ratfucker123132
Iron
- Joined
- Jan 20, 2026
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Yo does anyone else get absolutely wrecked by facial bloat on letrozole? 
Everything feels totally fine when I’m on anastrozole (Arimidex). No weird sides nothing noticeable. But the moment I switch to letro even something like 0.5 mg EOD my face just explodes overnight. Like cheeks puffed up, whole face looks swollen. I legit look like I ate a kilo of salt before bed.
What’s weird is everything else feels normal. It’s just the face that turns into a balloon.
Is this a thing with letro? Like does it mess with water retention or estrogen levels differently than arimidex? Or am I just unlucky with this one side effect?
Curious if anyone else had the same thing happen.

Everything feels totally fine when I’m on anastrozole (Arimidex). No weird sides nothing noticeable. But the moment I switch to letro even something like 0.5 mg EOD my face just explodes overnight. Like cheeks puffed up, whole face looks swollen. I legit look like I ate a kilo of salt before bed.
What’s weird is everything else feels normal. It’s just the face that turns into a balloon.
Is this a thing with letro? Like does it mess with water retention or estrogen levels differently than arimidex? Or am I just unlucky with this one side effect?
Curious if anyone else had the same thing happen.