I just got the Pfitzer Covid Vaccine. Over?

[TsarTsar444]

How the hell is permanent?

Is the mRNA magically gonna convert itself in DNA an then recombine with your genome, which is located inside the nucleus and is inaccessible to all cytoplasmic DNA?

Even at that point how is gonna express itself without a promoter?


Again you guys don't understand shit about biology, pls stop talking about it

Correct, a mRNA cant enter the nucleas normally if it doesn’t have a specific signal sequence on it so its recognized by the NPC on the nuclear membrane.

I mean if it somehow theoretically enters the nucleas and it reverse transcripts itself, it can insert itself on a location of the chromosome where there is already an active promotor for some existing genes, so when the promotor gets activated for that normal genes it also stimulates the former rna sequence.

Ofcourse this is just me saying how it could happen, not that it would

Problem with mRNA vaccines to me is that we can't be sure about the long term activity of that protein in those cells. Reminder that there is a whole group of diseases associ3with misfolded proteins like Alzheimer. Who knows if for some reason the enzymes and protosomes mutate so they can't effectively degrade the spike proteins in the future

 

[TsarTsar444]

Op, you should have taken the Chinese one, it isn't mRNA based. Literally nothing bad could happen long term from that one. Jfl at u

 

[Deleted member 13021]

The problem with mRNA vaccines to me is that we can't be sure about the long term activity of that protein in those cells. Reminder that there is a whole group of diseases associ3with misfolded proteins like Alzheimer.

I'm not gonna argue about the first part because it's all still theoretical and the possibility for what we have described would be highly remote.

Yes but after a couple of days at most the mRNA would be degraded, so the total concentration of the protein in the cells would remain the same, instead of it rising like in Alzheimer or Huntington.

Other than that missfolded proteins associated with disease like Alzheimer have some peculiar characteristics which make them undegradable or close to it: they're fibrous proteins (their AA sequence is highly repeated) and they're classified in the MHC-1 as self proteins.

The covid modified spike protein is a globular protein and will never be classified as a self protein.

The real issue wouldn't be if the proteasome or protease mutate, i don't think you'd be able to live if either of both isn't correctly working, but if the spike proteins mutate, which is impossible since you'd need the DNA to mutate for that, and with this vaccine you don't have the DNA but only a limited amount of mRNA.

 

[TsarTsar444]

I'm not gonna argue about the first part because it's all still theoretical and the possibility for what we have described would be highly remote.

Yes but after a couple of days at most the mRNA would be degraded, so the total concentration of the protein in the cells would remain the same, instead of it rising like in Alzheimer or Huntington.

Other than that missfolded proteins associated with disease like Alzheimer have some peculiar characteristics which make them undegradable or close to it: they're fibrous proteins (their AA sequence is highly repeated) and they're classified in the MHC-1 as self proteins.

The covid modified spike protein is a globular protein and will never be classified as a self protein.

The real issue wouldn't be if the proteasome or protease mutate, i don't think you'd be able to live if either of both isn't correctly working, but if the spike proteins mutate, which is impossible since you'd need the DNA to mutate for that, and with this vaccine you don't have the DNA but only a limited amount of mRNA.

Oh didn't know they degrade after a short time. But then wouldn't the immunity not last very long?

There are some illnesses associated with mutation of the heat shock proteins and the enzyme that that binds a specific signal protein to the target protein that should be degraded in the proteosome. They aren't total deactivations but more like mutations on the activators or supresors which can make the proteosomes more or less active.

 

[Deleted member 13021]

Oh didn't know they degrade after a short time. But then wouldn't the immunity not last very long?

No, in the case of the old vaccines the antibodies were built to be complementary to the proteins present in the vaccine derived from the inactivation of the virus, in this case the proteins are built by your ribosomes reading the mRNA injected.

The principle is the same, the only thing which is different is the protein origin.

Also all RNA products have a very short half life, they need to be often replaced: that's why ribosome and tRNA transcription is costitutive.

mRNA are degraded when their 3'-polyA tail gets removed or is too short to support translation.
With every subsequent translation process the tail gets shorter and shorter to signal the reduction of the remaining useful life of the molecule, this is a necessary step as the mRNA sequence might accumulate mutations over time which would lead to a different translated protein.

There are some illnesses associated with mutation of the heat shock proteins and the enzyme that that binds a specific signal protein to the target protein that should be degraded in the proteosome. They aren't total deactivations but more like mutations on the activators or supresors which can make the proteosomes more or less active.

Yes but in this case the issue lays with the mutation of the hsp and the proteasome, not with the mRNA itself, the same would happen with endogenous mRNA.

Also I haven't personally studied mutations on those proteins, but I don't think they're correlated with a very long life span for the organism bearing them, if they're viable at all.

 

[okaycute]

No, in the case of the old vaccines the antibodies were built to be complementary to the proteins present in the vaccine derived from the inactivation of the virus, in this case the proteins are built by your ribosomes reading the mRNA injected.

The principle is the same, the only thing which is different is the protein origin.

Also all RNA products have a very short half life, they need to be often replaced: that's why ribosome and tRNA transcription is costitutive.

mRNA are degraded when their 3'-polyA tail gets removed or is too short to support translation.
With every subsequent translation process the tail gets shorter and shorter to signal the reduction of the remaining useful life of the molecule, this is a necessary step as the mRNA sequence might accumulate mutations over time which would lead to a different translated protein.



Yes but in this case the issue lays with the mutation of the hsp and the proteasome, not with the mRNA itself, the same would happen with endogenous mRNA.

Also I haven't personally studied mutations on those proteins, but I don't think they're correlated with a very long life span for the organism bearing them, if they're viable at all.

Okay, am I safe then? What's the verdict? Is it over for me?

 

[Deleted member 13021]

Okay, am I safe then? What's the verdict? Is it over for me?

Over from the perspective of this forum userbase.

Safe from the perspective of the scientific community.

You choose who you want to trust

 

[Songe]

it’s over for your iq
just inject an experimental medical juice while you’re 18 bro, u won’t be able to watch some movies produced by shalom records at the cinema otherwise !!

 

[oldcelloser]

I am 18 and I don't feel any pain

I got it because FDA approved Fitzer for emergency use so why trust incels over scientists

No hair loss or any shit people really are over exaggerating this shit

Anyways, how long does it take for this shit to leave my body? Ok

make a will OP srs
ive just had Covid and its a flu/cold
over for you

 

[Amnesia]

womb to tomb

destiny for many vaxcucks

 

[DesperadoRatado]

how long will this vaccine be in my body? I have a mega immune system (I've never been sick before to the point where I couldn't be able to go to school but like maybe a simple cold from there and then)

then why did you take it retard

 

[okaycute]

then why did you take it retard

lol because covid lowers your IQ apparently