Growth Plate Fusion through Androgens?

[Kojo]

If anyone can justify this retarded concept I'll give them 50usd

There's been way too much stupid low iq fear mongering about this, Eviscerate me if I don't give the 50usd I'm that confident

THERE IS NO GROWTH PLATE FUSION THROUGH THE USE OF ANDROGENS OR ANY ANDROGEN RECEPTOR SIGNALLING. EVERYTHING IS THROUGH ESTROGEN.

WHOEVER IS WILLING TO DISAGREE WITH THIS LETS TALK ABOUT IT BEFORE I LEAVE THE SITE AGAIN.

 

[Kojo]

pah is very good at predicting the fah, also look at the age group of the ppl who had a negative pah

7.5cm is pretty steep if u ask me and honestly i can probably link a thread i made wayyy more direct than this one give me a moment

Pah always fluctuates, It's essentially a hsds without the comparison to others.

We see ai's on their own increase pah/hsds but still dont' increase fah. pah is really really irrelevant.

 

[Kojo]

The Effects of Trenbolone Supplementation on The Extremity Bones in Running Rats

Turkish Journal of Sport and Exercise | Volume: 21 Issue: 2

dergipark.org.tr

found one of the studies through one of my replies a few months ago with smth arguing the same exact thing

Yeah again, I already brought this up in this thread and debunked it.

Only the femur and humerus were measured, not overall height.

The study itself says that the results aren't statistically significant. Because there is barely any difference in the lengths if you actually read the study. Also, tren + exercise was higher than every other group there lmao so maybe just maybe it's the lack of exercising making them ever so slightly smaller in their femur

 

[AtrophicPyra]

Pah always fluctuates, It's essentially a hsds without the comparison to others.

We see ai's on their own increase pah/hsds but still dont' increase fah. pah is really really irrelevant.

ais obviously increase fah if ur taking ai for as long as u want

 

[AtrophicPyra]

Yeah again, I already brought this up in this thread and debunked it.

Only the femur and humerus were measured, not overall height.

The study itself says that the results aren't statistically significant. Because there is barely any difference in the lengths if you actually read the study. Also, tren + exercise was higher than every other group there lmao so maybe just maybe it's the lack of exercising making them ever so slightly smaller in their femur

femur and humerus growth plates fused prematurely what makes u think the spine didnt?

i mean in humans femurs close before the spine do maybe not the same in rats maybe it is who knows look it up

 

[Milktard]

I mean, you're mostly correct; it's just that anabolic androgens that aromatize like testosterone will aromatize to estradiol, which indirectly contributes to growth plate fusion.

I've roughly skimmed through the thread, but the study with the guy with the aromatase deficiency should not be used as evidence because he literally cannot make estradiol; hence, no advancement of bone age or epiphyseal closure when he took high dose of test.

Bringing that up is a bit nuanced because, assuming you have normal aromatase activity, taking high doses of testosterone by itself would most likely contribute to gp fusion.

Your claim, scientifically, is way too vague. Androgens themselves don't directly close plates, which is pretty much proven in all the studies you've provided.

Taking androgens that aromatize will indirectly contribute to growth plate fusion based on current human evidence.

This thread is just really autistic bait because you're claiming a legitimate mechanism that androgens don't cause GP fusion, but you also aren't addressing androgenic aromatizing compounds that indirectly cause GP fusion. People disagreeing with you seem to have a misunderstanding because of your entire wording.

Also want to address that scientific studies are mostly never definitive; that's just a fundamental principle of science. That is why reading scientific papers uses cautious language