how does mt2 cause acne scientifically?

[PsychoDsk]

apparently one of the sides is acne, anyone have any idea how mt2 causes this?

@Orc

 

[NZb6Air]

Was waiting for a reply but since nobody is replying, I looked it up and it's cause MT2 also binds to MCR3 and 4 which have hormonal implications (MC1R is the melanin production)

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food - PMC

Obesity is a major health problem worldwide. An understanding of the factors that drive feeding behaviors is key to the development of pharmaceuticals to decrease appetite and consumption. Proopiomelanocortin (POMC), the melanocortin peptide ...

www.ncbi.nlm.nih.gov

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food - PubMed

MT-II in the NAcc decreased both the motivation to eat and the amount of food consumed without inducing an aversive state or affecting metabolic rate, suggesting a role for melanocortin signaling in the NAcc that is selective for appetite and satiety without affecting metabolism or producing an...

pubmed.ncbi.nlm.nih.gov

 

[PsychoDsk]

Was waiting for a reply but since nobody is replying, I looked it up and it's cause MT2 also binds to MCR3 and 4 which have hormonal implications (MC1R is the melanin production)

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food - PMC

Obesity is a major health problem worldwide. An understanding of the factors that drive feeding behaviors is key to the development of pharmaceuticals to decrease appetite and consumption. Proopiomelanocortin (POMC), the melanocortin peptide ...

www.ncbi.nlm.nih.gov

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food - PubMed

MT-II in the NAcc decreased both the motivation to eat and the amount of food consumed without inducing an aversive state or affecting metabolic rate, suggesting a role for melanocortin signaling in the NAcc that is selective for appetite and satiety without affecting metabolism or producing an...

pubmed.ncbi.nlm.nih.gov

thanks for being my google bhai

 

[Deleted member 4633]

melanocortin receptor 1 & 5 both regulate sebaceous gland differentiation and lipogenesis. Yes chronic usage of Melanotan 2 can cause acne/oily skin without a doubt.

Melanotan 2 is honestly riddled with problems and I've only just now come to realise this after being a user for 4-5 years, the melanocortin system is incredibly complex and agonising it 24/7 with mt2 is a recipe for disaster (anhedonia, appetite issues, acne, melasma, etc)

Melanotan 1 doesn't enter the brain (ideal) and is far more selective than MT2, meaning it doesn't cause nausea, dysregulated appetite and anhedonia. Oh and it doesn't touch MC5 so acne will never be an issue

 

[Deleted member 155538]

melanocortin receptor 1 & 5 both regulate sebaceous gland differentiation and lipogenesis. Yes chronic usage of Melanotan 2 can cause acne/oily skin without a doubt.

Melanotan 2 is honestly riddled with problems and I've only just now come to realise this after being a user for 4-5 years, the melanocortin system is incredibly complex and agonising it 24/7 with mt2 is a recipe for disaster (anhedonia, appetite issues, acne, melasma, etc)

Melanotan 1 doesn't enter the brain (ideal) and is far more selective than MT2, meaning it doesn't cause nausea, dysregulated appetite and anhedonia. Oh and it doesn't touch MC5 so acne will never be an issue

but even mt1 causes hyperpigmentation no?

 

[exire]

melanocortin receptor 1 & 5 both regulate sebaceous gland differentiation and lipogenesis. Yes chronic usage of Melanotan 2 can cause acne/oily skin without a doubt.

Melanotan 2 is honestly riddled with problems and I've only just now come to realise this after being a user for 4-5 years, the melanocortin system is incredibly complex and agonising it 24/7 with mt2 is a recipe for disaster (anhedonia, appetite issues, acne, melasma, etc)

Melanotan 1 doesn't enter the brain (ideal) and is far more selective than MT2, meaning it doesn't cause nausea, dysregulated appetite and anhedonia. Oh and it doesn't touch MC5 so acne will never be an issue

why was mt1 abandoned but mt2 wasnt?

 

[deleteduser]

why was mt1 abandoned but mt2 wasnt?

it wasn't abandoned it was just developed into scenesse