Why do you have to use an AI for longer bones?
prevents ossification of growth plates
do you recommend hgh for one in puberty for height and increased bone mass gains considering its potential side effects?
Peptides, and other forms of IGF-1 increasing things will be ideal for height growth, DHT does have a role in it but far less than IGF-1. heightmaxxing thread soon.
abso-fucking-lutely
@Chintuck22
why?
Estrogen (peaking of estradiol) is what causes your plates to fuse, in short, plates fusing = no more growing. so we take AIs (aromatase inhibitors) to slow down this process as much as possible, this in combination with HGH treatment Is ideal.
Seriously though Rich piana made a video about his igf-1 use. He said nothing even compared to it.
incorrect
then don't take it, it's that simple
ok so let me put it this way, when in puberty you are moldable, this is good and bad, because bad habits, hormones, etc will mould and imprint into your body. shit sleep = reduced final height and so on and so forth. Using HGH when you are mouldable will grow your frame, your face ( jaw ), your bones and help you become taller if plates arent fused, it will also grow your hands and feet.
Let me rephrase that. Getting REAL IGF-1 is next to impossible for the average guy. Most igf-1 you'll buy is faked, but because you get insanely low blood sugar and a strong fat melting effect, you think it's real.
most igf i see is like £50-80 per 1mg bottle (IGF-LR3). personally IGF-DES is the way to go because its far more stable and robust doesn't get fucked up (transport, shaking etc) like IGF-1LR3 is known to.
I'm not about those, I'm strictly talking about regular igf-1.
yeah mate, those are the IGF-1s bodybuilders use.
this part is incorrect
however I agree with this
DM one so no trouble.
because growth plate closure is regulated by aromatase
are gh peptide stacks a cope?
also im p sure that your body tries to account for a lack of sleep by sending growth hormone pulses through out the day instead of gh being released during your sleep
not if you use a decent peptide stack. but a potent peptide stack would cost around the same for decent generic GH, which is superior. might as well just go for the GH at that point
depends what youre using it for
can you pm hgh sources
It doesn't play a role in dimorphism, it only positively affect dick size and beard growth during development.
www.ncbi.nlm.nih.gov
Did those studies only mention 5ar2? What about 5ar1?It doesn't play a role in dimorphism, it only positively affect dick size and beard growth during development.
5α-reductase-2 Deficiency’s Effect on Human Fertility
A most interesting and intriguing male disorder of sexual differentiation is due to 5α-reductase-2 isoenzyme deficiency. These males are born with ambiguous external genitalia due to a deficiency in their ability to catalyze the conversion of ...
If you read these 2 studies in detail I think you will understand.
pubmed.ncbi.nlm.nih.gov
Dont be so high inhib dude
The first studyDid those studies only mention 5ar2? What about 5ar1?
Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice - PubMed
Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the androgen receptor (AR) in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator...
"5α-reductase type 2 is predominantly expressed in male reproductive tissues whereas 5α-reductase type 1 is highly expressed in liver and moderately expressed in several other tissues including bone"
"In conclusion, 5α-reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength and we propose that these effects are due to lack of 5α-reductase type 1 expression in bone and muscle. In contrast, the increased cortical bone mass in female Srd5a1⁻/⁻ mice, is an indirect effect mediated by elevated circulating androgen levels."
If you look at the cases of guevedoces, people with 0 5AR, their bone density, height, and muscle mass are unaffected whatsoever. They do have micropenises though.Did those studies only mention 5ar2? What about 5ar1?
Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice - PubMed
Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the androgen receptor (AR) in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator...
"5α-reductase type 2 is predominantly expressed in male reproductive tissues whereas 5α-reductase type 1 is highly expressed in liver and moderately expressed in several other tissues including bone"
"In conclusion, 5α-reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength and we propose that these effects are due to lack of 5α-reductase type 1 expression in bone and muscle. In contrast, the increased cortical bone mass in female Srd5a1⁻/⁻ mice, is an indirect effect mediated by elevated circulating androgen levels."
5ar2 is only mentioned in the both of those studies. Nothing about 5ar1 is mentioned, which is responsible for increasing bone mass.
I will try and find the study about the guevedoces, meanwhile research it if u can. Guvedoces don't have any type of the 5AR enzyme yet their bodies mature perfectly aside from their penis and beards.
