Sachlichkeit
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LH and FSH axis Luteinizing hormone and follicle stimulating hormone is hormonal axis in testes that address fertility
LH = sperm count
FSH = sperm quality
The infertility concerns from steroid use is largely unfounded, the odds that you become permanently infertile is very low. Nevertheless, we run "HCG" human chorionic gonadatropin which is structurally similar to LH to keep HALF of the hormonal axis working in the testes
LH is responsible for >>> Cholesterol → Pregnenolone → Progesterone → Androgens → Testosterone → Estradiol pathway
if no LH, missing Preg + Prog, also downstream conversion from Preg & Prog to other "metabolites" via 5alphareductase, see 5alpha tradeoff. Preg + prog aside from being upstreams of natural Test and E are neuroprotective and their downstreams are neuroprotective (brain health, mental health, yadayadayda)
We can jump the LH cholesterol pathway by orally supplementing Pregnenolone. 25-50mg AM PM split because short half life though how it metabolizes from person to person varies. This is specifically for people cycling with no HCG support. Standard supplemental dosages for normal people is 10mg ED.
More common than infertility is negative changes in sperm shape/morphogenesis + DNA fragmentation as the FSH axis is shut down.
sperm shape = smaller head, two tails, premature, generally malformed or carrying incomplete dna
This results in fertility issues or miscarriage
Pituitary gland stimulates GNRH production gonadatropin releasing hormone, this then prompts body to produce LH & FSH. We can't supplement GNRH effectively as its pulsatile so we will have to Supplement HCG and HMG to retain the full LH/FSH axis.
HMG HUMAN MENOPAUSAL GONADOTROPIN stimulates both LH & FSH but LH much weaker so fertility clinics run both in tandem
HCG: 400IU Mon & Thurs subq
HMG 80 IU Mon & Thurs subq
LH = sperm count
FSH = sperm quality
The infertility concerns from steroid use is largely unfounded, the odds that you become permanently infertile is very low. Nevertheless, we run "HCG" human chorionic gonadatropin which is structurally similar to LH to keep HALF of the hormonal axis working in the testes
LH is responsible for >>> Cholesterol → Pregnenolone → Progesterone → Androgens → Testosterone → Estradiol pathway
if no LH, missing Preg + Prog, also downstream conversion from Preg & Prog to other "metabolites" via 5alphareductase, see 5alpha tradeoff. Preg + prog aside from being upstreams of natural Test and E are neuroprotective and their downstreams are neuroprotective (brain health, mental health, yadayadayda)
We can jump the LH cholesterol pathway by orally supplementing Pregnenolone. 25-50mg AM PM split because short half life though how it metabolizes from person to person varies. This is specifically for people cycling with no HCG support. Standard supplemental dosages for normal people is 10mg ED.
More common than infertility is negative changes in sperm shape/morphogenesis + DNA fragmentation as the FSH axis is shut down.
sperm shape = smaller head, two tails, premature, generally malformed or carrying incomplete dna
This results in fertility issues or miscarriage
Pituitary gland stimulates GNRH production gonadatropin releasing hormone, this then prompts body to produce LH & FSH. We can't supplement GNRH effectively as its pulsatile so we will have to Supplement HCG and HMG to retain the full LH/FSH axis.
HMG HUMAN MENOPAUSAL GONADOTROPIN stimulates both LH & FSH but LH much weaker so fertility clinics run both in tandem
HCG: 400IU Mon & Thurs subq
HMG 80 IU Mon & Thurs subq
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