Experimental method of opening GROWTH PLATES.

[bloodymanor]

​

As a rule, the growth zones in the bones of the legs and arms close by the age of 17-19. Although many of the patients under management had growth zones close to closing already at 15. You can find out which group you are in using X-ray of the hand/hip.

Spoiler: What growth zones are and what they consist of:

The growth zone is what growth cannot occur without, and it itself is divided into several zones.

1. Rest zone (reserve zone)

Located closest to the bone epiphysis, this zone contains small scattered chondrocytes (cartilage cells) embedded in a rich extracellular matrix. These cells are considered a reserve, a stable population of stem cells and anchorage of the epiphyseal cyst growth plate. This zone constantly provides a supply of chondrocytes for future growth.

2. Proliferative zone.

The chondrocytes here promote rapid division, organizing complex columns parallel to the bone axis. This proliferation is the main factor in bone stretching. Growth hormone and insulin-like growth factors strongly influence this zone, cell proliferation and production matrices.

3. Hypertrophic zone.

At this point, chondrocytes stop dividing and instead expand greatly (hypertrophy), secreting proteins that modify the surrounding matrix.

4. Ossification Zone

Although technically part of the metaphysis, this zone marks the transition from cartilage to bone. Osteoblasts invade the calcified matrix, depositing osteoid (unmolalized bone), which hardens into trabecular bone. This process, called endochondral ossification, integrates new bone tissue into the existing skeleton.

Spoiler: METHOD OF OPENNING GROWTH PLATES:

This method is based on the idea that even after the growth zones close, a certain amount of epiphyseal skeletal stem cells remain in their place. We can say that the growth zone "completely" closes much later than significant growth ends.

The method itself. We will not consider the preparation.

1. First, we need to drill a hole to gain access to the cavity with epiphyseal stem cells.

2. Introduction of a drug based on SAG and other growth factors.

Spoiler: WHAT IS SAG?

SAG (smoothed agonist) is a small molecule that activates the smoothed (SMO) receptor, a key component of the hedgehog (HH) signaling pathway. This pathway, especially the Indian hedgehog (IHH) subtype, plays a critical role in regulating growth plate activity, including chondrocyte proliferation, differentiation, and bone elongation during development.

SAG is a powerful molecule that stimulates the proliferation and differentiation of epiphyseal stem cells, causing them to build a new growth plate.

STUDY IS HERE: https://insight.jci.org/articles/view/165226

Next, you only need to maintain the viability of the growth zone and bone growth, for which there are stacks that we use on people with open growth zones.


studies that were mentioned:
https://insight.jci.org/articles/view/165226

 

[Thief]

RIP @Growth Plate

 

[inversions]

Dnr

But do this and lmk

 

[bloodymanor]

bump

 

[bloodymanor]

bump

 

[bloodymanor]

bump nigga

 

[grilldaddy❤️]

Sounds experimental

 

[AustrianMogger]

View attachment 3986432
​

As a rule, the growth zones in the bones of the legs and arms close by the age of 17-19. Although many of the patients under management had growth zones close to closing already at 15. You can find out which group you are in using X-ray of the hand/hip.

Spoiler: What growth zones are and what they consist of:

The growth zone is what growth cannot occur without, and it itself is divided into several zones.

1. Rest zone (reserve zone)

Located closest to the bone epiphysis, this zone contains small scattered chondrocytes (cartilage cells) embedded in a rich extracellular matrix. These cells are considered a reserve, a stable population of stem cells and anchorage of the epiphyseal cyst growth plate. This zone constantly provides a supply of chondrocytes for future growth.

2. Proliferative zone.

The chondrocytes here promote rapid division, organizing complex columns parallel to the bone axis. This proliferation is the main factor in bone stretching. Growth hormone and insulin-like growth factors strongly influence this zone, cell proliferation and production matrices.

3. Hypertrophic zone.

At this point, chondrocytes stop dividing and instead expand greatly (hypertrophy), secreting proteins that modify the surrounding matrix.

4. Ossification Zone

Although technically part of the metaphysis, this zone marks the transition from cartilage to bone. Osteoblasts invade the calcified matrix, depositing osteoid (unmolalized bone), which hardens into trabecular bone. This process, called endochondral ossification, integrates new bone tissue into the existing skeleton.

Spoiler: METHOD OF OPENNING GROWTH PLATES:

This method is based on the idea that even after the growth zones close, a certain amount of epiphyseal skeletal stem cells remain in their place. We can say that the growth zone "completely" closes much later than significant growth ends.

The method itself. We will not consider the preparation.

1. First, we need to drill a hole to gain access to the cavity with epiphyseal stem cells.

2. Introduction of a drug based on SAG and other growth factors.

Spoiler: WHAT IS SAG?

SAG (smoothed agonist) is a small molecule that activates the smoothed (SMO) receptor, a key component of the hedgehog (HH) signaling pathway. This pathway, especially the Indian hedgehog (IHH) subtype, plays a critical role in regulating growth plate activity, including chondrocyte proliferation, differentiation, and bone elongation during development.

SAG is a powerful molecule that stimulates the proliferation and differentiation of epiphyseal stem cells, causing them to build a new growth plate.

STUDY IS HERE: https://insight.jci.org/articles/view/165226

Next, you only need to maintain the viability of the growth zone and bone growth, for which there are stacks that we use on people with open growth zones.


studies that were mentioned:
https://insight.jci.org/articles/view/165226

If you can get into a study of tis and dont have to pay anything then its mog, else LL clearly mogs

 

[keife]

do a study

 

[keife]

I’ll be a lab rat rs

 

[bloodymanor]

Sounds experimental

as it is

 

[ezekiellllll]

View attachment 3986432
​

As a rule, the growth zones in the bones of the legs and arms close by the age of 17-19. Although many of the patients under management had growth zones close to closing already at 15. You can find out which group you are in using X-ray of the hand/hip.

Spoiler: What growth zones are and what they consist of:

The growth zone is what growth cannot occur without, and it itself is divided into several zones.

1. Rest zone (reserve zone)

Located closest to the bone epiphysis, this zone contains small scattered chondrocytes (cartilage cells) embedded in a rich extracellular matrix. These cells are considered a reserve, a stable population of stem cells and anchorage of the epiphyseal cyst growth plate. This zone constantly provides a supply of chondrocytes for future growth.

2. Proliferative zone.

The chondrocytes here promote rapid division, organizing complex columns parallel to the bone axis. This proliferation is the main factor in bone stretching. Growth hormone and insulin-like growth factors strongly influence this zone, cell proliferation and production matrices.

3. Hypertrophic zone.

At this point, chondrocytes stop dividing and instead expand greatly (hypertrophy), secreting proteins that modify the surrounding matrix.

4. Ossification Zone

Although technically part of the metaphysis, this zone marks the transition from cartilage to bone. Osteoblasts invade the calcified matrix, depositing osteoid (unmolalized bone), which hardens into trabecular bone. This process, called endochondral ossification, integrates new bone tissue into the existing skeleton.

Spoiler: METHOD OF OPENNING GROWTH PLATES:

This method is based on the idea that even after the growth zones close, a certain amount of epiphyseal skeletal stem cells remain in their place. We can say that the growth zone "completely" closes much later than significant growth ends.

The method itself. We will not consider the preparation.

1. First, we need to drill a hole to gain access to the cavity with epiphyseal stem cells.

2. Introduction of a drug based on SAG and other growth factors.

Spoiler: WHAT IS SAG?

SAG (smoothed agonist) is a small molecule that activates the smoothed (SMO) receptor, a key component of the hedgehog (HH) signaling pathway. This pathway, especially the Indian hedgehog (IHH) subtype, plays a critical role in regulating growth plate activity, including chondrocyte proliferation, differentiation, and bone elongation during development.

SAG is a powerful molecule that stimulates the proliferation and differentiation of epiphyseal stem cells, causing them to build a new growth plate.

STUDY IS HERE: https://insight.jci.org/articles/view/165226

Next, you only need to maintain the viability of the growth zone and bone growth, for which there are stacks that we use on people with open growth zones.


studies that were mentioned:
https://insight.jci.org/articles/view/165226

Bruh its copypast from tg ogr_iz_dnrd chanel

 

[333SchizoEthnic666]

Niggas be makin thread bout anyhting