HOW TO DOSE METFORMIN PROPERLY FOR BONE GROWTH PRE GROWTH PLATE CLOSURE

[jotunnr]

SOURCE: https://pubmed.ncbi.nlm.nih.gov/36166694/

Metformin's been shown to induce the autophagic degradation of RUNX2, which is CRUCIAL for osteogenesis and is upregulated at sites of calcification, a process that highly resembles physiological bone formation

HOW TO PROPERLY DOSE THIS WITHOUT GETTING ASSFUCKED BY THE SIDE EFFECTS:
500mg orally twice a day and titrate up from there

"Bu-but muh bloating! Lactic acidosis!" shut the fuck up ajnd pop an epl, most ur getting out of this is a headache

not saying this is gonna give u mms of bone mass but metformin costs like 2 cents with minimal side effects, might be sum worth trying

 

[maTTeoguarino]

eat dih

 

[TheOsei]

SOURCE: https://pubmed.ncbi.nlm.nih.gov/36166694/

Metformin's been shown to induce the autophagic degradation of RUNX2, which is CRUCIAL for osteogenesis and is upregulated at sites of calcification, a process that highly resembles physiological bone formation

HOW TO PROPERLY DOSE THIS WITHOUT GETTING ASSFUCKED BY THE SIDE EFFECTS:
500mg orally twice a day and titrate up from there

"Bu-but muh bloating! Lactic acidosis!" shut the fuck up ajnd pop an epl, most ur getting out of this is a headache

not saying this is gonna give u mms of bone mass but metformin costs like 2 cents with minimal side effects, might be sum worth trying

"degrades runx2!"

"will increase bonemass!"

brudda

 

[jotunnr]

"degrades runx2!"

"will increase bonemass!"

brudda

read the fucking study mate

it decreases it in VASCULAR SMOOTH CELLS

 

[ghost!]

i’ll try it hopefully it won’t fuck me up

 

[TheOsei]

read the fucking study mate

it decreases it in VASCULAR SMOOTH CELLS

does not matter

still shown not beneficial