on circulating systemic IGF1

Worse than all of this is that some of the posts I write are dead wrong and have 2 live forever on the internet

I shilled tren for a while only for me to completely reverse my opinion on it in favor of standard DHT & Test

nevertheless I post, I learn, I post again, I learn more, and so on and so forth

 

[Sachlichkeit]

yes tamoxifen is better than raloxifene in studies and also has been shown to have negative effects on circulating systemic IGF1

Worse than all of this is that some of the posts I write are dead wrong and have 2 live forever on the internet

I shilled tren for a while only for me to completely reverse my opinion on it in favor of standard DHT & Test

nevertheless I post, I learn, I post again, I learn more, and so on and so forth

I believe they are more "plug and play"

I am slowly learning that there is no "plug and play" drug as the body is too interconnected, there is always some counterbalance to growth and for good reason

 

[looks4life]

I am slowly learning that there is no "plug and play" drug as the body is too interconnected, there is always some counterbalance to growth and for good reason

Yeah mirin bros always researching, what do you think about Bazedoxifene vs Tamox? Seems more promising to me.

 

[itsovveerrrr]

yes that was hyperbole but im certain SERDS have more disastrous effects than AI's. Will u drop dead in gym? honestly, idk, probably not.
I view it more like a car running out of gas, u r running on fumes. u have had estrogen in ur body for 17yrs, it goes away for 3-4months ur body begins to drift into decay but theres no immediate "fentanyl overdose" moment. u could obv catch it and reverse post cycle

this is more of a mental masturbation thread

HGH & AI only put a person inside or slightly above the lognormal distribution for height as I believe they are more "plug and play" drugs

for ex. exo HGH counterregulates insulin desensitization as a compensatory mechanism, the downstream pathway is also bottlenecked by JAK2 & STAT5 whatever those are and SOCS proteins which shut down IGF-1 signaling when the HGH dose is supraphysiologic.

What I wasn't aware of was the NON systemic localized conversion of androgens into estrogen AT THE GROWTH PLATE, plate closure is partially from systemic estrogen, yes, but it is more contingent on local aromatase conversion at/in the bone. you cannot synthetically produce an aromatase deficient man using AI's as it only controls systemic estrogen. Thats why there is a height increase when using letrozole in teens, but its modest 2 inches I believe rather than the eunuchoid proportions of having either no aromatase enzyme or no testosterone to begin with.


Newgens have proposed something retarded but I admire the mental illness

shutting down the hpg axis with high dose non aromatizables & no test base. then supplementing with a little hcg/ or very low trt dosages.

will this work? idk.

regarding the "heightmaxxing" conversations via estrogen we are probably around hereView attachment 4655567

Gyazo

gyazo.com

elaborate the need for testosterone over these compounds please, why is it needed according to you?