How to become low inhibition- alcohol, pregablin and more- the truth about low inhibition drugs

Aryan Incel

Aryan Incel

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Intro

Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.


Pregabalin

How it works/ biology

Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.

IMG_7586.jpeg



Benefits

It's very orally bioavailable (around 90%, less affected by food etc).

Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.

The study shows it cures 90% of anxiety


https://pubmed.ncbi.nlm.nih.gov/12611835/

Does pregabalin offer potential as a first-line therapy for generalized anxiety ...


However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol


In addition it is quite liver friendly and has low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox


Due to its low amount of side effects it’s a good stacking drug as well


Side effects

A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist

Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage


Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored

Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?


Could cause erectile dysfunction if you’re abusing it

https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult


Dosage

Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.

You should take around 150-300 mg.

The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.


Conclusion

In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.


Alcohol

How it works/ biology

Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions

IMG_7589.jpeg



Benefits

It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...


It’s also very socially acceptable and you can even be encouraged to do it in public

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use


It’s a diuretic, it’s a mild diuretic which can reduce water retention.

https://www.nidirect.gov.uk/article...text=There is no immediate way,Types of drink


Side effects


Reduces your gym gains

https://www.projectinvictus.it/alcol-bodybuilding-palestra/


Excessive alcohol use leads to liver toxicity

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...


Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases

Alcoholism and Vertigo - Rehab Recovery


Long term use can cause erectile dysfunction

https://www.numan.com/erectile-dysf...ffects of alcohol,on your journey to recovery.


Dosage


Alcohol takes about 10 minutes to kick in and lasts for 12 hours

You should take around 6 standard units

The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.


Conclusion

In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding


Baclofen

How it works/ biology

Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.


IMG_7588.jpeg



Benefits

It’s very bioavailable


In addition it’s been proven to make you less anxious

https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449


In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.


It’s also not liver toxic

Baclofen - LiverTox - NCBI Bookshelf


Side effects

It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.

Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage


It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.


Some people may experience erectile dysfunction

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...


Dosage

Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours

You should take 50 mg

The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.

However it’s easy to overdose so keep the dosage on below 50 mg

In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.


Conclusion

A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects


Propranolol

How it works/ biology


Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response

IMG_7594.jpeg


Benefits


Extremely good at lowering anxiety

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...


Very low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox


Side effects

headaches

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

Dizziness

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk

https://healthmatch.io/erectile-dysfunction/propranolol-erectile-dysfunction

Decreases blood pressure

Propranolol (oral route) - Side effects & dosage - Mayo Clinic


Dosage


Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours

You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect

The long term use-

it’s not addictive

Propranolol (Inderal) - MentalHealth.com


Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do


Conclusion

If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.


Phenibut

How it works/ biology

It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm


IMG_7591.jpeg


Benefits


Improves mood

Phenibut: A Guide to History, Side Effects & Risk of Addiction


Works well in tandem with other low inhib drugs to extend the duration of their effects

Phenibut - Wikipedia


Side effects

Bad bioavailability

Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”


Liver damage

https://balancerehabclinic.com/phen...endence: In the long,when not taking the drug.


Extreme withdrawal symptoms - most extreme on the list

https://pmc.ncbi.nlm.nih.gov/articles/PMC10323501/


Dosage


Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours

You should take 1-3 g

The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.

https://pmc.ncbi.nlm.nih.gov/articl...butyric acid) is,nausea/vomiting, and tremors.


Conclusion

Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible


Xanax

How it works/ biology


It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression

IMG_7590.jpeg




Benefits

Good bioavailability

Alprazolam - StatPearls - NCBI Bookshelf


Very good for anxiety (duh), it’s also the most powerful drug on the list

National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...


Side effects

Harmful to the liver (not as much as alcohol though)

https://www.ncbi.nlm.nih.gov/books/...monly associated,their lack of hepatic injury.


Can’t be stacked as it makes it dependence greater

https://blackbearrehab.com/substanc...ties, unconsciousness and unintentional death.


Drowsiness and fatigue and similar (but less severe effects as being drunk)

https://www.healthline.com/health/d... is a mild side,some people may have diarrhea.


Erectile dysfunction is possible

https://www.healthline.com/health/d... is a mild side,some people may have diarrhea.


Dosage


Xanax takes just under an hour to kick in and lasts for 8 hours

You should take 0.5-1.0 mg

The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine


Conclusion

Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax


Conclusion

You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible


@Copercel @Sadist @Zagro @FlotPSL @MaracasMogs
 

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Intro

Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.


Pregabalin

How it works/ biology

Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.

View attachment 4133063


Benefits


It's very orally bioavailable (around 90%, less affected by food etc).

Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.

The study shows it cures 90% of anxiety


https://pubmed.ncbi.nlm.nih.gov/12611835/

Does pregabalin offer potential as a first-line therapy for generalized anxiety ...


However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol


In addition it is quite liver friendly and has low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox


Due to its low amount of side effects it’s a good stacking drug as well


Side effects

A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist

Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage


Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored

Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?


Could cause erectile dysfunction if you’re abusing it

https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult


Dosage

Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.

You should take around 150-300 mg.

The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.


Conclusion

In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.



Alcohol

How it works/ biology

Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions

View attachment 4133064


Benefits

It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...


It’s also very socially acceptable and you can even be encouraged to do it in public

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use


It’s a diuretic, it’s a mild diuretic which can reduce water retention.

https://www.nidirect.gov.uk/articles/what-happens-when-you-drink-alcohol#:~:text=There is no immediate way,Types of drink


Side effects


Reduces your gym gains

https://www.projectinvictus.it/alcol-bodybuilding-palestra/


Excessive alcohol use leads to liver toxicity

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...


Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases

Alcoholism and Vertigo - Rehab Recovery


Long term use can cause erectile dysfunction

https://www.numan.com/erectile-dysfunction/causes/does-alcohol-cause-erectile-dysfunction#:~:text=Long-term effects of alcohol,on your journey to recovery.


Dosage


Alcohol takes about 10 minutes to kick in and lasts for 12 hours

You should take around 6 standard units

The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.


Conclusion

In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding



Baclofen

How it works/ biology

Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.


View attachment 4133065


Benefits

It’s very bioavailable


In addition it’s been proven to make you less anxious

https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449


In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.


It’s also not liver toxic

Baclofen - LiverTox - NCBI Bookshelf


Side effects

It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.

Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage


It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.


Some people may experience erectile dysfunction

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...


Dosage

Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours

You should take 50 mg

The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.

However it’s easy to overdose so keep the dosage on below 50 mg

In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.


Conclusion

A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects



Propranolol

How it works/ biology


Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response

View attachment 4133068

Benefits


Extremely good at lowering anxiety

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...


Very low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox


Side effects

headaches

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

Dizziness

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk

https://healthmatch.io/erectile-dysfunction/propranolol-erectile-dysfunction

Decreases blood pressure

Propranolol (oral route) - Side effects & dosage - Mayo Clinic


Dosage


Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours

You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect

The long term use-

it’s not addictive

Propranolol (Inderal) - MentalHealth.com


Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do


Conclusion

If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.



Phenibut

How it works/ biology

It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm


View attachment 4133066

Benefits


Improves mood

Phenibut: A Guide to History, Side Effects & Risk of Addiction


Works well in tandem with other low inhib drugs to extend the duration of their effects

Phenibut - Wikipedia


Side effects

Bad bioavailability

Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”


Liver damage

https://balancerehabclinic.com/phenibut-addiction/#:~:text=Physical dependence: In the long,when not taking the drug.


Extreme withdrawal symptoms - most extreme on the list

https://pmc.ncbi.nlm.nih.gov/articles/PMC10323501/


Dosage


Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours

You should take 1-3 g

The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5952553/#:~:text=Phenibut (β-phenyl-γ-aminobutyric acid) is,nausea/vomiting, and tremors.


Conclusion

Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible



Xanax

How it works/ biology


It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression

View attachment 4133067



Benefits

Good bioavailability

Alprazolam - StatPearls - NCBI Bookshelf


Very good for anxiety (duh), it’s also the most powerful drug on the list

National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...


Side effects

Harmful to the liver (not as much as alcohol though)

https://www.ncbi.nlm.nih.gov/books/NBK548298/#:~:text=Benzodiazepine therapy is uncommonly associated,their lack of hepatic injury.


Can’t be stacked as it makes it dependence greater

https://blackbearrehab.com/substance-abuse/xanax-addiction/mix-xanax-drugs-alcohol/#:~:text=Combining drugs can augment the,difficulties, unconsciousness and unintentional death.


Drowsiness and fatigue and similar (but less severe effects as being drunk)

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Erectile dysfunction is possible

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Dosage


Xanax takes just under an hour to kick in and lasts for 8 hours

You should take 0.5-1.0 mg

The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine


Conclusion

Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax



Conclusion

You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible

@Copercel @Sadist @Zagro @FlotPSL @MaracasMogs
how is bro doing that much high iq threads :feelshmm:

BRO GOT UNBANNED :love:
 
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Tagging 5 others (mods don’t ban me :feelswah:)
@chadisbeingmade @edodalic29 @ybuyhgui @Lars2 @BigBallsLarry
 
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Intro

Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.


Pregabalin

How it works/ biology

Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.

View attachment 4133063


Benefits


It's very orally bioavailable (around 90%, less affected by food etc).

Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.

The study shows it cures 90% of anxiety


https://pubmed.ncbi.nlm.nih.gov/12611835/

Does pregabalin offer potential as a first-line therapy for generalized anxiety ...


However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol


In addition it is quite liver friendly and has low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox


Due to its low amount of side effects it’s a good stacking drug as well


Side effects

A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist

Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage


Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored

Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?


Could cause erectile dysfunction if you’re abusing it

https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult


Dosage

Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.

You should take around 150-300 mg.

The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.


Conclusion

In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.



Alcohol

How it works/ biology

Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions

View attachment 4133064


Benefits

It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...


It’s also very socially acceptable and you can even be encouraged to do it in public

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use


It’s a diuretic, it’s a mild diuretic which can reduce water retention.

https://www.nidirect.gov.uk/articles/what-happens-when-you-drink-alcohol#:~:text=There is no immediate way,Types of drink


Side effects


Reduces your gym gains

https://www.projectinvictus.it/alcol-bodybuilding-palestra/


Excessive alcohol use leads to liver toxicity

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...


Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases

Alcoholism and Vertigo - Rehab Recovery


Long term use can cause erectile dysfunction

https://www.numan.com/erectile-dysfunction/causes/does-alcohol-cause-erectile-dysfunction#:~:text=Long-term effects of alcohol,on your journey to recovery.


Dosage


Alcohol takes about 10 minutes to kick in and lasts for 12 hours

You should take around 6 standard units

The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.


Conclusion

In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding



Baclofen

How it works/ biology

Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.


View attachment 4133065


Benefits

It’s very bioavailable


In addition it’s been proven to make you less anxious

https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449


In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.


It’s also not liver toxic

Baclofen - LiverTox - NCBI Bookshelf


Side effects

It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.

Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage


It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.


Some people may experience erectile dysfunction

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...


Dosage

Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours

You should take 50 mg

The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.

However it’s easy to overdose so keep the dosage on below 50 mg

In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.


Conclusion

A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects



Propranolol

How it works/ biology


Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response

View attachment 4133068

Benefits


Extremely good at lowering anxiety

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...


Very low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox


Side effects

headaches

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

Dizziness

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk

https://healthmatch.io/erectile-dysfunction/propranolol-erectile-dysfunction

Decreases blood pressure

Propranolol (oral route) - Side effects & dosage - Mayo Clinic


Dosage


Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours

You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect

The long term use-

it’s not addictive

Propranolol (Inderal) - MentalHealth.com


Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do


Conclusion

If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.



Phenibut

How it works/ biology

It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm


View attachment 4133066

Benefits


Improves mood

Phenibut: A Guide to History, Side Effects & Risk of Addiction


Works well in tandem with other low inhib drugs to extend the duration of their effects

Phenibut - Wikipedia


Side effects

Bad bioavailability

Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”


Liver damage

https://balancerehabclinic.com/phenibut-addiction/#:~:text=Physical dependence: In the long,when not taking the drug.


Extreme withdrawal symptoms - most extreme on the list

https://pmc.ncbi.nlm.nih.gov/articles/PMC10323501/


Dosage


Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours

You should take 1-3 g

The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5952553/#:~:text=Phenibut (β-phenyl-γ-aminobutyric acid) is,nausea/vomiting, and tremors.


Conclusion

Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible



Xanax

How it works/ biology


It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression

View attachment 4133067



Benefits

Good bioavailability

Alprazolam - StatPearls - NCBI Bookshelf


Very good for anxiety (duh), it’s also the most powerful drug on the list

National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...


Side effects

Harmful to the liver (not as much as alcohol though)

https://www.ncbi.nlm.nih.gov/books/NBK548298/#:~:text=Benzodiazepine therapy is uncommonly associated,their lack of hepatic injury.


Can’t be stacked as it makes it dependence greater

https://blackbearrehab.com/substance-abuse/xanax-addiction/mix-xanax-drugs-alcohol/#:~:text=Combining drugs can augment the,difficulties, unconsciousness and unintentional death.


Drowsiness and fatigue and similar (but less severe effects as being drunk)

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Erectile dysfunction is possible

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Dosage


Xanax takes just under an hour to kick in and lasts for 8 hours

You should take 0.5-1.0 mg

The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine


Conclusion

Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax



Conclusion

You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible

@Copercel @Sadist @Zagro @FlotPSL @MaracasMogs
just smoke weed brah
 
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over for highinhibcels
 
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Propranolol is a jewish scam btw that shit does nothing

pregab + baclofen is legit though, but it removes some of my nt charisma
 
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drink before meeting a girl i know a few guys who do that.
 
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How are you making these guides so fast :feelswat:

IMG 3435


(You were right about this gif @Daddy's Home )
 
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In addition it’s got a weird synergy with pregab and they work reportedly insanely well together.
Tried 150mg Pregab + 50mg Baclofen before school and it obliterated my anxiety. It will leave you feeling like shit in the afternoon though. I was falling asleep by period 6.

SSRI’s are also good for anxiety. Propranolol is kind of trash for me as it only deals with physical symptoms not psychological
 
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Tried 150mg Pregab + 50mg Baclofen before school and it obliterated my anxiety. It will leave you feeling like shit in the afternoon though. I was falling asleep by period 6.
nigga needs inhibition drugs to make it through the school day jfl
 
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just alcoholmax
 
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nigga needs inhibition drugs to make it through the school day jfl
i don’t anymore jfl
all i take now is caffeine and l theanine (soft)
 
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@SlayerJonas thoughts?
 
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Intro

Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.


Pregabalin

How it works/ biology

Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.

View attachment 4133063


Benefits


It's very orally bioavailable (around 90%, less affected by food etc).

Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.

The study shows it cures 90% of anxiety


https://pubmed.ncbi.nlm.nih.gov/12611835/

Does pregabalin offer potential as a first-line therapy for generalized anxiety ...


However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol


In addition it is quite liver friendly and has low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox


Due to its low amount of side effects it’s a good stacking drug as well


Side effects

A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist

Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage


Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored

Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?


Could cause erectile dysfunction if you’re abusing it

https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult


Dosage

Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.

You should take around 150-300 mg.

The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.


Conclusion

In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.



Alcohol

How it works/ biology

Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions

View attachment 4133064


Benefits

It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...


It’s also very socially acceptable and you can even be encouraged to do it in public

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use


It’s a diuretic, it’s a mild diuretic which can reduce water retention.

https://www.nidirect.gov.uk/articles/what-happens-when-you-drink-alcohol#:~:text=There is no immediate way,Types of drink


Side effects


Reduces your gym gains

https://www.projectinvictus.it/alcol-bodybuilding-palestra/


Excessive alcohol use leads to liver toxicity

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...


Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases

Alcoholism and Vertigo - Rehab Recovery


Long term use can cause erectile dysfunction

https://www.numan.com/erectile-dysfunction/causes/does-alcohol-cause-erectile-dysfunction#:~:text=Long-term effects of alcohol,on your journey to recovery.


Dosage


Alcohol takes about 10 minutes to kick in and lasts for 12 hours

You should take around 6 standard units

The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.


Conclusion

In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding



Baclofen

How it works/ biology

Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.


View attachment 4133065


Benefits

It’s very bioavailable


In addition it’s been proven to make you less anxious

https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449


In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.


It’s also not liver toxic

Baclofen - LiverTox - NCBI Bookshelf


Side effects

It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.

Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage


It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.


Some people may experience erectile dysfunction

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...


Dosage

Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours

You should take 50 mg

The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.

However it’s easy to overdose so keep the dosage on below 50 mg

In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.


Conclusion

A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects



Propranolol

How it works/ biology


Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response

View attachment 4133068

Benefits


Extremely good at lowering anxiety

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...


Very low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox


Side effects

headaches

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

Dizziness

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk

https://healthmatch.io/erectile-dysfunction/propranolol-erectile-dysfunction

Decreases blood pressure

Propranolol (oral route) - Side effects & dosage - Mayo Clinic


Dosage


Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours

You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect

The long term use-

it’s not addictive

Propranolol (Inderal) - MentalHealth.com


Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do


Conclusion

If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.



Phenibut

How it works/ biology

It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm


View attachment 4133066

Benefits


Improves mood

Phenibut: A Guide to History, Side Effects & Risk of Addiction


Works well in tandem with other low inhib drugs to extend the duration of their effects

Phenibut - Wikipedia


Side effects

Bad bioavailability

Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”


Liver damage

https://balancerehabclinic.com/phenibut-addiction/#:~:text=Physical dependence: In the long,when not taking the drug.


Extreme withdrawal symptoms - most extreme on the list

https://pmc.ncbi.nlm.nih.gov/articles/PMC10323501/


Dosage


Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours

You should take 1-3 g

The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5952553/#:~:text=Phenibut (β-phenyl-γ-aminobutyric acid) is,nausea/vomiting, and tremors.


Conclusion

Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible



Xanax

How it works/ biology


It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression

View attachment 4133067



Benefits

Good bioavailability

Alprazolam - StatPearls - NCBI Bookshelf


Very good for anxiety (duh), it’s also the most powerful drug on the list

National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...


Side effects

Harmful to the liver (not as much as alcohol though)

https://www.ncbi.nlm.nih.gov/books/NBK548298/#:~:text=Benzodiazepine therapy is uncommonly associated,their lack of hepatic injury.


Can’t be stacked as it makes it dependence greater

https://blackbearrehab.com/substance-abuse/xanax-addiction/mix-xanax-drugs-alcohol/#:~:text=Combining drugs can augment the,difficulties, unconsciousness and unintentional death.


Drowsiness and fatigue and similar (but less severe effects as being drunk)

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Erectile dysfunction is possible

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Dosage


Xanax takes just under an hour to kick in and lasts for 8 hours

You should take 0.5-1.0 mg

The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine


Conclusion

Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax



Conclusion

You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible

@Copercel @Sadist @Zagro @FlotPSL @MaracasMogs
BOTB ASF!!!
 
@Aryan Incel so glad ur back bhai
 
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Reactions: Aryan Incel
Intro

Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.


Pregabalin

How it works/ biology

Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.

View attachment 4133063


Benefits


It's very orally bioavailable (around 90%, less affected by food etc).

Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.

The study shows it cures 90% of anxiety


https://pubmed.ncbi.nlm.nih.gov/12611835/

Does pregabalin offer potential as a first-line therapy for generalized anxiety ...


However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol


In addition it is quite liver friendly and has low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox


Due to its low amount of side effects it’s a good stacking drug as well


Side effects

A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist

Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage


Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored

Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?


Could cause erectile dysfunction if you’re abusing it

https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult


Dosage

Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.

You should take around 150-300 mg.

The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.


Conclusion

In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.



Alcohol

How it works/ biology

Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions

View attachment 4133064


Benefits

It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...


It’s also very socially acceptable and you can even be encouraged to do it in public

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use


It’s a diuretic, it’s a mild diuretic which can reduce water retention.

https://www.nidirect.gov.uk/articles/what-happens-when-you-drink-alcohol#:~:text=There is no immediate way,Types of drink


Side effects


Reduces your gym gains

https://www.projectinvictus.it/alcol-bodybuilding-palestra/


Excessive alcohol use leads to liver toxicity

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...


Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases

Alcoholism and Vertigo - Rehab Recovery


Long term use can cause erectile dysfunction

https://www.numan.com/erectile-dysfunction/causes/does-alcohol-cause-erectile-dysfunction#:~:text=Long-term effects of alcohol,on your journey to recovery.


Dosage


Alcohol takes about 10 minutes to kick in and lasts for 12 hours

You should take around 6 standard units

The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.


Conclusion

In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding



Baclofen

How it works/ biology

Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.


View attachment 4133065


Benefits

It’s very bioavailable


In addition it’s been proven to make you less anxious

https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449


In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.


It’s also not liver toxic

Baclofen - LiverTox - NCBI Bookshelf


Side effects

It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.

Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage


It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.


Some people may experience erectile dysfunction

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...


Dosage

Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours

You should take 50 mg

The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.

However it’s easy to overdose so keep the dosage on below 50 mg

In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.


Conclusion

A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects



Propranolol

How it works/ biology


Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response

View attachment 4133068

Benefits


Extremely good at lowering anxiety

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...


Very low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox


Side effects

headaches

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

Dizziness

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk

https://healthmatch.io/erectile-dysfunction/propranolol-erectile-dysfunction

Decreases blood pressure

Propranolol (oral route) - Side effects & dosage - Mayo Clinic


Dosage


Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours

You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect

The long term use-

it’s not addictive

Propranolol (Inderal) - MentalHealth.com


Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do


Conclusion

If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.



Phenibut

How it works/ biology

It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm


View attachment 4133066

Benefits


Improves mood

Phenibut: A Guide to History, Side Effects & Risk of Addiction


Works well in tandem with other low inhib drugs to extend the duration of their effects

Phenibut - Wikipedia


Side effects

Bad bioavailability

Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”


Liver damage

https://balancerehabclinic.com/phenibut-addiction/#:~:text=Physical dependence: In the long,when not taking the drug.


Extreme withdrawal symptoms - most extreme on the list

https://pmc.ncbi.nlm.nih.gov/articles/PMC10323501/


Dosage


Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours

You should take 1-3 g

The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5952553/#:~:text=Phenibut (β-phenyl-γ-aminobutyric acid) is,nausea/vomiting, and tremors.


Conclusion

Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible



Xanax

How it works/ biology


It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression

View attachment 4133067



Benefits

Good bioavailability

Alprazolam - StatPearls - NCBI Bookshelf


Very good for anxiety (duh), it’s also the most powerful drug on the list

National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...


Side effects

Harmful to the liver (not as much as alcohol though)

https://www.ncbi.nlm.nih.gov/books/NBK548298/#:~:text=Benzodiazepine therapy is uncommonly associated,their lack of hepatic injury.


Can’t be stacked as it makes it dependence greater

https://blackbearrehab.com/substance-abuse/xanax-addiction/mix-xanax-drugs-alcohol/#:~:text=Combining drugs can augment the,difficulties, unconsciousness and unintentional death.


Drowsiness and fatigue and similar (but less severe effects as being drunk)

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Erectile dysfunction is possible

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Dosage


Xanax takes just under an hour to kick in and lasts for 8 hours

You should take 0.5-1.0 mg

The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine


Conclusion

Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax



Conclusion

You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible

@Copercel @Sadist @Zagro @FlotPSL @MaracasMogs
Dnr js take 2mg xanax not that hard
 
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mirin. i heard gabapentin is good, some say it even mogs pregab:unsure:
 
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mirin. i heard gabapentin is good, some say it even mogs pregab:unsure:
It’s a decent alternative to pregab they are practically the same but I think fab takes a bit longer to kick in and less potent
 
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mirin. i heard gabapentin is good, some say it even mogs pregab:unsure:
Naw it’s not
Stole my moms Gabapentin and tried it
Simply made me feel nauseous and sleepy nothing else. Plus you will need to dose higher as it’s pretty weak.
Pregab is a better version of Gabapentin.
 
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Naw it’s not
Stole my moms Gabapentin and tried it
Simply made me feel nauseous and sleepy nothing else. Plus you will need to dose higher as it’s pretty weak.
Pregab is a better version of Gabapentin.
You need to take a lot of gab for it to kick in
 
Forgot to tag a couple people @Stacyslayerᛉ @iblamegenetics7681
 
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@menas @Jattgymmaxx @Daddy's Home @renos
 
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Intro

Imo 90% of this forum could get laid if they were low inhib and put themself out there. It may sound cringe but the normie saying ‘just be confident bro’ is sorta right. That’s why low inhibition drugs are in my top 5 best looksmaxes.


Pregabalin

How it works/ biology

Pregabalin works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels, which reduces the release of excitatory neurotransmitters like glutamate, substance-P, and norepinephrine in the brain and spinal cord. This action calms the overactive neuronal pathways in anxiety.

View attachment 4133063


Benefits


It's very orally bioavailable (around 90%, less affected by food etc).

Individual studies have shown a significant reduction in both the psychological and somatic symptoms of anxiety.

The study shows it cures 90% of anxiety


https://pubmed.ncbi.nlm.nih.gov/12611835/

Does pregabalin offer potential as a first-line therapy for generalized anxiety ...


However anecdotally the buzz/ high from pregab isn’t quite as good as something like alcohol


In addition it is quite liver friendly and has low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPregabalin - LiverTox


Due to its low amount of side effects it’s a good stacking drug as well


Side effects

A common side effect to pregablin is bloat/ water retention and weight , however this can be easily counter by a diuretic like furesomide or Epleronone and a glp 1 antagonist

Mayo Clinichttps://www.mayoclinic.orgPregabalin (oral route) - Side effects & dosage


Another is dizziness and drowsiness which isn’t too bad of a side effect and should probably be ignored

Drugs.comhttps://www.drugs.comDoes Lyrica (pregabalin) make you sleepy?


Could cause erectile dysfunction if you’re abusing it

https://pubmed.ncbi.nlm.nih.gov/30001248/#:~:text=Discontinuation of PGB resulted in,Young Adult


Dosage

Pregab takes about 1-3 hours to kick in and lasts for 5-7 hours.

You should take around 150-300 mg.

The long term use- it doesn’t really downregulate receptors compared to something like Phenibut but it still is quite addictive, that’s why you should only take it once or twice a week and lower doses.


Conclusion

In conclusion Pregablin is an all round good low inhib drug as it has small amount of side effects and its effectiveness. However should not be overused due to its withdrawal symptoms and should instead be used a maximum of 2 times a week.



Alcohol

How it works/ biology

Alcohol can provide temporary anxiety relief by affecting GABA and glutamate neurotransmitters, which calm the brain and slow its functions

View attachment 4133064


Benefits

It makes you less anxious, however your fear won’t reduce. So it’s not as good as pregab

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcohol selectively reduces anxiety but not fear: Startle response during ...


It’s also very socially acceptable and you can even be encouraged to do it in public

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSocial and Cultural Contexts of Alcohol Use


It’s a diuretic, it’s a mild diuretic which can reduce water retention.

https://www.nidirect.gov.uk/articles/what-happens-when-you-drink-alcohol#:~:text=There is no immediate way,Types of drink


Side effects


Reduces your gym gains

https://www.projectinvictus.it/alcol-bodybuilding-palestra/


Excessive alcohol use leads to liver toxicity

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govAlcoholic Liver Disease: Pathogenesis and Current ...


Another is dizziness and drowsiness and getting drunk which can be a lookism in some cases

Alcoholism and Vertigo - Rehab Recovery


Long term use can cause erectile dysfunction

https://www.numan.com/erectile-dysfunction/causes/does-alcohol-cause-erectile-dysfunction#:~:text=Long-term effects of alcohol,on your journey to recovery.


Dosage


Alcohol takes about 10 minutes to kick in and lasts for 12 hours

You should take around 6 standard units

The long term use- it initial alcohol consumption enhances inhibitory effects, but prolonged exposure leads to a decrease in receptor density or sensitivity. Similarly, alcohol consumption can lead to the down regulation of dopamine receptors which is linked to the development of alcohol use disorder. It’s quite addictive so I’d recommend using it as a one off like once a month.


Conclusion

In conclusion alcohol is a decent drug to lower inhibition however due to its side effects mainly the liver toxicity I’d recommend doing it infrequently especially if you’re roiding



Baclofen

How it works/ biology

Baclofen works for anxiety primarily by activating the brain's GABA-B receptors, which results in a calming effect on the central nervous system.


View attachment 4133065


Benefits

It’s very bioavailable


In addition it’s been proven to make you less anxious

https://www.sciencedirect.com/science/article/abs/pii/S0924977X21001449


In addition anecdotal evidence has shown that the high/ buzz is similar to alcohol.


It’s also not liver toxic

Baclofen - LiverTox - NCBI Bookshelf


Side effects

It’s got extreme drowsiness effect that’s why you have to take something like caffeine pills to stay awake.

Mayo Clinichttps://www.mayoclinic.orgBaclofen (oral route) - Side effects & dosage


It also has a similar effect to being drunk so it could be awkward explaining why you’re acting this way to friends etc if you use it in the daytimes and not nights out.


Some people may experience erectile dysfunction

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govSexual Dysfunction Associated With Intrathecal Baclofen Use: A Report ...


Dosage

Baclofen takes 1-2 hours to kick in and lasts for 2-4 hours

You should take 50 mg

The long term use- far less down-regulation and addiction potential compared with the other two compounds, you could potentially take it everyday if you wanted however I’d not recommend due to the side effect of acting drunk.

However it’s easy to overdose so keep the dosage on below 50 mg

In addition it’s got a weird synergy with pregab and they work reportedly insanely well together. However this is just anecdotal evidence and not being properly studied yet.


Conclusion

A good low inhib drug especially when combined with pregab. It would be a ‘safer’ alcohol alternative is used by its self. However I don’t recommend using unless on nights out due to it’s short time duration and adverse side effects



Propranolol

How it works/ biology


Propranolol is a non selective beta blocker that works by blocking the effects of adrenaline and noradrenaline on the heart and other organs, preventing them from binding to beta-1 and beta-2 adrenergic receptors. By blocking these receptors, propranolol slows the heart rate, decreases the force of heart contractions, and relaxes blood vessels, which lowers blood pressure and the heart's workload, leading to a reduction in the physical symptoms of the "fight-or-flight" response

View attachment 4133068

Benefits


Extremely good at lowering anxiety

National Institutes of Health (NIH) | (.gov)https://pmc.ncbi.nlm.nih.govPropranolol for the treatment of anxiety disorders: Systematic review and ...


Very low liver toxicity

National Institutes of Health (NIH) | (.gov)https://www.ncbi.nlm.nih.govPropranolol - LiverTox


Side effects

headaches

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

Dizziness

Propranolol (oral route) - Side effects & dosage - Mayo Clinic

cause erectile dysfunction (ED) in some men, although the relationship isn't always confirmed and may be dose-dependent, with higher doses potentially increasing risk

https://healthmatch.io/erectile-dysfunction/propranolol-erectile-dysfunction

Decreases blood pressure

Propranolol (oral route) - Side effects & dosage - Mayo Clinic


Dosage


Propranolol takes 1-2 hours to kick in and lasts for 8-12 hours

You should take 40 mg daily but take it in two doses (20mg x2) e.g. one in the morning other at lunch. For bets effect

The long term use-

it’s not addictive

Propranolol (Inderal) - MentalHealth.com


Because it doesn't interact with the brain's reward system, which is the primary mechanism behind addiction. Instead of creating pleasurable or euphoric feelings that drugs like cocaine or heroin do


Conclusion

If you have any signs of high inhib you should take propranolol twice a day unless you have low blood pressure and it’s a no brainer. It’s probably one of the most underrated looksmaxxing drug.



Phenibut

How it works/ biology

It’s a drug that reduces anxiety by acting as a depressant on the central nervous system. It is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is the brain's main inhibitory chemical. By mimicking and enhancing GABA's effects, phenibut decreases the overall excitability of nerve cells in the brain, inducing a sense of calm


View attachment 4133066

Benefits


Improves mood

Phenibut: A Guide to History, Side Effects & Risk of Addiction


Works well in tandem with other low inhib drugs to extend the duration of their effects

Phenibut - Wikipedia


Side effects

Bad bioavailability

Wiley Online Libraryhttps://onlinelibrary.wiley.comPhenibut: A drug with one too many “buts”


Liver damage

https://balancerehabclinic.com/phenibut-addiction/#:~:text=Physical dependence: In the long,when not taking the drug.


Extreme withdrawal symptoms - most extreme on the list

https://pmc.ncbi.nlm.nih.gov/articles/PMC10323501/


Dosage


Phenibut takes 1-2 hour to kick in and lasts for 15-24 hours

You should take 1-3 g

The long term use- Phenibut is biologically extremely addictive because it modifies key neural pathways, primarily by acting as a strong agonist for the inhibitory GABA-B receptors and blocking voltage-gated calcium channels (VGCCs). This neurochemical interference leads to physical dependence, rapid tolerance, and severe withdrawal symptoms upon cessation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5952553/#:~:text=Phenibut (β-phenyl-γ-aminobutyric acid) is,nausea/vomiting, and tremors.


Conclusion

Phenibut could’ve been very good because of its stacking abilite. However due to how toxic and addictive it is you should stay as far away from it as possible



Xanax

How it works/ biology


It works by binding to the benzodiazepine derivatives site on the GABA A receptor to enhance the affinity of channel opening by the agonist gamma-Aminobutyric acid (GABA), which leads to central nervous system depression

View attachment 4133067



Benefits

Good bioavailability

Alprazolam - StatPearls - NCBI Bookshelf


Very good for anxiety (duh), it’s also the most powerful drug on the list

National Institutes of Health (NIH) | (.gov)https://pubmed.ncbi.nlm.nih.govAlprazolam in the treatment of generalized anxiety and panic ...


Side effects

Harmful to the liver (not as much as alcohol though)

https://www.ncbi.nlm.nih.gov/books/NBK548298/#:~:text=Benzodiazepine therapy is uncommonly associated,their lack of hepatic injury.


Can’t be stacked as it makes it dependence greater

https://blackbearrehab.com/substance-abuse/xanax-addiction/mix-xanax-drugs-alcohol/#:~:text=Combining drugs can augment the,difficulties, unconsciousness and unintentional death.


Drowsiness and fatigue and similar (but less severe effects as being drunk)

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Erectile dysfunction is possible

https://www.healthline.com/health/drugs/xanax-side-effects#:~:text=Constipation is a mild side,some people may have diarrhea.


Dosage


Xanax takes just under an hour to kick in and lasts for 8 hours

You should take 0.5-1.0 mg

The long term use- downregulation and desensitization ofGABA-A receptors with chronic use, where the brain reduces the number of available receptors to compensate for the drug's presence. This adaptive process contributes to the development of tolerance, where higher doses are needed for the same effect, and is a key mechanism in benzodiazepine


Conclusion

Although Xanax probably is the most effective drug to lower inhibition in this thread it’s downsides like how it’s highly addictive vastly outweighs the slight upsides that is why I wouldn’t recommend Xanax



Conclusion

You should take propranolol twice a day (2x 20 mg) in addition to a combination of 150-300 mg of Pregabalin with 50 mg Baclofen before a big event but only a maximum of twice a week. If you can’t get anything else and are stuck with only being able to use alcohol you should use it but try to do so as infrequently as possible

@Copercel @Sadist @Zagro @FlotPSL @MaracasMogs
@menas @Jattgymmaxx @Daddy's Home @renos
Mirin I need pregab source :cop:
 
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