Hgh 2x week pin

[superiqlet]

I have a dumbass living situation rn would i be able to get and benefits if i dosed high on like friday and tuesday or something or would it just be waste of time

 

[realboyo]

There was a study where 38 children with ISS were either dosed daily or EOD, and the difference in growth velocity was measurable but imo it’s negligible.

Group I receiving the daily hGH injections first and second year velocity was 3.4 and 2.3 SD.

Group II receiving the alternate hGH inj. had 3.0 and 2.0 SD for first and second year, respectively.

However, every other day is the limit because it takes up to a day for circulating IGF-1 to reach a peak before it starts to degrade.

The half life of its primary binding protein around half a day, so on day 2 for the first 12 hours they had an avg of 75% of elevated peak IGF-1 and for the second 12 hours an average of 37.5% until the next dose

That’s the problem, by the end of day 2 you will have around a third of the elevated peak IGF-1. If you don’t pin by then, by the end of day 3 the potency of exogenous HGH is effectively nothing after one or two half lives

So you are potentially injecting 14-28 (maybe more) IU of HGH every 3.5 days which will give you insane sides, just to have shit results

On the stretch where you don’t pin for 4 days (Friday to Tuesday), the last day your IGF-1 will either be at baseline or crash below baseline (downregulation / endogenous secretion raped by exogenous GH) and it will be essentially unenhanced for the day leading up to day 4 as well. So for 3 days out of the week the HGH is not doing jack diddly squat, 2 will be fine, and 2 will be unoptimized.

Shit will just be a roller coaster of peaks and crashes, you will have severe sides, and its effectiveness will be reduced by potentially more than 50%.

This is a very retarded idea idk why you can only pin twice a week, but figure out a way you can pin daily or EOD at least

 

[Niebvll]

There was a study where 38 children with ISS were either dosed daily or EOD, and the difference in growth velocity was measurable but imo it’s negligible.

Group I receiving the daily hGH injections first and second year velocity was 3.4 and 2.3 SD.

Group II receiving the alternate hGH inj. had 3.0 and 2.0 SD for first and second year, respectively.

However, every other day is the limit because it takes up to a day for circulating IGF-1 to reach a peak before it starts to degrade.

The half life of its primary binding protein around half a day, so on day 2 for the first 12 hours they had an avg of 75% of elevated peak IGF-1 and for the second 12 hours an average of 37.5% until the next dose

That’s the problem, by the end of day 2 you will have around a third of the elevated peak IGF-1. If you don’t pin by then, by the end of day 3 the potency of exogenous HGH is effectively nothing after one or two half lives

So you are potentially injecting 14-28 (maybe more) IU of HGH every 3.5 days which will give you insane sides, just to have shit results

On the stretch where you don’t pin for 4 days (Friday to Tuesday), the last day your IGF-1 will either be at baseline or crash below baseline (downregulation / endogenous secretion raped by exogenous GH) and it will be essentially unenhanced for the day leading up to day 4 as well. So for 3 days out of the week the HGH is not doing jack diddly squat, 2 will be fine, and 2 will be unoptimized.

Shit will just be a roller coaster of peaks and crashes, you will have severe sides, and its effectiveness will be reduced by potentially more than 50%.

This is a very retarded idea idk why you can only pin twice a week, but figure out a way you can pin daily or EOD at least

None of this applies to him

 

[Niebvll]

I have a dumbass living situation rn would i be able to get and benefits if i dosed high on like friday and tuesday or something or would it just be waste of time

rHGH is absolute cope

 

[blinkers]

Just don’t hgh bro

 

[realboyo]

None of this applies to him

How so

 

[Niebvll]

How so

its fair to assume he doesn't have ISS

 

[realboyo]

its fair to assume he doesn't have ISS

Ofc, the study was solely used to illustrate why he can’t dose too far apart as he would experience extremely inconsistent IGF-1 levels, not to claim whether or not he will grow at all.

Realistically the only purpose of GH is to make sure he can reach his genetic potential, and administering it exogenously for a consistent IGF-1 would only be “cope” in a perfect scenario where he has 0 cortisol elevation, a perfect diet, no periods of sleep deprivation, inflammation etc.

Like yea I doubt he has genetic partial GHD and no one knows if it will help (literature says rHGH has no effect on final height, I agree that it is cope in that regard) but I still think it is reasonable and pragmatic to administer it either way to avoid uncertainties, as you cannot definitively prove whether rHGH will benefit a person without knowing every single factor.

In which case, if he so chooses to pin (ofc we don’t know if it will even make him grow .1 inch), then he should at least pin in a way where his IGF-1 levels will be consistent.

My reply to him was solely about why dosing every 3-4 days is retarded in the context of bound IGFBP-3 half life and serum IGF-1 levels. If he thinks it will make him grow a literal foot then that’s on him

 

[Niebvll]

Ofc, the study was solely used to illustrate why he can’t dose too far apart as he would experience extremely inconsistent IGF-1 levels, not to claim whether or not he will grow at all.

Realistically the only purpose of GH is to make sure he can reach his genetic potential, and administering it exogenously for a consistent IGF-1 would only be “cope” in a perfect scenario where he has 0 cortisol elevation, a perfect diet, no periods of sleep deprivation, inflammation etc.

Like yea I doubt he has genetic partial GHD and no one knows if it will help (literature says rHGH has no effect on final height, I agree that it is cope in that regard) but I still think it is reasonable and pragmatic to administer it either way to avoid uncertainties, as you cannot definitively prove whether rHGH will benefit a person without knowing every single factor.

In which case, if he so chooses to pin (ofc we don’t know if it will even make him grow .1 inch), then he should at least pin in a way where his IGF-1 levels will be consistent.

My reply to him was solely about why dosing every 3-4 days is retarded in the context of bound IGFBP-3 half life and serum IGF-1 levels. If he thinks it will make him grow a literal foot then that’s on him

1 theres no such defined thing as genetic limit
2 i never talked about ghd
3 you dont need such a perfect scenario as you described lol muh cortisol muh sleep did you get this from ai? None of these matter if not chronic and extreme
4 absolutely not worth taking even "to make sure", at his age, safe to be assumed mid teen, relevant proliferation has already been missed out on for more than a decade and the gh wont change the final result