homer2000
Iron
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- Feb 20, 2026
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This is a straightforward, rational way to make a small-batch GHK-Cu serum that is stable enough for short-term use
What you are making:
A water-based copper peptide serum designed for hydration and topical delivery. It uses a simple humectant system (glycerin + hyaluronic acid) and a preservative to prevent contamination
Strength options (per 10 mL total volume):
0.5% (recommended starting point)
50 mg GHK-Cu
1% (stronger)
100 mg GHK-Cu
2% (upper practical range)
200 mg GHK-Cu
Anything far above this is not realistic for topical use and does not scale linearly in effectiveness. GHK-Cu is biologically active at extremely low concentrations, and has been shown to produce biological effects at nanomolar (nM) levels of 1-10nM.
GHK-Cu does not behave like a dose-dependent bulk drug. Instead, it alters gene expression and cellular signaling pathways (Source 1, Source 2)
Base formula (10 mL batch)
GHK-Cu: (50-200mg as discussed above) (Example of what you'll be using -> LINK)
Distilled water: (10 mL worth at least)
Glycerin: 2–5% (0.2–0.5 mL)
Hyaluronic acid: 1% sodium hyaluronate solution (0.5–1 mL)
Liquid Germall Plus: 0.3–0.5% (0.03–0.05 mL)
Mixing procedure (order matters)
The serum has a practical shelf life of about 7–10 days once mixed, hence the 10mL batch size. It will gradually lose potency due to oxidation and light exposure.
If this is all too much, you can mix 50-200mg GHK-Cu into 10 mL of a basic hyaluronic acid serum.
Note:
The skin barrier limits topical delivery of GHK-Cu. Do research on derma stamp/roll not gonna get into that rn.
What you are making:
A water-based copper peptide serum designed for hydration and topical delivery. It uses a simple humectant system (glycerin + hyaluronic acid) and a preservative to prevent contamination
Strength options (per 10 mL total volume):
0.5% (recommended starting point)
50 mg GHK-Cu
1% (stronger)
100 mg GHK-Cu
2% (upper practical range)
200 mg GHK-Cu
Anything far above this is not realistic for topical use and does not scale linearly in effectiveness. GHK-Cu is biologically active at extremely low concentrations, and has been shown to produce biological effects at nanomolar (nM) levels of 1-10nM.
GHK-Cu does not behave like a dose-dependent bulk drug. Instead, it alters gene expression and cellular signaling pathways (Source 1, Source 2)
Base formula (10 mL batch)
GHK-Cu: (50-200mg as discussed above) (Example of what you'll be using -> LINK)
Distilled water: (10 mL worth at least)
Glycerin: 2–5% (0.2–0.5 mL)
Hyaluronic acid: 1% sodium hyaluronate solution (0.5–1 mL)
Liquid Germall Plus: 0.3–0.5% (0.03–0.05 mL)
Mixing procedure (order matters)
- Add approximately 7–8 mL distilled water to a clean container (preferably glass)
- Add the measured GHK-Cu and allow it to dissolve fully (The solution should become clear blue)
- Add the hyaluronic acid solution and mix gently
- Add glycerin and mix gently
- Add Liquid Germall Plus and mix gently
- Top up with distilled water until the total volume reaches 10 mL
The serum has a practical shelf life of about 7–10 days once mixed, hence the 10mL batch size. It will gradually lose potency due to oxidation and light exposure.
If this is all too much, you can mix 50-200mg GHK-Cu into 10 mL of a basic hyaluronic acid serum.
Note:
The skin barrier limits topical delivery of GHK-Cu. Do research on derma stamp/roll not gonna get into that rn.
