Ethanol to delay sexual development

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“Also, serum GH and LH levels were significantly lower in the ETOH-treated animals; however, FSH levels were not affected. Administration of the ETOH liquid diet through day 41 produced varying detrimental effects on the onset of puberty and subsequent removal of ETOH from the diet resulted in rapid growth of the animals, followed by the onset of puberty. These results demonstrate: (a) that ETOH administration during the peripubertal period delays the onset of female puberty in the rat; (b) that this effect is associated with deficiencies in both GH and LH secretion, and (c) that, although delayed, growth and sexual maturity can occur after removal from the drug from the diet.”

Effects of ethanol during the onset of female puberty - PubMed

To assess more closely the physiological mechanism(s) by which ethanol (ETOH) delays the onset of female puberty, we have evaluated its effects on body weight, the vaginal opening (VO)-first diestrus (D1) interval and the serum concentrations of growth hormone (GH), luteinizing hormone (LH) and...

pubmed.ncbi.nlm.nih.gov

 

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