Boshitoshi
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Supplements to Slow Growth Plate Closure (Besides Estrogen)
Most people only focus on lowering estrogen when trying to protect height, but there are other pathways that also cause growth plates to close. These include:
Here are the best oral supplements that can help target these pathways (ranked by how useful they actually are for height):
Dasatinib (often stacked with Quercetin) is currently one of the strongest and most researched senolytic combinations available. It has shown the ability to clear senescent cells in human trials.
Key Studies:
Stay safe. thanks for reading
Most people only focus on lowering estrogen when trying to protect height, but there are other pathways that also cause growth plates to close. These include:
- Direct androgen effects on chondrocytes
- Buildup of senescent (“zombie”) cells
- Inflammation inside the growth plate
- Epigenetic changes (DNA methylation)
- FGF signaling
Here are the best oral supplements that can help target these pathways (ranked by how useful they actually are for height):
| Supplement | Main Pathway(s) It Helps | Effectiveness (Out of 5) | Safety | Notes | Recommendation |
|---|---|---|---|---|---|
| Dasatinib + Quercetin (D+Q) | Senescence + Inflammation | 4.5 | Moderate | Strongest senolytic combo currently available orally | Strongly Recommended |
| Fisetin | Senescence + Inflammation | 4.0 | Good | Good standalone or stacked with D+Q | Strongly Recommended |
| Quercetin Phytosome | Senescence + Inflammation | 3.5 | Good | Better absorbed version of Quercetin | Recommended |
| Spermidine | Autophagy + Cellular Cleanup | 3.0 | Good | Helps clear damaged cells | Recommended |
| Luteolin | Senescence + Inflammation | 3.0 | Good | Good to add on D+Q + Fisetin days | Worth Adding |
| Metformin | mTOR inhibition + Mild Senolytic | 3.0 | Good | Slows cellular aging | Recommended |
| Berberine | mTOR + AMPK activation | 2.5 | Good | Similar to Metformin | Optional |
| High-dose Omega-3 | Inflammation | 3.0 | Very Good | Reduces inflammatory signals in plates | Recommended |
| SAM-e + MSM | DNA Methylation support | 2.0 | Good | May help slow epigenetic aging of plates | Low Priority |
| Glucosamine + Chondroitin | Growth plate matrix support | 2.0 | Very Good | Supports cartilage environment | Supportive only |
| High-quality Resveratrol | Mild senolytic + SIRT1 | 2.0 | Good | Weak but safe | Optional |
Important Addition: Dasatinib + Quercetin (D+Q)
Dasatinib (often stacked with Quercetin) is currently one of the strongest and most researched senolytic combinations available. It has shown the ability to clear senescent cells in human trials.
Key Studies:
- Mayo Clinic First Human Senolytic Trial (2019):Dasatinib + Quercetin improves physical function in idiopathic pulmonary fibrosis patients
- Mayo Clinic Trial on Diabetic Kidney Disease (2020):Senolytic therapy improves physical function in patients with diabetic kidney disease
- Review on Senolytics and Aging (2021):Senolytics: A new class of drugs with potential to slow aging
Realistic Take:
- Dasatinib + Quercetin is currently the strongest practical senolytic stack you can run orally.
- It is more potent than Fisetin alone for clearing senescent cells in growth plates.
- However, it is not risk-free. Dasatinib can cause fatigue, low blood counts, and other side effects, which is why it’s usually only taken for 2 days every 5–8 weeks rather than daily.
- Most people in height communities run it as D+Q + Fisetin together on the same 2-day protocol for better results.
Stay safe. thanks for reading
