Glucosamine might stunt clavicle growth

[Interested]

A lot of users take glucosamine to retain their morning height, however there might be a downside to that if you are under 25 years old.

Research shows that the clavicle continues growth up until age 25:

The growth of the clavicle is primarily regulated by growth hormone (GH) and insulin-like growth factors (IGFs). GH and IGFs stimulate the proliferation and differentiation of chondrocytes in the growth plates, resulting in bone growth.


Unfortunately, studies also show that glucosamine might inhibit IGF-I:

So it's possible that by taking glucosamine, it will effect IGF-I, which might also effect the clavicle growth negatively under the age of 25.


Studies used:

https://pubmed.ncbi.nlm.nih.gov/33380970/ (Clavicle growth)

https://pubmed.ncbi.nlm.nih.gov/127...o glucosamine also resulted,insulin IGF-I/HRs. (glucosamine and IGF-I)

 

[looksmidder]

i think @thereallegend found an alternative to glucosamine with collagen and something else. i forgot exactly what it was though

 

[Saint Casanova]

What’s the best way to increase IGF-1 and HGH without using the real deal? Would peptides and Mk help ?

 

[Interested]

What’s the best way to increase IGF-1 and HGH without using the real deal? Would peptides and Mk help ?

Honestly, I don't know. Would have to do indepth research on that

 

[thereallegend]

i think @thereallegend found an alternative to glucosamine with collagen and something else. i forgot exactly what it was though

Megadosing collagen gives the same relief on joints that glucosamine does

 

[Interested]

Megadosing collagen gives the same relief on joints that glucosamine does

Any known risks on megadosing collagen?

 

[Gonthar]

i think @thereallegend found an alternative to glucosamine with collagen and something else. i forgot exactly what it was though

This doesn't help us much...

 

[looksmidder]

This doesn't help us much...

Megadosing collagen gives the same relief on joints that glucosamine does

 

[thereallegend]

Any known risks on megadosing collagen?

No, you can take up to 15g a day. The benefits for bone kick in after 5g.

 

[Sondern]

A lot of users take glucosamine to retain their morning height, however there might be a downside to that if you are under 25 years old.

Research shows that the clavicle continues growth up until age 25:

View attachment 2242829


The growth of the clavicle is primarily regulated by growth hormone (GH) and insulin-like growth factors (IGFs). GH and IGFs stimulate the proliferation and differentiation of chondrocytes in the growth plates, resulting in bone growth.


Unfortunately, studies also show that glucosamine might inhibit IGF-I:

View attachment 2242832


So it's possible that by taking glucosamine, it will effect IGF-I, which might also effect the clavicle growth negatively under the age of 25.


Studies used:

https://pubmed.ncbi.nlm.nih.gov/33380970/ (Clavicle growth)

https://pubmed.ncbi.nlm.nih.gov/12746299/#:~:text=Exposure to glucosamine also resulted,insulin IGF-I/HRs. (glucosamine and IGF-I)

what about chondroitin

 

[Interested]

what about chondroitin

haven't found any study that says chondroitin inhibits IGF-I.

 

[Sondern]

haven't found any study that says chondroitin inhibits IGF-I.

Does chondroitin do the same exact thing? I've seen ppl say yes and some ppl say no

 

[Interested]

Does chondroitin do the same exact thing? I've seen ppl say yes and some ppl say no

In terms of stunting clavicle growth, probably no.

In terms of retaining morning height, also probably no.

 

[Kater Maxxing]

JFL

 

[ricetard]

shit I’m retarded

 

[ferbite666]

No, you can take up to 15g a day. The benefits for bone kick in after 5g.

How much height did u gain from megadosing collagen?

 

[cyprian_tomaszewski]

A lot of users take glucosamine to retain their morning height, however there might be a downside to that if you are under 25 years old.

Research shows that the clavicle continues growth up until age 25:

View attachment 2242829


The growth of the clavicle is primarily regulated by growth hormone (GH) and insulin-like growth factors (IGFs). GH and IGFs stimulate the proliferation and differentiation of chondrocytes in the growth plates, resulting in bone growth.


Unfortunately, studies also show that glucosamine might inhibit IGF-I:

View attachment 2242832


So it's possible that by taking glucosamine, it will effect IGF-I, which might also effect the clavicle growth negatively under the age of 25.


Studies used:

https://pubmed.ncbi.nlm.nih.gov/33380970/ (Clavicle growth)

https://pubmed.ncbi.nlm.nih.gov/12746299/#:~:text=Exposure to glucosamine also resulted,insulin IGF-I/HRs. (glucosamine and IGF-I)

From another thread: "
I've read the paper, it was done on HepG2 cells in vitro (on a petri dish lol). HepG2 cells come from a single 15 year old Argentinian incel in 1975 who had liver cancer which reduces the applicability of the results to regular people's body. The concentration of glucosamine at which it started to show marked inhibition on IGF-1 signalling was 20mM. A 70kg man has around 42L of fluid in his body meaning you'd need 20x42= 840millimoles of glucosamine in to somewhat replicate the concentration in real life. 840millimoles is 0.84 moles of glucosamine. 0.84 x 179.17 (molar mass of glucosamine) = 150.5 g of glucosamine (LOL). If it even works on normal human cells, you'd need to take 150g of glucosamine to to inhibit IGF-1 lmao.

TLDR; You'd have to take 150g of glucosamine to inhibit IGF-1 in the study which was done on cancer cells in a petri dish,. Chances are it has little to no effects IRL"

 

[JizzFarmer]

In vitro study done on cancer cells using extremely high concentrations well above the recommended dosage in humans. This is why you read papers instead of headlines like fucking retards.

 

[Roge]

From another thread: "
I've read the paper, it was done on HepG2 cells in vitro (on a petri dish lol). HepG2 cells come from a single 15 year old Argentinian incel in 1975 who had liver cancer which reduces the applicability of the results to regular people's body. The concentration of glucosamine at which it started to show marked inhibition on IGF-1 signalling was 20mM. A 70kg man has around 42L of fluid in his body meaning you'd need 20x42= 840millimoles of glucosamine in to somewhat replicate the concentration in real life. 840millimoles is 0.84 moles of glucosamine. 0.84 x 179.17 (molar mass of glucosamine) = 150.5 g of glucosamine (LOL). If it even works on normal human cells, you'd need to take 150g of glucosamine to to inhibit IGF-1 lmao.

TLDR; You'd have to take 150g of glucosamine to inhibit IGF-1 in the study which was done on cancer cells in a petri dish,. Chances are it has little to no effects IRL"

Thats from my thread by @JizzFarmer