HOW TO GET RID OF GYNECOMASTIA: INTRO INTO RALOXIFENE

[Miki]

GUIDE TO RALOXIFENE: HOW TO GET RID OF GYNECOMASTIA
To those of you struggling to get rid of gynecomastia aka 'man boobs', there may be a pharmaceutical option to help reduce and get rid of stubborn breast tissue so you lose that puffy chest and it returns fo normal size. This pharmaceutical being raloxifene

What is Raloxifene:

Raloxifene is a selective estrogen receptor modulator, a compound that has estrogen agonist activity at some sites and antagonist activity at others. In Breast and Uterine Tissue (Antagonism): The disrupted helix 12 configuration prevents the recruitment of key coactivators (such as the steroid receptor coactivator-1, SRC-1). Instead, it promotes the recruitment of corepressors (like NCoR or SMRT). This halts the transcription of oestrogen-responsive genes, preventing cellular proliferation and blocking oestrogen-dependent cell division

Citations: Seeman E. Raloxifene. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK, et al. Cell. 1998;95(7):927-937. (For the physical 1ERR crystal structure forcing Helix 12 out of alignment).Shang Y, Brown M. Science. 2002;295(5564):2465-2468. (For the tissue-specific recruitment of NCoR/SMRT over SRC-1 in breast cells to stop division). [1, 2, 3]

But what does this actually mean in simpler terms:

Raloxifene acts as an estrogen antagonist. It blocks estrogen from stimulating breast tissue, which lowers the risk of invasive breast cancer in high-risk postmenopausal women but can also reduce gynecomastia tissue quite substantially (gynecomastia is enlargement of breast glandular tissue in males)

Study to back this up:

Objectives: To assess the efficacy of the anti-estrogens raloxifen in the medical management of persistent pubertal gynecomastia.
Study design: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (Raloxifene).
Results: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Improvement was seen in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%). No side effects were seen in any patients.
Conclusion: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia.

Citations: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr. 2004 Jul;145(1):71-6. doi: 10.1016/j.jpeds.2004.03.057. PMID: 15238910.
– DISCLAIMER: This study also features tamoxifen however my main focus here is on the effects of raloxifene as I will be ordering this soon so I will eventually be able to provide anecdotal evidence.

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

Potential side effects: Hot flashes, leg cramps, joint pain and in rarer instances blood clots as there is also an increased risk of deep vein thrombosis.

Just a little guide, used some ai for the explanations to use correct vocabulary to help me out. Please tag friends to inform them about this and make my miniguide more popular.

@polonaecel @chris34 @sanguine @Cinnamon fan64 @true.perso.chad @dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem @nellii

 

[Miki]

Bump

 

[true.perso.chad]

GUIDE TO RALOXIFENE: HOW TO GET RID OF GYNECOMASTIA
To those of you struggling to get rid of gynecomastia aka 'man boobs', there may be a pharmaceutical option to help reduce and get rid of stubborn breast tissue so you lose that puffy chest and it returns fo normal size. This pharmaceutical being raloxifene

What is Raloxifene:

Raloxifene is a selective estrogen receptor modulator, a compound that has estrogen agonist activity at some sites and antagonist activity at others. In Breast and Uterine Tissue (Antagonism): The disrupted helix 12 configuration prevents the recruitment of key coactivators (such as the steroid receptor coactivator-1, SRC-1). Instead, it promotes the recruitment of corepressors (like NCoR or SMRT). This halts the transcription of oestrogen-responsive genes, preventing cellular proliferation and blocking oestrogen-dependent cell division

Citations: Seeman E. Raloxifene. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK, et al. Cell. 1998;95(7):927-937. (For the physical 1ERR crystal structure forcing Helix 12 out of alignment).Shang Y, Brown M. Science. 2002;295(5564):2465-2468. (For the tissue-specific recruitment of NCoR/SMRT over SRC-1 in breast cells to stop division). [1, 2, 3]

But what does this actually mean in simpler terms:

Raloxifene acts as an estrogen antagonist. It blocks estrogen from stimulating breast tissue, which lowers the risk of invasive breast cancer in high-risk postmenopausal women but can also reduce gynecomastia tissue quite substantially (gynecomastia is enlargement of breast glandular tissue in males)

Study to back this up:

Objectives: To assess the efficacy of the anti-estrogens raloxifen in the medical management of persistent pubertal gynecomastia.
Study design: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (Raloxifene).
Results: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Improvement was seen in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%). No side effects were seen in any patients.
Conclusion: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia.

Citations: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr. 2004 Jul;145(1):71-6. doi: 10.1016/j.jpeds.2004.03.057. PMID: 15238910.
– DISCLAIMER: This study also features tamoxifen however my main focus here is on the effects of raloxifene as I will be ordering this soon so I will eventually be able to provide anecdotal evidence.

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

Potential side effects: Hot flashes, leg cramps, joint pain and in rarer instances blood clots as there is also an increased risk of deep vein thrombosis.

Just a little guide, used some ai for the explanations to use correct vocabulary to help me out. Please tag friends to inform them about this and make my miniguide more popular.

@polonaecel @chris34 @sanguine @Cinnamon fan64 @true.perso.chad @dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem @nellii

w thread, thx for mention bhai + bump

 

[sziabattya]

TL;DR

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

good post tho i think

 

[xex]

couldn’t an AI accomplish this? anything that stops testosterone from aromatizing?

 

[sanguine]

only first 5 see the tags. so only me and the other first 4 people saw the mention. good post though

 

[Genio]

GUIDE TO RALOXIFENE: HOW TO GET RID OF GYNECOMASTIA
To those of you struggling to get rid of gynecomastia aka 'man boobs', there may be a pharmaceutical option to help reduce and get rid of stubborn breast tissue so you lose that puffy chest and it returns fo normal size. This pharmaceutical being raloxifene

What is Raloxifene:

Raloxifene is a selective estrogen receptor modulator, a compound that has estrogen agonist activity at some sites and antagonist activity at others. In Breast and Uterine Tissue (Antagonism): The disrupted helix 12 configuration prevents the recruitment of key coactivators (such as the steroid receptor coactivator-1, SRC-1). Instead, it promotes the recruitment of corepressors (like NCoR or SMRT). This halts the transcription of oestrogen-responsive genes, preventing cellular proliferation and blocking oestrogen-dependent cell division

Citations: Seeman E. Raloxifene. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK, et al. Cell. 1998;95(7):927-937. (For the physical 1ERR crystal structure forcing Helix 12 out of alignment).Shang Y, Brown M. Science. 2002;295(5564):2465-2468. (For the tissue-specific recruitment of NCoR/SMRT over SRC-1 in breast cells to stop division). [1, 2, 3]

But what does this actually mean in simpler terms:

Raloxifene acts as an estrogen antagonist. It blocks estrogen from stimulating breast tissue, which lowers the risk of invasive breast cancer in high-risk postmenopausal women but can also reduce gynecomastia tissue quite substantially (gynecomastia is enlargement of breast glandular tissue in males)

Study to back this up:

Objectives: To assess the efficacy of the anti-estrogens raloxifen in the medical management of persistent pubertal gynecomastia.
Study design: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (Raloxifene).
Results: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Improvement was seen in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%). No side effects were seen in any patients.
Conclusion: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia.

Citations: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr. 2004 Jul;145(1):71-6. doi: 10.1016/j.jpeds.2004.03.057. PMID: 15238910.
– DISCLAIMER: This study also features tamoxifen however my main focus here is on the effects of raloxifene as I will be ordering this soon so I will eventually be able to provide anecdotal evidence.

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

Potential side effects: Hot flashes, leg cramps, joint pain and in rarer instances blood clots as there is also an increased risk of deep vein thrombosis.

Just a little guide, used some ai for the explanations to use correct vocabulary to help me out. Please tag friends to inform them about this and make my miniguide more popular.

@polonaecel @chris34 @sanguine @Cinnamon fan64 @true.perso.chad @dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem @nellii

Would this work on Fibrotic Tissue?

I mean, SERM's (And many other Pharma) can prevent Gyno, but what if the Gyno is already set in place?

 

[cigcel]

Bump

 

[Miki]

only first 5 see the tags. so only me and the other first 4 people saw the mention. good post though

Should I mention them in comments then

 

[sanguine]

Should I mention them in comments then

yeah five at a time, you only tagged 10 so just do the last 5

 

[chris34]

Mirin bro, bumping and saving this

 

[volgaTz]

only have 9 tabs left need to order new ones asap

 

[Miki]

couldn’t an AI accomplish this? anything that stops testosterone from aromatizing?

AI is better for prevention, and AIs only work for this in some cases as they lower overall estrogen production whereas ralox binds to estrogen receptors in the breast which directly counters the gyno making it more effective

 

[Miki]

Would this work on Fibrotic Tissue?

I mean, SERM's (And many other Pharma) can prevent Gyno, but what if the Gyno is already set in place?

Can help but the effects are reduced i believe

 

[Miki]

Mirin bro, bumping and saving this

Thanks bhai

 

[Miki]

@dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem

 

[Miki]

@nellii

 

[Miki]

only have 9 tabs left need to order new ones asap

Where did you get it from, indiamart?

 

[Miki]

Bump

 

[nellii]

ty for the tag, high iq thread.
approved and bookmarked by nellii

 

[Miki]

ty for the tag, high iq thread.
approved and bookmarked by nellii

Thank you bro, very much appreciated means a lot

 

[160cmcurry]

nasty

gyno surgery’s an option too

 

[Miki]

nasty

gyno surgery’s an option too

Its like 3k per boob tho

 

[160cmcurry]

Its like 3k per boob tho

most people are better off shredding down first before getting surgery

not sure why so many fatties get it in the first place

probably confusing man boobs with gyno lol

 

[Miki]

most people are better off shredding down first before getting surgery

not sure why so many fatties get it in the first place

probably confusing man boobs with gyno lol

Yeah that's very true, shred wont help with hard rubbery tissue unfortunately

 

[dbdrFanboy]

Bump

 

[Miki]

Bump
View attachment 5202481

Thank yiu bro

 

[volgaTz]

Where did you get it from, indiamart?

yup indiamart triangle shipped to UK -> Germany

 

[socio]

Good thread bhai!

 

[Miki]

Good thread bhai!

Thanks man!

 

[Dio Brando]

Anything to watch out for in development on this other than basic aromatase and estrogen management related stuff.
Haven’t read while I’m posting this but still would appreciate a response reading now.

 

[Miki]

Anything to watch out for in development on this other than basic aromatase and estrogen management related stuff.
Haven’t read while I’m posting this but still would appreciate a response reading now.

Id say the significant increase in the risk of venous thromboembolism (VTE)

 

[heiwa]

GUIDE TO RALOXIFENE: HOW TO GET RID OF GYNECOMASTIA
To those of you struggling to get rid of gynecomastia aka 'man boobs', there may be a pharmaceutical option to help reduce and get rid of stubborn breast tissue so you lose that puffy chest and it returns fo normal size. This pharmaceutical being raloxifene

What is Raloxifene:

Raloxifene is a selective estrogen receptor modulator, a compound that has estrogen agonist activity at some sites and antagonist activity at others. In Breast and Uterine Tissue (Antagonism): The disrupted helix 12 configuration prevents the recruitment of key coactivators (such as the steroid receptor coactivator-1, SRC-1). Instead, it promotes the recruitment of corepressors (like NCoR or SMRT). This halts the transcription of oestrogen-responsive genes, preventing cellular proliferation and blocking oestrogen-dependent cell division

Citations: Seeman E. Raloxifene. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK, et al. Cell. 1998;95(7):927-937. (For the physical 1ERR crystal structure forcing Helix 12 out of alignment).Shang Y, Brown M. Science. 2002;295(5564):2465-2468. (For the tissue-specific recruitment of NCoR/SMRT over SRC-1 in breast cells to stop division). [1, 2, 3]

But what does this actually mean in simpler terms:

Raloxifene acts as an estrogen antagonist. It blocks estrogen from stimulating breast tissue, which lowers the risk of invasive breast cancer in high-risk postmenopausal women but can also reduce gynecomastia tissue quite substantially (gynecomastia is enlargement of breast glandular tissue in males)

Study to back this up:

Objectives: To assess the efficacy of the anti-estrogens raloxifen in the medical management of persistent pubertal gynecomastia.
Study design: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (Raloxifene).
Results: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Improvement was seen in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%). No side effects were seen in any patients.
Conclusion: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia.

Citations: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr. 2004 Jul;145(1):71-6. doi: 10.1016/j.jpeds.2004.03.057. PMID: 15238910.
– DISCLAIMER: This study also features tamoxifen however my main focus here is on the effects of raloxifene as I will be ordering this soon so I will eventually be able to provide anecdotal evidence.

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

Potential side effects: Hot flashes, leg cramps, joint pain and in rarer instances blood clots as there is also an increased risk of deep vein thrombosis.

Just a little guide, used some ai for the explanations to use correct vocabulary to help me out. Please tag friends to inform them about this and make my miniguide more popular.

@polonaecel @chris34 @sanguine @Cinnamon fan64 @true.perso.chad @dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem @nellii

bump
Only the first 5 got mentionned btw
good thread tho
(Do some formatting next please )

 

[Miki]

bump
Only the first 5 got mentionned btw
good thread tho
(Do some formatting next please )

Thanks man, yea I tagged the others in the comments after I was told. It's my first proper guide so formatting does need some work, you have any advice on how to structure it?

 

[heiwa]

Thanks man, yea I tagged the others in the comments after I was told. It's my first proper guide so formatting does need some work, you have any advice on how to structure it?

no sorry,
I have the same problem,
ask @Sayori he’s a good guy
@Nodal had good ones but he’s banned

 

[Miki]

no sorry,
I have the same problem,
ask @Sayori he’s a good guy
@Nodal had good ones but he’s banned

Great thanks man

 

[bluebandz]

GUIDE TO RALOXIFENE: HOW TO GET RID OF GYNECOMASTIA
To those of you struggling to get rid of gynecomastia aka 'man boobs', there may be a pharmaceutical option to help reduce and get rid of stubborn breast tissue so you lose that puffy chest and it returns fo normal size. This pharmaceutical being raloxifene

What is Raloxifene:

Raloxifene is a selective estrogen receptor modulator, a compound that has estrogen agonist activity at some sites and antagonist activity at others. In Breast and Uterine Tissue (Antagonism): The disrupted helix 12 configuration prevents the recruitment of key coactivators (such as the steroid receptor coactivator-1, SRC-1). Instead, it promotes the recruitment of corepressors (like NCoR or SMRT). This halts the transcription of oestrogen-responsive genes, preventing cellular proliferation and blocking oestrogen-dependent cell division

Citations: Seeman E. Raloxifene. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK, et al. Cell. 1998;95(7):927-937. (For the physical 1ERR crystal structure forcing Helix 12 out of alignment).Shang Y, Brown M. Science. 2002;295(5564):2465-2468. (For the tissue-specific recruitment of NCoR/SMRT over SRC-1 in breast cells to stop division). [1, 2, 3]

But what does this actually mean in simpler terms:

Raloxifene acts as an estrogen antagonist. It blocks estrogen from stimulating breast tissue, which lowers the risk of invasive breast cancer in high-risk postmenopausal women but can also reduce gynecomastia tissue quite substantially (gynecomastia is enlargement of breast glandular tissue in males)

Study to back this up:

Objectives: To assess the efficacy of the anti-estrogens raloxifen in the medical management of persistent pubertal gynecomastia.
Study design: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (Raloxifene).
Results: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Improvement was seen in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%). No side effects were seen in any patients.
Conclusion: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia.

Citations: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr. 2004 Jul;145(1):71-6. doi: 10.1016/j.jpeds.2004.03.057. PMID: 15238910.
– DISCLAIMER: This study also features tamoxifen however my main focus here is on the effects of raloxifene as I will be ordering this soon so I will eventually be able to provide anecdotal evidence.

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

Potential side effects: Hot flashes, leg cramps, joint pain and in rarer instances blood clots as there is also an increased risk of deep vein thrombosis.

Just a little guide, used some ai for the explanations to use correct vocabulary to help me out. Please tag friends to inform them about this and make my miniguide more popular.

@polonaecel @chris34 @sanguine @Cinnamon fan64 @true.perso.chad @dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem @nellii

wow interesting great thread

 

[Miki]

wow interesting great thread

Thanks man

 

[Kojo]

Would this work on Fibrotic Tissue?

I mean, SERM's (And many other Pharma) can prevent Gyno, but what if the Gyno is already set in place?

It does not work on fibrotic gyno no.

You'll need surgery for that

 

[Genio]

It does not work on fibrotic gyno no.

You'll need surgery for that

That's unfortunate

Thank's for the Info.

 

[Cinnamon fan64]

this sum good advice, mirin mirin

 

[Miki]

this sum good advice, mirin mirin

Thank you bro, much appreciated

 

[Cinnamon fan64]

Thank you bro, much appreciated

ur wellcum

 

[Askinov]

GUIDE TO RALOXIFENE: HOW TO GET RID OF GYNECOMASTIA
To those of you struggling to get rid of gynecomastia aka 'man boobs', there may be a pharmaceutical option to help reduce and get rid of stubborn breast tissue so you lose that puffy chest and it returns fo normal size. This pharmaceutical being raloxifene

What is Raloxifene:

Raloxifene is a selective estrogen receptor modulator, a compound that has estrogen agonist activity at some sites and antagonist activity at others. In Breast and Uterine Tissue (Antagonism): The disrupted helix 12 configuration prevents the recruitment of key coactivators (such as the steroid receptor coactivator-1, SRC-1). Instead, it promotes the recruitment of corepressors (like NCoR or SMRT). This halts the transcription of oestrogen-responsive genes, preventing cellular proliferation and blocking oestrogen-dependent cell division

Citations: Seeman E. Raloxifene. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK, et al. Cell. 1998;95(7):927-937. (For the physical 1ERR crystal structure forcing Helix 12 out of alignment).Shang Y, Brown M. Science. 2002;295(5564):2465-2468. (For the tissue-specific recruitment of NCoR/SMRT over SRC-1 in breast cells to stop division). [1, 2, 3]

But what does this actually mean in simpler terms:

Raloxifene acts as an estrogen antagonist. It blocks estrogen from stimulating breast tissue, which lowers the risk of invasive breast cancer in high-risk postmenopausal women but can also reduce gynecomastia tissue quite substantially (gynecomastia is enlargement of breast glandular tissue in males)

Study to back this up:

Objectives: To assess the efficacy of the anti-estrogens raloxifen in the medical management of persistent pubertal gynecomastia.
Study design: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (Raloxifene).
Results: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Improvement was seen in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%). No side effects were seen in any patients.
Conclusion: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia.

Citations: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr. 2004 Jul;145(1):71-6. doi: 10.1016/j.jpeds.2004.03.057. PMID: 15238910.
– DISCLAIMER: This study also features tamoxifen however my main focus here is on the effects of raloxifene as I will be ordering this soon so I will eventually be able to provide anecdotal evidence.

Dosage: 60mg daily until the lump shrinks (can take 3-6 months), then taper to 30mg. Maintenance: 30mg daily.

Potential side effects: Hot flashes, leg cramps, joint pain and in rarer instances blood clots as there is also an increased risk of deep vein thrombosis.

Just a little guide, used some ai for the explanations to use correct vocabulary to help me out. Please tag friends to inform them about this and make my miniguide more popular.

@polonaecel @chris34 @sanguine @Cinnamon fan64 @true.perso.chad @dbdrFanboy @Banana ★ 🍌 @tansel @psltristan1 @onfoenem @nellii

Gg's

 

[onfoenem]

very nice post man, mirin

 

[Miki]

very nice post man, mirin

Thanks bhai

 

[myxa8brah]

PRZEWODNIK PO RALOKSIFENIE: JAK POZBYĆ SIĘ GINEKOMASTII
Dla tych z Was, którzy zmagają się z pozbyciem się ginekomastii, czyli „męskich piersi", może istnieć opcja farmaceutyczna pomagająca zmniejszyć i pozbyć się uporczywej tkanki piersi, dzięki czemu stracisz opuchniętą klatkę piersiową i powróci ona do normalnego rozmiaru. Ta farmaceutyczna istota raloksyfen

Czym jest raloksifen:

Raloksyfen jest selektywnym modulatorem receptora estrogenowego, związkiem, który w niektórych miejscach wykazuje działanie agonistyczne wobec estrogenu, a w innych działanie antagonistyczne. W tkance piersi i macicy (antagonizm): Zaburzona konfiguracja helisy 12 zapobiega rekrutacji kluczowych koaktywatorów (takich jak koaktywator receptora steroidowego-1, SRC-1). Zamiast tego promuje rekrutację korepresorów (takich jak NCoR lub SMRT). Zatrzymuje to transkrypcję genów reagujących na estrogeny, zapobiegając proliferacji komórek i blokując zależny od estrogenów podział komórek

Cytaty: Seeman E. Raloksifen. J Bone Miner Metab. 2001;19(2):65-75. doi: 10.1007/s007740170043. PMID: 11281162.
Shiau AK i in. Komórka. 1998;95(7):927-937. (W przypadku fizycznej struktury krystalicznej 1ERR wymuszającej odchylenie helisy 12).Shang Y, Brown M. Nauka. 2002;295(5564):2465-2468. (Do tkankowo specyficznej rekrutacji NCoR/SMRT przez SRC-1 w komórkach piersi w celu zatrzymania podziału). [1, 2, 3]

Ale co to właściwie oznacza w prostszych słowach:

Raloksyfen działa jako antagonista estrogenu. Blokuje estrogen przed stymulacją tkanki piersi, co obniża ryzyko inwazyjnego raka piersi u kobiet wysokiego ryzyka po menopauzie, ale może również znacznie zmniejszyć tkankę ginekomastii (ginekomastia to powiększenie tkanki gruczołowej piersi u mężczyzn)

Badanie potwierdzające to:

Cele: Ocena skuteczności antyestrogenów raloksyfenu w leczeniu przewlekłej ginekomastii dojrzewania.
Projekt badania: Retrospektywny przegląd dokumentacji medycznej 38 kolejnych pacjentek z przewlekłą ginekomastią dojrzewania, które zgłosiły się do kliniki endokrynologii dziecięcej. Pacjenci otrzymywali same środki uspokajające lub 3–9-miesięczny cykl leczenia modyfikatorem receptora estrogenowego (Raloksifenem).
Wyniki: Średni (SD) wiek leczonych pacjentów wynosił 14,6 (1,5) lat, a czas trwania ginekomastii wynosił 28,3 (16,4) miesięcy. Średnie zmniejszenie średnicy guzka piersi o 2,5 cm (95% CI 1,7, 3,3, P <.0001) podczas stosowania raloksyfenu. Poprawę zaobserwowano u 91% pacjentów otrzymujących raloksifen, ale u większego odsetka zaobserwowano istotny spadek (>50%) w przypadku raloksifenu (86%). U żadnego pacjenta nie zaobserwowano działań niepożądanych.
Wniosek: Hamowanie działania receptora estrogenowego w piersi wydaje się być bezpieczne i skuteczne w zmniejszaniu utrzymującej się ginekomastii dojrzewania.

Cytaty: Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Korzystne działanie raloksyfenu i tamoksyfenu w leczeniu ginekomastii dojrzewania. J Pediatra. 2004 lipiec;145(1):71-6. doi: 10.1016/jjpeds.2004.03.057. 15238910.
– ZASTRZEŻENIE: W badaniu tym uwzględniono również tamoksifen, jednak skupiam się głównie na działaniu raloksifenu, ponieważ wkrótce go zamówię, więc ostatecznie będę mógł przedstawić dowody anegdotyczne.

Dawkowanie: 60 mg dziennie, aż guzek się skurczy (może to potrwać 3–6 miesięcy), a następnie zmniejszać dawkę do 30 mg. Konserwacja: 30 mg dziennie.

Potencjalne skutki uboczne: Uderzenia gorąca, skurcze nóg, bóle stawów, a w rzadszych przypadkach zakrzepy krwi, ponieważ istnieje również zwiększone ryzyko zakrzepicy żył głębokich.

Tylko mały przewodnik, użyłem trochę sztucznej inteligencji do wyjaśnień, aby użyć prawidłowego słownictwa, które mi pomoże. Proszę oznaczyć znajomych, aby ich o tym poinformować i zwiększyć popularność mojego miniprzewodnika.

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Ralox is E2-like for ER-alpha and it'll close ur plates