deepweb1298
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Quick overview of what actually causes acne:
Most topical acne treatments target 1,3 and 4 i.e. adapalene, tretinoin, azelaic acid, benzoyl peroxide but very few ingredients actually target the Increased sebaceous gland activity. This doesn't really need repeated, these are still good acne fighting ingredients and should be used in most skincare regimes.
A lot of people go on isotretinoin or accutane because it is one of the few ingredients that actually reduces sebaceous gland activity. But with new advances in drugs and other technologies you can have other options other than isotretinoin to target this particular problem of an overactive sebaceous gland.
1. Clascoterone (Winlevi)
It is basically a topical anti-androgen that targets the sebaceous gland itself. It is a unique ingredient that other topicals don't have. The result is a reduction in sebaceous gland activity and therefore less acne!
UNFORTUNATELY Winlevi is ONLY available in the USA and is EXTREMELY expensive if you do not have health insurance. This drug won't be available in Europe for another 15 years probably.
2. Octadecenedioic Acid ( Dioic Acid)
I have only recently came across this ingredient but it is largely unknown by a lot of people. The chemical structure of Dioic Acid is similar to Azelaic acid but with the exception of being a pan-PPAR agonist mainly the PPAR-Gamma and PPAR-alpha. The TL;DR is that PPAR-gamma and PPAR-Alpha regulate sebum production. Therefore, this is really good for cystic acne. I have attached an excerpt from the book "Acne and its Therapy by Guy F. Webster".
In regards to which products I recommend that contain Dioic acid:
uk.allies.shop
www.skinceuticals.co.uk
I actually found out about this ingredient when looking at the Skinceuticals ingredients list. I thought it was strange they marketed Dioic acid as a really good acne ingredient. On SK's website for Dioic Acid (https://www.skinceuticals.com/dioic-acid.html) it states:
"
dioic acid helps
reduce excess sebum while diminishing P.acnes bacteria
"
3. Aviclear by Cutera
www.cutera.com
Aviclear was recently FDA approved as a laser to specifically treat acne. It is a 1726nm that has been found to specifically target the sebaceous gland. This again is only approved for USA use so Europeans don't have this technology at the moment. Probably in the next 5 - 10 years.
FOR any females lurking:
4. Spironolactone
This is an oral anti-androgen that ONLY females can take. Males cannot take this drug but it basically targets the sebaceous gland again, thought i would add this because why not.
Acne was seriously one of my biggest looksmin. Hurt my confidence so much and really glad i managed to fix it and not have to go through any brutal isotretinoin bullshit.
Most topical acne treatments target 1,3 and 4 i.e. adapalene, tretinoin, azelaic acid, benzoyl peroxide but very few ingredients actually target the Increased sebaceous gland activity. This doesn't really need repeated, these are still good acne fighting ingredients and should be used in most skincare regimes.
A lot of people go on isotretinoin or accutane because it is one of the few ingredients that actually reduces sebaceous gland activity. But with new advances in drugs and other technologies you can have other options other than isotretinoin to target this particular problem of an overactive sebaceous gland.
1. Clascoterone (Winlevi)
It is basically a topical anti-androgen that targets the sebaceous gland itself. It is a unique ingredient that other topicals don't have. The result is a reduction in sebaceous gland activity and therefore less acne!
UNFORTUNATELY Winlevi is ONLY available in the USA and is EXTREMELY expensive if you do not have health insurance. This drug won't be available in Europe for another 15 years probably.
2. Octadecenedioic Acid ( Dioic Acid)
I have only recently came across this ingredient but it is largely unknown by a lot of people. The chemical structure of Dioic Acid is similar to Azelaic acid but with the exception of being a pan-PPAR agonist mainly the PPAR-Gamma and PPAR-alpha. The TL;DR is that PPAR-gamma and PPAR-Alpha regulate sebum production. Therefore, this is really good for cystic acne. I have attached an excerpt from the book "Acne and its Therapy by Guy F. Webster".
In regards to which products I recommend that contain Dioic acid:
Promise Keeper Nightly Blemish Treatment | Allies of Skin
A nightly moisturiser supercharged with a powerful blend of 2% Dioic Acid, 15 Antioxidants + Brighteners, Silver and Organic Rosehip Oil.
uk.allies.shop
Blemish + Age Defense | Corrective Serum | SkinCeuticals
Fight imperfections and improve the appearance of fine lines with the oil free & dual-action face serum Blemish + Age Defense from SkinCeuticals. Buy online.
I actually found out about this ingredient when looking at the Skinceuticals ingredients list. I thought it was strange they marketed Dioic acid as a really good acne ingredient. On SK's website for Dioic Acid (https://www.skinceuticals.com/dioic-acid.html) it states:
"
dioic acid helps
reduce excess sebum while diminishing P.acnes bacteria
"
3. Aviclear by Cutera
CUTERA | AviClear®
AviClear is the original FDA-cleared energy device designed with a 1726 nm wavelength to treat mild to severe acne at the source. Learn more.
www.cutera.com
Aviclear was recently FDA approved as a laser to specifically treat acne. It is a 1726nm that has been found to specifically target the sebaceous gland. This again is only approved for USA use so Europeans don't have this technology at the moment. Probably in the next 5 - 10 years.
FOR any females lurking:
4. Spironolactone
This is an oral anti-androgen that ONLY females can take. Males cannot take this drug but it basically targets the sebaceous gland again, thought i would add this because why not.
Acne was seriously one of my biggest looksmin. Hurt my confidence so much and really glad i managed to fix it and not have to go through any brutal isotretinoin bullshit.
