GLUCOSAMINE STUNTS GROWTH? OPENPLATECEL HEIGHTMAXXERS GTFIH

[TeenAscender]

GLUCOSAMINE INHIBITS IGF-1?!

"An overnight exposure to glucosamine markedly attenuated the effects of insulin and IGF-I in stimulating glycogen synthesis. ... Exposure to glucosamine also resulted in a reduction in the ability of IGF-I or insulin to stimulate phosphorylation of insulin IGF-I/HRs."

Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors - PubMed

IGF-I stimulates insulin-like actions directly through its receptor, and it also enhances sensitivity to insulin-mediated effects in vivo. These studies were undertaken to analyze the role of IGF-I, insulin, and insulin/IGF-I hybrid receptors (HRs) in mediating IGF-I and insulin signaling in...

pubmed.ncbi.nlm.nih.gov

We know glucosamine may or may not help with closedplate cels due to glucosamine's ability to facilitate cartilage hypertrophy and prevent disc related daily height loss, but for someone like me whose a teen taking it would it actually inhibit growth b/c it inhibits IGF-1 (idrkif simulating phosphorylation of insulin IGF-1 is what facilitates bone growth so plz lmk in the thread)

if I might've been voluntarily stunting my growth for 3 weeks

 

[Preoximerianas]

Those three weeks were the difference between being 6'2 and 4'11.

 

[Deleted member 4946]

GLUCOSAMINE INHIBITS IGF-1?!

"An overnight exposure to glucosamine markedly attenuated the effects of insulin and IGF-I in stimulating glycogen synthesis. ... Exposure to glucosamine also resulted in a reduction in the ability of IGF-I or insulin to stimulate phosphorylation of insulin IGF-I/HRs."

Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors - PubMed

IGF-I stimulates insulin-like actions directly through its receptor, and it also enhances sensitivity to insulin-mediated effects in vivo. These studies were undertaken to analyze the role of IGF-I, insulin, and insulin/IGF-I hybrid receptors (HRs) in mediating IGF-I and insulin signaling in...

pubmed.ncbi.nlm.nih.gov

We know glucosamine may or may not help with closedplate cels due to glucosamine's ability to facilitate cartilage hypertrophy and prevent disc related daily height loss, but for someone like me whose a teen taking it would it actually inhibit growth b/c it inhibits IGF-1 (idrkif simulating phosphorylation of insulin IGF-1 is what facilitates bone growth so plz lmk in the thread)

if I might've been voluntarily stunting my growth for 3 weeks

just take gluco and stretch before you have any important function, easy 1-1.5 inch boost

 

[AscendingHero]

just take gluco and stretch before you have any important function, easy 1-1.5 inch boost

what stretches do u recommend?

and what abt OP? of gluco inhibiting igf-1?

 

[Cope>rope]

Does chondroitin do the same ?

 

[Deleted member 16456]

Oral Glucosamine Effect on Blood Glucose and Insulin Levels in Patients With Non-Diabetic Osteoarthritis: A Double-Blind, Placebo-Controlled Clinical Trial

This study aims to determine the effects of oral glucosamine on glucose metabolism and insulin resistance in non-diabetic patients with osteoarthritis in Northeastern Iran. This placebo-controlled, randomized clinical trial included 40 non-diabetic ...

www.ncbi.nlm.nih.gov

Oral glucosamine with routine dosage was safe in our non-diabetic patients with osteoarthritis and had no significant effect on glucose metabolism and insulin resistance. Dunno about igf-1 tho

 

[morticious]

would msm have a similar effect?

 

[trey123]

what? i thought glucosamine iblncreased height. i was about to order more. im so confused now

 

[Deleted member 17429]

>new study comes out
>looksmax is a looksmin
>new study comes out
>looksmin is actually a looksmax

 

[Mike141]

>new study comes out
>looksmax is a looksmin
>new study comes out
>looksmin is actually a looksmax

so gluco is safe for teens?

 

[Deleted member 17429]

so gluco is safe for teens?

Wouldn’t take it just to be safe. Ask mr freakkforlofe

 

[FreakkForLife]

so gluco is safe for teens?

If u can inject igf1+inuslin,then it's good, otherwise it's not.

It impairs the insulin receptors and igf1 receptors which can hamper height gains,so i don't recommend it in puberty

 

[Deleted member 15854]

 

[Deleted member 15854]

would msm have a similar effect?

hmmm

 

[thereallegend]

Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats

The growth plate consists of organized hyaline cartilage and serves as a scaffold for endochondral ossification, a process that mediates longitudinal bone growth. Based on evidence showing that the oral administration of glucosamine sulfate (GS) and/or ...

www.ncbi.nlm.nih.gov

https://www.sciencedirect.com/science/article/abs/pii/S0753332217361425

2014 & 2018 studies show glucosamine promoting osteoblasts as well. New bone along with new cartilage.

 

[Jigen]

GLUCOSAMINE INHIBITS IGF-1?!

"An overnight exposure to glucosamine markedly attenuated the effects of insulin and IGF-I in stimulating glycogen synthesis. ... Exposure to glucosamine also resulted in a reduction in the ability of IGF-I or insulin to stimulate phosphorylation of insulin IGF-I/HRs."

Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors - PubMed

IGF-I stimulates insulin-like actions directly through its receptor, and it also enhances sensitivity to insulin-mediated effects in vivo. These studies were undertaken to analyze the role of IGF-I, insulin, and insulin/IGF-I hybrid receptors (HRs) in mediating IGF-I and insulin signaling in...

pubmed.ncbi.nlm.nih.gov

We know glucosamine may or may not help with closedplate cels due to glucosamine's ability to facilitate cartilage hypertrophy and prevent disc related daily height loss, but for someone like me whose a teen taking it would it actually inhibit growth b/c it inhibits IGF-1 (idrkif simulating phosphorylation of insulin IGF-1 is what facilitates bone growth so plz lmk in the thread)

if I might've been voluntarily stunting my growth for 3 weeks

That’s why I just take It in the morning.

 

[Deleted member 19766]

That’s why I just take It in the morning.

So you'd say it's totally safe to take and wouldn't affect growth at all?

 

[Deleted member 20631]

So you'd say it's totally safe to take and wouldn't affect growth at all?

He can’t tell you that for sure, but try to take it as early as possible so it doesn’t affect the GH release you get when sleeping

 

[GigaAscender]

Glucosamine and chondroitin sulfate association increases tibial epiphyseal growth plate proliferation and bone formation in ovariectomized rats

The growth plate consists of organized hyaline cartilage and serves as a scaffold for endochondral ossification, a process that mediates longitudinal bone growth. Based on evidence showing that the oral administration of glucosamine sulfate (GS) and/or ...

www.ncbi.nlm.nih.gov

https://www.sciencedirect.com/science/article/abs/pii/S0753332217361425

2014 & 2018 studies show glucosamine promoting osteoblasts as well. New bone along with new cartilage.

gluco also increases wnt, which is proliferative for resting zone chondrocytes and osteoblasts, so that probably balances out with the lower IGF-1. Wnt is probably more important tbh. If you megadose HGH + IGF-1, i’m sure gluco is fine since it increases chondrogenesis so should delay senescence in theory.

 

[ferbite666]

If u can inject igf1+inuslin,then it's good, otherwise it's not.

It impairs the insulin receptors and igf1 receptors which can hamper height gains,so i don't recommend it in puberty

Im injecting CJC and Ipamorelin while taking 3000mg of glucosamine/chondrotin. Good idea?