Vrowding
RoidMoid
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Overview:
Focal Adhesion Kinase Signaling works upstream of mTORC1 and WNT pathways, Successfully upregulating it results in many positive effects such as
Boosting Load Induced Periosteal Apposition/Kinda boosts Bonesmashing gains through increased mechanotransduction
Direct WNT and mTORC1 upregulation
Overview 2:
Proline-rich tyrosine kinase 2 is generally a negative regulator of bone growth unlike FAK due to these facts:
PYK2 is present in osteoclasts and inhibits differentiation of osteoblasts
PYK2 rises when FAK decreases and vice versa
Exhibit A:
Abaloparatide+WAY316606+BT-amide
Using this combination of compounds can significantly boost FAK signaling by a milestone
Abaloparatide, which is a PTH analog, upregulates baseline FAK and mTORC1 levels
WAY316606, A WNT upregulator, attenuates the osteoclastgenesis which directly mirrors PYK2 inhibition, thus resulting in higher FAK levels
BT-amide is a PYK2 inhibitor, and as already mentioned, when PYK2 level decline, FAK levels rise
Exhibit B:
Period Blood and Breast milk
Period Blood and breast milk contain Mesenchymal cells, these mesenchymal cells boost FAK by a great amount
Period blood should be the priority though since it contains more/better mesenchymal cells
Summary:
Boosting FAK and inhibiting PYK2 is most optimal for bone growth whether you use exhibit A's example or exhibit B's
Focal Adhesion Kinase Signaling works upstream of mTORC1 and WNT pathways, Successfully upregulating it results in many positive effects such as
Boosting Load Induced Periosteal Apposition/Kinda boosts Bonesmashing gains through increased mechanotransduction
Direct WNT and mTORC1 upregulation
Overview 2:
Proline-rich tyrosine kinase 2 is generally a negative regulator of bone growth unlike FAK due to these facts:
PYK2 is present in osteoclasts and inhibits differentiation of osteoblasts
PYK2 rises when FAK decreases and vice versa
Exhibit A:
Abaloparatide+WAY316606+BT-amide
Using this combination of compounds can significantly boost FAK signaling by a milestone
Abaloparatide, which is a PTH analog, upregulates baseline FAK and mTORC1 levels
WAY316606, A WNT upregulator, attenuates the osteoclastgenesis which directly mirrors PYK2 inhibition, thus resulting in higher FAK levels
BT-amide is a PYK2 inhibitor, and as already mentioned, when PYK2 level decline, FAK levels rise
Exhibit B:
Period Blood and Breast milk
Period Blood and breast milk contain Mesenchymal cells, these mesenchymal cells boost FAK by a great amount
Period blood should be the priority though since it contains more/better mesenchymal cells
Summary:
Boosting FAK and inhibiting PYK2 is most optimal for bone growth whether you use exhibit A's example or exhibit B's
No Idea if this is water info, sorry if it's a bad thread, I haven't written one in a couple months
@hate @nwed @jotunnr @blinkers @flowiza @Diyorldar @Joeseminate (RIP) @chot @Dewhey321 @fraudster#1
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