I might have been wrong about fin and AD

[Deleted member 20914]

So basically finasteride blocks only type 2 5 alpha reductase, and so your body can still make allopregnanolone.

soz

 

[Nims]

soz

Dw no one read your post anyways greycel.

 

[Deleted member 20914]

Dw no one read your post anyways greycel.

actually a lot of people did.

A warning about Finasteride, Neurosteroids, and Alzheimer's disease.

Doesn't really concern me that much hopping off fin the first chance I get, just maintaining my hair until new treatments come out. It’s good that you researched it since this is something that you seem to be genetically prone to. What about getting allopregnanolone exogenously? How long does...

looksmax.org

 

[Kama]

It’s the opposite, finesteride blocks type 1 prevalent in skin and liver, dutesteride blocks type 1 & 2 (type 2 prevalence in prostate). Either way, DHT is the effective form of test so I’ll never mess with that unless I get prostate cancer when I’m old.

 

[Deleted member 20914]

It’s the opposite, finesteride blocks type 1 prevalent in skin and liver, dutesteride blocks type 1 & 2 (type 2 prevalence in prostate). Either way, DHT is the effective form of test so I’ll never mess with that unless I get prostate cancer when I’m old.

how long does it take you to search google.

Finasteride blocks type 2


"The enzyme 5α-reductase, which catalyzes the conversion of testosterone to its 5α-reduced form dihydrotestosterone (DHT), exists in 2 forms: Type 1 and Type 2. Finasteride inhibits Type 1 only, whereas dutasteride inhibits both Types 1 and 2."

What do you mean DHT is the effective form of testosterone? Testosterone does most of the work in the body after puberty

 

[Deleted member 20914]

It’s the opposite, finesteride blocks type 1 prevalent in skin and liver, dutesteride blocks type 1 & 2 (type 2 prevalence in prostate). Either way, DHT is the effective form of test so I’ll never mess with that unless I get prostate cancer when I’m old.

OK become a baldcel then

 

[Kama]

OK become a baldcel then

There’s other options like Follicular unit extraction you could do

 

[lasthope]

There’s other options like Follicular unit extraction you could do

Low iq greycel when will you learn

You will still lose hair behindert your HT until you run out of donor

 

[Deleted member 20914]

There’s other options like Follicular unit extraction you could do

You have no idea what you are talking about, lasthope is right.

You can transplant those hairs, but the non-transplanted ones will just continue to fall out and your hair will be super thin, and you don't have enough hair in the donor area to transplant a decent head of hair.

 

[Kama]

Low iq greycel when will you learn

You will still lose hair behindert your HT until you run out of donor

There’s downstream effects that cause miniaturization/loss of follicles/loss of telogenic phase, that science should be focusing on. Taking effective hormone blockers will effect lots of other organs, not just your hair. It’s like nuking entire country to kill 1 terror cell. And, no one really knows how blocking dht cause more hair growth precisely. The theory is that it preserves blood supply to hair follicle, but the medication wasn’t invented to cure baldness. For the sake of science, scientists made a compound and then figured out a way to make money by marketing to desperate baldies.

 

[Deleted member 20914]

There’s downstream effects that cause miniaturization/loss of follicles/loss of telogenic phase, that science should be focusing on. Taking effective hormone blockers will effect lots of other organs, not just your hair. It’s like nuking entire country to kill 1 terror cell. And, no one really knows how blocking dht cause more hair growth precisely. The theory is that it preserves blood supply to hair follicle, but the medication wasn’t invented to cure baldness. For the sake of science, scientists made a compound and then figured out a way to make money by marketing to desperate baldies.

Bro, go and do some research, you are making a fool of yourself.

Finasteride is not meant to regrow hair like minoxidil, rather, it is intended to prevent hair loss in the first place by reducing DHT, which causes MPB. Also, many scientists agree that DHT has very little purpose in the human body beyond puberty.

Additionally, finasteride was not a drug that was even made to treat baldness, it is made to treat prostate disease. It was just noticed as a side-effect that these guys were not losing their hair.

Stop coping and just take fin, or don't and go bald.

 

[lasthope]

There’s downstream effects that cause miniaturization/loss of follicles/loss of telogenic phase, that science should be focusing on. Taking effective hormone blockers will effect lots of other organs, not just your hair. It’s like nuking entire country to kill 1 terror cell. And, no one really knows how blocking dht cause more hair growth precisely. The theory is that it preserves blood supply to hair follicle, but the medication wasn’t invented to cure baldness. For the sake of science, scientists made a compound and then figured out a way to make money by marketing to desperate baldies.

Yeah you are right that there are some downstream effects we don’t know of
But it Doesn’t change the fact that fin is the only proven and effective way to treat hairloss

There is no another cure right now

 

[Deleted member 20914]

Yeah you are right that there are some downstream effects we don’t know of
But it Doesn’t change the fact that fin is the only proven and effective way to treat hairloss

There is no another cure right now

How do you know there are downstream effects? Fin has been taken safely for decades

 

[Deleted member 20914]

Yeah you are right that there are some downstream effects we don’t know of
But it Doesn’t change the fact that fin is the only proven and effective way to treat hairloss

There is no another cure right now

I was only concerned about neurosteroids, but it appears that finasteride shouldn't even impact that.

 

[lasthope]

How do you know there are downstream effects? Fin has been taken safely for decades

I mean downstream effects why hairloss happen in the first place

But yeah fin is safe for Most people

 

[Mr.Proper]

https://www.sciencedirect.com/science/article/abs/pii/S2451965022000254
"However, finasteride treatment also blocks the conversion of progesterone into allopregnanolone [50]. Therefore, this treatment is associated with significant side-effects, which are part of the post-finasteride syndrome [51,52]. As such, treatment with finasteride has been associated with severe depressive symptoms, anxiety, increased suicidality, and sexual dysfunction [27]. In addition to decreasing allopregnanolone levels, finasteride treatment is also associated with changes in the expression of GABAA receptor subunits that may contribute to the aberrant behavior observed in humans or animals after this treatment [51]. As supporting evidence, animals treated with a repeated finasteride administration show reduced formation of neuroactive steroids as well as they show depressive-like behaviors [53]."

 

[Deleted member 20914]

https://www.sciencedirect.com/science/article/abs/pii/S2451965022000254
"However, finasteride treatment also blocks the conversion of progesterone into allopregnanolone [50]. Therefore, this treatment is associated with significant side-effects, which are part of the post-finasteride syndrome [51,52]. As such, treatment with finasteride has been associated with severe depressive symptoms, anxiety, increased suicidality, and sexual dysfunction [27]. In addition to decreasing allopregnanolone levels, finasteride treatment is also associated with changes in the expression of GABAA receptor subunits that may contribute to the aberrant behavior observed in humans or animals after this treatment [51]. As supporting evidence, animals treated with a repeated finasteride administration show reduced formation of neuroactive steroids as well as they show depressive-like behaviors [53]."

Is that in humans or rats?

 

[Deleted member 20914]

https://www.sciencedirect.com/science/article/abs/pii/S2451965022000254
"However, finasteride treatment also blocks the conversion of progesterone into allopregnanolone [50]. Therefore, this treatment is associated with significant side-effects, which are part of the post-finasteride syndrome [51,52]. As such, treatment with finasteride has been associated with severe depressive symptoms, anxiety, increased suicidality, and sexual dysfunction [27]. In addition to decreasing allopregnanolone levels, finasteride treatment is also associated with changes in the expression of GABAA receptor subunits that may contribute to the aberrant behavior observed in humans or animals after this treatment [51]. As supporting evidence, animals treated with a repeated finasteride administration show reduced formation of neuroactive steroids as well as they show depressive-like behaviors [53]."

Yeah the study they referencesd was done in mice.

In mice Finasteride inhibits both type II and type I 5a-reductase, whereas in humans only type II is inhibited. Type I is responsible for Allo generation.

'Allopregnanolone is synthesized from progesterone by the sequential actions of two enzymes, 5α-reductase type I (5α-RI), which transforms progesterone into 5α-dihydroprogesterone, and 3α-hydroxysteroid dehydrogenase (3α-HSD)'

 

[Mr.Proper]

Yeah the study they referencesd was done in mice.

In mice Finasteride inhibits both type II and type I 5a-reductase, whereas in humans only type II is inhibited. Type I is responsible for Allo generation.

'Allopregnanolone is synthesized from progesterone by the sequential actions of two enzymes, 5α-reductase type I (5α-RI), which transforms progesterone into 5α-dihydroprogesterone, and 3α-hydroxysteroid dehydrogenase (3α-HSD)'

Cases of worsened mood and depression, however, are pretty known and I'm not against finasteride itself, but I'd like to know what's mechanism behind it in humans. Dht suppression alone shouldn't cause this.
Speaking about treatment - the novel prolactin (unexpectedly?) antibody is being tested now with good results and no similar side effects, but it's gonna be patented and I'm not sure if "knockoffs" (biosimilars) from India or other countries known for creating them can be available soon (would be great).

 

[Deleted member 20631]

Cases of worsened mood and depression, however, are pretty known and I'm not against finasteride itself, but I'd like to know what's mechanism behind it in humans. Dht suppression alone shouldn't cause this.
Speaking about treatment - the novel prolactin (unexpectedly?) antibody is being tested now with good results and no similar side effects, but it's gonna be patented and I'm not sure if "knockoffs" (biosimilars) from India or other countries known for creating them can be available soon (would be great).

Prolactin antibody results look insane. Regrowth of dormant hair follicles literally reverses balding.

Hopefully it’s out ASAP

 

[Buci]

I was only concerned about neurosteroids, but it appears that finasteride shouldn't even impact that.

You're an idiot. You literally cant produce alopregnanolone without 5alpha reductase

 

[Deleted member 20914]

You're an idiot. You literally cant produce alopregnanolone without 5alpha reductase

Yeah I know I was right all along, some articles say that only 5AR Type 1 is needed to produce Allo, which is true in the brain (debatable), but the brain relies on Allopregnanolone produced in many other organs which use 5AR Type 2.

It isn't actually 5AR which directly produces Allo, rather 5AR produced 5a-DHP, and this is needed to produce Allo.

5a-DHP is made with both type 1 and type 2 5AR, so by blocking all of type 2 there is far less of this available to produce Allo.

Long story short, I am not taking finasteride.

 

[Buci]

Yeah the study they referencesd was done in mice.

In mice Finasteride inhibits both type II and type I 5a-reductase, whereas in humans only type II is inhibited. Type I is responsible for Allo generation.

'Allopregnanolone is synthesized from progesterone by the sequential actions of two enzymes, 5α-reductase type I (5α-RI), which transforms progesterone into 5α-dihydroprogesterone, and 3α-hydroxysteroid dehydrogenase (3α-HSD)'

That true, where did you read that? Any other good in depth info on dht effects, neurosteroids and other shitck somewhere?

Also, isnt dht responsable for bigger jaw, wider shoulders etc in males, so wont these structure feminize over time without that hormone? Just like typical bone reasorbtion with age or loss of teeth?

 

[Deleted member 20914]

That true, where did you read that? Any other good in depth info on dht effects, neurosteroids and other shitck somewhere?

Also, isnt dht responsable for bigger jaw, wider shoulders etc in males, so wont these structure feminize over time without that hormone? Just like typical bone reasorbtion with age or loss of teeth?

Idk, I only care about neurosteroids tbh

And despite Haircafe copers it is clear that finasteride by its very mechanism inhibits Allopregnanolone production.

 

[Deleted member 15698]

Finasteride is a cult. People in that cult irrationally deny all side effects as part of a self gaslighting ritual.

Take it if you need to. But facts: finasteride nukes allopregnolone levels in your brain and causes the penis to shrink over the course of years

 

[lasthope]

Finasteride is a cult. People in that cult irrationally deny all side effects as part of a self gaslighting ritual.

Take it if you need to. But facts: finasteride nukes allopregnolone levels in your brain and causes the penis to shrink over the course of years

Cope

 

[Deleted member 15698]

Cope

Case in point. No intelligent rebuttal, just a 70 IQ “cope”

 

[Oberyn]

Finasteride is a cult. People in that cult irrationally deny all side effects as part of a self gaslighting ritual.

Take it if you need to. But facts: finasteride nukes allopregnolone levels in your brain and causes the penis to shrink over the course of years

yeah my dick has shrinked 3 inches dick after 4 years.

 

[Deleted member 20914]

Finasteride is a cult. People in that cult irrationally deny all side effects as part of a self gaslighting ritual.

Take it if you need to. But facts: finasteride nukes allopregnolone levels in your brain and causes the penis to shrink over the course of years

Idk about the penis part, but the allopregnanolone part is just basic biology.

The only part of the body where allopregnanolone can continue to be made whilst on finasteride is in the brain, as this is type 1 5AR. However, finasteride does still inhibit this significantly, but not completely.

This is a point that hair cafe makes, but he fails to recognize that the brain relies heavily on allo produced in many other organs, which use the type 2 isoenzyme of 5AR, which finasteride completely inhibits.

So you will still produce some allopregnanolone, namely, in the brain, just your brain won't be able to get external allopregnanolone, which is actually needs.