Kojo
18 | 160mg Isotret | 500mg Test
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Just a topic I want to shortly touch on that I'm surprised I forgot to even mention before.
Tissue diffusion
I'm going to keep this short and low effort, but I presume anyone that talks about pharma/biology understands the foundational concept of diffusion.
Now, with certain compounds they have to diffuse into tissues to obviously exhibit their effects and bind to what they want to bind to like I covered BINDING in my recent thread..
So a lot of these lipophilic compounds that we love to use bind to fatty plasma proteins in the blood and use them as carriers to get into tissues they want to get to, (albumin/vldl/ldl/hdl) being prior examples.
However, for anyone to make claims on specific compounds for height must address it's natural physiological purpose, but ALSO it's purpose in the growth plate. If your compound cannot even diffuse into the growth plate properly to exhibit it's effects, it is useless.
The Growth Plate is a cartilagenous tissue that is avascular meaning it lacks blood vessels. Those plasma proteins want to travel and diffuse into tissues using blood vessels but you cannot do this for the growth plate given it's avascular. This means they have to get in very slowly through PASSIVE DIFFUSION.
Fulvestrants relevance to this comes here, it is a highly lipophilic compound such that 99% of it binds to lipoproteins which have an absurd amount of mass beyond the cutoff the growth plate allows for passive diffusion. Making fulvestrant too large of a molecule to even get into the growth plate and degrade the receptors.
So make sure when you check some of these compounds you are using, you factor something like this in.
Side note: This also could explain why fulvestrant administration in mice did not change bone maturation at all. Ignore the trash conclusion that the study derives, what I'm saying about fulvestrant in this thread fully debunks the "androgens may fuse on their own" no fulvestrant is just shit
-- https://hero.epa.gov/reference/6319620/
As always, do your own research. Everything I've said can be completely fact checked. I will never make a thread without learning/studying the topic for every pixel I type on this site
@AtrophicPyra @Paul.jnxy @flowiza @zanenenene + anyone else who cares idk
Tissue diffusion
I'm going to keep this short and low effort, but I presume anyone that talks about pharma/biology understands the foundational concept of diffusion.
Now, with certain compounds they have to diffuse into tissues to obviously exhibit their effects and bind to what they want to bind to like I covered BINDING in my recent thread..
So a lot of these lipophilic compounds that we love to use bind to fatty plasma proteins in the blood and use them as carriers to get into tissues they want to get to, (albumin/vldl/ldl/hdl) being prior examples.
However, for anyone to make claims on specific compounds for height must address it's natural physiological purpose, but ALSO it's purpose in the growth plate. If your compound cannot even diffuse into the growth plate properly to exhibit it's effects, it is useless.
The Growth Plate is a cartilagenous tissue that is avascular meaning it lacks blood vessels. Those plasma proteins want to travel and diffuse into tissues using blood vessels but you cannot do this for the growth plate given it's avascular. This means they have to get in very slowly through PASSIVE DIFFUSION.
Fulvestrants relevance to this comes here, it is a highly lipophilic compound such that 99% of it binds to lipoproteins which have an absurd amount of mass beyond the cutoff the growth plate allows for passive diffusion. Making fulvestrant too large of a molecule to even get into the growth plate and degrade the receptors.
So make sure when you check some of these compounds you are using, you factor something like this in.
Side note: This also could explain why fulvestrant administration in mice did not change bone maturation at all. Ignore the trash conclusion that the study derives, what I'm saying about fulvestrant in this thread fully debunks the "androgens may fuse on their own" no fulvestrant is just shit
-- https://hero.epa.gov/reference/6319620/As always, do your own research. Everything I've said can be completely fact checked. I will never make a thread without learning/studying the topic for every pixel I type on this site
@AtrophicPyra @Paul.jnxy @flowiza @zanenenene + anyone else who cares idk
