Ibutamoren 101 (MK-677): The Basics + How to Start

[Deroga]

im trying to ask jewgpt to calculate how much total APA and Chromium picolinate i need to order for a 2 month cycle and this mf is tryna say im putting myself in danger. That nigga wants to descend me or smth.

300mg twice a day of ala and 200mcg twice a day of pico

 

[ifidonthit6irope]

Want to be 6'5

Understandable but I have friends who are like 6 6 and 6 5 and they said they can't date girls who were regular height and they have a much harder time fitting into things then when they were a little shorter (6 - 6 2)

 

[whiteperson]

Understandable but I have friends who are like 6 6 and 6 5 and they said they can't date girls who were regular height and they have a much harder time fitting into things then when they were a little shorter (6 - 6 2)

theyre helping u cope brah

 

[ifidonthit6irope]

theyre helping u cope brah

Yea probably

 

[Deroga]

Understandable but I have friends who are like 6 6 and 6 5 and they said they can't date girls who were regular height and they have a much harder time fitting into things then when they were a little shorter (6 - 6 2)

My uncles 6'6 and i genuinely feel inferior around him even tho im 6'2, have to hit at least 6'4

 

[Navity]

Yes but the main benefit is increased gh production. The other ones are just improved sleep and recovery which can be attained through changing your habits grey

12 posts ngr talking bout greys

 

[looksmaxxer29]

mk side effects arent that deep i ran like 30 mg for 3 months without berberine or any support nothing happend

 

[chudpiller]

@Deroga Have you started MK yet?
When I took it I got fat lwk.

My uncles 6'6 and i genuinely feel inferior around him even tho im 6'2, have to hit at least 6'4

Feel u brah, my dad is 6’6 and i’m 5’11. I get made fun of at family gatherings .

 

[Deroga]

@Deroga Have you started MK yet?
When I took it I got fat lwk.


Feel u brah, my dad is 6’6 and i’m 5’11. I get made fun of at family gatherings .

No but just ordered. 5'11 isn't a bad height, im like 6'1.5 barefoo tand i dont feel that much taller next to ppl 5'11. U can also larp 6'1 if u get good shoes prob

 

[Deroga]

mk side effects arent that deep i ran like 30 mg for 3 months without berberine or any support nothing happend

Your anecdotal expierence = for all cmon bro

 

[gymcelld]

Why you promoting such a shit drug you fucking brainlet

 

[Deroga]

Why you promoting such a shit drug you fucking brainlet

Your low iq genuinely makes my blood boil

 

[gymcelld]

Your low iq genuinely makes my blood boil

Mk 667 in 2026 holy shit well done on reducing competition mate

 

[Deroga]

Mk 667 in 2026 holy shit well done on reducing competition mate

Mk is equivalent to hgh essentially please do some fucking research and red pubmed articles instead of asking ChatGPT and thinking org threads with NO NUANCE will give u all the info available

 

[Navity]

What is Ibutamoren? (aka M-677, although Ibutamoren is the clinical name)

MK-677 is a growth hormone secretagogue. It works by mimicking the hunger hormone ghrelin, activating ghrelin (GHS-R1a) receptors in the brain and pituitary to boost pulsatile GH and IGF-1 release, which then feeds back on sleep-regulating centers/REM sleep.
As mentioned before, MK-677 is a selective, orally active agonist at the GH secretagogue receptor (GHS-R1a), the same receptor activated by endogenous ghrelin in the hypothalamus and pituitary. GHS-R1a activation leads to an increase in hypothalamic GHRH signaling and a reduction in somatostatin tone. Together, this stimulates somatotrophs in the pituitary to secrete GH in pulses. The liver and peripheral tissues respond to these repeated GH pulses with higher IGF-1 production.


Does this shit even work?
Short answer. Yes, and it is honestly underrated asf + a good way for new greycels to get into pharma without needing to inject shit into their bodies (which most will do incorrectly).

In calorie-restricted healthy adults, a single oral dose of MK-677 produced a peak GH concentration of 55.9 ± 31.7 micrograms/L on day 1 and 22.6 ± 9.3 micrograms/L after one week of daily dosing, still well above placebo. In that same study, mean IGF-1 fell with calorie restriction but then rose during MK-677 treatment to 264 ± 31 ng/mL versus 188 ± 19 ng/mL with placebo (P < 0.01), effectively reversing diet-induced IGF-1 decline and overshooting baseline.

In another JCEM study, MK-677 treatment in adults led to a 36% average increase in serum IGF-1 compared with placebo, along with a positive nitrogen balance.

I wouldn’t recommend being a pussy and taking 12.5mg, as it probably won’t have much effect. Take 25 mg/day, as this is what most clinical studies use and what is most reviewed in terms of the effects it produces.

You should do this 1–2 hours before bed, as we want to match and maximize your body’s natural nighttime GH and sleep rhythms. This also limits side effects such as daytime lethargy and hunger.

As we know, MK mimics ghrelin, which triggers a large GH pulse and a sustained IGF-1 rise. These hormones are naturally highest at night, especially during the first few sleep cycles, so a nighttime dose makes sense. Data also show that MK is absorbed rapidly when taken orally (reaching peak blood levels in 1–2 hours), so taking MK 1–2 hours before sleep is ideal.

As an added benefit, taking it in the evening before sleep aligns the GH-boosting window with your strongest natural GH pulses instead of shifting them into the middle of the daytime, when they can cause lethargy and unusual or excessive hunger.

Sleep studies that observed improvements in slow-wave and REM sleep used bedtime/evening dosing (e.g., 25 mg nightly for 7–14 days) and reported approximately 50% more deep stage IV sleep and over 20% more REM in young adults.

To align this with sleep optimization, you should avoid eating any food 3 hours before sleep (to prevent insulin from blunting GH). Take the MK-677, then go to bed about 1.5 hours later (for example, I go to bed at 9:30 PM (ik lmfao) so taking MK at 8:00 PM is optimal for me).


The most imperative issue to address with MK is its effect on gluconeogenesis and insulin sensitivity, meaning elevated blood glucose levels.

MK mimics ghrelin → increases GH/IGF-1 → increases gluconeogenesis in the liver → induces insulin resistance → reduces the body’s ability to regulate and control glucose (which can become elevated).

How do we address this? I often see people recommending berberine (even I used to, so shout out to @Zagro for helping me learn the downsides of it).

The best options are ALA and chromium picolinate, while worse options include berberine, metformin-related approaches, jaundice-related approaches, etc.

ALA (alpha-lipoic acid) = beneficial because it enhances insulin sensitivity, reduces MK-677–induced glucose spikes, and protects against oxidative stress without reducing IGF-1. Dosing = 300–600 mg daily, split into morning and night doses with meals (taken during an MK-677 cycle of 12.5 or 25 mg).

Chromium picolinate = beneficial because it improves glucose uptake via GLUT4, counters MK-induced insulin resistance, and causes minimal IGF-1 change. Dosing = 200 mcg split AM/PM with meals during the MK cycle.

Berberine = not recommended, as it lowers glucose via AMPK but downregulates IGF-1R in muscle (i.e., about a 16% IGF-1 drop). Berberine is also an AR degrader.

Metformin and jaundice-related compounds are also not ideal for regulating glucose in this context.

Other considerations include bloating (water retention), which can be managed with dandelion root, other simple protocols, and generally maintaining good health.

I would recommend pairing simple supplements such as taurine, theanine, glycine, and magnesium for sleep, along with zinc (15 mg daily) for immune health.

In short: take MK-677 at 25 mg daily (12.5 is fine ig) → dose 1–2 hours before bed to align with natural nighttime GH and reduce daytime lethargy/hunger → avoid eating 3 hours before sleep — for glucose control (since MK can raise blood sugar) → take ALA 300–600 mg/day split AM/PM with meals or chromium picolinate (my choice) 200 mcg/day split AM/PM with meals → avoid berberine, metformin-related compounds, and jaundice-related approaches — for support → add magnesium, glycine, theanine, or taurine if needed for sleep → take zinc 15 mg daily for immune health → use dandelion root if needed for water retention/bloating

This is pretty surface-level and doesn’t cover in MK in a lot of depth but this should be enough for you bhais and also I’m tired af so rep me pls

mirin

 

[azuo_las]

What is Ibutamoren? (aka M-677, although Ibutamoren is the clinical name)

MK-677 is a growth hormone secretagogue. It works by mimicking the hunger hormone ghrelin, activating ghrelin (GHS-R1a) receptors in the brain and pituitary to boost pulsatile GH and IGF-1 release, which then feeds back on sleep-regulating centers/REM sleep.
As mentioned before, MK-677 is a selective, orally active agonist at the GH secretagogue receptor (GHS-R1a), the same receptor activated by endogenous ghrelin in the hypothalamus and pituitary. GHS-R1a activation leads to an increase in hypothalamic GHRH signaling and a reduction in somatostatin tone. Together, this stimulates somatotrophs in the pituitary to secrete GH in pulses. The liver and peripheral tissues respond to these repeated GH pulses with higher IGF-1 production.


Does this shit even work?
Short answer. Yes, and it is honestly underrated asf + a good way for new greycels to get into pharma without needing to inject shit into their bodies (which most will do incorrectly).

In calorie-restricted healthy adults, a single oral dose of MK-677 produced a peak GH concentration of 55.9 ± 31.7 micrograms/L on day 1 and 22.6 ± 9.3 micrograms/L after one week of daily dosing, still well above placebo. In that same study, mean IGF-1 fell with calorie restriction but then rose during MK-677 treatment to 264 ± 31 ng/mL versus 188 ± 19 ng/mL with placebo (P < 0.01), effectively reversing diet-induced IGF-1 decline and overshooting baseline.

In another JCEM study, MK-677 treatment in adults led to a 36% average increase in serum IGF-1 compared with placebo, along with a positive nitrogen balance.

I wouldn’t recommend being a pussy and taking 12.5mg, as it probably won’t have much effect. Take 25 mg/day, as this is what most clinical studies use and what is most reviewed in terms of the effects it produces.

You should do this 1–2 hours before bed, as we want to match and maximize your body’s natural nighttime GH and sleep rhythms. This also limits side effects such as daytime lethargy and hunger.

As we know, MK mimics ghrelin, which triggers a large GH pulse and a sustained IGF-1 rise. These hormones are naturally highest at night, especially during the first few sleep cycles, so a nighttime dose makes sense. Data also show that MK is absorbed rapidly when taken orally (reaching peak blood levels in 1–2 hours), so taking MK 1–2 hours before sleep is ideal.

As an added benefit, taking it in the evening before sleep aligns the GH-boosting window with your strongest natural GH pulses instead of shifting them into the middle of the daytime, when they can cause lethargy and unusual or excessive hunger.

Sleep studies that observed improvements in slow-wave and REM sleep used bedtime/evening dosing (e.g., 25 mg nightly for 7–14 days) and reported approximately 50% more deep stage IV sleep and over 20% more REM in young adults.

To align this with sleep optimization, you should avoid eating any food 3 hours before sleep (to prevent insulin from blunting GH). Take the MK-677, then go to bed about 1.5 hours later (for example, I go to bed at 9:30 PM (ik lmfao) so taking MK at 8:00 PM is optimal for me).


The most imperative issue to address with MK is its effect on gluconeogenesis and insulin sensitivity, meaning elevated blood glucose levels.

MK mimics ghrelin → increases GH/IGF-1 → increases gluconeogenesis in the liver → induces insulin resistance → reduces the body’s ability to regulate and control glucose (which can become elevated).

How do we address this? I often see people recommending berberine (even I used to, so shout out to @Zagro for helping me learn the downsides of it).

The best options are ALA and chromium picolinate, while worse options include berberine, metformin-related approaches, jaundice-related approaches, etc.

ALA (alpha-lipoic acid) = beneficial because it enhances insulin sensitivity, reduces MK-677–induced glucose spikes, and protects against oxidative stress without reducing IGF-1. Dosing = 300–600 mg daily, split into morning and night doses with meals (taken during an MK-677 cycle of 12.5 or 25 mg).

Chromium picolinate = beneficial because it improves glucose uptake via GLUT4, counters MK-induced insulin resistance, and causes minimal IGF-1 change. Dosing = 200 mcg split AM/PM with meals during the MK cycle.

Berberine = not recommended, as it lowers glucose via AMPK but downregulates IGF-1R in muscle (i.e., about a 16% IGF-1 drop). Berberine is also an AR degrader.

Metformin and jaundice-related compounds are also not ideal for regulating glucose in this context.

Other considerations include bloating (water retention), which can be managed with dandelion root, other simple protocols, and generally maintaining good health.

I would recommend pairing simple supplements such as taurine, theanine, glycine, and magnesium for sleep, along with zinc (15 mg daily) for immune health.

In short: take MK-677 at 25 mg daily (12.5 is fine ig) → dose 1–2 hours before bed to align with natural nighttime GH and reduce daytime lethargy/hunger → avoid eating 3 hours before sleep — for glucose control (since MK can raise blood sugar) → take ALA 300–600 mg/day split AM/PM with meals or chromium picolinate (my choice) 200 mcg/day split AM/PM with meals → avoid berberine, metformin-related compounds, and jaundice-related approaches — for support → add magnesium, glycine, theanine, or taurine if needed for sleep → take zinc 15 mg daily for immune health → use dandelion root if needed for water retention/bloating

This is pretty surface-level and doesn’t cover in MK in a lot of depth but this should be enough for you bhais and also I’m tired af so rep me pls

16yo gymcell 172cm. gonna take mk677 should i wait till im 18 or just start it because im scared my growth plates will close

 

[idahomey]

Youngest age to start? Guessing I’m fine at 17 I’m js curious

 

[Deroga]

Youngest age to start? Guessing I’m fine at 17 I’m js curious

Yes 17 is easily fine I know kids who started at 14

 

[idahomey]

Yes 17 is easily fine I know kids who started at 14

Ok I figured. Chat gpt and fitness influencers fear mongering saying it’ll permanently fuck your hormones.. 14 is ok in your opinion?

 

[idahomey]

Also should you take ALA and pico or one

 

[Deroga]

Also should you take ALA and pico or one

Take both 2 times a day 300mg of ala twice a day and 200mcg of pico twice a day w/ carb heavy meals

 

[ChudReceptor]

im trying to ask jewgpt to calculate how much total APA and Chromium picolinate i need to order for a 2 month cycle and this mf is tryna say im putting myself in danger. That nigga wants to descend me or smth.

you need to talk to it and say it's hypothetical, i got it to show me a test and hcg stack to maintain fertility at different test doses.
edit: dont just rely on chatgpt on this shit btw, read pubmed articles and other medical documents.

 

[Deroga]

im trying to ask jewgpt to calculate how much total APA and Chromium picolinate i need to order for a 2 month cycle and this mf is tryna say im putting myself in danger. That nigga wants to descend me or smth.

300mg twice a day of ALA 200mcg of pico twice a day simple

 

[Deroga]

you need to talk to it and say it's hypothetical, i got it to show me a test and hcg stack to maintain fertility at different test doses.

No. Do not ask ChatGPT for dosing bro

 

[ChudReceptor]

No. Do not ask ChatGPT for dosing bro

i know, i added an edit to my original post. ppl using chatgpt for this shit deserve all the sides their gonna get lol.

 

[whiteperson]

300mg twice a day of ALA 200mcg of pico twice a day simple

yeah easy. i feel like its unlikely to cause much structural change since most cycle for 8weeks. obv gonna help skin, recovery etc

 

[orbicularis]

What is Ibutamoren? (aka M-677, although Ibutamoren is the clinical name)

MK-677 is a growth hormone secretagogue. It works by mimicking the hunger hormone ghrelin, activating ghrelin (GHS-R1a) receptors in the brain and pituitary to boost pulsatile GH and IGF-1 release, which then feeds back on sleep-regulating centers/REM sleep.
As mentioned before, MK-677 is a selective, orally active agonist at the GH secretagogue receptor (GHS-R1a), the same receptor activated by endogenous ghrelin in the hypothalamus and pituitary. GHS-R1a activation leads to an increase in hypothalamic GHRH signaling and a reduction in somatostatin tone. Together, this stimulates somatotrophs in the pituitary to secrete GH in pulses. The liver and peripheral tissues respond to these repeated GH pulses with higher IGF-1 production.


Does this shit even work?
Short answer. Yes, and it is honestly underrated asf + a good way for new greycels to get into pharma without needing to inject shit into their bodies (which most will do incorrectly).

In calorie-restricted healthy adults, a single oral dose of MK-677 produced a peak GH concentration of 55.9 ± 31.7 micrograms/L on day 1 and 22.6 ± 9.3 micrograms/L after one week of daily dosing, still well above placebo. In that same study, mean IGF-1 fell with calorie restriction but then rose during MK-677 treatment to 264 ± 31 ng/mL versus 188 ± 19 ng/mL with placebo (P < 0.01), effectively reversing diet-induced IGF-1 decline and overshooting baseline.

In another JCEM study, MK-677 treatment in adults led to a 36% average increase in serum IGF-1 compared with placebo, along with a positive nitrogen balance.

I wouldn’t recommend being a pussy and taking 12.5mg, as it probably won’t have much effect. Take 25 mg/day, as this is what most clinical studies use and what is most reviewed in terms of the effects it produces.

You should do this 1–2 hours before bed, as we want to match and maximize your body’s natural nighttime GH and sleep rhythms. This also limits side effects such as daytime lethargy and hunger.

As we know, MK mimics ghrelin, which triggers a large GH pulse and a sustained IGF-1 rise. These hormones are naturally highest at night, especially during the first few sleep cycles, so a nighttime dose makes sense. Data also show that MK is absorbed rapidly when taken orally (reaching peak blood levels in 1–2 hours), so taking MK 1–2 hours before sleep is ideal.

As an added benefit, taking it in the evening before sleep aligns the GH-boosting window with your strongest natural GH pulses instead of shifting them into the middle of the daytime, when they can cause lethargy and unusual or excessive hunger.

Sleep studies that observed improvements in slow-wave and REM sleep used bedtime/evening dosing (e.g., 25 mg nightly for 7–14 days) and reported approximately 50% more deep stage IV sleep and over 20% more REM in young adults.

To align this with sleep optimization, you should avoid eating any food 3 hours before sleep (to prevent insulin from blunting GH). Take the MK-677, then go to bed about 1.5 hours later (for example, I go to bed at 9:30 PM (ik lmfao) so taking MK at 8:00 PM is optimal for me).


The most imperative issue to address with MK is its effect on gluconeogenesis and insulin sensitivity, meaning elevated blood glucose levels.

MK mimics ghrelin → increases GH/IGF-1 → increases gluconeogenesis in the liver → induces insulin resistance → reduces the body’s ability to regulate and control glucose (which can become elevated).

How do we address this? I often see people recommending berberine (even I used to, so shout out to @Zagro for helping me learn the downsides of it).

The best options are ALA and chromium picolinate, while worse options include berberine, metformin-related approaches, jaundice-related approaches, etc.

ALA (alpha-lipoic acid) = beneficial because it enhances insulin sensitivity, reduces MK-677–induced glucose spikes, and protects against oxidative stress without reducing IGF-1. Dosing = 300–600 mg daily, split into morning and night doses with meals (taken during an MK-677 cycle of 12.5 or 25 mg).

Chromium picolinate = beneficial because it improves glucose uptake via GLUT4, counters MK-induced insulin resistance, and causes minimal IGF-1 change. Dosing = 200 mcg split AM/PM with meals during the MK cycle.

Berberine = not recommended, as it lowers glucose via AMPK but downregulates IGF-1R in muscle (i.e., about a 16% IGF-1 drop). Berberine is also an AR degrader.

Metformin and jaundice-related compounds are also not ideal for regulating glucose in this context.

Other considerations include bloating (water retention), which can be managed with dandelion root, other simple protocols, and generally maintaining good health.

I would recommend pairing simple supplements such as taurine, theanine, glycine, and magnesium for sleep, along with zinc (15 mg daily) for immune health.

In short: take MK-677 at 25 mg daily (12.5 is fine ig) → dose 1–2 hours before bed to align with natural nighttime GH and reduce daytime lethargy/hunger → avoid eating 3 hours before sleep — for glucose control (since MK can raise blood sugar) → take ALA 300–600 mg/day split AM/PM with meals or chromium picolinate (my choice) 200 mcg/day split AM/PM with meals → avoid berberine, metformin-related compounds, and jaundice-related approaches — for support → add magnesium, glycine, theanine, or taurine if needed for sleep → take zinc 15 mg daily for immune health → use dandelion root if needed for water retention/bloating

This is pretty surface-level and doesn’t cover in MK in a lot of depth but this should be enough for you bhais and also I’m tired af so rep me pls

Stoped reading when i saw it was a Mk guide , mirin effort tho

 

[HubertSkeletrix]

syringemax nga

 

[AlphaLooksmaxxer666]

good guide BUT
Still mogged by hgh.
I would try both tho

 

[chadbobbins]

what about Chromium + ALA?