FIRST. NMN trials on humans results are in. for anti aging maxxing oldies

[eduardkoopman]

 

[Deleted member 7651]

will watch later, could be a good addition to the guide im writing

 

[Mongrelcel]

What is nmn?

 

[homo_faber]

where is the hairloss cure

 

[Deleted member 5799]

where is the hairloss cure

you cant cure death

 

[noodlelover]

I saw some stuff that Niacin increased whole blood NAD amounts in patients by 8.2 times, after 10 months of supplementation. So I'm probably going to do Niacin because it's cheaper and still increases NAD levels.

Also I want my body to be able to regulate NMN levels incase too much NMN is unhealthy, which it can do if I supplement with Niacin instead of NMN.

Hopefully they do a human NMN vs Niacin study, but I do not expect that to happen.

I'm thinking that those of us who ride the longevity escape velocity curve, and live long enough that we're alive when all aging is cured, need to make really good decisions on the right supplements, foods, and habits in a state of incomplete evidence, which is challenging.

 

[Deleted member 17872]

Just drink a young virgin's blood for breakfast and eat a foreskin for dinner.

Atleast that what me and my family does.

 

[eduardkoopman]

I saw some stuff that Niacin increased whole blood NAD amounts in patients by 8.2 times, after 10 months of supplementation. So I'm probably going to do Niacin because it's cheaper and still increases NAD levels.

Also I want my body to be able to regulate NMN levels incase too much NMN is unhealthy, which it can do if I supplement with Niacin instead of NMN.

Hopefully they do a human NMN vs Niacin study, but I do not expect that to happen.

I'm thinking that those of us who ride the longevity escape velocity curve, and live long enough that we're alive when all aging is cured, need to make really good decisions on the right supplements, foods, and habits in a state of incomplete evidence, which is challenging.

Get ready for a flush

 

[PURE ARYAN GENETICS]

tldr?

I'm thinking that those of us who ride the longevity escape velocity curve, and live long enough that we're alive when all aging is cured, need to make really good decisions on the right supplements, foods, and habits in a state of incomplete evidence, which is challenging.

that's a meme tier cope made up by kurzweil. we will live longer and longer but it will be a good fucking while until all aging is 'cured'. thousands of years at the very least

 

[noodlelover]

tldr?

that's a meme tier cope made up by kurzweil. we will live longer and longer but it will be a good fucking while until all aging is 'cured'. thousands of years at the very least

Maybe. The concept of Longevity escape velocity was something Aubrey De Grey came up with. I know Kurzweil came to similar conclusions, but he seems to conclude it will be less about a gradual slowing down of aging, and we'll arrive at a full cure quicker. His reasoning is that antiaging will come about because of the convergence of nanotechnology and Ai, as he's used trends to make predictions. The concept of Longevity escape velocity is more concervative.

Quantum Immortality may guarantee that at least from the perspective of the portion of us that survives, we will come out with things that slow down aging fast enough that "we" will be able to survive. Other portions of us will also experience death. You have to take the good with the bad. Of course the portion that does survive will expand in space across the other ten or more dimensions that exist over time, but from an experience point of view it will only feel like life is going on as normal.

 

[eduardkoopman]

Maybe. The concept of Longevity escape velocity was something Aubrey De Grey came up with. I know Kurzweil came to similar conclusions, but he seems to conclude it will be less about a gradual slowing down of aging, and we'll arrive at a full cure quicker. His reasoning is that antiaging will come about because of the convergence of nanotechnology and Ai, as he's used trends to make predictions. The concept of Longevity escape velocity is more concervative.

Quantum Immortality may guarantee that at least from the perspective of the portion of us that survives, we will come out with things that slow down aging fast enough that "we" will be able to survive. Other portions of us will also experience death. You have to take the good with the bad. Of course the portion of that does survive will expand in space across the other ten or more dimensions that exist over time, but from an experience point of view it will only feel like life is going on as normal.

imagine a world full off old people

 

[noodlelover]

imagine a world full off old people

Imagine every one is looksmaxed and health maxed.

Fat people have lower IQ's and are going to wind up being hit by busses, dying of cancer, and other diseases regardless, and they won't be smart enough to hop on the right supplements in time, at least in the beginning.

Being the first generation that survives, means we will be richer and smarter than every one else, and more NT if we keep working on that .

But the world would be full of "old" people that look young and good. So women you date would look like an 19 year old super model, but instead of being vapid and bitchy, be emotionally mature, intelligent and highly introspective, a pleasure to talk to and hang out with, and have their own interests that they've pursued for hundreds of years that caused them to grow and change.

This would be the same for most people. Most people would be more emotionally mature, intelligent, and experienced which could boost the world's economy more than we could imagine making all of us insanely rich. Regular vacations to mars, under ground super mansions, every looksmax possible, our own amusement parks, and more could be possible for most of us. It could get cazy fun.

 

[eduardkoopman]

Imagine every one is looksmaxed and health maxed.

Fat people have lower IQ's and are going to wind up being hit by busses, dying of cancer, and other diseases regardless, and they won't be smart enough to hop on the right supplements in time, at least in the beginning.

Being the first generation that survives, means we will be richer and smarter than every one else, and more NT if we keep working on that .

But the world would be full of "old" people that look young and good. So women you date would look like an 19 year old super model, but instead of being vapid and bitchy, be emotionally mature, intelligent and highly introspective, a pleasure to talk to and hang out with, and have their own interests that they've pursued for hundreds of years that caused them to grow and change.

This would be the same for most people. Most people would be more emotionally mature, intelligent, and experienced which could boost the world's economy more than we could imagine making all of us insanely rich. Regular vacations to mars, under ground super mansions, every looksmax possible, our own amusement parks, and more could be possible for most of us. It could get cazy fun.

it can't add up.
if people stil have babies/children.

 

[noodlelover]

it can't add up.
if people stil have babies/children.

Population decline (for now)

population is decreasing, and the rate at which it decreases will continue to increase.

Birth control methods continue to get more affordable, easy, and wide spread. Apps like Tinder ensure most men remain celibate while a smaller and smaller percentage of men actually get laid. That percentage may continue to decrease as travel between countries and locations becomes more common, with more and more women choosing to fly to have sex with a gigachad once a few years rather than waiting their turn with the Chads of their local town or city.

Then there's factors like processed foods, and estrogen promoting chemicals in skincare products that massively lower people's desire for sex that continue to be more and more wide spread and prevalent, so both men and women put less effort into getting laid. Along with gradual increase in porn availability and eventually better porn, vr sex, sex robots, etc.

And at first most people will be too stupid to take the right supplements or do what's necessary to live forever. I do not think the general population will catch on until there's people that have already lived past 160 years or so.

Earth's Carrying Capacity

Then there's how many people the earth and a terraformed mars can sustain, and other planets as we spread out. Looking at only earth... the base of the earth's crust is about 62 miles. So if the surface of the earth has enough airable farm land to sustain 10 billion people, with 14 feet per floor, that's around 23,000 floors which could be used for underground farming and residence. That's even before we start to cool the earths core to build further down, which may happen naturally as we air condition lower and lower levels.

So let's say, just half of that is used for farming (probably a higher percentage will be), we are talking about 115 trillion people, and that doesn't even take into account advances in agriculture and food growth we are going to be making. Eventually we may make laws requiring sterilization after you've had a certain amount of children but that might not be necessary. We'll have to see.

Rather than thinking in terms of population, we might eventually think only in terms of organic matter, and matter that has not yet been made organic. This is because it might be hard to distinguish what counts as an individual entity as the data transfer rate between entities increases. Different parts of our brains may disagree but the data transfer rate is high enough that we often consider ourselves a single entity, rather than separate entities that vote on decisions. Hive minds and the like will be interesting.

 

[PURE ARYAN GENETICS]

Imagine every one is looksmaxed and health maxed.

Fat people have lower IQ's and are going to wind up being hit by busses, dying of cancer, and other diseases regardless, and they won't be smart enough to hop on the right supplements in time, at least in the beginning.

Being the first generation that survives, means we will be richer and smarter than every one else, and more NT if we keep working on that .

But the world would be full of "old" people that look young and good. So women you date would look like an 19 year old super model, but instead of being vapid and bitchy, be emotionally mature, intelligent and highly introspective, a pleasure to talk to and hang out with, and have their own interests that they've pursued for hundreds of years that caused them to grow and change.

This would be the same for most people. Most people would be more emotionally mature, intelligent, and experienced which could boost the world's economy more than we could imagine making all of us insanely rich. Regular vacations to mars, under ground super mansions, every looksmax possible, our own amusement parks, and more could be possible for most of us. It could get cazy fun.

super copium

 

[noodlelover]

super copium

Do you have reasons for why you think it will take thousands of years to cure aging?

 

[PURE ARYAN GENETICS]

Do you have reasons for why you think it will take thousands of years to cure aging?

same reason musk is larping hard and it will take thousands of years to even begin settling Mars. it's an extremely hard, complex problem. we've had scientists researching longevity for a century now and all we have are a few pills that work maybe. even if some progress is made new roadblocks will be found because that's just science and biology for you. like we're not even toddler level in this shit but people need their copium

 

[eduardkoopman]

Population decline (for now)

population is decreasing

Decline ??????????

copy-paste text:
In 2021, the world’s population growth rate is 1.03%, half the peak level of 2.09 percent in 1968. That annual growth rate is expected to continue declining, reaching 0.5 percent by mid-century and moving close to zero by 2100. In the period 1965-1972, the global population growth rate was above 2% each year.

World population 2024 - StatisticsTimes.com

Year wise World population, population growth rate and net change from 1950 to 2100 by United Nations. Data tables and charts.

statisticstimes.com

 

[noodlelover]

same reason musk is larping hard and it will take thousands of years to even begin settling Mars. it's an extremely hard, complex problem. we've had scientists researching longevity for a century now and all we have are a few pills that work maybe. even if some progress is made new roadblocks will be found because that's just science and biology for you. like we're not even toddler level in this shit but people need their copium

Fair enough.

But to work with biology, you do not need to fully understand biology. Such as with genetically engineered crops, cross-breeding, organ transplants, and bio-fuels. You only need a minimal understanding of some of the specific aspect of biology you're focusing on, and biology does the rest in keeping the organisms alive.

To reverse aging damage we do not need to fully understand biology. We only need to find ways to reverse or clean up damage that occurs. We don't even need to know what caused the damage, we just look at it and see it has occurred and find a way to clean it up. This is made even easier by the fact that the body already fixes most things on it's own such as DNA repair, and replacing cells, so there's an even smaller area that's necessary to understand.

So one example is advanced glycation end products, which would fall under the category of extracellular waste products, which we have recently found a way to do outside the body so we are making progress.

Aubrey de Grey: Rejuvenation Technology — Will "Age" Soon Cease to Mean "Aging"? | Effective Altruism

Around the world, people are living longer — not just because child mortality is dropping, but also because we’re staying healthy for more years as we age. In the future, regenerative medicine and oth

www.effectivealtruism.org

You can see the seven types of aging, and the solutions we are working on above. So it is not an infinitely complex problem, as it might appear, although it is complex and challenging. Advances in computer simulations may accelerate solutions for some of these.

Decline ??????????

copy-paste text:
In 2021, the world’s population growth rate is 1.03%, half the peak level of 2.09 percent in 1968. That annual growth rate is expected to continue declining, reaching 0.5 percent by mid-century and moving close to zero by 2100. In the period 1965-1972, the global population growth rate was above 2% each year.

World population 2024 - StatisticsTimes.com

Year wise World population, population growth rate and net change from 1950 to 2100 by United Nations. Data tables and charts.

statisticstimes.com

Yah, that's what I ment. Declining growth, possible declining population.

Birth rate is declining in developed countries.

Declining birth rate in Developed Countries: A radical policy re-think is required

www.ncbi.nlm.nih.gov

So that leaves China, which all the specific provinces may be inflating their numbers to collect more money from their central government, so there's no reason to believe their population stats. So the world population might already be declining.

But certainly once the rest of the world becomes "developed" the entire world will be declining, if it isn't already.

 

[eduardkoopman]

same reason musk is larping hard and it will take thousands of years to even begin settling Mars. it's an extremely hard, complex problem. we've had scientists researching longevity for a century now and all we have are a few pills that work maybe. even if some progress is made new roadblocks will be found because that's just science and biology for you. like we're not even toddler level in this shit but people need their copium

Aging is programmed into the DNA.
That needs to be changed, for aging to change most, imo.

 

[PURE ARYAN GENETICS]

Fair enough.

But to work with biology, you do not need to fully understand biology. Such as with genetically engineered crops, cross-breeding, organ transplants, and bio-fuels. You only need a minimal understanding of some of the specific aspect of biology you're focusing on, and biology does the rest in keeping the organisms alive.

To reverse aging damage we do not need to fully understand biology. We only need to find ways to reverse or clean up damage that occurs. We don't even need to know what caused the damage, we just look at it and see it has occurred and find a way to clean it up. This is made even easier by the fact that the body already fixes most things on it's own such as DNA repair, and replacing cells, so there's an even smaller area that's necessary to understand.

So one example is advanced glycation end products, which would fall under the category of extracellular waste products, which we have recently found a way to do outside the body so we are making progress.

Aubrey de Grey: Rejuvenation Technology — Will "Age" Soon Cease to Mean "Aging"? | Effective Altruism

Around the world, people are living longer — not just because child mortality is dropping, but also because we’re staying healthy for more years as we age. In the future, regenerative medicine and oth

www.effectivealtruism.org

You can see the seven types of aging, and the solutions we are working on above. So it is not an infinitely complex problem, as it might appear, although it is complex and challenging. Advances in computer simulations may accelerate solutions for some of these.

for it to be completely cured you NEED to fully understand biology which is my point. and I don't understand how aging damage would be reversed outside of some giga high tech nano treatment. since the damage is done, information is lost with no way to retrieve it. kind of like lossy compression. you can do some ai fuckery to upscale/improve quality/"reverse" information loss but never all of it

 

[eduardkoopman]

for it to be completely cured you NEED to fully understand biology which is my point. and I don't understand how aging damage would be reversed outside of some giga high tech nano treatment. since the damage is done, information is lost with no way to retrieve it. kind of like lossy compression. you can do some ai fuckery to upscale/improve quality/"reverse" information loss but never all of it

nowadays, they try to minimise and reverse damage.
The "damage", aging, is programmed into the DNA.
Only with changing the programming in the DNA, can massive improvements be made.

It's like you have an operating system on your cmputer, that is programmed to go slower and shittier over time. One can try to put extra software on top of that operationg system to try to minimze the effects of that. As they are doing now. But the root cause remains.

 

[noodlelover]

for it to be completely cured you NEED to fully understand biology which is my point. and I don't understand how aging damage would be reversed outside of some giga high tech nano treatment. since the damage is done, information is lost with no way to retrieve it.

The Information is in all our cells. It's called DNA. We also have repair mechanisms that repair DNA, so we only need to boost our repair mechanisms.

There are also organisms that don't age, so nature has already solved the problem in some organisms. It's not some impossible problem.

What you are describing sounds like David Sinclair's information theory of aging, which he has a solution his lab is working on.



But that's only one of the seven types of cellular aging. Which is why I'm more of a fan of Sens research, because it addresses all of the aging that occurs, with it's company spins off to focus on subproblems while making money for investors with their alternative use cases in disease.

Intro to SENS Research - SENS Research Foundation

A Reimagined Research Strategy for Aging Many things go wrong with aging bodies, but at the root of them all is the burden of decades of unrepaired damage to the cellular and molecular structures that make up the functional units of our tissues. As each essential microscopic structure fails...

www.sens.org

 

[eduardkoopman]

The Information is in all our cells. It's called DNA. We also have repair mechanisms that repair DNA, so we only need to boost our repair mechanisms.

There are also organisms that don't age, so nature has already solved the problem in some organisms. It's not some impossible problem.

What you are describing sounds like David Sinclair's information theory of aging, which he has a solution his lab is working on.



But that's only one of the seven types of cellular aging. Which is why I'm more of a fan of Sens research, because it addresses all of the aging that occurs, with it's company spins off to focus on subproblems while making money for investors with their alternative use cases in disease.

Intro to SENS Research - SENS Research Foundation

A Reimagined Research Strategy for Aging Many things go wrong with aging bodies, but at the root of them all is the burden of decades of unrepaired damage to the cellular and molecular structures that make up the functional units of our tissues. As each essential microscopic structure fails...

www.sens.org

cool info.

I wish research the best of luck, with getting there.

For us, I think. it's kinda to late all that,

 

[noodlelover]

cool info.

I wish research the best of luck, with getting there.

Same.

For us, I think. it's kinda to late all that,

Maybe. I'm not afraid to die but doing what I can to maximize my health span, and looking young span for life enjoyment, and if the right stuff is there in time, even better. But We'll see.

 

[PURE ARYAN GENETICS]

The Information is in all our cells. It's called DNA. We also have repair mechanisms that repair DNA, so we only need to boost our repair mechanisms.

There are also organisms that don't age, so nature has already solved the problem in some organisms. It's not some impossible problem.

What you are describing sounds like David Sinclair's information theory of aging, which he has a solution his lab is working on.



But that's only one of the seven types of cellular aging. Which is why I'm more of a fan of Sens research, because it addresses all of the aging that occurs, with it's company spins off to focus on subproblems while making money for investors with their alternative use cases in disease.

Intro to SENS Research - SENS Research Foundation

A Reimagined Research Strategy for Aging Many things go wrong with aging bodies, but at the root of them all is the burden of decades of unrepaired damage to the cellular and molecular structures that make up the functional units of our tissues. As each essential microscopic structure fails...

www.sens.org

damn is that the guy from battlestar galactica

 

[eduardkoopman]

I'm not afraid to die but doing what I can to maximize my health span, and looking young span for life enjoyment, and if the right stuff is there in time, even better. But We'll see.

I'm like this also.
I do feel okay also, at doing things that make me look younger or wil be better SMV for me NOW. BUT, will make me age faster/worse, or take away a few years from life compared to living perfectly for getting as old as possible