Thodian
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"WHY DO ROIDS CLOSE GROWTH PLATES EARLY?"
They dont. Its the over conversion of e2 from higher doses of test or other compounds.
High levels of e2 will cause growth plates to prematurely fuse this is why girls are shorter and stop growing younger than guys.
"HOW DO I PREVENT PLATES FROM FUSING THEN?"
DHED.
DHED is an inactive prodrug that selectively produces estrogen solely in the brain.
Meaning u can NUKE ur body e2 but still give ur brain the e2 it needs to function and for development.
And preventing ur growth plates from fusing.
pmc.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
They dont. Its the over conversion of e2 from higher doses of test or other compounds.
High levels of e2 will cause growth plates to prematurely fuse this is why girls are shorter and stop growing younger than guys.
Effect of estrogen on growth plate structure. Ovariectomized rabbits were treated with either i.m. E2 cypionate (●) or vehicle (○) beginning at age 16 weeks. Quantitative histology (mean ± SEM) was performed on sagittal, Masson Trichrome-stained sections by using a video measurement system. Heights were measured parallel to the chondrocyte columns. (C) Hypertrophic chondrocytes were operationally defined by a height of at least 10 μm. (D) Cell height was measured in the terminal hypertrophic chondrocyte, the chondrocyte located closest to the metaphysis. (E) Column density = the number of chondrocyte columns per 1-mm growth plate width. †, growth plates completely or nearly (>50%) fused were excluded from the analysis.
"HOW DO I PREVENT PLATES FROM FUSING THEN?"
DHED.
DHED is an inactive prodrug that selectively produces estrogen solely in the brain.
Meaning u can NUKE ur body e2 but still give ur brain the e2 it needs to function and for development.
And preventing ur growth plates from fusing.
Effect of estrogen on growth plate structure. Ovariectomized rabbits were treated with either i.m. E2 cypionate (●) or vehicle (○) beginning at age 16 weeks. Quantitative histology (mean ± SEM) was performed on sagittal, Masson Trichrome-stained sections by using a video measurement system. Heights were measured parallel to the chondrocyte columns. (C) Hypertrophic chondrocytes were operationally defined by a height of at least 10 μm. (D) Cell height was measured in the terminal hypertrophic chondrocyte, the chondrocyte located closest to the metaphysis. (E) Column density = the number of chondrocyte columns per 1-mm growth plate width. †, growth plates completely or nearly (>50%) fused were excluded from the analysis.
In conclusion, you can do roids and blast at a younger age and possibly get the dimo gains that would otherwise be harder past puberty without the worry of fusing growth plates.
Effects of estrogen on growth plate senescence and epiphyseal fusion - PMC
Estrogen is critical for epiphyseal fusion in both young men and women. In this study, we explored the cellular mechanisms by which estrogen causes this phenomenon. Juvenile ovariectomized female rabbits received either 70 μg/kg estradiol cypionate ...
pmc.ncbi.nlm.nih.gov
The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders - PMC
Many neurological and psychiatric maladies originate from the deprivation of the human brain from estrogens. However, current hormone therapies cannot be used safely to treat these conditions commonly associated with menopause because of detrimental ...
pmc.ncbi.nlm.nih.gov
