General Peptides Cycling Guide for Teens

softmaxxed LTN · 2025-07-19T15:08:11-0500

Never seen a thread discussing this for this specific age group so I'll try to be as detailed as possible below:
*NOT RECOMMENDING NOR TELLING YOU TO USE PEPTIDES BELOW THE AGE OF 18 THIS THREAD IS PURELY FOR EDUCATIONAL PURPOSES IN REGARD TO DISCUSSING THE SAFEST AND MOST OPTIMAL WAY FOR ITS USAGE IN A HYPOTHETICAL SITUATION*

1. GH–IGF-1 Axis Activation

CJC‑1295 and Ipamorelin both act to increase endogenous growth hormone (GH), thereby raising IGF‑1. CJC‑1295 is a synthetic GHRH analog that binds the pituitary GHRH receptor to trigger GH release. When modified with a “Drug Affinity Complex” (DAC), CJC‑1295 binds albumin and has a very long half-life (on the order of days). In humans, a single CJC‑1295 injection at 30–60 µg/kg SC (≈2–4 mg in a 70 kg adult) produced large, prolonged GH spikes and sustained IGF‑1 elevations. Ipamorelin is a pentapeptide ghrelin-receptor agonist that selectively triggers GH secretion without significantly raising cortisol or ACTH. It has a short half-life (~1.5–2.5 h), inducing a sharp GH pulse ~30–60 min after injection. These GH surges stimulate liver IGF‑1 production and raise levels of IGF‑binding proteins. GH and IGF‑1 promote anabolic effects on bone: GH acts on receptors in osteoblasts and cartilage to directly stimulate bone cells, while IGF‑1 drives longitudinal and appositional growth via endocrine and paracrine signaling. (In other words, the CJC-1295 and Ipamorelin triggered increases in production for chemicals like GH and IGF-1 in the body.)

2. Bone Mechanotransduction and Modeling

Bone adapts to mechanical load through osteocytes and hormonal signals. Osteocytes sense strain via mechanotransduction and signal osteoblasts and osteoclasts accordingly. GH/IGF‑1 amplify this remodeling by increasing osteoblast proliferation/activity and stimulating osteoclast turnover, with a net effect of bone formation In craniofacial bones, GH promotes periosteal apposition (outer surface bone thickening) and cartilage-driven growth (e.g., mandibular condyle.) Overall, the GH/IGF‑1 axis is anabolic for bone modeling: it triggers collagen and matrix production and interacts with BMPs to drive osteoblast differentiation.

3. Dosing Protocols (HYPOTHETICAL)

CJC‑1295 (with DAC): Inject subcutaneously. Clinical studies used 30–60 µg/kg (~2–4 mg in a 70 kg person) weekly or biweekly (https://pubmed.ncbi.nlm.nih.gov/17012593).
CJC‑1295 (no DAC): Very short-acting (half-life ≈30 min), requiring multiple daily injections. Anecdotal protocols suggest 100–200 µg SC 1–2 times daily. In a mouse model, 2 µg daily normalized growth (human doses scaled accordingly) (https://pubmed.ncbi.nlm.nih.gov/18360408).
Ipamorelin: Injected SC; half-life ~2 h. Typical regimens: 100–300 µg per injection, 1–3 times daily. A clinical trial infused 0.03 mg/kg (~2 mg for a 70 kg adult) twice daily for 7 days, well tolerated (https://pubmed.ncbi.nlm.nih.gov/15816432). Common usage (e.g. anti-aging protocols) is 100–200 µg pre-sleep or fasted.
Administration & Timing: SC injection in fasted state or before sleep aligns with natural GH surges. Ipamorelin GH peak occurs ~40 min post-dose (https://pubmed.ncbi.nlm.nih.gov/10425602). CJC‑1295 with DAC requires weekly dosing; without DAC may need daily injections.
Duration: Published trials lasted weeks (CJC‑1295 up to 4–5 weeks, ipamorelin 7 days) (https://pubmed.ncbi.nlm.nih.gov/17012593, https://pubmed.ncbi.nlm.nih.gov/15816432).

4. Effects on Bone Growth and Facial Structure

GH/IGF‑1 are essential in skeletal growth, especially pre-puberty. Children with GH deficiency exhibit reduced craniofacial dimensions (lower face height, jaw length); GH therapy increases mandibular ramus length and posterior face height. After puberty, linear craniofacial growth mostly ceases due to epiphyseal fusion; remodeling continues but is limited. Evidence in adults is scarce. In rodent models, ipamorelin increased tibial length in young adults, even without raised IGF‑1. By analogy, facial bones could theoretically remodel under GH stimulation. In humans, overt GH excess (acromegaly) enlarges facial bones post-growth, jaw protrusion, forehead widening, thicker skull bones, demonstrating that adult bone can respond to high GH/IGF‑1 which can help increase ur SMV (as long as you don't overdo it and become an ogre.)

6. Comparison with Other GH Secretagogues

Ipamorelin vs GHRP-6: Both bind the ghrelin receptor to release GH. Ipamorelin increases GH selectively without raising cortisol or prolactin, while GHRP‑6 increases appetite and other hormones. Both have similar half-lives (~2 h).
Ipamorelin vs MK‑677: MK‑677 is an oral, non-peptide ghrelin mimetic with a ~24 h half-life. In older adults, 25 mg/day increased mean 24h GH and IGF‑1 but also appetite and weight, with modest body composition changes. MK‑677 produces tonic GH release, which may cause quicker tolerance compared to pulsed peptides. Ipamorelin offers transient GH spikes without strong feeding responses.
CJC‑1295 vs Sermorelin: Sermorelin is a short GHRH analog (half-life ~10–20 min), while CJC‑1295 (no DAC) has a longer half-life (~30 min). CJC‑1295 with DAC extends GH/IGF‑1 elevation for approximately 6–8 days.. Sermorelin requires daily injections; DAC formulation allows for weekly dosing.
Desensitization and Pulsatility: Continuous GHS activation (e.g. daily MK‑677 or continuous peptide infusion) can blunt GH pulses. Pulsatile dosing (e.g. injecting peptides 1–2×/day) better mimics physiology. Secretagogues amplify endogenous GH pulsatility, unlike exogenous GH injections that flood the system. CJC‑1295 with DAC provides persistent drive, whereas ipamorelin produces discrete GH peaks.

softmaxxed LTN · 2025-07-19T15:08:40-0500

lmk if you think there's anything I should add about this or not

General Peptides Cycling Guide for Teens

softmaxxed LTN

Iron

1. GH–IGF-1 Axis Activation

2. Bone Mechanotransduction and Modeling

3. Dosing Protocols (HYPOTHETICAL)

4. Effects on Bone Growth and Facial Structure

6. Comparison with Other GH Secretagogues

softmaxxed LTN

Iron

Similar threads

Users who are viewing this thread

General Peptides Cycling Guide for Teens

softmaxxed LTN

Iron

​

1. GH–IGF-1 Axis Activation​

2. Bone Mechanotransduction and Modeling ​

3. Dosing Protocols (HYPOTHETICAL)​

4. Effects on Bone Growth and Facial Structure ​

6. Comparison with Other GH Secretagogues ​

softmaxxed LTN

Iron

Similar threads

Users who are viewing this thread

1. GH–IGF-1 Axis Activation

2. Bone Mechanotransduction and Modeling

3. Dosing Protocols (HYPOTHETICAL)

4. Effects on Bone Growth and Facial Structure

6. Comparison with Other GH Secretagogues