How to manage your cholesterol effectively - The last secret about longevity

[Claymoreboy0118]

not true

 

[Hernan]

i just smoke for stress relief.

 

[Jonasㅤㅤ]

i just smoke for stress relief.

The stress relief is only temporary. The downsides outweigh the supposed benefits fully.

"Smoking acutely increases cortisol levels and it has been shown that this stimulation is dose-dependent (Rohleder and Kirschbaum, 2006)."

Studies in large samples of younger adults demonstrated that, relative to non-smokers current smokers have higher overall basal cortisol levels, greater morning increases, and lesser declines in cortisol over the day (Kumari et al., 2010, Rohleder and Kirschbaum, 2006)

It also increases oxidative stress.(1)

The relief from smoking is as with any other drug, it's temporary and not mediated via a reduction in cortisol but rather other pathways in the brain like agonism of nicotinic acetylcholine receptors. Nicotine upregulates these receptors causing a higher demand in receptor activation leading to withdrawal symptoms.

 

[menas]

How to manage your cholesterol effectively - The last secret about longevity
View attachment 3788453


What is cholesterol?

Disclaimer: For the sake of this thread, I want you to forget everything you’ve ever heard about cholesterol.

Cholesterol is a fatty substance essential for many processes in the body and is found in every animal cell.

View attachment 3788906

Managing your cholesterol is extremely important. Cardiovascular diseases remain the leading cause of death worldwide.

View attachment 3788463

The Role of cholesterol in the body

Now unlike DHT after puberty, cholesterol is quite important and you should think twice before nuking it to the ground.

Cholesterol is required to build and maintain membranes and helps in regulating their fluidity. It also affects substrate presentation and plays a major role in the epidermis and has its own signalling pathways.

View attachment 3788494

The most important aspect of cholesterol though is the steroidogenesis, the process by which many sex hormones including testosterone and adrenal gland hormones are synthesized.

I'm sure you've seen this image before.

View attachment 3788507

There are a few studies claiming there is a weak correlation between dietary cholesterol and total testosterone levels.

This study suggests that HDL levels are correlated with androgen levels.

And this one suggests the opposite.

View attachment 3788631

It is only logical that cholesterol affects hormone levels via the steroidogenesis pathway. Though additional dietary cholesterol intake may not result in increased testosterone levels.

Additionally the body compensates for dietary cholesterol intake by reducing its own cholesterol production.(1)

Unlike what many believe dietary cholesterol doesn't cross the blood-brain barrier.

The brain produces its own supply via astrocytes.(2)

What does this tell us?

Cholesterol isn't bad at all. The dose makes the poison. The thing is, you can't know if it is the poison without getting a blood test.

Stay better safe than sorry. Use this table as a general guide.

View attachment 3788530

Additionally you can use Apob/ApoA as guidance, since all those values correlate with eachother.

View attachment 3788557

Atherosclerosis

Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous elements in the large arteries in response to oxidative stress.(3)

Let me make it more clear: There are multiple factors contributing to atherosclerosis.

Gene polymorphisms heavily influence whether your body can effectively clear LDL cholesterol.

I checked my genome and found a mutation in the LDL-R

View attachment 3788672

Apart from that obviously LDL and HDL levels directly influence the risk of developing atherosclerosis. Oxidative stress is a heavily underestimated factor too.

The best way to mitigate the risks would be decreasing all of those factors.

This is where the real thread starts.

Effective ways to reduce your risk of developing atherosclerosis

Low bodyfat%

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

View attachment 3788702

It can improve your lipids naturally without pharmacological intervention.(4)

Exercise

Be it aerobic exercise or strength training, just be the fuck in shape and move.

View attachment 3789069

This will also manage your blood pressure naturally.(5)

Antioxidants

To mitigate the oxidative stress aspect of atherosclerosis you should eat a balanced, non-processed diet. It is fucking simple.

Extremely beneficial antioxidants include coQ10, OPC and NAC just to name a few.

Quit smoking

Smoking is one of the worst things you could do for your lipids and health in general.

There are three primary ways in how smoking affects coronary heart disease.(6)

1. Carbon monoxide promotes atherogenesis by damaging the endothelium and reducing oxygen delivery.

2. Nicotine stimulates the adrenergic system, leading to increased blood pressure and myocardial oxygen demand.

3. Smoking disrupts the lipid metabolism resulting in higher LDL and lower HDL cholesterol levels.

View attachment 3788747

Also keep in mind smokers usually maintain a lower bf%, meaning smoking completely negates the benefits of being at a low bf% in the first place.
There are countless other risks associated with smoking. If you insist on continuing, don’t call yourself a Looksmaxxer.

Pharmacology

Now that we covered the water topics let's discuss the real shit. This is for you if you want to take your longevity protocol to the next level.

Statins

Spoiler: Statins

General info

Let’s cover this first. It’s the primary normie method for lowering cholesterol and LDL levels.

They’re also the best-selling pharmaceuticals ever in history so if you’re skeptical about biased/manipulated studies, this is one of the first compounds you should question.(7)

Statins are generally less effective in treating individuals with genetic disorders such as familial hypercholesterolemia.

Mechanisms of action

Statins work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway.

They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream.

Benefits

Reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins.

Statins also slightly activate PPARα via overexpression of COX-2.

Side effects

We can differentiate between two groups of statins:

Hydrophilic statins: Won't cross the blood-brain barrier, more inflammation.

Examples: Rosuvastatin and pravastatin.

Lipophilic statins: Crosses the blood-brain barrier, less inflammation.

Examples: Pitavastatin, atorvastatin and simvastatin.

Besides that statins have a ±10% risk of diabetes in men.(8)

Recommendation

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile.

Pitavastatin

A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks.(9)

Dosage: Take 1-4mg daily.

Rosuvastatin

This is by far one of the best statins besides pitavastatin in terms of side effect profile and effectiveness.

View attachment 3788822

Dosage: You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.(10)

Ezetimibe

Spoiler: Ezetimibe

Ezetimibe inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol.

It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein.(11)

It doesn't affect fat-soluble vitamins unlike popular belief.(12)

View attachment 3788827

Ezetimibe monotherapy isn't as effective as combining it with another compound like statins.

Dosage: 5-10mg once daily.

Obicetrapip

Spoiler: Obicetrapib

Obicetrapip is the first CETP inhibitor that effectively manages lipids without being utter garbage. It is significantly better than torcetrapib, dalcetrapib and evacetrapib combined.

The compound is quite new and already showed promising results. Besides that it improves alzheimer's disease.

"LDL-C decreased from baseline to week 12 by 63.4%, 43.5%, and 6.35% in combination, monotherapy, and placebo groups, respectively (p<0.0001 vs. Placebo)."(13)

Both active treatments also significantly reduced concentrations of non-HDL-C, apolipoprotein B, and total and small LDL particles. Obicetrapib was well tolerated and no safety issues were identified.(13)

Combining it with another compound would be a good choice as with ezetimibe.

Dosage: 5-10mg daily.

PCSK-9 inhibitors

Spoiler: PCSK-9 inhibitors

This is one of the best pathways to improve your lipids drastically.

PCSK-9 inhibitors are fully humanized monoclonal antibodies that prevent the enzyme PCSK-9 from binding to LDL receptors in the liver. This leads to an upregulation in receptors leading to a reduction in LDL.

The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies.(14)

Dosage: Alirocumab and evolocumab are injected subcutaneously every 2 to 4 weeks. Sourcing is extremely hard and you are better off trying to get a prescription.

Here is my personal alirocumab.

View attachment 3788838

It is extremely expensive, so try to have the cost covered by your health insurance.

SR9009

Spoiler: SR9009

SR9009 (Stenabolic) is an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. It is being used to boost mitochondrial activity and fat metabolism. It can also have a positive impact on your circadian rhythm, endurance and inflammation.

View attachment 3788846

You can see a few benefits of agonizing this pathway below.

View attachment 3788847

You should use this compound ideally for the lipid aspect, in conjunction with the tons of other benefits. If you're trying to negate some side effects of PEDs, you should look into SR9009/SR9011 as well.(15)

Dosage: 10-40mg.(16)

Retatrutide

Spoiler: Retatrutide

Retatrutide is a godsent molecule. It is a triple agonist of GLP-1, GIP and the glucagon receptor.

You can expect an inprovement in insulin sensitivity, increased energy expenditure, appetite supression and barely any side effects.

It also can support lipids drastically.

"apoB was reduced by up to 19.6% and 24.2% at 24 and 48 weeks"(17)

"At 48 weeks, the drug reduced triglycerides and apoC-III levels by up to 40.6% and 38.0%"(17)

"Retatrutide also reduced the number of total and highly atherogenic small LDL particles (LDLP)"(17)

Retatrutide is by far one of the best compounds for literally anything, be it Looksmaxxing or just general health.

Dosage: Anything between 4-8mg weekly is a good effective dose. Dosages above 8mg have extreme diminishing returns in terms of effectiveness. You can split the dosage to twice a week.

Bempedoic acid

Spoiler: Bempedoic acid

Bempedoic Acid is an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins.

"At week 12, bempedoic acid reduced the mean LDL cholesterol level by 19.2 mg per deciliter (0.50 mmol per liter)."(18)

Dosage: 180mg daily.(19)

Spoiler: Tags

@chadisbeingmade @Clavicular @Orc @Eltrē @Magnum Opus

​

Mirin'

 

[VrillFatNoob24]

How to manage your cholesterol effectively - The last secret about longevity
View attachment 3788453


What is cholesterol?

Disclaimer: For the sake of this thread, I want you to forget everything you’ve ever heard about cholesterol.

Cholesterol is a fatty substance essential for many processes in the body and is found in every animal cell.

View attachment 3788906

Managing your cholesterol is extremely important. Cardiovascular diseases remain the leading cause of death worldwide.

View attachment 3788463

The Role of cholesterol in the body

Now unlike DHT after puberty, cholesterol is quite important and you should think twice before nuking it to the ground.

Cholesterol is required to build and maintain membranes and helps in regulating their fluidity. It also affects substrate presentation and plays a major role in the epidermis and has its own signalling pathways.

View attachment 3788494

The most important aspect of cholesterol though is the steroidogenesis, the process by which many sex hormones including testosterone and adrenal gland hormones are synthesized.

I'm sure you've seen this image before.

View attachment 3788507

There are a few studies claiming there is a weak correlation between dietary cholesterol and total testosterone levels.

This study suggests that HDL levels are correlated with androgen levels.

And this one suggests the opposite.

View attachment 3788631

It is only logical that cholesterol affects hormone levels via the steroidogenesis pathway. Though additional dietary cholesterol intake may not result in increased testosterone levels.

Additionally the body compensates for dietary cholesterol intake by reducing its own cholesterol production.(1)

Unlike what many believe dietary cholesterol doesn't cross the blood-brain barrier.

The brain produces its own supply via astrocytes.(2)

What does this tell us?

Cholesterol isn't bad at all. The dose makes the poison. The thing is, you can't know if it is the poison without getting a blood test.

Stay better safe than sorry. Use this table as a general guide.

View attachment 3788530

Additionally you can use Apob/ApoA as guidance, since all those values correlate with eachother.

View attachment 3788557

Atherosclerosis

Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous elements in the large arteries in response to oxidative stress.(3)

Let me make it more clear: There are multiple factors contributing to atherosclerosis.

Gene polymorphisms heavily influence whether your body can effectively clear LDL cholesterol.

I checked my genome and found a mutation in the LDL-R

View attachment 3788672

Apart from that obviously LDL and HDL levels directly influence the risk of developing atherosclerosis. Oxidative stress is a heavily underestimated factor too.

The best way to mitigate the risks would be decreasing all of those factors.

This is where the real thread starts.

Effective ways to reduce your risk of developing atherosclerosis

Low bodyfat%

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

View attachment 3788702

It can improve your lipids naturally without pharmacological intervention.(4)

Exercise

Be it aerobic exercise or strength training, just be the fuck in shape and move.

View attachment 3789069

This will also manage your blood pressure naturally.(5)

Antioxidants

To mitigate the oxidative stress aspect of atherosclerosis you should eat a balanced, non-processed diet. It is fucking simple.

Extremely beneficial antioxidants include coQ10, OPC and NAC just to name a few.

Quit smoking

Smoking is one of the worst things you could do for your lipids and health in general.

There are three primary ways in how smoking affects coronary heart disease.(6)

1. Carbon monoxide promotes atherogenesis by damaging the endothelium and reducing oxygen delivery.

2. Nicotine stimulates the adrenergic system, leading to increased blood pressure and myocardial oxygen demand.

3. Smoking disrupts the lipid metabolism resulting in higher LDL and lower HDL cholesterol levels.

View attachment 3788747

Also keep in mind smokers usually maintain a lower bf%, meaning smoking completely negates the benefits of being at a low bf% in the first place.
There are countless other risks associated with smoking. If you insist on continuing, don’t call yourself a Looksmaxxer.

Pharmacology

Now that we covered the water topics let's discuss the real shit. This is for you if you want to take your longevity protocol to the next level.

Statins

Spoiler: Statins

General info

Let’s cover this first. It’s the primary normie method for lowering cholesterol and LDL levels.

They’re also the best-selling pharmaceuticals ever in history so if you’re skeptical about biased/manipulated studies, this is one of the first compounds you should question.(7)

Statins are generally less effective in treating individuals with genetic disorders such as familial hypercholesterolemia.

Mechanisms of action

Statins work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway.

They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream.

Benefits

Reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins.

Statins also slightly activate PPARα via overexpression of COX-2.

Side effects

We can differentiate between two groups of statins:

Hydrophilic statins: Won't cross the blood-brain barrier, more inflammation.

Examples: Rosuvastatin and pravastatin.

Lipophilic statins: Crosses the blood-brain barrier, less inflammation.

Examples: Pitavastatin, atorvastatin and simvastatin.

Besides that statins have a ±10% risk of diabetes in men.(8)

Recommendation

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile.

Pitavastatin

A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks.(9)

Dosage: Take 1-4mg daily.

Rosuvastatin

This is by far one of the best statins besides pitavastatin in terms of side effect profile and effectiveness.

View attachment 3788822

Dosage: You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.(10)

Ezetimibe

Spoiler: Ezetimibe

Ezetimibe inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol.

It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein.(11)

It doesn't affect fat-soluble vitamins unlike popular belief.(12)

View attachment 3788827

Ezetimibe monotherapy isn't as effective as combining it with another compound like statins.

Dosage: 5-10mg once daily.

Obicetrapip

Spoiler: Obicetrapib

Obicetrapip is the first CETP inhibitor that effectively manages lipids without being utter garbage. It is significantly better than torcetrapib, dalcetrapib and evacetrapib combined.

The compound is quite new and already showed promising results. Besides that it improves alzheimer's disease.

"LDL-C decreased from baseline to week 12 by 63.4%, 43.5%, and 6.35% in combination, monotherapy, and placebo groups, respectively (p<0.0001 vs. Placebo)."(13)

Both active treatments also significantly reduced concentrations of non-HDL-C, apolipoprotein B, and total and small LDL particles. Obicetrapib was well tolerated and no safety issues were identified.(13)

Combining it with another compound would be a good choice as with ezetimibe.

Dosage: 5-10mg daily.

PCSK-9 inhibitors

Spoiler: PCSK-9 inhibitors

This is one of the best pathways to improve your lipids drastically.

PCSK-9 inhibitors are fully humanized monoclonal antibodies that prevent the enzyme PCSK-9 from binding to LDL receptors in the liver. This leads to an upregulation in receptors leading to a reduction in LDL.

The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies.(14)

Dosage: Alirocumab and evolocumab are injected subcutaneously every 2 to 4 weeks. Sourcing is extremely hard and you are better off trying to get a prescription.

Here is my personal alirocumab.

View attachment 3788838

It is extremely expensive, so try to have the cost covered by your health insurance.

SR9009

Spoiler: SR9009

SR9009 (Stenabolic) is an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. It is being used to boost mitochondrial activity and fat metabolism. It can also have a positive impact on your circadian rhythm, endurance and inflammation.

View attachment 3788846

You can see a few benefits of agonizing this pathway below.

View attachment 3788847

You should use this compound ideally for the lipid aspect, in conjunction with the tons of other benefits. If you're trying to negate some side effects of PEDs, you should look into SR9009/SR9011 as well.(15)

Dosage: 10-40mg.(16)

Retatrutide

Spoiler: Retatrutide

Retatrutide is a godsent molecule. It is a triple agonist of GLP-1, GIP and the glucagon receptor.

You can expect an inprovement in insulin sensitivity, increased energy expenditure, appetite supression and barely any side effects.

It also can support lipids drastically.

"apoB was reduced by up to 19.6% and 24.2% at 24 and 48 weeks"(17)

"At 48 weeks, the drug reduced triglycerides and apoC-III levels by up to 40.6% and 38.0%"(17)

"Retatrutide also reduced the number of total and highly atherogenic small LDL particles (LDLP)"(17)

Retatrutide is by far one of the best compounds for literally anything, be it Looksmaxxing or just general health.

Dosage: Anything between 4-8mg weekly is a good effective dose. Dosages above 8mg have extreme diminishing returns in terms of effectiveness. You can split the dosage to twice a week.

Bempedoic acid

Spoiler: Bempedoic acid

Bempedoic Acid is an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins.

"At week 12, bempedoic acid reduced the mean LDL cholesterol level by 19.2 mg per deciliter (0.50 mmol per liter)."(18)

Dosage: 180mg daily.(19)

Spoiler: Tags

@chadisbeingmade @Clavicular @Orc @Eltrē @Magnum Opus

​

dnr but seens high iq si bookmarked

 

[LegendaryKennen]

water

tl:dr: eat good, low-bf%, exercise, no smoking

 

[King_Schnitzel]

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

So usually I'd agree, balanced body fat, lower than average nowadays equals healthy.

You said "it may not look healthy to normies" though, do you refer to normies manipulated by Goatis or how come you think a normie would despise a low bodyfat percentage?

 

[chadbeingmade]

So usually I'd agree, balanced body fat, lower than average nowadays equals healthy.

You said "it may not look healthy to normies" though, do you refer to normies manipulated by Goatis or how come you think a normie would despise a low bodyfat percentage?

8-12% bf is ideal

 

[Evgeniy291]

@copercel123 thoughts

 

[Williamson0]

How to manage your cholesterol effectively - The last secret about longevity
View attachment 3788453


What is cholesterol?

Disclaimer: For the sake of this thread, I want you to forget everything you’ve ever heard about cholesterol.

Cholesterol is a fatty substance essential for many processes in the body and is found in every animal cell.

View attachment 3788906

Managing your cholesterol is extremely important. Cardiovascular diseases remain the leading cause of death worldwide.

View attachment 3788463

The Role of cholesterol in the body

Now unlike DHT after puberty, cholesterol is quite important and you should think twice before nuking it to the ground.

Cholesterol is required to build and maintain membranes and helps in regulating their fluidity. It also affects substrate presentation and plays a major role in the epidermis and has its own signalling pathways.

View attachment 3788494

The most important aspect of cholesterol though is the steroidogenesis, the process by which many sex hormones including testosterone and adrenal gland hormones are synthesized.

I'm sure you've seen this image before.

View attachment 3788507

There are a few studies claiming there is a weak correlation between dietary cholesterol and total testosterone levels.

This study suggests that HDL levels are correlated with androgen levels.

And this one suggests the opposite.

View attachment 3788631

It is only logical that cholesterol affects hormone levels via the steroidogenesis pathway. Though additional dietary cholesterol intake may not result in increased testosterone levels.

Additionally the body compensates for dietary cholesterol intake by reducing its own cholesterol production.(1)

Unlike what many believe dietary cholesterol doesn't cross the blood-brain barrier.

The brain produces its own supply via astrocytes.(2)

What does this tell us?

Cholesterol isn't bad at all. The dose makes the poison. The thing is, you can't know if it is the poison without getting a blood test.

Stay better safe than sorry. Use this table as a general guide.

View attachment 3788530

Additionally you can use Apob/ApoA as guidance, since all those values correlate with eachother.

View attachment 3788557

Atherosclerosis

Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous elements in the large arteries in response to oxidative stress.(3)

Let me make it more clear: There are multiple factors contributing to atherosclerosis.

Gene polymorphisms heavily influence whether your body can effectively clear LDL cholesterol.

I checked my genome and found a mutation in the LDL-R

View attachment 3788672

Apart from that obviously LDL and HDL levels directly influence the risk of developing atherosclerosis. Oxidative stress is a heavily underestimated factor too.

The best way to mitigate the risks would be decreasing all of those factors.

This is where the real thread starts.

Effective ways to reduce your risk of developing atherosclerosis

Low bodyfat%

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

View attachment 3788702

It can improve your lipids naturally without pharmacological intervention.(4)

Exercise

Be it aerobic exercise or strength training, just be the fuck in shape and move.

View attachment 3789069

This will also manage your blood pressure naturally.(5)

Antioxidants

To mitigate the oxidative stress aspect of atherosclerosis you should eat a balanced, non-processed diet. It is fucking simple.

Extremely beneficial antioxidants include coQ10, OPC and NAC just to name a few.

Quit smoking

Smoking is one of the worst things you could do for your lipids and health in general.

There are three primary ways in how smoking affects coronary heart disease.(6)

1. Carbon monoxide promotes atherogenesis by damaging the endothelium and reducing oxygen delivery.

2. Nicotine stimulates the adrenergic system, leading to increased blood pressure and myocardial oxygen demand.

3. Smoking disrupts the lipid metabolism resulting in higher LDL and lower HDL cholesterol levels.

View attachment 3788747

Also keep in mind smokers usually maintain a lower bf%, meaning smoking completely negates the benefits of being at a low bf% in the first place.
There are countless other risks associated with smoking. If you insist on continuing, don’t call yourself a Looksmaxxer.

Pharmacology

Now that we covered the water topics let's discuss the real shit. This is for you if you want to take your longevity protocol to the next level.

Statins

Spoiler: Statins

General info

Let’s cover this first. It’s the primary normie method for lowering cholesterol and LDL levels.

They’re also the best-selling pharmaceuticals ever in history so if you’re skeptical about biased/manipulated studies, this is one of the first compounds you should question.(7)

Statins are generally less effective in treating individuals with genetic disorders such as familial hypercholesterolemia.

Mechanisms of action

Statins work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway.

They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream.

Benefits

Reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins.

Statins also slightly activate PPARα via overexpression of COX-2.

Side effects

We can differentiate between two groups of statins:

Hydrophilic statins: Won't cross the blood-brain barrier, more inflammation.

Examples: Rosuvastatin and pravastatin.

Lipophilic statins: Crosses the blood-brain barrier, less inflammation.

Examples: Pitavastatin, atorvastatin and simvastatin.

Besides that statins have a ±10% risk of diabetes in men.(8)

Recommendation

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile.

Pitavastatin

A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks.(9)

Dosage: Take 1-4mg daily.

Rosuvastatin

This is by far one of the best statins besides pitavastatin in terms of side effect profile and effectiveness.

View attachment 3788822

Dosage: You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.(10)

Ezetimibe

Spoiler: Ezetimibe

Ezetimibe inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol.

It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein.(11)

It doesn't affect fat-soluble vitamins unlike popular belief.(12)

View attachment 3788827

Ezetimibe monotherapy isn't as effective as combining it with another compound like statins.

Dosage: 5-10mg once daily.

Obicetrapip

Spoiler: Obicetrapib

Obicetrapip is the first CETP inhibitor that effectively manages lipids without being utter garbage. It is significantly better than torcetrapib, dalcetrapib and evacetrapib combined.

The compound is quite new and already showed promising results. Besides that it improves alzheimer's disease.

"LDL-C decreased from baseline to week 12 by 63.4%, 43.5%, and 6.35% in combination, monotherapy, and placebo groups, respectively (p<0.0001 vs. Placebo)."(13)

Both active treatments also significantly reduced concentrations of non-HDL-C, apolipoprotein B, and total and small LDL particles. Obicetrapib was well tolerated and no safety issues were identified.(13)

Combining it with another compound would be a good choice as with ezetimibe.

Dosage: 5-10mg daily.

PCSK-9 inhibitors

Spoiler: PCSK-9 inhibitors

This is one of the best pathways to improve your lipids drastically.

PCSK-9 inhibitors are fully humanized monoclonal antibodies that prevent the enzyme PCSK-9 from binding to LDL receptors in the liver. This leads to an upregulation in receptors leading to a reduction in LDL.

The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies.(14)

Dosage: Alirocumab and evolocumab are injected subcutaneously every 2 to 4 weeks. Sourcing is extremely hard and you are better off trying to get a prescription.

Here is my personal alirocumab.

View attachment 3788838

It is extremely expensive, so try to have the cost covered by your health insurance.

SR9009

Spoiler: SR9009

SR9009 (Stenabolic) is an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. It is being used to boost mitochondrial activity and fat metabolism. It can also have a positive impact on your circadian rhythm, endurance and inflammation.

View attachment 3788846

You can see a few benefits of agonizing this pathway below.

View attachment 3788847

You should use this compound ideally for the lipid aspect, in conjunction with the tons of other benefits. If you're trying to negate some side effects of PEDs, you should look into SR9009/SR9011 as well.(15)

Dosage: 10-40mg.(16)

Retatrutide

Spoiler: Retatrutide

Retatrutide is a godsent molecule. It is a triple agonist of GLP-1, GIP and the glucagon receptor.

You can expect an inprovement in insulin sensitivity, increased energy expenditure, appetite supression and barely any side effects.

It also can support lipids drastically.

"apoB was reduced by up to 19.6% and 24.2% at 24 and 48 weeks"(17)

"At 48 weeks, the drug reduced triglycerides and apoC-III levels by up to 40.6% and 38.0%"(17)

"Retatrutide also reduced the number of total and highly atherogenic small LDL particles (LDLP)"(17)

Retatrutide is by far one of the best compounds for literally anything, be it Looksmaxxing or just general health.

Dosage: Anything between 4-8mg weekly is a good effective dose. Dosages above 8mg have extreme diminishing returns in terms of effectiveness. You can split the dosage to twice a week.

Bempedoic acid

Spoiler: Bempedoic acid

Bempedoic Acid is an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins.

"At week 12, bempedoic acid reduced the mean LDL cholesterol level by 19.2 mg per deciliter (0.50 mmol per liter)."(18)

Dosage: 180mg daily.(19)

Spoiler: Tags

@chadisbeingmade @Clavicular @Orc @Eltrē @Magnum Opus

​

Thank you for this informative post,
Cholesterol often gets a bad rap, but it’s actually essential for your body—helping build cells, produce hormones, and support brain health. While your body makes most of what it needs, lifestyle factors like diet, exercise, and smoking play a big role in keeping your cholesterol balanced. Managing it well is key to preventing heart issues. Simple steps like staying active, eating antioxidant-rich foods, and avoiding smoking can make a huge difference. If needed, medications like statins can help too. Remember, cholesterol isn’t the enemy it’s all about balance!

 

[Jonasㅤㅤ]

water

tl:dr: eat good, low-bf%, exercise, no smoking

That was just a fraction of the thread.

So usually I'd agree, balanced body fat, lower than average nowadays equals healthy.

You said "it may not look healthy to normies" though, do you refer to normies manipulated by Goatis or how come you think a normie would despise a low bodyfat percentage?

My example was about non-gymmaxxed individuals.

Normies and "blackpilled" normies on here both think this is unhealthy, even though it is the epitome of health.

@copercel123 thoughts

How about you use your own brain, my bad 404.

Thank you for this informative post,
Cholesterol often gets a bad rap, but it’s actually essential for your body—helping build cells, produce hormones, and support brain health. While your body makes most of what it needs, lifestyle factors like diet, exercise, and smoking play a big role in keeping your cholesterol balanced. Managing it well is key to preventing heart issues. Simple steps like staying active, eating antioxidant-rich foods, and avoiding smoking can make a huge difference. If needed, medications like statins can help too. Remember, cholesterol isn’t the enemy it’s all about balance!

You clearly didn't read it judging by this AI reply.

 

[King_Schnitzel]

Normies and "blackpilled" normies on here both think this is unhealthy, even though it is the epitome of health

While it is not as bad as being just fat, he definetly lacks proper muscle mass.

 

[DNRDniggerking]

How to manage your cholesterol effectively - The last secret about longevity
View attachment 3788453


What is cholesterol?

Disclaimer: For the sake of this thread, I want you to forget everything you’ve ever heard about cholesterol.

Cholesterol is a fatty substance essential for many processes in the body and is found in every animal cell.

View attachment 3788906

Managing your cholesterol is extremely important. Cardiovascular diseases remain the leading cause of death worldwide.

View attachment 3788463

The Role of cholesterol in the body

Now unlike DHT after puberty, cholesterol is quite important and you should think twice before nuking it to the ground.

Cholesterol is required to build and maintain membranes and helps in regulating their fluidity. It also affects substrate presentation and plays a major role in the epidermis and has its own signalling pathways.

View attachment 3788494

The most important aspect of cholesterol though is the steroidogenesis, the process by which many sex hormones including testosterone and adrenal gland hormones are synthesized.

I'm sure you've seen this image before.

View attachment 3788507

There are a few studies claiming there is a weak correlation between dietary cholesterol and total testosterone levels.

This study suggests that HDL levels are correlated with androgen levels.

And this one suggests the opposite.

View attachment 3788631

It is only logical that cholesterol affects hormone levels via the steroidogenesis pathway. Though additional dietary cholesterol intake may not result in increased testosterone levels.

Additionally the body compensates for dietary cholesterol intake by reducing its own cholesterol production.(1)

Unlike what many believe dietary cholesterol doesn't cross the blood-brain barrier.

The brain produces its own supply via astrocytes.(2)

What does this tell us?

Cholesterol isn't bad at all. The dose makes the poison. The thing is, you can't know if it is the poison without getting a blood test.

Stay better safe than sorry. Use this table as a general guide.

View attachment 3788530

Additionally you can use Apob/ApoA as guidance, since all those values correlate with eachother.

View attachment 3788557

Atherosclerosis

Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous elements in the large arteries in response to oxidative stress.(3)

Let me make it more clear: There are multiple factors contributing to atherosclerosis.

Gene polymorphisms heavily influence whether your body can effectively clear LDL cholesterol.

I checked my genome and found a mutation in the LDL-R

View attachment 3788672

Apart from that obviously LDL and HDL levels directly influence the risk of developing atherosclerosis. Oxidative stress is a heavily underestimated factor too.

The best way to mitigate the risks would be decreasing all of those factors.

This is where the real thread starts.

Effective ways to reduce your risk of developing atherosclerosis

Low bodyfat%

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

View attachment 3788702

It can improve your lipids naturally without pharmacological intervention.(4)

Exercise

Be it aerobic exercise or strength training, just be the fuck in shape and move.

View attachment 3789069

This will also manage your blood pressure naturally.(5)

Antioxidants

To mitigate the oxidative stress aspect of atherosclerosis you should eat a balanced, non-processed diet. It is fucking simple.

Extremely beneficial antioxidants include coQ10, OPC and NAC just to name a few.

Quit smoking

Smoking is one of the worst things you could do for your lipids and health in general.

There are three primary ways in how smoking affects coronary heart disease.(6)

1. Carbon monoxide promotes atherogenesis by damaging the endothelium and reducing oxygen delivery.

2. Nicotine stimulates the adrenergic system, leading to increased blood pressure and myocardial oxygen demand.

3. Smoking disrupts the lipid metabolism resulting in higher LDL and lower HDL cholesterol levels.

View attachment 3788747

Also keep in mind smokers usually maintain a lower bf%, meaning smoking completely negates the benefits of being at a low bf% in the first place.
There are countless other risks associated with smoking. If you insist on continuing, don’t call yourself a Looksmaxxer.

Pharmacology

Now that we covered the water topics let's discuss the real shit. This is for you if you want to take your longevity protocol to the next level.

Statins

Spoiler: Statins

General info

Let’s cover this first. It’s the primary normie method for lowering cholesterol and LDL levels.

They’re also the best-selling pharmaceuticals ever in history so if you’re skeptical about biased/manipulated studies, this is one of the first compounds you should question.(7)

Statins are generally less effective in treating individuals with genetic disorders such as familial hypercholesterolemia.

Mechanisms of action

Statins work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway.

They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream.

Benefits

Reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins.

Statins also slightly activate PPARα via overexpression of COX-2.

Side effects

We can differentiate between two groups of statins:

Hydrophilic statins: Won't cross the blood-brain barrier, more inflammation.

Examples: Rosuvastatin and pravastatin.

Lipophilic statins: Crosses the blood-brain barrier, less inflammation.

Examples: Pitavastatin, atorvastatin and simvastatin.

Besides that statins have a ±10% risk of diabetes in men.(8)

Recommendation

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile.

Pitavastatin

A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks.(9)

Dosage: Take 1-4mg daily.

Rosuvastatin

This is by far one of the best statins besides pitavastatin in terms of side effect profile and effectiveness.

View attachment 3788822

Dosage: You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.(10)

Ezetimibe

Spoiler: Ezetimibe

Ezetimibe inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol.

It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein.(11)

It doesn't affect fat-soluble vitamins unlike popular belief.(12)

View attachment 3788827

Ezetimibe monotherapy isn't as effective as combining it with another compound like statins.

Dosage: 5-10mg once daily.

Obicetrapip

Spoiler: Obicetrapib

Obicetrapip is the first CETP inhibitor that effectively manages lipids without being utter garbage. It is significantly better than torcetrapib, dalcetrapib and evacetrapib combined.

The compound is quite new and already showed promising results. Besides that it improves alzheimer's disease.

"LDL-C decreased from baseline to week 12 by 63.4%, 43.5%, and 6.35% in combination, monotherapy, and placebo groups, respectively (p<0.0001 vs. Placebo)."(13)

Both active treatments also significantly reduced concentrations of non-HDL-C, apolipoprotein B, and total and small LDL particles. Obicetrapib was well tolerated and no safety issues were identified.(13)

Combining it with another compound would be a good choice as with ezetimibe.

Dosage: 5-10mg daily.

PCSK-9 inhibitors

Spoiler: PCSK-9 inhibitors

This is one of the best pathways to improve your lipids drastically.

PCSK-9 inhibitors are fully humanized monoclonal antibodies that prevent the enzyme PCSK-9 from binding to LDL receptors in the liver. This leads to an upregulation in receptors leading to a reduction in LDL.

The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies.(14)

Dosage: Alirocumab and evolocumab are injected subcutaneously every 2 to 4 weeks. Sourcing is extremely hard and you are better off trying to get a prescription.

Here is my personal alirocumab.

View attachment 3788838

It is extremely expensive, so try to have the cost covered by your health insurance.

SR9009

Spoiler: SR9009

SR9009 (Stenabolic) is an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. It is being used to boost mitochondrial activity and fat metabolism. It can also have a positive impact on your circadian rhythm, endurance and inflammation.

View attachment 3788846

You can see a few benefits of agonizing this pathway below.

View attachment 3788847

You should use this compound ideally for the lipid aspect, in conjunction with the tons of other benefits. If you're trying to negate some side effects of PEDs, you should look into SR9009/SR9011 as well.(15)

Dosage: 10-40mg.(16)

Retatrutide

Spoiler: Retatrutide

Retatrutide is a godsent molecule. It is a triple agonist of GLP-1, GIP and the glucagon receptor.

You can expect an inprovement in insulin sensitivity, increased energy expenditure, appetite supression and barely any side effects.

It also can support lipids drastically.

"apoB was reduced by up to 19.6% and 24.2% at 24 and 48 weeks"(17)

"At 48 weeks, the drug reduced triglycerides and apoC-III levels by up to 40.6% and 38.0%"(17)

"Retatrutide also reduced the number of total and highly atherogenic small LDL particles (LDLP)"(17)

Retatrutide is by far one of the best compounds for literally anything, be it Looksmaxxing or just general health.

Dosage: Anything between 4-8mg weekly is a good effective dose. Dosages above 8mg have extreme diminishing returns in terms of effectiveness. You can split the dosage to twice a week.

Bempedoic acid

Spoiler: Bempedoic acid

Bempedoic Acid is an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins.

"At week 12, bempedoic acid reduced the mean LDL cholesterol level by 19.2 mg per deciliter (0.50 mmol per liter)."(18)

Dosage: 180mg daily.(19)

Spoiler: Tags

@chadisbeingmade @Clavicular @Orc @Eltrē @Magnum Opus

​

why do you wanna live long?

 

[org3cel.RR]

How to manage your cholesterol effectively - The last secret about longevity
View attachment 3788453


What is cholesterol?

Disclaimer: For the sake of this thread, I want you to forget everything you’ve ever heard about cholesterol.

Cholesterol is a fatty substance essential for many processes in the body and is found in every animal cell.

View attachment 3788906

Managing your cholesterol is extremely important. Cardiovascular diseases remain the leading cause of death worldwide.

View attachment 3788463

The Role of cholesterol in the body

Now unlike DHT after puberty, cholesterol is quite important and you should think twice before nuking it to the ground.

Cholesterol is required to build and maintain membranes and helps in regulating their fluidity. It also affects substrate presentation and plays a major role in the epidermis and has its own signalling pathways.

View attachment 3788494

The most important aspect of cholesterol though is the steroidogenesis, the process by which many sex hormones including testosterone and adrenal gland hormones are synthesized.

I'm sure you've seen this image before.

View attachment 3788507

There are a few studies claiming there is a weak correlation between dietary cholesterol and total testosterone levels.

This study suggests that HDL levels are correlated with androgen levels.

And this one suggests the opposite.

View attachment 3788631

It is only logical that cholesterol affects hormone levels via the steroidogenesis pathway. Though additional dietary cholesterol intake may not result in increased testosterone levels.

Additionally the body compensates for dietary cholesterol intake by reducing its own cholesterol production.(1)

Unlike what many believe dietary cholesterol doesn't cross the blood-brain barrier.

The brain produces its own supply via astrocytes.(2)

What does this tell us?

Cholesterol isn't bad at all. The dose makes the poison. The thing is, you can't know if it is the poison without getting a blood test.

Stay better safe than sorry. Use this table as a general guide.

View attachment 3788530

Additionally you can use Apob/ApoA as guidance, since all those values correlate with eachother.

View attachment 3788557

Atherosclerosis

Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous elements in the large arteries in response to oxidative stress.(3)

Let me make it more clear: There are multiple factors contributing to atherosclerosis.

Gene polymorphisms heavily influence whether your body can effectively clear LDL cholesterol.

I checked my genome and found a mutation in the LDL-R

View attachment 3788672

Apart from that obviously LDL and HDL levels directly influence the risk of developing atherosclerosis. Oxidative stress is a heavily underestimated factor too.

The best way to mitigate the risks would be decreasing all of those factors.

This is where the real thread starts.

Effective ways to reduce your risk of developing atherosclerosis

Low bodyfat%

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

View attachment 3788702

It can improve your lipids naturally without pharmacological intervention.(4)

Exercise

Be it aerobic exercise or strength training, just be the fuck in shape and move.

View attachment 3789069

This will also manage your blood pressure naturally.(5)

Antioxidants

To mitigate the oxidative stress aspect of atherosclerosis you should eat a balanced, non-processed diet. It is fucking simple.

Extremely beneficial antioxidants include coQ10, OPC and NAC just to name a few.

Quit smoking

Smoking is one of the worst things you could do for your lipids and health in general.

There are three primary ways in how smoking affects coronary heart disease.(6)

1. Carbon monoxide promotes atherogenesis by damaging the endothelium and reducing oxygen delivery.

2. Nicotine stimulates the adrenergic system, leading to increased blood pressure and myocardial oxygen demand.

3. Smoking disrupts the lipid metabolism resulting in higher LDL and lower HDL cholesterol levels.

View attachment 3788747

Also keep in mind smokers usually maintain a lower bf%, meaning smoking completely negates the benefits of being at a low bf% in the first place.
There are countless other risks associated with smoking. If you insist on continuing, don’t call yourself a Looksmaxxer.

Pharmacology

Now that we covered the water topics let's discuss the real shit. This is for you if you want to take your longevity protocol to the next level.

Statins

Spoiler: Statins

General info

Let’s cover this first. It’s the primary normie method for lowering cholesterol and LDL levels.

They’re also the best-selling pharmaceuticals ever in history so if you’re skeptical about biased/manipulated studies, this is one of the first compounds you should question.(7)

Statins are generally less effective in treating individuals with genetic disorders such as familial hypercholesterolemia.

Mechanisms of action

Statins work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway.

They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream.

Benefits

Reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins.

Statins also slightly activate PPARα via overexpression of COX-2.

Side effects

We can differentiate between two groups of statins:

Hydrophilic statins: Won't cross the blood-brain barrier, more inflammation.

Examples: Rosuvastatin and pravastatin.

Lipophilic statins: Crosses the blood-brain barrier, less inflammation.

Examples: Pitavastatin, atorvastatin and simvastatin.

Besides that statins have a ±10% risk of diabetes in men.(8)

Recommendation

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile.

Pitavastatin

A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks.(9)

Dosage: Take 1-4mg daily.

Rosuvastatin

This is by far one of the best statins besides pitavastatin in terms of side effect profile and effectiveness.

View attachment 3788822

Dosage: You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.(10)

Ezetimibe

Spoiler: Ezetimibe

Ezetimibe inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol.

It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein.(11)

It doesn't affect fat-soluble vitamins unlike popular belief.(12)

View attachment 3788827

Ezetimibe monotherapy isn't as effective as combining it with another compound like statins.

Dosage: 5-10mg once daily.

Obicetrapip

Spoiler: Obicetrapib

Obicetrapip is the first CETP inhibitor that effectively manages lipids without being utter garbage. It is significantly better than torcetrapib, dalcetrapib and evacetrapib combined.

The compound is quite new and already showed promising results. Besides that it improves alzheimer's disease.

"LDL-C decreased from baseline to week 12 by 63.4%, 43.5%, and 6.35% in combination, monotherapy, and placebo groups, respectively (p<0.0001 vs. Placebo)."(13)

Both active treatments also significantly reduced concentrations of non-HDL-C, apolipoprotein B, and total and small LDL particles. Obicetrapib was well tolerated and no safety issues were identified.(13)

Combining it with another compound would be a good choice as with ezetimibe.

Dosage: 5-10mg daily.

PCSK-9 inhibitors

Spoiler: PCSK-9 inhibitors

This is one of the best pathways to improve your lipids drastically.

PCSK-9 inhibitors are fully humanized monoclonal antibodies that prevent the enzyme PCSK-9 from binding to LDL receptors in the liver. This leads to an upregulation in receptors leading to a reduction in LDL.

The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies.(14)

Dosage: Alirocumab and evolocumab are injected subcutaneously every 2 to 4 weeks. Sourcing is extremely hard and you are better off trying to get a prescription.

Here is my personal alirocumab.

View attachment 3788838

It is extremely expensive, so try to have the cost covered by your health insurance.

SR9009

Spoiler: SR9009

SR9009 (Stenabolic) is an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. It is being used to boost mitochondrial activity and fat metabolism. It can also have a positive impact on your circadian rhythm, endurance and inflammation.

View attachment 3788846

You can see a few benefits of agonizing this pathway below.

View attachment 3788847

You should use this compound ideally for the lipid aspect, in conjunction with the tons of other benefits. If you're trying to negate some side effects of PEDs, you should look into SR9009/SR9011 as well.(15)

Dosage: 10-40mg.(16)

Retatrutide

Spoiler: Retatrutide

Retatrutide is a godsent molecule. It is a triple agonist of GLP-1, GIP and the glucagon receptor.

You can expect an inprovement in insulin sensitivity, increased energy expenditure, appetite supression and barely any side effects.

It also can support lipids drastically.

"apoB was reduced by up to 19.6% and 24.2% at 24 and 48 weeks"(17)

"At 48 weeks, the drug reduced triglycerides and apoC-III levels by up to 40.6% and 38.0%"(17)

"Retatrutide also reduced the number of total and highly atherogenic small LDL particles (LDLP)"(17)

Retatrutide is by far one of the best compounds for literally anything, be it Looksmaxxing or just general health.

Dosage: Anything between 4-8mg weekly is a good effective dose. Dosages above 8mg have extreme diminishing returns in terms of effectiveness. You can split the dosage to twice a week.

Bempedoic acid

Spoiler: Bempedoic acid

Bempedoic Acid is an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins.

"At week 12, bempedoic acid reduced the mean LDL cholesterol level by 19.2 mg per deciliter (0.50 mmol per liter)."(18)

Dosage: 180mg daily.(19)

Spoiler: Tags

@chadisbeingmade @Clavicular @Orc @Eltrē @Magnum Opus

​

Do you study science or is this just for the fun of the game?

 

[illmogsoonenuf]

How to manage your cholesterol effectively - The last secret about longevity
View attachment 3788453


What is cholesterol?

Disclaimer: For the sake of this thread, I want you to forget everything you’ve ever heard about cholesterol.

Cholesterol is a fatty substance essential for many processes in the body and is found in every animal cell.

View attachment 3788906

Managing your cholesterol is extremely important. Cardiovascular diseases remain the leading cause of death worldwide.

View attachment 3788463

The Role of cholesterol in the body

Now unlike DHT after puberty, cholesterol is quite important and you should think twice before nuking it to the ground.

Cholesterol is required to build and maintain membranes and helps in regulating their fluidity. It also affects substrate presentation and plays a major role in the epidermis and has its own signalling pathways.

View attachment 3788494

The most important aspect of cholesterol though is the steroidogenesis, the process by which many sex hormones including testosterone and adrenal gland hormones are synthesized.

I'm sure you've seen this image before.

View attachment 3788507

There are a few studies claiming there is a weak correlation between dietary cholesterol and total testosterone levels.

This study suggests that HDL levels are correlated with androgen levels.

And this one suggests the opposite.

View attachment 3788631

It is only logical that cholesterol affects hormone levels via the steroidogenesis pathway. Though additional dietary cholesterol intake may not result in increased testosterone levels.

Additionally the body compensates for dietary cholesterol intake by reducing its own cholesterol production.(1)

Unlike what many believe dietary cholesterol doesn't cross the blood-brain barrier.

The brain produces its own supply via astrocytes.(2)

What does this tell us?

Cholesterol isn't bad at all. The dose makes the poison. The thing is, you can't know if it is the poison without getting a blood test.

Stay better safe than sorry. Use this table as a general guide.

View attachment 3788530

Additionally you can use Apob/ApoA as guidance, since all those values correlate with eachother.

View attachment 3788557

Atherosclerosis

Atherosclerosis is a progressive disease marked by the accumulation of lipids and fibrous elements in the large arteries in response to oxidative stress.(3)

Let me make it more clear: There are multiple factors contributing to atherosclerosis.

Gene polymorphisms heavily influence whether your body can effectively clear LDL cholesterol.

I checked my genome and found a mutation in the LDL-R

View attachment 3788672

Apart from that obviously LDL and HDL levels directly influence the risk of developing atherosclerosis. Oxidative stress is a heavily underestimated factor too.

The best way to mitigate the risks would be decreasing all of those factors.

This is where the real thread starts.

Effective ways to reduce your risk of developing atherosclerosis

Low bodyfat%

It may not look healthy to normies, but being at a low bodyfat% in general is extremely healthy while being the biggest Looksmax simultaneously.

View attachment 3788702

It can improve your lipids naturally without pharmacological intervention.(4)

Exercise

Be it aerobic exercise or strength training, just be the fuck in shape and move.

View attachment 3789069

This will also manage your blood pressure naturally.(5)

Antioxidants

To mitigate the oxidative stress aspect of atherosclerosis you should eat a balanced, non-processed diet. It is fucking simple.

Extremely beneficial antioxidants include coQ10, OPC and NAC just to name a few.

Quit smoking

Smoking is one of the worst things you could do for your lipids and health in general.

There are three primary ways in how smoking affects coronary heart disease.(6)

1. Carbon monoxide promotes atherogenesis by damaging the endothelium and reducing oxygen delivery.

2. Nicotine stimulates the adrenergic system, leading to increased blood pressure and myocardial oxygen demand.

3. Smoking disrupts the lipid metabolism resulting in higher LDL and lower HDL cholesterol levels.

View attachment 3788747

Also keep in mind smokers usually maintain a lower bf%, meaning smoking completely negates the benefits of being at a low bf% in the first place.
There are countless other risks associated with smoking. If you insist on continuing, don’t call yourself a Looksmaxxer.

Pharmacology

Now that we covered the water topics let's discuss the real shit. This is for you if you want to take your longevity protocol to the next level.

Statins

Spoiler: Statins

General info

Let’s cover this first. It’s the primary normie method for lowering cholesterol and LDL levels.

They’re also the best-selling pharmaceuticals ever in history so if you’re skeptical about biased/manipulated studies, this is one of the first compounds you should question.(7)

Statins are generally less effective in treating individuals with genetic disorders such as familial hypercholesterolemia.

Mechanisms of action

Statins work by inhibiting HMG-CoA reductase, an enzyme involved in a key step of the cholesterol synthesis pathway.

They also increase LDL receptors in the liver meaning more LDL can be removed from the bloodstream.

Benefits

Reduction in C-Reactive protein, tumornecrosis factor alpha and interleukins.

Statins also slightly activate PPARα via overexpression of COX-2.

Side effects

We can differentiate between two groups of statins:

Hydrophilic statins: Won't cross the blood-brain barrier, more inflammation.

Examples: Rosuvastatin and pravastatin.

Lipophilic statins: Crosses the blood-brain barrier, less inflammation.

Examples: Pitavastatin, atorvastatin and simvastatin.

Besides that statins have a ±10% risk of diabetes in men.(8)

Recommendation

The best statins by far are pitavastatin and rosuvastatin as they have the best side effect profile.

Pitavastatin

A study shows that pitavastatin reduces total cholesterol by 21%, LDL-C by 31% and increases HDL-C by 14% and 25% at 12 and 104 weeks.(9)

Dosage: Take 1-4mg daily.

Rosuvastatin

This is by far one of the best statins besides pitavastatin in terms of side effect profile and effectiveness.

View attachment 3788822

Dosage: You can take anything from 5 to 40mg. Even a low dosage of 5mg seems to be quite effective.(10)

Ezetimibe

Spoiler: Ezetimibe

Ezetimibe inhibits the absorption of dietary cholesterol. You can expect a reduction of around 30% in total cholesterol.

It can improve nonalcoholic fatty liver disease. Besides that ezetimibe reduces c-reactive protein.(11)

It doesn't affect fat-soluble vitamins unlike popular belief.(12)

View attachment 3788827

Ezetimibe monotherapy isn't as effective as combining it with another compound like statins.

Dosage: 5-10mg once daily.

Obicetrapip

Spoiler: Obicetrapib

Obicetrapip is the first CETP inhibitor that effectively manages lipids without being utter garbage. It is significantly better than torcetrapib, dalcetrapib and evacetrapib combined.

The compound is quite new and already showed promising results. Besides that it improves alzheimer's disease.

"LDL-C decreased from baseline to week 12 by 63.4%, 43.5%, and 6.35% in combination, monotherapy, and placebo groups, respectively (p<0.0001 vs. Placebo)."(13)

Both active treatments also significantly reduced concentrations of non-HDL-C, apolipoprotein B, and total and small LDL particles. Obicetrapib was well tolerated and no safety issues were identified.(13)

Combining it with another compound would be a good choice as with ezetimibe.

Dosage: 5-10mg daily.

PCSK-9 inhibitors

Spoiler: PCSK-9 inhibitors

This is one of the best pathways to improve your lipids drastically.

PCSK-9 inhibitors are fully humanized monoclonal antibodies that prevent the enzyme PCSK-9 from binding to LDL receptors in the liver. This leads to an upregulation in receptors leading to a reduction in LDL.

The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies.(14)

Dosage: Alirocumab and evolocumab are injected subcutaneously every 2 to 4 weeks. Sourcing is extremely hard and you are better off trying to get a prescription.

Here is my personal alirocumab.

View attachment 3788838

It is extremely expensive, so try to have the cost covered by your health insurance.

SR9009

Spoiler: SR9009

SR9009 (Stenabolic) is an agonist of Rev-Erbα/ß along with SR9011 and other synthetic Rev-Erbα/ß ligands. It is being used to boost mitochondrial activity and fat metabolism. It can also have a positive impact on your circadian rhythm, endurance and inflammation.

View attachment 3788846

You can see a few benefits of agonizing this pathway below.

View attachment 3788847

You should use this compound ideally for the lipid aspect, in conjunction with the tons of other benefits. If you're trying to negate some side effects of PEDs, you should look into SR9009/SR9011 as well.(15)

Dosage: 10-40mg.(16)

Retatrutide

Spoiler: Retatrutide

Retatrutide is a godsent molecule. It is a triple agonist of GLP-1, GIP and the glucagon receptor.

You can expect an inprovement in insulin sensitivity, increased energy expenditure, appetite supression and barely any side effects.

It also can support lipids drastically.

"apoB was reduced by up to 19.6% and 24.2% at 24 and 48 weeks"(17)

"At 48 weeks, the drug reduced triglycerides and apoC-III levels by up to 40.6% and 38.0%"(17)

"Retatrutide also reduced the number of total and highly atherogenic small LDL particles (LDLP)"(17)

Retatrutide is by far one of the best compounds for literally anything, be it Looksmaxxing or just general health.

Dosage: Anything between 4-8mg weekly is a good effective dose. Dosages above 8mg have extreme diminishing returns in terms of effectiveness. You can split the dosage to twice a week.

Bempedoic acid

Spoiler: Bempedoic acid

Bempedoic Acid is an oral prodrug that inhibits ATP citrate lyase, which is involved in the liver's biosynthesis of cholesterol upstream of HMG-CoA reductase, the enzyme that is blocked by statins.

"At week 12, bempedoic acid reduced the mean LDL cholesterol level by 19.2 mg per deciliter (0.50 mmol per liter)."(18)

Dosage: 180mg daily.(19)

Spoiler: Tags

@chadisbeingmade @Clavicular @Orc @Eltrē @Magnum Opus

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Does the smoking shit also apply to vaping cuz that might explain why my hdl is low and vldl is high even though I eat healthy, excersize and sleep

 

[yuuwaku]

saar but lord Goatisss sad that extremely high cholesterol is good

dietary cholesterol literally has 0 affect to blood cholesterol

 

[yoojoordaan]

“But cholesterol” kys

 

[yoojoordaan]

blud ghost tagged me

Kys

 

[blameurself]

Mirin'

does smoking weed versus nicotine make a difference in terms of the impact it has on your cholesterol?

 

[Aden.]

How do i get Pitavastatin

 

[Xazzy]

hmm

 

[Jonasㅤㅤ]

why do you wanna live long?

That should be your reason. If you don't have any answer to that question yourself, spend your life trying to find a reason.

Without being healthy you'll have a hard time doing that.

Does the smoking shit also apply to vaping cuz that might explain why my hdl is low and vldl is high even though I eat healthy, excersize and sleep

Even if it didn't affect your lipids, you shouldn't vape or smoke at all.

And yes, it affects your lipid profile.

Lipid profiles in users of combustible and electronic cigarettes - PMC

Electronic cigarette use has especially risen among adolescents and young adults. The aim of this study was to investigate fasting blood glucose and lipid profiles in chronic combustible cigarette and electronic cigarette users. We evaluated ...

pmc.ncbi.nlm.nih.gov

does smoking weed versus nicotine make a difference in terms of the impact it has on your cholesterol?

Just stunt your brain development instead, great idea.

Do you really need someone to reassure you that something is bad, use your own fucking brain.

Effects of Cannabis on the Adolescent Brain - PMC

This article reviews neuroimaging, neurocognitive, and preclinical findings on the effects of cannabis on the adolescent brain. Marijuana is the second most widely used intoxicant in adolescence, and teens who engage in heavy marijuana use often ...

pmc.ncbi.nlm.nih.gov

How do i get Pitavastatin

You can buy it the legal way with a prescription.

Or you simply buy it online and no, I won't give you a source.

@chadbeingmade @imontheloose

 

[org3cel.RR]

That should be your reason. If you don't have any answer to that question yourself, spend your life trying to find a reason.

Without being healthy you'll have a hard time doing that.

Even if it didn't affect your lipids, you shouldn't vape or smoke at all.

And yes, it affects your lipid profile.

View attachment 3861298

Lipid profiles in users of combustible and electronic cigarettes - PMC

Electronic cigarette use has especially risen among adolescents and young adults. The aim of this study was to investigate fasting blood glucose and lipid profiles in chronic combustible cigarette and electronic cigarette users. We evaluated ...

pmc.ncbi.nlm.nih.gov

Just stunt your brain development instead, great idea.

Do you really need someone to reassure you that something is bad, use your own fucking brain.

Effects of Cannabis on the Adolescent Brain - PMC

This article reviews neuroimaging, neurocognitive, and preclinical findings on the effects of cannabis on the adolescent brain. Marijuana is the second most widely used intoxicant in adolescence, and teens who engage in heavy marijuana use often ...

pmc.ncbi.nlm.nih.gov

You can buy it the legal way with a prescription.

Or you simply buy it online and no, I won't give you a source.

@chadbeingmade @imontheloose

Nice post, most substances like cannabis and alcohol can ruin brain development in many ways.
Every time you make a good response like this mark me too if possible so I could learn more

 

[imontheloose]

Nice post, most substances like cannabis and alcohol can ruin brain development in many ways.
Every time you make a good response like this mark me too if possible so I could learn more

I’m drunk right now.

 

[org3cel.RR]

I’m drunk right now.

I dont think I ever got fully drunk, how much did you drink?

 

[imontheloose]

I dont think I ever got fully drunk, how much did you drink?

On my 9th pint.

 

[org3cel.RR]

On my 9th pint.

Mirin I normally drink 4 max, I dont like the taste of beer at all, I prefer to drink "caipirinha" or "tequilla". Depending on where you live you may or not have them

 

[imontheloose]

Mirin I normally drink 4 max, I dont like the taste of beer at all, I prefer to drink "caipirinha" or "tequilla". Depending on where you live you may or not have them

I’m in England. Anything with alcohol in it we have mate. I’ve had a shot of whisky but that does fuck all to me. I’m drunk but not hammered. Takes me about a dozen-odd to get hammered.

 

[org3cel.RR]

I’m in England.

nice one im in Portugal, we are best buddies since 1373 haha

Anything with alcohol in it we have mate.

Same here we love getting hang over

I’ve had a shot of whisky but that does fuck all to me.

4 shots of vodka dont hurt anyone haha
never did shots of whisky tho

I’m drunk but not hammered. Takes me about a dozen-odd to get hammered.

Impressive u must be heavy

 

[imontheloose]

nice one im in Portugal, we are best buddies since 1373 haha

I’ve been wanting to visit Portugal for ages. Was thinking of visiting vila nova de gaia soon. And yes! Old comrade! We are very good friends. Most people are unaware how good of friends we’ve been throughout the years.

Same here we love getting hang over

No wonder the English and the Portuguese are friends then!

4 shots of vodka dont hurt anyone haha
never did shots of whisky tho

I love both vodka and whisky. I love rum much more, however. I’m a rum guy. I don’t have it often though. I prefer a little voddy shot or a whisky shot.

Impressive u must be heavy

I’m skinny. I can just drink so much alcohol because we have a culture for this. Not only is it in my genes, but we used to drink in parks and stuff as teens.

 

[org3cel.RR]

I’ve been wanting to visit Portugal for ages. Was thinking of visiting vila nova de gaia soon. And yes!

hell yeah mate, Im going to albufeira this summer its gonna be lit, its almost 70% brits only

Old comrade! We are very good friends. Most people are unaware how good of friends we’ve been throughout the years.

I totally agree, its our little secret

No wonder the English and the Portuguese are friends then!

Heck yeah! Different country same traditions

I love both vodka and whisky. I love rum much more, however. I’m a rum guy. I don’t have it often though. I prefer a little voddy shot or a whisky shot.

I dont know why I never tried rum, I dont think I even ever saw a bottle of it. Maybe I drank it but didnt know lol. Does it taste like vodka?

I’m skinny. I can just drink so much alcohol because we have a culture for this. Not only is it in my genes, but we used to drink in parks and stuff as teens.

Same for me im 70kg but I can drink alot even tho im a teen, its in our genes we can handle a dozen of shots in a row!

 

[imontheloose]

hell yeah mate, Im going to albufeira this summer its gonna be lit, its almost 70% brits only

Nothing I hate more than 50-year-old footy hooligans.

I totally agree, its our little secret

The oldest alliance still in history today. We had a pretty big day about it in 2023 as it was 650 years since the treaty. I love Portugal. I’ve got a little soft spot for it. It’s in my Anglo blood. The only other country I’d fight for would be Portugal. If it wasn’t for the Portuguese, we’d be under French rule. It will stay a perpetual friendship.

Heck yeah! Different country same traditions

True!

I dont know why I never tried rum, I dont think I even ever saw a bottle of it. Maybe I drank it but didnt know lol. Does it taste like vodka?

You probably have. It’s most commonly mixed into things like sprite. Rum and vodka are pretty different. Vodka’s rather neutral in flavour, just an ethanol burn. Even some white rum can have sweetness. If it’s aged then it’ll have even more layers to it.

Same for me im 70kg but I can drink alot even tho im a teen, its in our genes we can handle a dozen of shots in a row!

Very true indeed.

 

[FlotPSL]

Nothing I hate more than 50-year-old footy hooligans.

The oldest alliance still in history today. We had a pretty big day about it in 2023 as it was 650 years since the treaty. I love Portugal. I’ve got a little soft spot for it. It’s in my Anglo blood. The only other country I’d fight for would be Portugal. If it wasn’t for the Portuguese, we’d be under French rule. It will stay a perpetual friendship.View attachment 3862253View attachment 3862255View attachment 3862256
View attachment 3862257

True!

You probably have. It’s most commonly mixed into things like sprite. Rum and vodka are pretty different. Vodka’s rather neutral in flavour, just an ethanol burn. Even some white rum can have sweetness. If it’s aged then it’ll have even more layers to it.

Very true indeed.

Todays portuguese are mixed with arabs

 

[imontheloose]

Todays portuguese are mixed with arabs

Yes. Just learning about Meds?

 

[FlotPSL]

Just learning about Meds?

Ofcourse not,i just though u werent aware they are mixed

 

[imontheloose]

Ofcourse not,i just though u werent aware they are mixed

Of course I am. I still like the Portuguese. They’ve put their soldiers up to die for Britain for centuries. We’d be speaking French if it wasn’t for them. That doesn’t mean they’re white. If I was a British Hitler, Portugal could be my Italy.

 

[swagstar]

The stress relief is only temporary. The downsides outweigh the supposed benefits fully.




It also increases oxidative stress.(1)

View attachment 3791012

The relief from smoking is as with any other drug, it's temporary and not mediated via a reduction in cortisol but rather other pathways in the brain like agonism of nicotinic acetylcholine receptors. Nicotine upregulates these receptors causing a higher demand in receptor activation leading to withdrawal symptoms.

drn it has so much aura

 

[swagstar]

Does the smoking shit also apply to vaping cuz that might explain why my hdl is low and vldl is high even though I eat healthy, excersize and sleep

ofc

 

[DNRDniggerking]

That should be your reason. If you don't have any answer to that question yourself, spend your life trying to find a reason.

Without being healthy you'll have a hard time doing that.

life is shit,miserable and full of suffering and pain.

 

[blameurself]

That should be your reason. If you don't have any answer to that question yourself, spend your life trying to find a reason.

Without being healthy you'll have a hard time doing that.

Even if it didn't affect your lipids, you shouldn't vape or smoke at all.

And yes, it affects your lipid profile.

View attachment 3861298

Lipid profiles in users of combustible and electronic cigarettes - PMC

Electronic cigarette use has especially risen among adolescents and young adults. The aim of this study was to investigate fasting blood glucose and lipid profiles in chronic combustible cigarette and electronic cigarette users. We evaluated ...

pmc.ncbi.nlm.nih.gov

Just stunt your brain development instead, great idea.

Do you really need someone to reassure you that something is bad, use your own fucking brain.

Effects of Cannabis on the Adolescent Brain - PMC

This article reviews neuroimaging, neurocognitive, and preclinical findings on the effects of cannabis on the adolescent brain. Marijuana is the second most widely used intoxicant in adolescence, and teens who engage in heavy marijuana use often ...

pmc.ncbi.nlm.nih.gov

You can buy it the legal way with a prescription.

Or you simply buy it online and no, I won't give you a source.

@chadbeingmade @imontheloose

Weed obv bad for ur brain but I dont care about that I care about my cholesterol lmao thats why im asking you if it has the same impact as nicotine because different substances impact different parts of your body. But since you dont want to answer the question ill just go research myself.

 

[RoadToLowMTN]

Any tips on how to reduce chronic inflammation in the body besides diet? Like CRP and ESR?