Deleted member 1973
pastebin.com/Tb8AYcyk
- Joined
- Jun 8, 2019
- Posts
- 5,826
- Reputation
- 6,879
heat may have an impact on stem cells.
“warm ambient temperature increases bone blood supply and bone length in young mice ”
“Local heat could be an alternative to surgery and a supplement to systemic bone -lengthening drugs to noninvasively achieve limb length equalization.”
“Ear area and hindfoot length on the heat-treated side were increased 8.8% and 3.5%, respectively, compared to the non-treated contralateral side at 5-weeks. Femoral and tibial lengths were increased 1.3% and 1.5%, respectively. "
Importantly, ear area and tibial length were still significantly increased on the heat-treated side of adults”
grantome.com
localized heating increases molecular uptake in growth plate cartilage in vivo, suggesting that heat could be a noninvasive and inexpensive alternative for augmenting delivery of bone-lengthening drugs
heat localizes delivery of systemic IGF-I into growth plates to promote additive bone lengthening{so this implies that the heat increases delivery of IGF-1 already in the body to the growth plates}.
Although to recreate a growth plate would require more than just IGF-1.
Unilateral Heat Accelerates Bone Elongation and Lengthens Extremities of Growing Mice
Exposure to warm ambient temperature during growth increases limb length, suggesting that targeted heat could noninvasively enhance bone elongation. Daily heat exposure on one side of the body unilaterally increases femoral and tibial lengths.
Unilateral increases in ear (8.8%), hindfoot (3.5%), femoral (1.3%) and tibial(1.5%) lengths were obtained.Tibial elongation rate was >12% greater (15 µm/day) on the heat-treated side.
t’s interesting that heat only worked for certain bones} were unaffected.
According to Periodic heat shock accelerated the chondrogenic differentiation of human mesenchymal stem cells in pellet culture., Heat increased chondrogenic differentiation although they were cells already committed to the chondrogenic lineage. 41C for 1 hour was the stimulus used.
The SPOILER demonstrate that heat enhances vascular carrying capacity and bioavailability of large molecules around growth plates, suggesting that temperature could be a noninvasive strategy for modulating delivery of therapeutics to impaired growth plates of children.”
Tummo To Increase Internal Body Heat And Temperature
TUMMO MEDITATION TECHNIQUE IS PRACTICED: imagine your body as a hollow balloon and visualize that a hot lamp is placed at the center of that hollow balloon discharging heat. Slowly, your body will start heating up.
onlinelibrary.wiley.com
study found that heat did not increase bone length however there was some promise in that decalcification could be caused by the heat and that could enable longitudinal bone growth. ... heat itself actually didn’t stimulate the growth plate itself. It was only the heat degeneration the calcified bone matrix and stimulating the creation of growth plate islands that incurred new growth.
“In only one animal (465) did an increase in bone length occur. This animal was heated for two days and, the wires having broken, the resistor was left unheated for a further 36 days. Although the increase in length of the limb was considerable, aid was associated with a generalized decalcification of the forelimb, suggesting an increase in the vascularity of this member, the difference in length of the limbs may have been due to some abnormality of growth on the control side. “<-So decalcification is key to growing taller. High levels of heat can was found to cause necrosis which reduced growth but if decalcification can enhance growth. Then maybe heat could enhance growth by decalcifying bones.
heat has been shown to stimulate the production of cartilage around the resistor and to produce islands of endochondral ossification within the bony epiphysis and along the shaft of the radius.”<-islands of endochondral ossification is promising because it shows new induction of bone growth.
Cartilage islands within the diaphysis would be key to seeing if heat can induce new growth plates.
“warm ambient temperature increases bone blood supply and bone length in young mice ”
“Local heat could be an alternative to surgery and a supplement to systemic bone -lengthening drugs to noninvasively achieve limb length equalization.”
“Ear area and hindfoot length on the heat-treated side were increased 8.8% and 3.5%, respectively, compared to the non-treated contralateral side at 5-weeks. Femoral and tibial lengths were increased 1.3% and 1.5%, respectively. "
Importantly, ear area and tibial length were still significantly increased on the heat-treated side of adults”
Heat enhanced molecular delivery to growth plates for targeted bone lengthening
Linear growth deficiencies have multiple etiologies, ranging from injury and illness to genetic bone disease. Bone elongation disorders are particularly challenging to treat because of the relative in...
heat localizes delivery of systemic IGF-I into growth plates to promote additive bone lengthening{so this implies that the heat increases delivery of IGF-1 already in the body to the growth plates}.
Although to recreate a growth plate would require more than just IGF-1.
Unilateral Heat Accelerates Bone Elongation and Lengthens Extremities of Growing Mice
Exposure to warm ambient temperature during growth increases limb length, suggesting that targeted heat could noninvasively enhance bone elongation. Daily heat exposure on one side of the body unilaterally increases femoral and tibial lengths.
Unilateral increases in ear (8.8%), hindfoot (3.5%), femoral (1.3%) and tibial(1.5%) lengths were obtained.Tibial elongation rate was >12% greater (15 µm/day) on the heat-treated side.
t’s interesting that heat only worked for certain bones} were unaffected.
According to Periodic heat shock accelerated the chondrogenic differentiation of human mesenchymal stem cells in pellet culture., Heat increased chondrogenic differentiation although they were cells already committed to the chondrogenic lineage. 41C for 1 hour was the stimulus used.
“Advances in understanding the molecular regulation of longitudinal growth have led to development of novel drug therapies for growth plate disorders. Despite progress, a major unmet challenge is delivering therapeutic agents to avascular-cartilage plates. Dense extracellular matrix and lack of penetrating blood vessels create a semipermeable “barrier,” which hinders molecular transport at the vascular-cartilage interface. To overcome this obstacle, we used a hindlimb heating model to manipulate bone circulation in 5-wk-old female mice (n = 22). Temperatures represented a physiological range of normal human knee joints. We used in vivo multiphoton microscopy to quantify temperature-enhanced delivery of large molecules into tibial growth plates. We tested the hypothesis that increasing hindlimb temperature from 22°C to 34°C increases vascular access of large systemic molecules{This is a limited temperature range so we don’t know if there’s a cap on how much temperature can increase height}, modeled using 10, 40, and 70 kDa dextrans that approximate sizes of physiological regulators. Vascular access was quantified by vessel diameter, velocity, and dextran leakage from subperichondrial plexus vessels and accumulation in growth plate cartilage. Growth plate entry of 10 kDa dextrans increased >150% at 34°C. Entry of 40 and 70 kDa dextrans increased <50%, suggesting a size-dependent temperature enhancement. Total dextran levels in the plexus increased at 34°C, but relative leakage out of vessels was not temperature dependent. Blood velocity and vessel diameter increased 118% and 31%, respectively, at 34°C.
Tummo To Increase Internal Body Heat And Temperature
TUMMO MEDITATION TECHNIQUE IS PRACTICED: imagine your body as a hollow balloon and visualize that a hot lamp is placed at the center of that hollow balloon discharging heat. Slowly, your body will start heating up.
Error - Cookies Turned Off
“In only one animal (465) did an increase in bone length occur. This animal was heated for two days and, the wires having broken, the resistor was left unheated for a further 36 days. Although the increase in length of the limb was considerable, aid was associated with a generalized decalcification of the forelimb, suggesting an increase in the vascularity of this member, the difference in length of the limbs may have been due to some abnormality of growth on the control side. “<-So decalcification is key to growing taller. High levels of heat can was found to cause necrosis which reduced growth but if decalcification can enhance growth. Then maybe heat could enhance growth by decalcifying bones.
heat has been shown to stimulate the production of cartilage around the resistor and to produce islands of endochondral ossification within the bony epiphysis and along the shaft of the radius.”<-islands of endochondral ossification is promising because it shows new induction of bone growth.
Cartilage islands within the diaphysis would be key to seeing if heat can induce new growth plates.
