inhib_
Iron
- Joined
- Aug 8, 2026
- Posts
- 25
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disclaimer this is very over the top don't do everything 
HYPERPHOSPHATEMIA
Phosphate binders
- Lanthanum carboante (MOST EFFECTIVE)
- Sevelamer carbonate (CHEAPER)
Should only really be using a binder with meals containing phosphate, the most optimal way to avoid phos is..
Keeping phosphate levels 600-800mg per day
With the use of a binder you can push to 800-1000 mg daily
Read my phosphate guide for minor info
KIDNEY LOAD
2-4 litres of water daily will excrete some excess phosphate from the kidneys and can combat GI issues you may experience.
TUDCA is a optional anc you can take, forcefully stimulating bile flow, flushing out the trapped erda metabolites out before they may cause oxidative damage.
Calcium citrate is helpful, because as phosphate builds in your blood it reduced calcium leading to exhaustion+ brittle hair and nails.
JOINT PAIN
Ibuprofen and forget lol
MSM + GLUCOSAMINE and Boswellia Seretta are some good supps for this too
DIARRHEA
Loperamide slows your bowel movements and reduces intestinal muscle contractions leading to less bathroom urgency and firmer stools.
To handle abdominal pain and cramps from this take Buscopan or Drotaverine or Mebeverine as these act as smooth muscle spasmolytics which block calcium channels in the gut, as calcium is needed for muscles to tighten up.
OCULAR ISSUES
Firstly if you are experiencing serious eye problems, literally just take a week break lmao it's that simple stop fearmongering and cycle it if you have to
Take Lubricating eye drops every 2 hours awake to prevent dry irritated eyes, believe it or not this can greatly lower your odds of the surface toxicity erda causes
Theoreticals
Acetazolamide (Diamox) this may reduce the accumulation of subretinal fluid by promoting fluid absorption through the retinal pigment epithelium
Sulforaphane may boost cell antioxidant defence and protect the RPE from oxidative stress, the very vulnerability FGFR inhibition creates meaning it makes the RPE and retina more resistant to oxidative stress than Pan FGFR causes.
Saffron extract could reduce retina thickness and improve function paired with it's anti-inflammatory +antioxidant effects. It can also potentially protect photoreceptors and RPE from oxidative and light induced stress. This can happen through Nfr2 mediated antoxidant activation suppression of ER stress signaling reduced capcase -mediated apoptosis.
Dorzolamide eye drops acting as a carbonic anhydrase inhibitor which could acidify the subretinal space and enhances the RPEs ability to pump fluid out of your eyes. ( note use Diamox or this as they are both counterparts)
Klotho + SS31 are cope lolll
SCOLIOSIS
Stretch every morning I repeat!!!
Cat cow stretch, Childs pose, Cobra pose,Seated spinal twist,Standing forward fold,Thread the needle stretch are recommended stretches for overall spinal mobility.
Limit growth to Under 15cm a year to reduce the potential risks
Melatonin reduced scoliosis from 80-22% in bipedal mice, meaning it could improve bone quality and reduce osteoclast activity,therefore protecting the spine
NOSE BLEEDS + SKIN
Moisturizing your skin is essential to keep it looking nice
A Sea salt nasal spray helps moisturise your nose
As your skin is very sensitive on erdafitinhib, if your nasopharynx is damaged (resulting in nose bleeds) use Olyfrin as it operates as a topical tissue regenerating barrier
If experiencing palmar-plantar erythrodysesthesia, use Thick emollients containing urea or salicylic acid
HAIR AND NAIL DEFORMITIES
For onycholsis, apply Petroleum jelly nightly, as it protects and protects and hydrated the exposed nail bed preventing the brittle cracking that worsens nail lifting.
Oral minoxidil is literally a lifesaver for hair loss due to the use of erda, as when processed by the liver into its active form, systemic blood flow brings nutrients to the scalp, extending hair growth cycle and thickening hair.
Strengthening nail polish combats the brittle nails erda causes, while Opaque Varnishes cover differences in nail colour.
Chemo nail polish can also be used to strengthen nails in worst case scenario
METHYLATION BURDEN
Methylation moves a methyl group from SAM-E to other molecules. Gene expression, neurotransmitter synthesis drug metabolism all draw on it. Erdafitinhib consumes SAM-E and this can mean demand overpowers diet causing a rise in homocysteine risking blood clots, cardiovascular disease and cognitive decline.
Creatine and Betaine can act as methyl support by bypassing the body's creatine synthesis freeing up SAM-E elsewhere while Betaine donates methyl groups directly by converting homocysteine through a non dependent of B12 or Folate pathway
SUPPRESSED cAMP SIGNALLING
cAMP the intercellular messenger that controls energy metabolism, inflammation, cell survival and hormone response etc, erdafitinhib feeds into its production almost cutting the input. This can cause lower mitochondrial output,impaired fat metabolism,reduced stress tolerance and is displayed by awful fatigue.
Abaloparatide is the best option but is very expensive so another option which could theoretically work is..
Forskolin, activating adenylyl cyclase directly without needing a receptor, raising cAMP significantly. cAMP PKA activity directly intersects with PTHrP mediated chondrocyte regulation, important to growth plate kinetics.
Forskolin therefore helps maintain more controlled cartilage maturity and structural symmetry.
DRY MOUTH (XEROSTOMIA)
Xylitol chewing gum
ERECTILE DYSFUNCTION
Cialis
Viagra
ESOPHAGEAL DAMAGE
Take pills upright and remain upright for 30 minutes, have to be an iqlet to do this
HEADACHES
Acetaminophen
VOMITING
ondansetron, aprepitant, dexamethasone, and dronabinol can all work as anti-nausea medication
TENDON RUPTURE
Avoid corticosteroids
EXTRA SUPPLEMENTS
L-Lysine
Zinc
L-Proline
Vitamin K2
THIS TOOK ME MULTIPLE HOURS, NO AI OR COPY PAST OF ORG POSTS. THX FOR READING
HYPERPHOSPHATEMIA
Phosphate binders
- Lanthanum carboante (MOST EFFECTIVE)
- Sevelamer carbonate (CHEAPER)
Should only really be using a binder with meals containing phosphate, the most optimal way to avoid phos is..
Keeping phosphate levels 600-800mg per day
With the use of a binder you can push to 800-1000 mg daily
Read my phosphate guide for minor info
KIDNEY LOAD
2-4 litres of water daily will excrete some excess phosphate from the kidneys and can combat GI issues you may experience.
TUDCA is a optional anc you can take, forcefully stimulating bile flow, flushing out the trapped erda metabolites out before they may cause oxidative damage.
Calcium citrate is helpful, because as phosphate builds in your blood it reduced calcium leading to exhaustion+ brittle hair and nails.
JOINT PAIN
Ibuprofen and forget lol
MSM + GLUCOSAMINE and Boswellia Seretta are some good supps for this too
DIARRHEA
Loperamide slows your bowel movements and reduces intestinal muscle contractions leading to less bathroom urgency and firmer stools.
To handle abdominal pain and cramps from this take Buscopan or Drotaverine or Mebeverine as these act as smooth muscle spasmolytics which block calcium channels in the gut, as calcium is needed for muscles to tighten up.
OCULAR ISSUES
Firstly if you are experiencing serious eye problems, literally just take a week break lmao it's that simple stop fearmongering and cycle it if you have to
Take Lubricating eye drops every 2 hours awake to prevent dry irritated eyes, believe it or not this can greatly lower your odds of the surface toxicity erda causes
Theoreticals
Acetazolamide (Diamox) this may reduce the accumulation of subretinal fluid by promoting fluid absorption through the retinal pigment epithelium
Sulforaphane may boost cell antioxidant defence and protect the RPE from oxidative stress, the very vulnerability FGFR inhibition creates meaning it makes the RPE and retina more resistant to oxidative stress than Pan FGFR causes.
Saffron extract could reduce retina thickness and improve function paired with it's anti-inflammatory +antioxidant effects. It can also potentially protect photoreceptors and RPE from oxidative and light induced stress. This can happen through Nfr2 mediated antoxidant activation suppression of ER stress signaling reduced capcase -mediated apoptosis.
Dorzolamide eye drops acting as a carbonic anhydrase inhibitor which could acidify the subretinal space and enhances the RPEs ability to pump fluid out of your eyes. ( note use Diamox or this as they are both counterparts)
Klotho + SS31 are cope lolll
SCOLIOSIS
Stretch every morning I repeat!!!
Cat cow stretch, Childs pose, Cobra pose,Seated spinal twist,Standing forward fold,Thread the needle stretch are recommended stretches for overall spinal mobility.
Limit growth to Under 15cm a year to reduce the potential risks
Melatonin reduced scoliosis from 80-22% in bipedal mice, meaning it could improve bone quality and reduce osteoclast activity,therefore protecting the spine
NOSE BLEEDS + SKIN
Moisturizing your skin is essential to keep it looking nice
A Sea salt nasal spray helps moisturise your nose
As your skin is very sensitive on erdafitinhib, if your nasopharynx is damaged (resulting in nose bleeds) use Olyfrin as it operates as a topical tissue regenerating barrier
If experiencing palmar-plantar erythrodysesthesia, use Thick emollients containing urea or salicylic acid
HAIR AND NAIL DEFORMITIES
For onycholsis, apply Petroleum jelly nightly, as it protects and protects and hydrated the exposed nail bed preventing the brittle cracking that worsens nail lifting.
Oral minoxidil is literally a lifesaver for hair loss due to the use of erda, as when processed by the liver into its active form, systemic blood flow brings nutrients to the scalp, extending hair growth cycle and thickening hair.
Strengthening nail polish combats the brittle nails erda causes, while Opaque Varnishes cover differences in nail colour.
Chemo nail polish can also be used to strengthen nails in worst case scenario
METHYLATION BURDEN
Methylation moves a methyl group from SAM-E to other molecules. Gene expression, neurotransmitter synthesis drug metabolism all draw on it. Erdafitinhib consumes SAM-E and this can mean demand overpowers diet causing a rise in homocysteine risking blood clots, cardiovascular disease and cognitive decline.
Creatine and Betaine can act as methyl support by bypassing the body's creatine synthesis freeing up SAM-E elsewhere while Betaine donates methyl groups directly by converting homocysteine through a non dependent of B12 or Folate pathway
SUPPRESSED cAMP SIGNALLING
cAMP the intercellular messenger that controls energy metabolism, inflammation, cell survival and hormone response etc, erdafitinhib feeds into its production almost cutting the input. This can cause lower mitochondrial output,impaired fat metabolism,reduced stress tolerance and is displayed by awful fatigue.
Abaloparatide is the best option but is very expensive so another option which could theoretically work is..
Forskolin, activating adenylyl cyclase directly without needing a receptor, raising cAMP significantly. cAMP PKA activity directly intersects with PTHrP mediated chondrocyte regulation, important to growth plate kinetics.
Forskolin therefore helps maintain more controlled cartilage maturity and structural symmetry.
DRY MOUTH (XEROSTOMIA)
Xylitol chewing gum
ERECTILE DYSFUNCTION
Cialis
Viagra
ESOPHAGEAL DAMAGE
Take pills upright and remain upright for 30 minutes, have to be an iqlet to do this
HEADACHES
Acetaminophen
VOMITING
ondansetron, aprepitant, dexamethasone, and dronabinol can all work as anti-nausea medication
TENDON RUPTURE
Avoid corticosteroids
EXTRA SUPPLEMENTS
L-Lysine
Zinc
L-Proline
Vitamin K2
THIS TOOK ME MULTIPLE HOURS, NO AI OR COPY PAST OF ORG POSTS. THX FOR READING
Last edited:
idk bro I don’t post on here much either but we see him on dc I guess that’s why
